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The map label for this gene is lepB [H]

Identifier: 82702875

GI number: 82702875

Start: 2005538

End: 2006344

Strand: Direct

Name: lepB [H]

Synonym: Nmul_A1752

Alternate gene names: 82702875

Gene position: 2005538-2006344 (Clockwise)

Preceding gene: 82702874

Following gene: 82702876

Centisome position: 62.98

GC content: 51.67

Gene sequence:

>807_bases
ATGAACTTTCCGCTCATTATGCTGATATTGCTGTTAATCACCGGCAGTATCGCCCTGCTCGATCGTACCGTGCTGCACCG
ACACCGCGCGCCGGGAGACCAGGGGCCATGGTGGGTGGAGTATCCGAAAAGCTTTTTCCCGGTGATTCTTGTCGTGTTCT
GCCTGCGCTCTTTCCTGGTTGAGCCTTTCAAAATCCCCTCGGGCTCGATGATTCCGACTCTGCTGGTAGGAGACTTCATT
CTCGTCAATAAATATACTTATGGTATCCGATTGCCGGTCGCCAACGTCAAGCTGATGGATATAAACTCCCCTCAGCGTGG
AGAGGTCATGGTTTTCCGCTACCCGGTCGATCCCTCCATGGATTACATTAAGCGTATCGTAGGGATACCGGGAGATATCA
TCACCTATCGTGACAAGCAGCTGAGCGTCAACAACGTGCCGGTGAGGATGGAGCCGAACGGGGAATATACCTATGTGGAA
TCGGGCCTGAAATTCGTTTACAGCCGCAGCTATACGGAGTCACTCGGAAATCACCGCTATAATGTCCTTATCAATCCCCT
GGAGGAGCATAGTATCCAGCTAGGGGGCGTGCTTCCCTTCCCCCATCATGAAAATTGCAGCTATAACGATCGTGGATTTA
CCTGCAAGGTTCCTCCCGGCAACTACTTTGCCATGGGAGACAACCGCGACAGCAGCAGTGACAGTCGTTATTGGGGATTC
GTACCCGACCAGAACATTGTGGGCAAGGCTTTCATGATCTGGTGGAATTTCAGCGACCTGAAACGCATCGGATTATCGAT
CAAGTAA

Upstream 100 bases:

>100_bases
ATACGATGGATCGCCTTCAACAAGGGGCACATGCTCACCAGGAAAATCCCGTTTCCGGGAGAGCAATGGACTGTTCACCC
GAAGGGAATAAGGAACAAGA

Downstream 100 bases:

>100_bases
TTCGGGCGGCAATCAGGACCTTGAGCATGTGGTGGATCAGTCGCCATAATTGGTCGGAGGGGACGCGCAAAATTGGGGAC
AGCTTACCGGAATACGGAGA

Product: peptidase S26A, signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MNFPLIMLILLLITGSIALLDRTVLHRHRAPGDQGPWWVEYPKSFFPVILVVFCLRSFLVEPFKIPSGSMIPTLLVGDFI
LVNKYTYGIRLPVANVKLMDINSPQRGEVMVFRYPVDPSMDYIKRIVGIPGDIITYRDKQLSVNNVPVRMEPNGEYTYVE
SGLKFVYSRSYTESLGNHRYNVLINPLEEHSIQLGGVLPFPHHENCSYNDRGFTCKVPPGNYFAMGDNRDSSSDSRYWGF
VPDQNIVGKAFMIWWNFSDLKRIGLSIK

Sequences:

>Translated_268_residues
MNFPLIMLILLLITGSIALLDRTVLHRHRAPGDQGPWWVEYPKSFFPVILVVFCLRSFLVEPFKIPSGSMIPTLLVGDFI
LVNKYTYGIRLPVANVKLMDINSPQRGEVMVFRYPVDPSMDYIKRIVGIPGDIITYRDKQLSVNNVPVRMEPNGEYTYVE
SGLKFVYSRSYTESLGNHRYNVLINPLEEHSIQLGGVLPFPHHENCSYNDRGFTCKVPPGNYFAMGDNRDSSSDSRYWGF
VPDQNIVGKAFMIWWNFSDLKRIGLSIK
>Mature_268_residues
MNFPLIMLILLLITGSIALLDRTVLHRHRAPGDQGPWWVEYPKSFFPVILVVFCLRSFLVEPFKIPSGSMIPTLLVGDFI
LVNKYTYGIRLPVANVKLMDINSPQRGEVMVFRYPVDPSMDYIKRIVGIPGDIITYRDKQLSVNNVPVRMEPNGEYTYVE
SGLKFVYSRSYTESLGNHRYNVLINPLEEHSIQLGGVLPFPHHENCSYNDRGFTCKVPPGNYFAMGDNRDSSSDSRYWGF
VPDQNIVGKAFMIWWNFSDLKRIGLSIK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=312, Percent_Identity=37.8205128205128, Blast_Score=189, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 30703; Mature: 30703

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFPLIMLILLLITGSIALLDRTVLHRHRAPGDQGPWWVEYPKSFFPVILVVFCLRSFLV
CCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHC
EPFKIPSGSMIPTLLVGDFILVNKYTYGIRLPVANVKLMDINSPQRGEVMVFRYPVDPSM
CCEECCCCCCCHHHHHCCEEEEEEEEEEEEEEECCEEEEECCCCCCCCEEEEEECCCCCH
DYIKRIVGIPGDIITYRDKQLSVNNVPVRMEPNGEYTYVESGLKFVYSRSYTESLGNHRY
HHHHHHHCCCCCEEEECCCEEEECCCEEEECCCCCEEEEECCHHHHHHCHHHHHHCCCEE
NVLINPLEEHSIQLGGVLPFPHHENCSYNDRGFTCKVPPGNYFAMGDNRDSSSDSRYWGF
EEEECCHHHCCEEECCEECCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEECC
VPDQNIVGKAFMIWWNFSDLKRIGLSIK
CCCCCCCCEEEEEEECHHHHHHHCCCCC
>Mature Secondary Structure
MNFPLIMLILLLITGSIALLDRTVLHRHRAPGDQGPWWVEYPKSFFPVILVVFCLRSFLV
CCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHC
EPFKIPSGSMIPTLLVGDFILVNKYTYGIRLPVANVKLMDINSPQRGEVMVFRYPVDPSM
CCEECCCCCCCHHHHHCCEEEEEEEEEEEEEEECCEEEEECCCCCCCCEEEEEECCCCCH
DYIKRIVGIPGDIITYRDKQLSVNNVPVRMEPNGEYTYVESGLKFVYSRSYTESLGNHRY
HHHHHHHCCCCCEEEECCCEEEECCCEEEECCCCCEEEEECCHHHHHHCHHHHHHCCCEE
NVLINPLEEHSIQLGGVLPFPHHENCSYNDRGFTCKVPPGNYFAMGDNRDSSSDSRYWGF
EEEECCHHHCCEEECCEECCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEECC
VPDQNIVGKAFMIWWNFSDLKRIGLSIK
CCCCCCCCEEEEEEECHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]