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The map label for this gene is syrD [H]

Identifier: 82702946

GI number: 82702946

Start: 2081331

End: 2082998

Strand: Reverse

Name: syrD [H]

Synonym: Nmul_A1823

Alternate gene names: 82702946

Gene position: 2082998-2081331 (Counterclockwise)

Preceding gene: 82702951

Following gene: 82702945

Centisome position: 65.42

GC content: 54.5

Gene sequence:

>1668_bases
ATGCTCAAGTATCTCATCAACCAATCCCGGGTATTATTGGCAGGCGCTTCATTGGTCACAGTATTCCATGGTACTTGCAG
CGTGTTGCTCATCGCGCAGATCAGTTCCGCGCTCACCGCGACCGAGAGCGAACGCGGAACCCTGGCACTCGTTTTTATTG
CCACTGCCGTGGCCGTGATGCTGAGTTATGTAAGCGCAGCGATCCTTTTCGAGCGCCTGGGACAACGGGCGCACGCGGAA
TTGCGCAGCTTTGTCGCCAGAAAGGTGCTTGCTGCCGACTACCGTAATCTTGAAACGGTGGGGGCTGCCCGCATACAGTC
GGCCCTTGCCGAGCATTGCACGCACGTTGCCGAATTCTTTGTGAGCTTTCCCATCATCCTGATGAATGCCGTCATCGTCG
CAGGATGTCTGCTTTATATGGCGTGGCTTTCATGGCAAGTATTCCTGCTCGCTATCCTTGTGGTTGGCCTGGGGTGCGTG
GGATATCATCTTGCGCACCTGCGCGCAATACGTCATTTGAATATTGCGTCCGAAGAGCAGGATAAACTGTTTTCCTATTT
TCGATCCCTGACCGACGGGGCCAAGGAGCTTCGCCTCAATAACCGGAAGCGGAAGGCATTCTATGAGGATGTACTGTCAG
GCTCGATCGAGACTGTGCGCCGCGAAAGGACTTTTGGAATGTCCGTCTTCGTCGCATCCGGTGGATGGGCCCAATTCCTG
CTCTATGTGTTTATCGGGATGGTATTATTTGCGCTGGTGAGTGATGGTCCTGACCGGGCTCTGGTCATGACGGGCTACGC
GCTGGTGTTCGTTTACATGGTGGGACCGCTCGAAGCGCTTCTGTTGAATATTCCCCGTGCCAATCTGGCCAAGGTTTCTG
CGGAGCGGATCGAGGAAATAACGCGGGCGATGACGACCCAGGAGATCGAGACCGATAACTCTTCTCTCCCCGGCTTGCAG
TCCCTTGCACTCCGGGGCGTGCTGCACCGGTATTATCATGAGCAGAGCGATGAATTGTTTACGCTCGGCCCCATAGATCT
GGATTTCCGTCCCGGAGAGATTACTTTTCTGGTGGGAGGCAACGGCAGCGGCAAGACCACTCTGGCCAAATTGCTGGTTG
GACTCTATCCGCCGGAGGAAGGCCAGATAATTTTCAATGGGAAAGCGGTCGATGAAACAAACCGCGATTGCTACAGGCAG
CTTTTTTCGACGGTTTTTTCGGATTTTCATCTTTTCGACCGCTTGCTTGAAACGGACAGGGTCGACCTGGATAATGAAGG
CAACCGGCTTTTAGCCAAACTGCACCTGCAAAACAAGGTTAAGGTACAGGATGGGGCTTTCACTACGCTTGCGCTTTCGC
AAGGACAGCGCAAACGTCTCGCTTTGGTGGTTGCCTATCTGGAGAACCGCCCGTTTTTTATATTCGACGAATGGGCGGCG
GATCAGGACCCGGTATTCAAGGAGGTCTTTTACCGCGAGCTCCTTCCGGAATTGCGCGCCATGGGCAAGGCCGTATTGGT
GATATCGCACGATGACCGTTACTTTCATCTTGCAGACCGGTTGATACGCATGGAGAGCGGATGCCTGACGTTCAACGCTT
GCCCATCGCTGAAAGATGCCCTGCACGCAACCCCGGCCCCGCCGCTGGTACTTAACGGTGTGACATGA

Upstream 100 bases:

>100_bases
TGGGAGATGACGTGAACCGAGAGGGGATATGAACGTTCAGGCGTAAATAATTGTAATTCTCATTCGTCTTCCCTCATATC
CATTTCATTGCGGGACAGCC

Downstream 100 bases:

>100_bases
AGCAATGAAACGAGTGATCACGGTGCCGCCGGGCGTAGCCAGGGCACAGGATACCCGGCGCGTGGAGAAACTTTCGGTCG
GGCGCAACTTTCTAGTACTG

Product: cyclic peptide transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MLKYLINQSRVLLAGASLVTVFHGTCSVLLIAQISSALTATESERGTLALVFIATAVAVMLSYVSAAILFERLGQRAHAE
LRSFVARKVLAADYRNLETVGAARIQSALAEHCTHVAEFFVSFPIILMNAVIVAGCLLYMAWLSWQVFLLAILVVGLGCV
GYHLAHLRAIRHLNIASEEQDKLFSYFRSLTDGAKELRLNNRKRKAFYEDVLSGSIETVRRERTFGMSVFVASGGWAQFL
LYVFIGMVLFALVSDGPDRALVMTGYALVFVYMVGPLEALLLNIPRANLAKVSAERIEEITRAMTTQEIETDNSSLPGLQ
SLALRGVLHRYYHEQSDELFTLGPIDLDFRPGEITFLVGGNGSGKTTLAKLLVGLYPPEEGQIIFNGKAVDETNRDCYRQ
LFSTVFSDFHLFDRLLETDRVDLDNEGNRLLAKLHLQNKVKVQDGAFTTLALSQGQRKRLALVVAYLENRPFFIFDEWAA
DQDPVFKEVFYRELLPELRAMGKAVLVISHDDRYFHLADRLIRMESGCLTFNACPSLKDALHATPAPPLVLNGVT

Sequences:

>Translated_555_residues
MLKYLINQSRVLLAGASLVTVFHGTCSVLLIAQISSALTATESERGTLALVFIATAVAVMLSYVSAAILFERLGQRAHAE
LRSFVARKVLAADYRNLETVGAARIQSALAEHCTHVAEFFVSFPIILMNAVIVAGCLLYMAWLSWQVFLLAILVVGLGCV
GYHLAHLRAIRHLNIASEEQDKLFSYFRSLTDGAKELRLNNRKRKAFYEDVLSGSIETVRRERTFGMSVFVASGGWAQFL
LYVFIGMVLFALVSDGPDRALVMTGYALVFVYMVGPLEALLLNIPRANLAKVSAERIEEITRAMTTQEIETDNSSLPGLQ
SLALRGVLHRYYHEQSDELFTLGPIDLDFRPGEITFLVGGNGSGKTTLAKLLVGLYPPEEGQIIFNGKAVDETNRDCYRQ
LFSTVFSDFHLFDRLLETDRVDLDNEGNRLLAKLHLQNKVKVQDGAFTTLALSQGQRKRLALVVAYLENRPFFIFDEWAA
DQDPVFKEVFYRELLPELRAMGKAVLVISHDDRYFHLADRLIRMESGCLTFNACPSLKDALHATPAPPLVLNGVT
>Mature_555_residues
MLKYLINQSRVLLAGASLVTVFHGTCSVLLIAQISSALTATESERGTLALVFIATAVAVMLSYVSAAILFERLGQRAHAE
LRSFVARKVLAADYRNLETVGAARIQSALAEHCTHVAEFFVSFPIILMNAVIVAGCLLYMAWLSWQVFLLAILVVGLGCV
GYHLAHLRAIRHLNIASEEQDKLFSYFRSLTDGAKELRLNNRKRKAFYEDVLSGSIETVRRERTFGMSVFVASGGWAQFL
LYVFIGMVLFALVSDGPDRALVMTGYALVFVYMVGPLEALLLNIPRANLAKVSAERIEEITRAMTTQEIETDNSSLPGLQ
SLALRGVLHRYYHEQSDELFTLGPIDLDFRPGEITFLVGGNGSGKTTLAKLLVGLYPPEEGQIIFNGKAVDETNRDCYRQ
LFSTVFSDFHLFDRLLETDRVDLDNEGNRLLAKLHLQNKVKVQDGAFTTLALSQGQRKRLALVVAYLENRPFFIFDEWAA
DQDPVFKEVFYRELLPELRAMGKAVLVISHDDRYFHLADRLIRMESGCLTFNACPSLKDALHATPAPPLVLNGVT

Specific function: ATP-driven efflux pump necessary for the secretion of syringomycin. May specifically bind syringomycin and translocate it to the periplasmic space. SyrD is also required for full expression of the syrB gene [H]

COG id: COG4615

COG function: function code QP; ABC-type siderophore export system, fused ATPase and permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI150417984, Length=231, Percent_Identity=29.8701298701299, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI9665248, Length=530, Percent_Identity=23.3962264150943, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI255708477, Length=233, Percent_Identity=25.7510729613734, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788540, Length=502, Percent_Identity=31.2749003984064, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI48994943, Length=273, Percent_Identity=27.1062271062271, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1787105, Length=239, Percent_Identity=25.9414225941423, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787143, Length=436, Percent_Identity=23.6238532110092, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787112, Length=246, Percent_Identity=28.4552845528455, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081834, Length=218, Percent_Identity=28.8990825688073, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789672, Length=211, Percent_Identity=27.4881516587678, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789873, Length=176, Percent_Identity=30.1136363636364, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786654, Length=455, Percent_Identity=23.956043956044, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789891, Length=225, Percent_Identity=28.4444444444444, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788225, Length=246, Percent_Identity=28.4552845528455, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789032, Length=207, Percent_Identity=27.536231884058, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081791, Length=196, Percent_Identity=26.0204081632653, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788450, Length=204, Percent_Identity=24.0196078431373, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1786253, Length=167, Percent_Identity=28.1437125748503, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1786872, Length=207, Percent_Identity=28.9855072463768, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI1787029, Length=209, Percent_Identity=25.3588516746411, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17558664, Length=197, Percent_Identity=28.4263959390863, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI193208177, Length=203, Percent_Identity=26.6009852216749, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71996550, Length=164, Percent_Identity=32.9268292682927, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71984940, Length=350, Percent_Identity=24.5714285714286, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17541710, Length=233, Percent_Identity=25.3218884120172, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323959, Length=187, Percent_Identity=29.9465240641711, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6322640, Length=207, Percent_Identity=27.0531400966184, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323217, Length=477, Percent_Identity=24.3186582809224, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24666092, Length=213, Percent_Identity=29.1079812206573, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593
- InterPro:   IPR005898 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 61794; Mature: 61794

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2 ; PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKYLINQSRVLLAGASLVTVFHGTCSVLLIAQISSALTATESERGTLALVFIATAVAVM
CCCHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LSYVSAAILFERLGQRAHAELRSFVARKVLAADYRNLETVGAARIQSALAEHCTHVAEFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
VSFPIILMNAVIVAGCLLYMAWLSWQVFLLAILVVGLGCVGYHLAHLRAIRHLNIASEEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DKLFSYFRSLTDGAKELRLNNRKRKAFYEDVLSGSIETVRRERTFGMSVFVASGGWAQFL
HHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCEEEEEECCCHHHHH
LYVFIGMVLFALVSDGPDRALVMTGYALVFVYMVGPLEALLLNIPRANLAKVSAERIEEI
HHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TRAMTTQEIETDNSSLPGLQSLALRGVLHRYYHEQSDELFTLGPIDLDFRPGEITFLVGG
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCEEECCCCCEEEEEEEC
NGSGKTTLAKLLVGLYPPEEGQIIFNGKAVDETNRDCYRQLFSTVFSDFHLFDRLLETDR
CCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VDLDNEGNRLLAKLHLQNKVKVQDGAFTTLALSQGQRKRLALVVAYLENRPFFIFDEWAA
CCCCCCCCCEEEEEECCCCEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCC
DQDPVFKEVFYRELLPELRAMGKAVLVISHDDRYFHLADRLIRMESGCLTFNACPSLKDA
CCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCEEECCCCCHHHH
LHATPAPPLVLNGVT
HCCCCCCCEEECCCC
>Mature Secondary Structure
MLKYLINQSRVLLAGASLVTVFHGTCSVLLIAQISSALTATESERGTLALVFIATAVAVM
CCCHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LSYVSAAILFERLGQRAHAELRSFVARKVLAADYRNLETVGAARIQSALAEHCTHVAEFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
VSFPIILMNAVIVAGCLLYMAWLSWQVFLLAILVVGLGCVGYHLAHLRAIRHLNIASEEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DKLFSYFRSLTDGAKELRLNNRKRKAFYEDVLSGSIETVRRERTFGMSVFVASGGWAQFL
HHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCEEEEEECCCHHHHH
LYVFIGMVLFALVSDGPDRALVMTGYALVFVYMVGPLEALLLNIPRANLAKVSAERIEEI
HHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TRAMTTQEIETDNSSLPGLQSLALRGVLHRYYHEQSDELFTLGPIDLDFRPGEITFLVGG
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCEEECCCCCEEEEEEEC
NGSGKTTLAKLLVGLYPPEEGQIIFNGKAVDETNRDCYRQLFSTVFSDFHLFDRLLETDR
CCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VDLDNEGNRLLAKLHLQNKVKVQDGAFTTLALSQGQRKRLALVVAYLENRPFFIFDEWAA
CCCCCCCCCEEEEEECCCCEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCC
DQDPVFKEVFYRELLPELRAMGKAVLVISHDDRYFHLADRLIRMESGCLTFNACPSLKDA
CCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCEEECCCCCHHHH
LHATPAPPLVLNGVT
HCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8231810 [H]