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The map label for this gene is dnaX [H]

Identifier: 82702979

GI number: 82702979

Start: 2140463

End: 2142205

Strand: Reverse

Name: dnaX [H]

Synonym: Nmul_A1858

Alternate gene names: 82702979

Gene position: 2142205-2140463 (Counterclockwise)

Preceding gene: 82702980

Following gene: 82702978

Centisome position: 67.28

GC content: 53.82

Gene sequence:

>1743_bases
GTGTCCTCCCCGACTCAAGTCCTTGCCCGCAAATGGCGTCCCCGGCGCTTTTCCGAACTGACCGGACAGGATCATGTTGT
TCGTGCACTTACCAATGCTCTCGAACAGAAGCGTTTACATCATGCTTATCTGTTTACGGGCACGCGCGGGATCGGCAAGA
CGACCATAGCGCGCATTCTGGCAAAGGCGCTCAACTGCCAGGCCGGAGTTACATCGGAGCCTTGCGGGGTCTGTTCTGCT
TGTATCGAAATTGACGGCGGGCGTTTTGTTGACCTGATCGAAGTTGATGCCGCCTCCAATACGCAGGTGGAAAAAATGCG
TGAACTGCTGGAGAACGCGCTGTATGCTCCCACGGTTGCACGCTATAAGGTGTACATCATTGATGAAGTACATATGCTTT
CCAAATCAGCTTTCAACGCCATGCTGAAAACGCTGGAAGAGCCGCCGGAACATGTCAAATTCATACTTGCGACCACTGAT
CCGCAGAAGATTCCGGTAACGGTTTTGTCTCGCTGCCTGCAATTCAACCTCAAGCAGATTCCGTTTCCGCTGATCGTCTC
GCACCTCAGGCATGTGCTCGAACAGGAGCATATAAACTGTGATGCCACTTCCCTGCAGTTATTGGCGCGCGCGGCGCAGG
GCAGTATGCGTGATGCCTTGAGCATTCTGGATCAGGCCATCGCTTTTGGCGAGGGAAAGATCGAAGAAGCAGGAGTGCGC
GATATGCTTGGTGCGGTCGATCAGGGGTATCTGTTTGATCTGCTGGAGGCACTGGCGCAACGAGATGGCGCCCGAATGCT
TGCGATCGCGGATGCGATGGAAACCCGCAGTCTCTCGTTTGACGCCGCTTTGCAGGATCTGGCGACCCTGCTGCATCGTC
TGACCCTGGCGCAAATCGTTCCCGCAGCGATTGGTGATGATGAACCTGAGCGGGATCGGATTTTCCGGCTGGCGAAAACA
TTCACGCCAGAAGATATTCAATTGTTCTATCAGATTGCCATACACGGGCGCGAGGACCTCGGGCGGGCACCGGATGAGTA
TGCGGGTTTCACCATGACGTTGCTGCGTATGCTGGCTTTCATTCCGGAAGATTTCCTGTCAGGAGGAGGGAAGGCAGGCA
GGGACGGAGGAACGCCAGGTTTTTTGCCTACAAAACCAGGAAGTGGCAAATATCCTTCGACCCCTCGACAGGCTCAGCAG
TCAGACCGAACAGAGATGGCAGAGATAGAAAAGGAAGGAAACTCCCAGGAAGAGAGGGCGGCCAGGAATGCTGCCAACGG
GGATTCAAGGGAGCCGACAGGACCCGTGCCGGCTTCGCTGGAGCGCGATCCCACGCCGGTAAAGCCGAGCTTCGTACAGT
CTTTCAGTCATAGCTGGATTACCATAGTCGGCCAATTGAAGGTAAGCGGATTGACCAGAATGCTGGCTCAATATTGCGAG
GTGAAGAGTTCTTCCGAGGATGAAATAGAATTTTGCGTACCGGAACTCCATAAGCATTTGCTGGACAAGACCTATCAGGA
CAGACTGCAAGCCGCCGTGAGGGAGTATCTTGATAAGCCGGTGCGGCTGAAGTTTGCAGTGGGAATCGTTAACGGCATGA
GCCCGGCTGAGCAGGAAAATCGTGAAAAGCAGGAGAAGCAATCGCAGGCCATCGCGGCTATCGAGTCCGATCCGTTCGTG
CGTGAACTCGTTGAAAATTTTGATGCAAAATTGATCGTTTCTTCGATCAAACCTATTCAATAG

Upstream 100 bases:

>100_bases
CCATCTTCCCAACTGCACGCTTCAATGATTCATACCATCAGTTACAGCCTCCGCTGAAAATCTGAAATAACCGTTTCGCC
GATTCGATTCTCGACATAGC

Downstream 100 bases:

>100_bases
TGGAGGTAAAAATGATGAAAGGTGGCTTGGGCAACCTGATGAAGCAGGCTCAGCAGATGCAGGAGAACATGAAAGCCATG
CAGGAGAAATTGGCTTCGAT

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MSSPTQVLARKWRPRRFSELTGQDHVVRALTNALEQKRLHHAYLFTGTRGIGKTTIARILAKALNCQAGVTSEPCGVCSA
CIEIDGGRFVDLIEVDAASNTQVEKMRELLENALYAPTVARYKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTD
PQKIPVTVLSRCLQFNLKQIPFPLIVSHLRHVLEQEHINCDATSLQLLARAAQGSMRDALSILDQAIAFGEGKIEEAGVR
DMLGAVDQGYLFDLLEALAQRDGARMLAIADAMETRSLSFDAALQDLATLLHRLTLAQIVPAAIGDDEPERDRIFRLAKT
FTPEDIQLFYQIAIHGREDLGRAPDEYAGFTMTLLRMLAFIPEDFLSGGGKAGRDGGTPGFLPTKPGSGKYPSTPRQAQQ
SDRTEMAEIEKEGNSQEERAARNAANGDSREPTGPVPASLERDPTPVKPSFVQSFSHSWITIVGQLKVSGLTRMLAQYCE
VKSSSEDEIEFCVPELHKHLLDKTYQDRLQAAVREYLDKPVRLKFAVGIVNGMSPAEQENREKQEKQSQAIAAIESDPFV
RELVENFDAKLIVSSIKPIQ

Sequences:

>Translated_580_residues
MSSPTQVLARKWRPRRFSELTGQDHVVRALTNALEQKRLHHAYLFTGTRGIGKTTIARILAKALNCQAGVTSEPCGVCSA
CIEIDGGRFVDLIEVDAASNTQVEKMRELLENALYAPTVARYKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTD
PQKIPVTVLSRCLQFNLKQIPFPLIVSHLRHVLEQEHINCDATSLQLLARAAQGSMRDALSILDQAIAFGEGKIEEAGVR
DMLGAVDQGYLFDLLEALAQRDGARMLAIADAMETRSLSFDAALQDLATLLHRLTLAQIVPAAIGDDEPERDRIFRLAKT
FTPEDIQLFYQIAIHGREDLGRAPDEYAGFTMTLLRMLAFIPEDFLSGGGKAGRDGGTPGFLPTKPGSGKYPSTPRQAQQ
SDRTEMAEIEKEGNSQEERAARNAANGDSREPTGPVPASLERDPTPVKPSFVQSFSHSWITIVGQLKVSGLTRMLAQYCE
VKSSSEDEIEFCVPELHKHLLDKTYQDRLQAAVREYLDKPVRLKFAVGIVNGMSPAEQENREKQEKQSQAIAAIESDPFV
RELVENFDAKLIVSSIKPIQ
>Mature_579_residues
SSPTQVLARKWRPRRFSELTGQDHVVRALTNALEQKRLHHAYLFTGTRGIGKTTIARILAKALNCQAGVTSEPCGVCSAC
IEIDGGRFVDLIEVDAASNTQVEKMRELLENALYAPTVARYKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDP
QKIPVTVLSRCLQFNLKQIPFPLIVSHLRHVLEQEHINCDATSLQLLARAAQGSMRDALSILDQAIAFGEGKIEEAGVRD
MLGAVDQGYLFDLLEALAQRDGARMLAIADAMETRSLSFDAALQDLATLLHRLTLAQIVPAAIGDDEPERDRIFRLAKTF
TPEDIQLFYQIAIHGREDLGRAPDEYAGFTMTLLRMLAFIPEDFLSGGGKAGRDGGTPGFLPTKPGSGKYPSTPRQAQQS
DRTEMAEIEKEGNSQEERAARNAANGDSREPTGPVPASLERDPTPVKPSFVQSFSHSWITIVGQLKVSGLTRMLAQYCEV
KSSSEDEIEFCVPELHKHLLDKTYQDRLQAAVREYLDKPVRLKFAVGIVNGMSPAEQENREKQEKQSQAIAAIESDPFVR
ELVENFDAKLIVSSIKPIQ

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI194306571, Length=287, Percent_Identity=24.0418118466899, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI194306567, Length=287, Percent_Identity=24.0418118466899, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI6677723, Length=284, Percent_Identity=24.6478873239437, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4506491, Length=273, Percent_Identity=25.2747252747253, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI31881687, Length=273, Percent_Identity=25.2747252747253, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1786676, Length=652, Percent_Identity=40.3374233128834, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1787341, Length=146, Percent_Identity=32.1917808219178, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=295, Percent_Identity=23.728813559322, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17554730, Length=222, Percent_Identity=27.027027027027, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322528, Length=267, Percent_Identity=27.7153558052434, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324039, Length=312, Percent_Identity=24.0384615384615, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI18859927, Length=275, Percent_Identity=24.3636363636364, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 64248; Mature: 64117

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPTQVLARKWRPRRFSELTGQDHVVRALTNALEQKRLHHAYLFTGTRGIGKTTIARIL
CCCHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHH
AKALNCQAGVTSEPCGVCSACIEIDGGRFVDLIEVDAASNTQVEKMRELLENALYAPTVA
HHHHCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCHH
RYKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNLKQI
HEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCCCCHHHHHHHHHCCHHHC
PFPLIVSHLRHVLEQEHINCDATSLQLLARAAQGSMRDALSILDQAIAFGEGKIEEAGVR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHH
DMLGAVDQGYLFDLLEALAQRDGARMLAIADAMETRSLSFDAALQDLATLLHRLTLAQIV
HHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
PAAIGDDEPERDRIFRLAKTFTPEDIQLFYQIAIHGREDLGRAPDEYAGFTMTLLRMLAF
HHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHCCCCCHHHCCHHHHHHHHHHH
IPEDFLSGGGKAGRDGGTPGFLPTKPGSGKYPSTPRQAQQSDRTEMAEIEKEGNSQEERA
CCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
ARNAANGDSREPTGPVPASLERDPTPVKPSFVQSFSHSWITIVGQLKVSGLTRMLAQYCE
HHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
VKSSSEDEIEFCVPELHKHLLDKTYQDRLQAAVREYLDKPVRLKFAVGIVNGMSPAEQEN
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCHHHH
REKQEKQSQAIAAIESDPFVRELVENFDAKLIVSSIKPIQ
HHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHCCCCC
>Mature Secondary Structure 
SSPTQVLARKWRPRRFSELTGQDHVVRALTNALEQKRLHHAYLFTGTRGIGKTTIARIL
CCHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHH
AKALNCQAGVTSEPCGVCSACIEIDGGRFVDLIEVDAASNTQVEKMRELLENALYAPTVA
HHHHCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCHH
RYKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNLKQI
HEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCCCCHHHHHHHHHCCHHHC
PFPLIVSHLRHVLEQEHINCDATSLQLLARAAQGSMRDALSILDQAIAFGEGKIEEAGVR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHH
DMLGAVDQGYLFDLLEALAQRDGARMLAIADAMETRSLSFDAALQDLATLLHRLTLAQIV
HHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
PAAIGDDEPERDRIFRLAKTFTPEDIQLFYQIAIHGREDLGRAPDEYAGFTMTLLRMLAF
HHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHCCCCCHHHCCHHHHHHHHHHH
IPEDFLSGGGKAGRDGGTPGFLPTKPGSGKYPSTPRQAQQSDRTEMAEIEKEGNSQEERA
CCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
ARNAANGDSREPTGPVPASLERDPTPVKPSFVQSFSHSWITIVGQLKVSGLTRMLAQYCE
HHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
VKSSSEDEIEFCVPELHKHLLDKTYQDRLQAAVREYLDKPVRLKFAVGIVNGMSPAEQEN
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCHHHH
REKQEKQSQAIAAIESDPFVRELVENFDAKLIVSSIKPIQ
HHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]