Click here to switch to the map view.

The map label for this gene is hslU

Identifier: 82703661

GI number: 82703661

Start: 2914557

End: 2915888

Strand: Direct

Name: hslU

Synonym: Nmul_A2546

Alternate gene names: 82703661

Gene position: 2914557-2915888 (Clockwise)

Preceding gene: 82703660

Following gene: 82703667

Centisome position: 91.53

GC content: 54.13

Gene sequence:

>1332_bases
ATGTCTCAACTGACTCCCCGTGAAATCGTCCACGAGCTTGACAAGCACATCATAGGTCAGGATGCCGCCAAACGTTCGGT
TGCCATCGCGCTCAGGAATCGCTGGCGCCGGCAGCAGGTACAGGATCCACTGCGCCAGGAGATCACACCCAAGAATATTT
TGATGATCGGTCCCACGGGTGTCGGCAAGACGGAAATAGCGCGCCGGCTCGCGAAACTTGCGGATGCGCCGTTCATCAAG
GTGGAGGCAACCAAATTTACCGAAGTAGGGTATGTTGGGCGTGATGTGGATTCGATCATCCGTGATCTTGTGGAAGCGGC
GGTCAAGCAATCCCGGGAGCGTGAAACGCAAAAGATGCGGGCGCGCGCGGAAGACCATGCCGAGGAGCGCATTCTCGATG
TGCTATTGCCTGTGGCCAGGGAAACGGGGCTGCAGATGGACTCCATCGAAGCGGAAAGTGCTACCCGCCAGAAATTTCGA
AAGAAGCTGCGCGAGGGAGAGCTCAACGATAAGGAGATCGAAATCGAGTTGGCAACCCCGCATACCCACATGGAAATCTT
TGCCCCCCCCGGAATGGAAGAGCTGACAACGCAGATTCAAGGCATGTTCCAGAATCTGGGTGCGGAAAGAAAAAGGATGC
GAAAGCTTAAAATCCGCGAAGCGATGAAGCTCCTTATTGATGAGGAAGCCTCGAAGCTGGTTAATGATGAGGAATTGAAA
CTGCGCGCGGTGCAGAATGTCGAGCAGAACGGCATCGTGTTTCTGGATGAAATCGACAAGATCACGAGCCGTTCCGAGAC
TTCGGGGGCAGACGTATCGCGCCAGGGCGTTCAACGGGACCTGCTGCCTCTGGTCGAAGGTACCACGATTTCCACCAAAT
ATGGCATGATCAAGACAGATCATATTCTGTTTATCGCCAGCGGAGCCTTTCACCTCGCCAAGCCTTCCGATCTGATTCCC
GAGTTGCAGGGCCGTTTTCCAATCCGGGTCGAACTCACCAGTCTCAGCGCTGGCGATTTTGTACAAATCCTCACCAATAC
CGATGCCTGTTTGAAACGTCAATATGAAGCGCTGCTGGAAACCGAAGGGGTGAGGCTGGAATTTACCCCTGATGCGGTCA
AGCGTCTGGCGGAGATCGCCTTTGCAGTCAACGAAAAAACAGAGAATATTGGAGCACGGCGTCTTTATACCGCCATGGAA
AAACTGCTGGAGGATGTTTCGTTCGATGCGGAGAAACACCATGGAGATGCGGTTGTCATTGATGCCGCCTATGTGGATAA
ACGGCTCGGCGACCTGGCGCAAAGCGAGGATCTCGCCCGCTACGTGCTTTAA

Upstream 100 bases:

>100_bases
ATAGGACTGGCACCTCTATTCCGGTATAACCTTATGCCTTGTATCGTTTGTACTATTGCTTTGATTTCTCTCACCCCTTG
CCTTTATCGCTGACCTGATC

Downstream 100 bases:

>100_bases
GGAATCTCGGAACAAGTCTCCGCAGAGCGCGTTGCTGTTAAAATTGGGATGATCACAAGGCACAGTTCGAAGGTCGTAAT
CCAAACTACAATACTAAGAA

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSQLTPREIVHELDKHIIGQDAAKRSVAIALRNRWRRQQVQDPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIK
VEATKFTEVGYVGRDVDSIIRDLVEAAVKQSRERETQKMRARAEDHAEERILDVLLPVARETGLQMDSIEAESATRQKFR
KKLREGELNDKEIEIELATPHTHMEIFAPPGMEELTTQIQGMFQNLGAERKRMRKLKIREAMKLLIDEEASKLVNDEELK
LRAVQNVEQNGIVFLDEIDKITSRSETSGADVSRQGVQRDLLPLVEGTTISTKYGMIKTDHILFIASGAFHLAKPSDLIP
ELQGRFPIRVELTSLSAGDFVQILTNTDACLKRQYEALLETEGVRLEFTPDAVKRLAEIAFAVNEKTENIGARRLYTAME
KLLEDVSFDAEKHHGDAVVIDAAYVDKRLGDLAQSEDLARYVL

Sequences:

>Translated_443_residues
MSQLTPREIVHELDKHIIGQDAAKRSVAIALRNRWRRQQVQDPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIK
VEATKFTEVGYVGRDVDSIIRDLVEAAVKQSRERETQKMRARAEDHAEERILDVLLPVARETGLQMDSIEAESATRQKFR
KKLREGELNDKEIEIELATPHTHMEIFAPPGMEELTTQIQGMFQNLGAERKRMRKLKIREAMKLLIDEEASKLVNDEELK
LRAVQNVEQNGIVFLDEIDKITSRSETSGADVSRQGVQRDLLPLVEGTTISTKYGMIKTDHILFIASGAFHLAKPSDLIP
ELQGRFPIRVELTSLSAGDFVQILTNTDACLKRQYEALLETEGVRLEFTPDAVKRLAEIAFAVNEKTENIGARRLYTAME
KLLEDVSFDAEKHHGDAVVIDAAYVDKRLGDLAQSEDLARYVL
>Mature_442_residues
SQLTPREIVHELDKHIIGQDAAKRSVAIALRNRWRRQQVQDPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKV
EATKFTEVGYVGRDVDSIIRDLVEAAVKQSRERETQKMRARAEDHAEERILDVLLPVARETGLQMDSIEAESATRQKFRK
KLREGELNDKEIEIELATPHTHMEIFAPPGMEELTTQIQGMFQNLGAERKRMRKLKIREAMKLLIDEEASKLVNDEELKL
RAVQNVEQNGIVFLDEIDKITSRSETSGADVSRQGVQRDLLPLVEGTTISTKYGMIKTDHILFIASGAFHLAKPSDLIPE
LQGRFPIRVELTSLSAGDFVQILTNTDACLKRQYEALLETEGVRLEFTPDAVKRLAEIAFAVNEKTENIGARRLYTAMEK
LLEDVSFDAEKHHGDAVVIDAAYVDKRLGDLAQSEDLARYVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Escherichia coli, GI1790366, Length=443, Percent_Identity=67.7200902934537, Blast_Score=612, Evalue=1e-176,
Organism=Escherichia coli, GI1786642, Length=102, Percent_Identity=47.0588235294118, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982905, Length=56, Percent_Identity=48.2142857142857, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71982908, Length=56, Percent_Identity=48.2142857142857, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319704, Length=123, Percent_Identity=40.650406504065, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_NITMU (Q2Y5Y6)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_413227.1
- ProteinModelPortal:   Q2Y5Y6
- SMR:   Q2Y5Y6
- STRING:   Q2Y5Y6
- GeneID:   3786272
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A2546
- eggNOG:   COG1220
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- PhylomeDB:   Q2Y5Y6
- ProtClustDB:   PRK05201
- BioCyc:   NMUL323848:NMUL_A2546-MONOMER
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 50037; Mature: 49906

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: BINDING 18-18 BINDING 256-256 BINDING 321-321 BINDING 393-393

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLTPREIVHELDKHIIGQDAAKRSVAIALRNRWRRQQVQDPLRQEITPKNILMIGPTG
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLADAPFIKVEATKFTEVGYVGRDVDSIIRDLVEAAVKQSRERETQKMR
CCHHHHHHHHHHHCCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ARAEDHAEERILDVLLPVARETGLQMDSIEAESATRQKFRKKLREGELNDKEIEIELATP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
HTHMEIFAPPGMEELTTQIQGMFQNLGAERKRMRKLKIREAMKLLIDEEASKLVNDEELK
CCCEEEECCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LRAVQNVEQNGIVFLDEIDKITSRSETSGADVSRQGVQRDLLPLVEGTTISTKYGMIKTD
HHHHHCCCCCCEEEEECHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEC
HILFIASGAFHLAKPSDLIPELQGRFPIRVELTSLSAGDFVQILTNTDACLKRQYEALLE
CEEEEECCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHH
TEGVRLEFTPDAVKRLAEIAFAVNEKTENIGARRLYTAMEKLLEDVSFDAEKHHGDAVVI
CCCCEEEECHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEE
DAAYVDKRLGDLAQSEDLARYVL
EHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQLTPREIVHELDKHIIGQDAAKRSVAIALRNRWRRQQVQDPLRQEITPKNILMIGPTG
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLADAPFIKVEATKFTEVGYVGRDVDSIIRDLVEAAVKQSRERETQKMR
CCHHHHHHHHHHHCCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ARAEDHAEERILDVLLPVARETGLQMDSIEAESATRQKFRKKLREGELNDKEIEIELATP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
HTHMEIFAPPGMEELTTQIQGMFQNLGAERKRMRKLKIREAMKLLIDEEASKLVNDEELK
CCCEEEECCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LRAVQNVEQNGIVFLDEIDKITSRSETSGADVSRQGVQRDLLPLVEGTTISTKYGMIKTD
HHHHHCCCCCCEEEEECHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEC
HILFIASGAFHLAKPSDLIPELQGRFPIRVELTSLSAGDFVQILTNTDACLKRQYEALLE
CEEEEECCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHH
TEGVRLEFTPDAVKRLAEIAFAVNEKTENIGARRLYTAMEKLLEDVSFDAEKHHGDAVVI
CCCCEEEECHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEE
DAAYVDKRLGDLAQSEDLARYVL
EHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA