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The map label for this gene is rnc [H]

Identifier: 82702876

GI number: 82702876

Start: 2006417

End: 2007109

Strand: Direct

Name: rnc [H]

Synonym: Nmul_A1753

Alternate gene names: 82702876

Gene position: 2006417-2007109 (Clockwise)

Preceding gene: 82702875

Following gene: 82702877

Centisome position: 63.01

GC content: 57.29

Gene sequence:

>693_bases
TTGGGGACAGCTTACCGGAATACGGAGAGTGCGGCACTGTGCCGGAAACTCGGTTACACCTTCCGTCGACCCGAACTGCT
GCGGCAAGCCCTGACGCACCGCAGCCACAGCATACCTCACAACGAACGGCTTGAATTTCTGGGTGACGCCGTCCTCAACT
GCGCCGTCGCCGGATTGATATTCCATCATTTTCCCGATCTCAGCGAAGGTAGTTTGTCCCGGATACGGGCAAACCTCGTA
AACCAGAAGATGCTGGCCGAACTGGCGCAAACGCTTGAGCTGGGAAAGCTTATCCGATTTGGCGAAGGTGAGCTCAAAAG
TGGAGGAGACAAGCGGCCTTCGATTCTTGCGGATGCGCTGGAAGCTGTGATTGGCGCCATATATCTCGACGCGGGTTTTG
AGCAGGCCGAGAAGACAGTTGAAAATCTTTTCATTCCCTCCCTGGGGGAGCTGAACACCCATGCCCTCGGCAAGGATCCC
AAAACCCTTTTGCAGGAATATCTCCAGAGCCGCAAGCTGGCGCTACCCCGGTATGCTGTCGTTGCTACCCGAGGCGAAGC
TCACCAGCAGCAGTTTCAGGTGGAATGCGTGATTTCCCGGCCTCAAATCCGCACCCTGGGCGAAGGCACGAGCCGTCGCA
GTGCGGAACAGCACGCGGCCCGGCAAGCTTATGAGCAACTCCAGTCGCATTAG

Upstream 100 bases:

>100_bases
GAAACGCATCGGATTATCGATCAAGTAATTCGGGCGGCAATCAGGACCTTGAGCATGTGGTGGATCAGTCGCCATAATTG
GTCGGAGGGGACGCGCAAAA

Downstream 100 bases:

>100_bases
AACTGCCTTTCGTGCTTTTCTGGACTGTGAAGCGCTTCCTGCCACAGCCAAAATATTCCAACAGCAAGGCTGCGAGGGAG
TTACCCGAATGTATATGACG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MGTAYRNTESAALCRKLGYTFRRPELLRQALTHRSHSIPHNERLEFLGDAVLNCAVAGLIFHHFPDLSEGSLSRIRANLV
NQKMLAELAQTLELGKLIRFGEGELKSGGDKRPSILADALEAVIGAIYLDAGFEQAEKTVENLFIPSLGELNTHALGKDP
KTLLQEYLQSRKLALPRYAVVATRGEAHQQQFQVECVISRPQIRTLGEGTSRRSAEQHAARQAYEQLQSH

Sequences:

>Translated_230_residues
MGTAYRNTESAALCRKLGYTFRRPELLRQALTHRSHSIPHNERLEFLGDAVLNCAVAGLIFHHFPDLSEGSLSRIRANLV
NQKMLAELAQTLELGKLIRFGEGELKSGGDKRPSILADALEAVIGAIYLDAGFEQAEKTVENLFIPSLGELNTHALGKDP
KTLLQEYLQSRKLALPRYAVVATRGEAHQQQFQVECVISRPQIRTLGEGTSRRSAEQHAARQAYEQLQSH
>Mature_229_residues
GTAYRNTESAALCRKLGYTFRRPELLRQALTHRSHSIPHNERLEFLGDAVLNCAVAGLIFHHFPDLSEGSLSRIRANLVN
QKMLAELAQTLELGKLIRFGEGELKSGGDKRPSILADALEAVIGAIYLDAGFEQAEKTVENLFIPSLGELNTHALGKDPK
TLLQEYLQSRKLALPRYAVVATRGEAHQQQFQVECVISRPQIRTLGEGTSRRSAEQHAARQAYEQLQSH

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=225, Percent_Identity=32, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI155030234, Length=225, Percent_Identity=32, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1788920, Length=201, Percent_Identity=53.7313432835821, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17506883, Length=234, Percent_Identity=29.4871794871795, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193202651, Length=234, Percent_Identity=29.4871794871795, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323895, Length=102, Percent_Identity=35.2941176470588, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17137682, Length=220, Percent_Identity=30.9090909090909, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25596; Mature: 25464

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTAYRNTESAALCRKLGYTFRRPELLRQALTHRSHSIPHNERLEFLGDAVLNCAVAGLI
CCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
FHHFPDLSEGSLSRIRANLVNQKMLAELAQTLELGKLIRFGEGELKSGGDKRPSILADAL
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
EAVIGAIYLDAGFEQAEKTVENLFIPSLGELNTHALGKDPKTLLQEYLQSRKLALPRYAV
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCCHHHE
VATRGEAHQQQFQVECVISRPQIRTLGEGTSRRSAEQHAARQAYEQLQSH
EECCCHHHHHHHHHHHEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GTAYRNTESAALCRKLGYTFRRPELLRQALTHRSHSIPHNERLEFLGDAVLNCAVAGLI
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
FHHFPDLSEGSLSRIRANLVNQKMLAELAQTLELGKLIRFGEGELKSGGDKRPSILADAL
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
EAVIGAIYLDAGFEQAEKTVENLFIPSLGELNTHALGKDPKTLLQEYLQSRKLALPRYAV
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCCHHHE
VATRGEAHQQQFQVECVISRPQIRTLGEGTSRRSAEQHAARQAYEQLQSH
EECCCHHHHHHHHHHHEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]