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The map label for this gene is era [H]

Identifier: 82702877

GI number: 82702877

Start: 2007224

End: 2008132

Strand: Direct

Name: era [H]

Synonym: Nmul_A1754

Alternate gene names: 82702877

Gene position: 2007224-2008132 (Clockwise)

Preceding gene: 82702876

Following gene: 82702878

Centisome position: 63.04

GC content: 50.5

Gene sequence:

>909_bases
ATGAACACTGAAGCTTCCCTTGCAGACCCTGTTTATCGCAGCGGGTATATTGCCATTGTTGGCCGCCCCAACGTAGGAAA
ATCCACTCTGTTAAACAGGTTGGTCGGCCAAAAGATCAGTATTACATCAAAAAAATCCCAGACGACGCGGCACCGCATAC
ATGGAATTTTCACTGATGAATACTCCCAGTTTGTTTTTGTCGACACTCCGGGCTTCCAGACACGGCATACAAACCGTTTG
AACAGCGGAATGAACCGTCTGGTCACTCAGACGCTGCGGGATGTGGATATCGTGATACTGGTGATCGAAGCGATGCGCTT
CGACGATCGCGACAAGCTGGTGGTGAAACTCCTGCCAAAGAGCAAGCCTGTGGTTCTTGCCCTGAACAAAATAGACCGCT
TGACGGATAAATCCCAACTGCTTCCCTTCCTCGAAAAGATGTCAAAGGAATTTGATTTCGCAGCCATGGTGCCGATAAGT
GCCGAGAATGGAGGGCAGTTGCCCGAATTGATAGCTGCGATACGGCCGCACCTGCCGCAAAATCCGCCATTATTCCTGGA
AGATGAAGTAACCGACCGGGATGAACGCTTCATAGCGGCGGAACTGGTTCGCGAAAAGTTGTTCCGGCTGTTGGGAGAAG
AGATTCCTTATTCCACCAGCGTCATCATTGACCAGTTTACGGTGGAAGACGAGCTGCGCAGGATTCACGCTTCCATTGTG
GTCGATAAATCCAGCCAGAAAGCAATTGTCATCGGCAAGGACGGAGAAAAATTGAAGCTGATCGCTACCCAGGCGCGCAA
AGACATGGAAGAAAGCTTCGGTGGCAAGGTTTATCTCAAGATCTGGGTAAAGATCAAAAGCGGCTGGGCCGAAGATGCAC
GGATGCTGAAGACGCTCGGGTATGAGTAA

Upstream 100 bases:

>100_bases
CTTTTCTGGACTGTGAAGCGCTTCCTGCCACAGCCAAAATATTCCAACAGCAAGGCTGCGAGGGAGTTACCCGAATGTAT
ATGACGCAAAACCTCTTCTG

Downstream 100 bases:

>100_bases
CCCGCGGAGGGTGGAACAGTGCCTTCCAAAGGAAGGTGTGACCCGGAGCGGGTTTACTGGCGCCATGAATATCAGGTTTC
TGTACCGCTCAATCAATTTT

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MNTEASLADPVYRSGYIAIVGRPNVGKSTLLNRLVGQKISITSKKSQTTRHRIHGIFTDEYSQFVFVDTPGFQTRHTNRL
NSGMNRLVTQTLRDVDIVILVIEAMRFDDRDKLVVKLLPKSKPVVLALNKIDRLTDKSQLLPFLEKMSKEFDFAAMVPIS
AENGGQLPELIAAIRPHLPQNPPLFLEDEVTDRDERFIAAELVREKLFRLLGEEIPYSTSVIIDQFTVEDELRRIHASIV
VDKSSQKAIVIGKDGEKLKLIATQARKDMEESFGGKVYLKIWVKIKSGWAEDARMLKTLGYE

Sequences:

>Translated_302_residues
MNTEASLADPVYRSGYIAIVGRPNVGKSTLLNRLVGQKISITSKKSQTTRHRIHGIFTDEYSQFVFVDTPGFQTRHTNRL
NSGMNRLVTQTLRDVDIVILVIEAMRFDDRDKLVVKLLPKSKPVVLALNKIDRLTDKSQLLPFLEKMSKEFDFAAMVPIS
AENGGQLPELIAAIRPHLPQNPPLFLEDEVTDRDERFIAAELVREKLFRLLGEEIPYSTSVIIDQFTVEDELRRIHASIV
VDKSSQKAIVIGKDGEKLKLIATQARKDMEESFGGKVYLKIWVKIKSGWAEDARMLKTLGYE
>Mature_302_residues
MNTEASLADPVYRSGYIAIVGRPNVGKSTLLNRLVGQKISITSKKSQTTRHRIHGIFTDEYSQFVFVDTPGFQTRHTNRL
NSGMNRLVTQTLRDVDIVILVIEAMRFDDRDKLVVKLLPKSKPVVLALNKIDRLTDKSQLLPFLEKMSKEFDFAAMVPIS
AENGGQLPELIAAIRPHLPQNPPLFLEDEVTDRDERFIAAELVREKLFRLLGEEIPYSTSVIIDQFTVEDELRRIHASIV
VDKSSQKAIVIGKDGEKLKLIATQARKDMEESFGGKVYLKIWVKIKSGWAEDARMLKTLGYE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=326, Percent_Identity=25.1533742331288, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1788919, Length=290, Percent_Identity=48.9655172413793, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI87082120, Length=167, Percent_Identity=31.7365269461078, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646434, Length=309, Percent_Identity=28.1553398058252, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34237; Mature: 34237

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTEASLADPVYRSGYIAIVGRPNVGKSTLLNRLVGQKISITSKKSQTTRHRIHGIFTDE
CCCCCCCCCHHHHCCEEEEEECCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHEEEECC
YSQFVFVDTPGFQTRHTNRLNSGMNRLVTQTLRDVDIVILVIEAMRFDDRDKLVVKLLPK
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCCCCCCEEEEECCC
SKPVVLALNKIDRLTDKSQLLPFLEKMSKEFDFAAMVPISAENGGQLPELIAAIRPHLPQ
CCCEEEEECHHHHHCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHCCCCCC
NPPLFLEDEVTDRDERFIAAELVREKLFRLLGEEIPYSTSVIIDQFTVEDELRRIHASIV
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHEE
VDKSSQKAIVIGKDGEKLKLIATQARKDMEESFGGKVYLKIWVKIKSGWAEDARMLKTLG
EECCCCCEEEEECCCCEEEEEHHHHHHHHHHHCCCEEEEEEEEEEECCCHHHHHHHHHHC
YE
CC
>Mature Secondary Structure
MNTEASLADPVYRSGYIAIVGRPNVGKSTLLNRLVGQKISITSKKSQTTRHRIHGIFTDE
CCCCCCCCCHHHHCCEEEEEECCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHEEEECC
YSQFVFVDTPGFQTRHTNRLNSGMNRLVTQTLRDVDIVILVIEAMRFDDRDKLVVKLLPK
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCCCCCCEEEEECCC
SKPVVLALNKIDRLTDKSQLLPFLEKMSKEFDFAAMVPISAENGGQLPELIAAIRPHLPQ
CCCEEEEECHHHHHCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHCCCCCC
NPPLFLEDEVTDRDERFIAAELVREKLFRLLGEEIPYSTSVIIDQFTVEDELRRIHASIV
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHEE
VDKSSQKAIVIGKDGEKLKLIATQARKDMEESFGGKVYLKIWVKIKSGWAEDARMLKTLG
EECCCCCEEEEECCCCEEEEEHHHHHHHHHHHCCCEEEEEEEEEEECCCHHHHHHHHHHC
YE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA