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The map label for this gene is lysC [H]

Identifier: 82703062

GI number: 82703062

Start: 2233154

End: 2234383

Strand: Reverse

Name: lysC [H]

Synonym: Nmul_A1941

Alternate gene names: 82703062

Gene position: 2234383-2233154 (Counterclockwise)

Preceding gene: 82703064

Following gene: 82703061

Centisome position: 70.17

GC content: 54.63

Gene sequence:

>1230_bases
GTGACATTTATCGTTCAAAAATACGGCGGCACATCGGTGGGCAGCACGGAGCGCATCAAGAATGTTGCGCGCCGGGTGGC
GAGATTCCAGGCCCGGGGCGATCGGGTGGTGGTCGTGGTATCCGCCATGAGCGGAGAGACAAATCGTCTTATTGCGCTGG
CCCGGGAATTCCAGGCCCATCCGGATCCCCGGGAGCTGGATGTCATGGTTTCCACCGGGGAGCAGGTTTCTGTCGCTCTG
CTGTCAATGGCGCTGATGGATCTGGGCATCAAGGCGAAGAGCTACACCGGTGCCCAGGTGCGCATTCACACCGATAGTGC
CTATACCAAGGCGCGCATACTCAAAATCGATGAAGACAGGATACGCGCCGATCTCGATGCGGGATACGTGGTGGCAGTAG
CGGGCTTTCAGGGAGTGGACGAGGCGGGGAGTATCACAACATTGGGCCGGGGAGGTTCCGACACCACGGCTGTGGCCCTC
GCGGCAGCGCTCAAGGCGGATGAATGCCAGATCTATACGGATGTAGACGGAGTTTACACGACCGATCCCCGAATTGTGCC
CGAAGCGCGCAAACTCAAGACTGTTACCTTTGAAGAAATGCTTGAAATGGCAAGCCTCGGTTCCAAGGTGCTGCAAATCC
GCGCGGTGGAGTTCGCGGGTAAATACAAGGTTAAATTGCGGGTGCTCTCCAGTTTCGAGGAAGAAGGAGAAGGTACCCTC
ATCACTTTCGAGGAAGAGAAAAACATGGAACGGGCGATTATTTCAGGCATCGCATTCAATCGTGACGAAGCCAAGATTAC
GGTGCTGGGTGTGCCGGACCGTCCCGGTATCGCCTATCAGATTCTCGGTCCCGTGGCGGAGGCAAATATCGATGTAGACA
TGATCATCCAGAATGTCGGCCACGATGGCATGACCGATTTTTCATTTACCGTGAATCGCAATGAATTTGCGAGAACGATG
GATATCCTGAAAAATCAGGTGCAGCCTCATATCGGTGCCCGGGGTGTGATCGGAGGCGACAGAATCGCGAAAGTCTCGGT
AGTGGGCGTCGGCATGCGTTCGCATGTGGGCATTGCCAGCAGAATGTTCCGTACGCTGGCCGAAGAGGGCATCAATATCC
AGATGATCTCCACCTCTGAAATCAAGATTTCAGTAGTCGTGGATGAAAAATACATGGAGTTGGCGGTACGTGTCTTGCAC
AAGGTATTCGAACTCGATCAGATATCATGA

Upstream 100 bases:

>100_bases
ATTCGAACACAATATCCATGCCAGGACTTTAATCCCCTGAATTGATCCGACATATGGCATTTTGTCCACGGCTTTGCCAT
TCCCAGTTAAGCAGGTTATC

Downstream 100 bases:

>100_bases
ATATTCCGCTTACCGGTCCCTTTCATAACCTTTGTTTGACCCAGGAGTTCTAAACCGCTATCCTAGTGCGGCTTTGTTGG
AGAGATGGCCGAGTGGTCGA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MTFIVQKYGGTSVGSTERIKNVARRVARFQARGDRVVVVVSAMSGETNRLIALAREFQAHPDPRELDVMVSTGEQVSVAL
LSMALMDLGIKAKSYTGAQVRIHTDSAYTKARILKIDEDRIRADLDAGYVVAVAGFQGVDEAGSITTLGRGGSDTTAVAL
AAALKADECQIYTDVDGVYTTDPRIVPEARKLKTVTFEEMLEMASLGSKVLQIRAVEFAGKYKVKLRVLSSFEEEGEGTL
ITFEEEKNMERAIISGIAFNRDEAKITVLGVPDRPGIAYQILGPVAEANIDVDMIIQNVGHDGMTDFSFTVNRNEFARTM
DILKNQVQPHIGARGVIGGDRIAKVSVVGVGMRSHVGIASRMFRTLAEEGINIQMISTSEIKISVVVDEKYMELAVRVLH
KVFELDQIS

Sequences:

>Translated_409_residues
MTFIVQKYGGTSVGSTERIKNVARRVARFQARGDRVVVVVSAMSGETNRLIALAREFQAHPDPRELDVMVSTGEQVSVAL
LSMALMDLGIKAKSYTGAQVRIHTDSAYTKARILKIDEDRIRADLDAGYVVAVAGFQGVDEAGSITTLGRGGSDTTAVAL
AAALKADECQIYTDVDGVYTTDPRIVPEARKLKTVTFEEMLEMASLGSKVLQIRAVEFAGKYKVKLRVLSSFEEEGEGTL
ITFEEEKNMERAIISGIAFNRDEAKITVLGVPDRPGIAYQILGPVAEANIDVDMIIQNVGHDGMTDFSFTVNRNEFARTM
DILKNQVQPHIGARGVIGGDRIAKVSVVGVGMRSHVGIASRMFRTLAEEGINIQMISTSEIKISVVVDEKYMELAVRVLH
KVFELDQIS
>Mature_408_residues
TFIVQKYGGTSVGSTERIKNVARRVARFQARGDRVVVVVSAMSGETNRLIALAREFQAHPDPRELDVMVSTGEQVSVALL
SMALMDLGIKAKSYTGAQVRIHTDSAYTKARILKIDEDRIRADLDAGYVVAVAGFQGVDEAGSITTLGRGGSDTTAVALA
AALKADECQIYTDVDGVYTTDPRIVPEARKLKTVTFEEMLEMASLGSKVLQIRAVEFAGKYKVKLRVLSSFEEEGEGTLI
TFEEEKNMERAIISGIAFNRDEAKITVLGVPDRPGIAYQILGPVAEANIDVDMIIQNVGHDGMTDFSFTVNRNEFARTMD
ILKNQVQPHIGARGVIGGDRIAKVSVVGVGMRSHVGIASRMFRTLAEEGINIQMISTSEIKISVVVDEKYMELAVRVLHK
VFELDQIS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=303, Percent_Identity=33.993399339934, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1790455, Length=346, Percent_Identity=28.6127167630058, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790376, Length=217, Percent_Identity=26.7281105990783, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=503, Percent_Identity=27.4353876739563, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44634; Mature: 44503

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFIVQKYGGTSVGSTERIKNVARRVARFQARGDRVVVVVSAMSGETNRLIALAREFQAH
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHCCC
PDPRELDVMVSTGEQVSVALLSMALMDLGIKAKSYTGAQVRIHTDSAYTKARILKIDEDR
CCCCEEEEEEECCCHHHHHHHHHHHHHCCCEECCCCCCEEEEECCCCCCEEEEEEECHHH
IRADLDAGYVVAVAGFQGVDEAGSITTLGRGGSDTTAVALAAALKADECQIYTDVDGVYT
HHCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCEEE
TDPRIVPEARKLKTVTFEEMLEMASLGSKVLQIRAVEFAGKYKVKLRVLSSFEEEGEGTL
CCCCCCCCHHHHEEECHHHHHHHHHCCCCEEEEEEEEECCCEEEEEEEEHHHHHCCCCEE
ITFEEEKNMERAIISGIAFNRDEAKITVLGVPDRPGIAYQILGPVAEANIDVDMIIQNVG
EEEECCCCHHHHHHHHEEECCCCCEEEEEECCCCCCEEEEEECCHHHCCCCHHHHHHHCC
HDGMTDFSFTVNRNEFARTMDILKNQVQPHIGARGVIGGDRIAKVSVVGVGMRSHVGIAS
CCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECHHHHHHHHH
RMFRTLAEEGINIQMISTSEIKISVVVDEKYMELAVRVLHKVFELDQIS
HHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TFIVQKYGGTSVGSTERIKNVARRVARFQARGDRVVVVVSAMSGETNRLIALAREFQAH
EEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHCCC
PDPRELDVMVSTGEQVSVALLSMALMDLGIKAKSYTGAQVRIHTDSAYTKARILKIDEDR
CCCCEEEEEEECCCHHHHHHHHHHHHHCCCEECCCCCCEEEEECCCCCCEEEEEEECHHH
IRADLDAGYVVAVAGFQGVDEAGSITTLGRGGSDTTAVALAAALKADECQIYTDVDGVYT
HHCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCEEE
TDPRIVPEARKLKTVTFEEMLEMASLGSKVLQIRAVEFAGKYKVKLRVLSSFEEEGEGTL
CCCCCCCCHHHHEEECHHHHHHHHHCCCCEEEEEEEEECCCEEEEEEEEHHHHHCCCCEE
ITFEEEKNMERAIISGIAFNRDEAKITVLGVPDRPGIAYQILGPVAEANIDVDMIIQNVG
EEEECCCCHHHHHHHHEEECCCCCEEEEEECCCCCCEEEEEECCHHHCCCCHHHHHHHCC
HDGMTDFSFTVNRNEFARTMDILKNQVQPHIGARGVIGGDRIAKVSVVGVGMRSHVGIAS
CCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECHHHHHHHHH
RMFRTLAEEGINIQMISTSEIKISVVVDEKYMELAVRVLHKVFELDQIS
HHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]