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The map label for this gene is nadC [H]

Identifier: 82702672

GI number: 82702672

Start: 1764718

End: 1765587

Strand: Direct

Name: nadC [H]

Synonym: Nmul_A1543

Alternate gene names: 82702672

Gene position: 1764718-1765587 (Clockwise)

Preceding gene: 82702667

Following gene: 82702676

Centisome position: 55.42

GC content: 54.02

Gene sequence:

>870_bases
ATGTTTTACGATCATTTCACGTATCTGGAAACCGAAGTCAAGAATAACGTCAGCCAGGCGCTGCTCGAAGATGTGGGTGC
AGGTGATCTCACCGCCAGCCTTGTTCCCTGTGACGAAACTGCGACCGCTACTGTGATCAGTCGTAAAGAGGCTGTGATGT
GTGGAAGCCGCTGGTTTGAGGAATGTTTTCGGCAACTGGAACCGCATGTCGAAGTGCGCTGGCATACGCGGGACGGCGAA
ACAGTCGGTGCCGGGCAGAAACTTTGTGCAGTGAAGGGTACTGCCAGGGCACTGCTGACAGGTGAACGGACAGCTCTCAA
TTTTCTGCAACTGCTTTCGGCTGTCTCCACCCAGACCCGGAGTTACGTGAATGCAATATCCGGAACGGGTGCAGTCATCG
TCGATACCCGCAAGACCTTGCCGGGATTACGGCTGGCGCAAAAATATGCGGTTAAATGCGGGGGGGGAACAAACCACCGG
ATCGGTTTATATGATGGCATTCTGATCAAGGAAAACCATATCATGGCTGCCGGCGGTATTGAACCGGCACTGCGTGCAGC
AAGGAGAATTGCCGCCCGGGGAATATTCATTCAGATCGAAGTGGAAACACTTCAAGACCTTCGTACCGCCTTGGATGCCG
GAGCGACGTTGATACTGCTGGATAACTTCGACCTGGAAGAACTGAGGGAAGCAGTAGTATTGAACGCGCGGCTAACCAAT
AAAGGCGCAGTGCTGGAAGCCTCCGGCGGAATCACGCTCGACAATGTCCGCGCAGTAGCCAGAACCGGTGTGGACCGCAT
CTCCATCGGCGGCCTTACCAAGGATATAAAGGCCATAGACCTGTCGATGCGGTTTTCTTCCCGTAGTTGA

Upstream 100 bases:

>100_bases
GTGCCGAAACCGTATGAGATTACTTTCAATGCATCAGACATGATGCCTCCGTATCACATTCAGCTAAAATACTCCATTCG
TTCCGGTGAACATAATAAAA

Downstream 100 bases:

>100_bases
CATGACCCCGCGACAGGCGCAGTAGTCGCCTAATCAACCCATGGGTGAAAGAAAATAGCGAAAGGGGAGGAAATCCCATG
TCTCTTTCATGGGTTTTTGA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MFYDHFTYLETEVKNNVSQALLEDVGAGDLTASLVPCDETATATVISRKEAVMCGSRWFEECFRQLEPHVEVRWHTRDGE
TVGAGQKLCAVKGTARALLTGERTALNFLQLLSAVSTQTRSYVNAISGTGAVIVDTRKTLPGLRLAQKYAVKCGGGTNHR
IGLYDGILIKENHIMAAGGIEPALRAARRIAARGIFIQIEVETLQDLRTALDAGATLILLDNFDLEELREAVVLNARLTN
KGAVLEASGGITLDNVRAVARTGVDRISIGGLTKDIKAIDLSMRFSSRS

Sequences:

>Translated_289_residues
MFYDHFTYLETEVKNNVSQALLEDVGAGDLTASLVPCDETATATVISRKEAVMCGSRWFEECFRQLEPHVEVRWHTRDGE
TVGAGQKLCAVKGTARALLTGERTALNFLQLLSAVSTQTRSYVNAISGTGAVIVDTRKTLPGLRLAQKYAVKCGGGTNHR
IGLYDGILIKENHIMAAGGIEPALRAARRIAARGIFIQIEVETLQDLRTALDAGATLILLDNFDLEELREAVVLNARLTN
KGAVLEASGGITLDNVRAVARTGVDRISIGGLTKDIKAIDLSMRFSSRS
>Mature_289_residues
MFYDHFTYLETEVKNNVSQALLEDVGAGDLTASLVPCDETATATVISRKEAVMCGSRWFEECFRQLEPHVEVRWHTRDGE
TVGAGQKLCAVKGTARALLTGERTALNFLQLLSAVSTQTRSYVNAISGTGAVIVDTRKTLPGLRLAQKYAVKCGGGTNHR
IGLYDGILIKENHIMAAGGIEPALRAARRIAARGIFIQIEVETLQDLRTALDAGATLILLDNFDLEELREAVVLNARLTN
KGAVLEASGGITLDNVRAVARTGVDRISIGGLTKDIKAIDLSMRFSSRS

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=260, Percent_Identity=37.6923076923077, Blast_Score=160, Evalue=1e-39,
Organism=Escherichia coli, GI1786299, Length=280, Percent_Identity=48.5714285714286, Blast_Score=248, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6321162, Length=294, Percent_Identity=29.5918367346939, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31273; Mature: 31273

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYDHFTYLETEVKNNVSQALLEDVGAGDLTASLVPCDETATATVISRKEAVMCGSRWFE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ECFRQLEPHVEVRWHTRDGETVGAGQKLCAVKGTARALLTGERTALNFLQLLSAVSTQTR
HHHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCHHEEECCCHHHHHHHHHHHHHHHHHH
SYVNAISGTGAVIVDTRKTLPGLRLAQKYAVKCGGGTNHRIGLYDGILIKENHIMAAGGI
HHHHHHCCCCEEEEECHHCCCCHHHHHHHEEECCCCCCCEEEEECCEEEECCEEEEECCC
EPALRAARRIAARGIFIQIEVETLQDLRTALDAGATLILLDNFDLEELREAVVLNARLTN
CHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHEEEEEECC
KGAVLEASGGITLDNVRAVARTGVDRISIGGLTKDIKAIDLSMRFSSRS
CCCEEECCCCEEHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECCCC
>Mature Secondary Structure
MFYDHFTYLETEVKNNVSQALLEDVGAGDLTASLVPCDETATATVISRKEAVMCGSRWFE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ECFRQLEPHVEVRWHTRDGETVGAGQKLCAVKGTARALLTGERTALNFLQLLSAVSTQTR
HHHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCHHEEECCCHHHHHHHHHHHHHHHHHH
SYVNAISGTGAVIVDTRKTLPGLRLAQKYAVKCGGGTNHRIGLYDGILIKENHIMAAGGI
HHHHHHCCCCEEEEECHHCCCCHHHHHHHEEECCCCCCCEEEEECCEEEECCEEEEECCC
EPALRAARRIAARGIFIQIEVETLQDLRTALDAGATLILLDNFDLEELREAVVLNARLTN
CHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHEEEEEECC
KGAVLEASGGITLDNVRAVARTGVDRISIGGLTKDIKAIDLSMRFSSRS
CCCEEECCCCEEHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]