Click here to switch to the map view.

The map label for this gene is fumC [H]

Identifier: 82703586

GI number: 82703586

Start: 2824597

End: 2825985

Strand: Direct

Name: fumC [H]

Synonym: Nmul_A2471

Alternate gene names: 82703586

Gene position: 2824597-2825985 (Clockwise)

Preceding gene: 82703585

Following gene: 82703587

Centisome position: 88.71

GC content: 57.31

Gene sequence:

>1389_bases
ATGAATTACCGTGATGAACGGGATACCATGGGCTCAATACAGGTGCCCGCGCACGCGCTGTGGGGCGCGCAGACCCAGCG
CTCCTTGCAGAATTTCAGAATTTCAGGCGAACGCATGCCGCCTGCGCTGCTTCACGCGCTGGCACTCGTGAAGCGGGCGG
CAGCTGCCATAAACCGTGATCTGGGGGTTCTGGATGACGGGCGCGCTACCGCCATCATCCAGGCTGCGGATGAGGTGATC
GCAGGCGATCATGATGCAGAGTTTCCGCTGGTCGTGTGGCAGACCGGCTCGGGCACCCAGACCAACATGAATATGAACGA
AGTGCTGGCAAATCGCGCTTCTGAACTGCTGGGAGGCGGAAGAGGAGGGGATTGCAGGATCCATCCCAACGACGATGTAA
ACAAGGGGCAGTCATCCAATGACGTGTTTCCCTCTGCCATGCATGTGGCGGCCGCCTGCTCCCTCAATCATCAGTTGAAG
CCTGGCATTGCCGCGTTGCGGCATACGCTGGCCGCCAAAGCGGAGGCATTTTCAGGCATTGTCAAAATCGGCCGCACCCA
TTTGCAGGATGCTACTCCCCTCACCTTGGGGCAGGAATTCTCGGGGTATGTTTCCCAACTGGACCACGGGTTGGGGCATG
TCGACGCCGCGCTTCCGCATGTATATGAACTGGCTCTGGGAGGGACGGCGGTGGGTACCGGATTGAATGCCCACCCTGAG
TTTGCGGTGCGGATCGCAGCGGAATTGGCAAGATTGACGGGCCTGCCTTTTGTGACAGCTCCCAACAAGTTTGAAGCCCT
CGCTGCCAACGATGCGCTCGTCCATGCGCACGGTGCGCTCAAGACCCTGGCAGCCTCGCTCATGAAGATCGCCAATGATA
TCCGCTGGCTTGCGTCGGGCCCGCGCTGCGGAATCGGCGAACTGAAAATTCCTGAAAACGAGCCGGGCAGTTCCATCATG
CCCGGCAAAGTCAATCCGACACAGTCAGAGGCGCTTACCATGCTGTGCTGCCAGGTAATGGGCAATGATGTCGCCATCAA
TATGGGTGGCGCAATGGGGAATTTTGAGCTCAACGTCATGAAACCGCTTATCATTCACAATTTCCTGCAAAGCGTGCGCC
TGCTCGCGGATGGTATGATAAGCTTCAACGAGCATTGCGCGATCGGAATCACCGCAAACATCGATCGCATAGATGAATTG
CTGCGCAAATCGCTGATGCTGGTGACTGCACTCGCGCCCCACATCGGCTACGACAAGGCGTCTGAAATCGCGAAGAAAGC
GCATCGCGAAGGCACTACACTGGAACAGGCAGCCGTTGCAACCGGCTATATTACCGTCGATCAATTTCAGGATTGGGTAA
GACCGGAAGACATGATTCACCCGCAATGA

Upstream 100 bases:

>100_bases
GCTTTTATTTCCTGCCTTCACCGGCGAATGTGCGTGCCCGGGTATCTCTTCTTGGATATTTCTTATATGGCCGCCTGTCT
TTCCTTGATCCAAGGCTGAT

Downstream 100 bases:

>100_bases
TGCTTGGGTTGAATAAATGTTGCTGCTCCTGCGGCTTCTGCCGCCAGGGTGAATGAGCTTGCTCCCGTCATCCTCACGGG
TACCGAAAGTGGGCCTCGTC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MNYRDERDTMGSIQVPAHALWGAQTQRSLQNFRISGERMPPALLHALALVKRAAAAINRDLGVLDDGRATAIIQAADEVI
AGDHDAEFPLVVWQTGSGTQTNMNMNEVLANRASELLGGGRGGDCRIHPNDDVNKGQSSNDVFPSAMHVAAACSLNHQLK
PGIAALRHTLAAKAEAFSGIVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLGHVDAALPHVYELALGGTAVGTGLNAHPE
FAVRIAAELARLTGLPFVTAPNKFEALAANDALVHAHGALKTLAASLMKIANDIRWLASGPRCGIGELKIPENEPGSSIM
PGKVNPTQSEALTMLCCQVMGNDVAINMGGAMGNFELNVMKPLIIHNFLQSVRLLADGMISFNEHCAIGITANIDRIDEL
LRKSLMLVTALAPHIGYDKASEIAKKAHREGTTLEQAAVATGYITVDQFQDWVRPEDMIHPQ

Sequences:

>Translated_462_residues
MNYRDERDTMGSIQVPAHALWGAQTQRSLQNFRISGERMPPALLHALALVKRAAAAINRDLGVLDDGRATAIIQAADEVI
AGDHDAEFPLVVWQTGSGTQTNMNMNEVLANRASELLGGGRGGDCRIHPNDDVNKGQSSNDVFPSAMHVAAACSLNHQLK
PGIAALRHTLAAKAEAFSGIVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLGHVDAALPHVYELALGGTAVGTGLNAHPE
FAVRIAAELARLTGLPFVTAPNKFEALAANDALVHAHGALKTLAASLMKIANDIRWLASGPRCGIGELKIPENEPGSSIM
PGKVNPTQSEALTMLCCQVMGNDVAINMGGAMGNFELNVMKPLIIHNFLQSVRLLADGMISFNEHCAIGITANIDRIDEL
LRKSLMLVTALAPHIGYDKASEIAKKAHREGTTLEQAAVATGYITVDQFQDWVRPEDMIHPQ
>Mature_462_residues
MNYRDERDTMGSIQVPAHALWGAQTQRSLQNFRISGERMPPALLHALALVKRAAAAINRDLGVLDDGRATAIIQAADEVI
AGDHDAEFPLVVWQTGSGTQTNMNMNEVLANRASELLGGGRGGDCRIHPNDDVNKGQSSNDVFPSAMHVAAACSLNHQLK
PGIAALRHTLAAKAEAFSGIVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLGHVDAALPHVYELALGGTAVGTGLNAHPE
FAVRIAAELARLTGLPFVTAPNKFEALAANDALVHAHGALKTLAASLMKIANDIRWLASGPRCGIGELKIPENEPGSSIM
PGKVNPTQSEALTMLCCQVMGNDVAINMGGAMGNFELNVMKPLIIHNFLQSVRLLADGMISFNEHCAIGITANIDRIDEL
LRKSLMLVTALAPHIGYDKASEIAKKAHREGTTLEQAAVATGYITVDQFQDWVRPEDMIHPQ

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=463, Percent_Identity=60.6911447084233, Blast_Score=573, Evalue=1e-164,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=46.7532467532467, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=73.6842105263158, Blast_Score=695, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=463, Percent_Identity=39.3088552915767, Blast_Score=325, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=61.822125813449, Blast_Score=592, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=64.1104294478528, Blast_Score=444, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=58.963282937365, Blast_Score=555, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=61.3390928725702, Blast_Score=588, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=61.3390928725702, Blast_Score=587, Evalue=1e-168,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=58.4051724137931, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=59.7402597402597, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24583245, Length=465, Percent_Identity=50.9677419354839, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49335; Mature: 49335

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYRDERDTMGSIQVPAHALWGAQTQRSLQNFRISGERMPPALLHALALVKRAAAAINRD
CCCCCCCCCCCCEECCHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCC
LGVLDDGRATAIIQAADEVIAGDHDAEFPLVVWQTGSGTQTNMNMNEVLANRASELLGGG
CCCCCCCCCEEHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
RGGDCRIHPNDDVNKGQSSNDVFPSAMHVAAACSLNHQLKPGIAALRHTLAAKAEAFSGI
CCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEFSGYVSQLDHGLGHVDAALPHVYELALGGTAVGTGLNAHPE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHCCCCCCCHH
FAVRIAAELARLTGLPFVTAPNKFEALAANDALVHAHGALKTLAASLMKIANDIRWLASG
HHHHHHHHHHHHCCCCEEECCCCCHHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCC
PRCGIGELKIPENEPGSSIMPGKVNPTQSEALTMLCCQVMGNDVAINMGGAMGNFELNVM
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEHHHH
KPLIIHNFLQSVRLLADGMISFNEHCAIGITANIDRIDELLRKSLMLVTALAPHIGYDKA
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHH
SEIAKKAHREGTTLEQAAVATGYITVDQFQDWVRPEDMIHPQ
HHHHHHHHHCCCCHHHHHHHHCCEEHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNYRDERDTMGSIQVPAHALWGAQTQRSLQNFRISGERMPPALLHALALVKRAAAAINRD
CCCCCCCCCCCCEECCHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCC
LGVLDDGRATAIIQAADEVIAGDHDAEFPLVVWQTGSGTQTNMNMNEVLANRASELLGGG
CCCCCCCCCEEHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
RGGDCRIHPNDDVNKGQSSNDVFPSAMHVAAACSLNHQLKPGIAALRHTLAAKAEAFSGI
CCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEFSGYVSQLDHGLGHVDAALPHVYELALGGTAVGTGLNAHPE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHCCCCCCCHH
FAVRIAAELARLTGLPFVTAPNKFEALAANDALVHAHGALKTLAASLMKIANDIRWLASG
HHHHHHHHHHHHCCCCEEECCCCCHHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCC
PRCGIGELKIPENEPGSSIMPGKVNPTQSEALTMLCCQVMGNDVAINMGGAMGNFELNVM
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEHHHH
KPLIIHNFLQSVRLLADGMISFNEHCAIGITANIDRIDELLRKSLMLVTALAPHIGYDKA
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHH
SEIAKKAHREGTTLEQAAVATGYITVDQFQDWVRPEDMIHPQ
HHHHHHHHHCCCCHHHHHHHHCCEEHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]