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The map label for this gene is nrdB [H]

Identifier: 82703584

GI number: 82703584

Start: 2822568

End: 2823794

Strand: Direct

Name: nrdB [H]

Synonym: Nmul_A2469

Alternate gene names: 82703584

Gene position: 2822568-2823794 (Clockwise)

Preceding gene: 82703583

Following gene: 82703585

Centisome position: 88.64

GC content: 53.87

Gene sequence:

>1227_bases
ATGTTGATATTCGAGGATGAAATCATGCCATCGGCGCCGCGGAGAAACGGCGAGCCGGGATTGCTTGACGGAACCCGCGC
GGGCCCTGAAGCAGCGAGCCGCCTTGACGGCACGAACGGGACGGAGGCAGAAGGTGGCGTGAGCGATGTGACTGGGTCGC
ATGGAGGGAATGGCATGGGAGAAAAGGACTATTCCGCAGAGGACATCCATCGGCGCGTGTCGGTGGAAGACAAGCGCATC
ATCAATTGCAAGGCGGATGTCAACCAACTGGTGCCTTTCAAGTACAAATGGGCGTGGGAGAAGTATCTGGCGGCCTGCGC
CAACCATTGGATGCCTCAGGAAATCAACATGAGCCGCGATATCGCTCTCTGGAAAGATCCGAACGGACTGACCGAGGATG
AGCGGCGGATAGTCAAGCGCAACCTGGGCTTCTTCGTTACCGCGGATTCGCTCGCGGCCAACAACATCGTGCTCGGCACT
TACCGGCACGTCACCAATCCGGAATGCCGCCAGTACCTGTTACGGCAAGCCTTTGAAGAGGCGATTCATACGCATGCCTA
TCAGTACATCGTCGAATCGCTGGGGCTGGACGAAGGCGAGATTTTCAACGCCTATCACGAAGTGAGATCCATCCGCGAGA
AGGATGAATTCCTGATTCCCTTTATCGATACGCTCACTGATCCATCATTCAGGACGGGCACGCTCGAAGCGGATCAGAAG
TTGCTTAAAAGCCTGATCGTATTCGCCTGCATCATGGAAGGCCTGTTCTTTTATGTAGGTTTCATACAGATCCTGGCGCT
CGGAAGGCAGAACAAGATGACGGGCTCGGCCGAGCAGTATCAATACATTCTGCGGGATGAATCCATGCACTGCAATTTCG
GCATCGATGTCGTGAATCAGATCAAAATGGAAAACCCGCATTTGTGGACGAAAGAATTTCGCAGCGAAATCAGTGCGCTG
ATGCAAAAAGCGGTGGAACTGGAATACCGTTATGCCGAGGACACCATGCCGCGAGGCGTTCTGGGATTGAACGCGCCCAT
GTTCAAGGAATACCTGCGCTATATCGCCAACCGCCGCTGCCAGCAGATAGGTCTGGATATTCTCTATCCGGGAGCGAGCA
ACCCCTTCCCCTGGATGTCTGAAATGATCGATCTGAAAAAGGAAAAGAACTTTTTTGAAACACGCGTTACCGAGTATCAG
ACTGGCGGTGTGCTGAACTGGGACTAA

Upstream 100 bases:

>100_bases
CGGCGGCAGTGCCGGCGACAGACGTATCGTTCTGTTCCGTCGATGATCCGGAATGTGAATCATGCCAATAACAATTAAAA
TGTAATGTTAGGAGAAAGAT

Downstream 100 bases:

>100_bases
ACAACTAGAATACTAGAATAATAATGAGGGACAGCAGGCGCGTCACGAAGGGTCTGCCTGCCTCACTCCCCGCTTTAAGC
AACTCTTCGCATTTCGGATT

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MLIFEDEIMPSAPRRNGEPGLLDGTRAGPEAASRLDGTNGTEAEGGVSDVTGSHGGNGMGEKDYSAEDIHRRVSVEDKRI
INCKADVNQLVPFKYKWAWEKYLAACANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGT
YRHVTNPECRQYLLRQAFEEAIHTHAYQYIVESLGLDEGEIFNAYHEVRSIREKDEFLIPFIDTLTDPSFRTGTLEADQK
LLKSLIVFACIMEGLFFYVGFIQILALGRQNKMTGSAEQYQYILRDESMHCNFGIDVVNQIKMENPHLWTKEFRSEISAL
MQKAVELEYRYAEDTMPRGVLGLNAPMFKEYLRYIANRRCQQIGLDILYPGASNPFPWMSEMIDLKKEKNFFETRVTEYQ
TGGVLNWD

Sequences:

>Translated_408_residues
MLIFEDEIMPSAPRRNGEPGLLDGTRAGPEAASRLDGTNGTEAEGGVSDVTGSHGGNGMGEKDYSAEDIHRRVSVEDKRI
INCKADVNQLVPFKYKWAWEKYLAACANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGT
YRHVTNPECRQYLLRQAFEEAIHTHAYQYIVESLGLDEGEIFNAYHEVRSIREKDEFLIPFIDTLTDPSFRTGTLEADQK
LLKSLIVFACIMEGLFFYVGFIQILALGRQNKMTGSAEQYQYILRDESMHCNFGIDVVNQIKMENPHLWTKEFRSEISAL
MQKAVELEYRYAEDTMPRGVLGLNAPMFKEYLRYIANRRCQQIGLDILYPGASNPFPWMSEMIDLKKEKNFFETRVTEYQ
TGGVLNWD
>Mature_408_residues
MLIFEDEIMPSAPRRNGEPGLLDGTRAGPEAASRLDGTNGTEAEGGVSDVTGSHGGNGMGEKDYSAEDIHRRVSVEDKRI
INCKADVNQLVPFKYKWAWEKYLAACANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGT
YRHVTNPECRQYLLRQAFEEAIHTHAYQYIVESLGLDEGEIFNAYHEVRSIREKDEFLIPFIDTLTDPSFRTGTLEADQK
LLKSLIVFACIMEGLFFYVGFIQILALGRQNKMTGSAEQYQYILRDESMHCNFGIDVVNQIKMENPHLWTKEFRSEISAL
MQKAVELEYRYAEDTMPRGVLGLNAPMFKEYLRYIANRRCQQIGLDILYPGASNPFPWMSEMIDLKKEKNFFETRVTEYQ
TGGVLNWD

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI42544136, Length=321, Percent_Identity=27.4143302180685, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI289177074, Length=321, Percent_Identity=27.4143302180685, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI260064013, Length=335, Percent_Identity=27.4626865671642, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4557845, Length=335, Percent_Identity=27.4626865671642, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI289177076, Length=297, Percent_Identity=27.2727272727273, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1788567, Length=292, Percent_Identity=25.6849315068493, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17551968, Length=321, Percent_Identity=28.3489096573209, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193206379, Length=305, Percent_Identity=23.6065573770492, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17567153, Length=224, Percent_Identity=25, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322434, Length=330, Percent_Identity=31.5151515151515, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321619, Length=316, Percent_Identity=23.7341772151899, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=27.1875, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 46749; Mature: 46749

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIFEDEIMPSAPRRNGEPGLLDGTRAGPEAASRLDGTNGTEAEGGVSDVTGSHGGNGMG
CEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
EKDYSAEDIHRRVSVEDKRIINCKADVNQLVPFKYKWAWEKYLAACANHWMPQEINMSRD
CCCCCHHHHHHHCCCCCCEEEECHHCHHHCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCC
IALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHVTNPECRQYLLRQAFEE
EEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
AIHTHAYQYIVESLGLDEGEIFNAYHEVRSIREKDEFLIPFIDTLTDPSFRTGTLEADQK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCCCCCHHHHH
LLKSLIVFACIMEGLFFYVGFIQILALGRQNKMTGSAEQYQYILRDESMHCNFGIDVVNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHH
IKMENPHLWTKEFRSEISALMQKAVELEYRYAEDTMPRGVLGLNAPMFKEYLRYIANRRC
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
QQIGLDILYPGASNPFPWMSEMIDLKKEKNFFETRVTEYQTGGVLNWD
HHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLIFEDEIMPSAPRRNGEPGLLDGTRAGPEAASRLDGTNGTEAEGGVSDVTGSHGGNGMG
CEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
EKDYSAEDIHRRVSVEDKRIINCKADVNQLVPFKYKWAWEKYLAACANHWMPQEINMSRD
CCCCCHHHHHHHCCCCCCEEEECHHCHHHCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCC
IALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHVTNPECRQYLLRQAFEE
EEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
AIHTHAYQYIVESLGLDEGEIFNAYHEVRSIREKDEFLIPFIDTLTDPSFRTGTLEADQK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCCCCCHHHHH
LLKSLIVFACIMEGLFFYVGFIQILALGRQNKMTGSAEQYQYILRDESMHCNFGIDVVNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHH
IKMENPHLWTKEFRSEISALMQKAVELEYRYAEDTMPRGVLGLNAPMFKEYLRYIANRRC
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
QQIGLDILYPGASNPFPWMSEMIDLKKEKNFFETRVTEYQTGGVLNWD
HHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]