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The map label for this gene is uvrY [H]

Identifier: 82702465

GI number: 82702465

Start: 1525537

End: 1526163

Strand: Direct

Name: uvrY [H]

Synonym: Nmul_A1336

Alternate gene names: 82702465

Gene position: 1525537-1526163 (Clockwise)

Preceding gene: 82702464

Following gene: 82702466

Centisome position: 47.91

GC content: 55.82

Gene sequence:

>627_bases
ATGAATGTACTGATTGTGGACGACCATGCCATCGTGCGTCAGGGCTTAAGGCAGATTCTGACTGAAAGCGGAAAAATCGA
TCTTATCGCTGAAGCGGAATCGGGTGGAGAGGCAATGCGGCAACTGCGTGAAGGGGAATGGAGCGTAGTGGTGCTGGATA
TCTCCCTGCCCGACAGGAACGGTATCGAAGTGTTGAAGCAGATCAGGAAAGAGCGTCCCAAATTACCCGTGCTCATGTTG
AGCATGCACGAGGAGGGGCTTTATGCGATCCGGGCACTGAAGGCGGGAGCCTTTGGTTATATAACCAAGCAGAGCGCTCC
CAATGAGTTGATGGCCGCCATCAACCAGGCGGCCAGGGGGCGCAAGTACCTGACACCCGCAGTGGCTGAAGCCATGGCGG
AAAGTCTTGGCACGGACCACGATCGTCCGCTGCATGAAACACTGTCCGATCGTGAATACCAGACCCTGCGCCTGATCGCT
TCAGGCAAGAGTCTCACAGACGCGGCCGAGGAAATGCATCTGTCGGTCAAGACTGTGAGTGTCTACCGCGGCCGCCTCCT
GCAAAAGATGAAGCTCAAGAACAATGCGGAAGTGACCCACTACGCCATCAAGAACGGCCTCGCTTGA

Upstream 100 bases:

>100_bases
AGGCAAGGCAAGGTACTCTGGTTCATCTCTCGATTCCACTCGCTGCGGAAGCACGGCCAACGGTCCCTGCGACGGTTATT
TCAGGAAAATCCACCCCGTC

Downstream 100 bases:

>100_bases
GCCCCTTAGTCCCTTGGTCCCTCAGCCCGTGGGCCGGATTACCCTTCACGCCAATTCGCTGATTCGCTGCTTCTTCATGG
GGGCGGCAGCATGGCGCCTC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MNVLIVDDHAIVRQGLRQILTESGKIDLIAEAESGGEAMRQLREGEWSVVVLDISLPDRNGIEVLKQIRKERPKLPVLML
SMHEEGLYAIRALKAGAFGYITKQSAPNELMAAINQAARGRKYLTPAVAEAMAESLGTDHDRPLHETLSDREYQTLRLIA
SGKSLTDAAEEMHLSVKTVSVYRGRLLQKMKLKNNAEVTHYAIKNGLA

Sequences:

>Translated_208_residues
MNVLIVDDHAIVRQGLRQILTESGKIDLIAEAESGGEAMRQLREGEWSVVVLDISLPDRNGIEVLKQIRKERPKLPVLML
SMHEEGLYAIRALKAGAFGYITKQSAPNELMAAINQAARGRKYLTPAVAEAMAESLGTDHDRPLHETLSDREYQTLRLIA
SGKSLTDAAEEMHLSVKTVSVYRGRLLQKMKLKNNAEVTHYAIKNGLA
>Mature_208_residues
MNVLIVDDHAIVRQGLRQILTESGKIDLIAEAESGGEAMRQLREGEWSVVVLDISLPDRNGIEVLKQIRKERPKLPVLML
SMHEEGLYAIRALKAGAFGYITKQSAPNELMAAINQAARGRKYLTPAVAEAMAESLGTDHDRPLHETLSDREYQTLRLIA
SGKSLTDAAEEMHLSVKTVSVYRGRLLQKMKLKNNAEVTHYAIKNGLA

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=209, Percent_Identity=34.4497607655502, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790102, Length=198, Percent_Identity=35.8585858585859, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=31.25, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786747, Length=201, Percent_Identity=28.3582089552239, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788546, Length=205, Percent_Identity=28.780487804878, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788521, Length=201, Percent_Identity=28.8557213930348, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787473, Length=186, Percent_Identity=30.6451612903226, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788191, Length=105, Percent_Identity=36.1904761904762, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786599, Length=152, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790552, Length=122, Percent_Identity=37.7049180327869, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1790437, Length=120, Percent_Identity=31.6666666666667, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787375, Length=119, Percent_Identity=31.0924369747899, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790299, Length=115, Percent_Identity=31.304347826087, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23069; Mature: 23069

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLIVDDHAIVRQGLRQILTESGKIDLIAEAESGGEAMRQLREGEWSVVVLDISLPDRN
CEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCCC
GIEVLKQIRKERPKLPVLMLSMHEEGLYAIRALKAGAFGYITKQSAPNELMAAINQAARG
CHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCC
RKYLTPAVAEAMAESLGTDHDRPLHETLSDREYQTLRLIASGKSLTDAAEEMHLSVKTVS
CCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHEEECCCCHHHHHHHHHHHHHHHH
VYRGRLLQKMKLKNNAEVTHYAIKNGLA
HHHHHHHHHHHHCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MNVLIVDDHAIVRQGLRQILTESGKIDLIAEAESGGEAMRQLREGEWSVVVLDISLPDRN
CEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCCC
GIEVLKQIRKERPKLPVLMLSMHEEGLYAIRALKAGAFGYITKQSAPNELMAAINQAARG
CHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCC
RKYLTPAVAEAMAESLGTDHDRPLHETLSDREYQTLRLIASGKSLTDAAEEMHLSVKTVS
CCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHEEECCCCHHHHHHHHHHHHHHHH
VYRGRLLQKMKLKNNAEVTHYAIKNGLA
HHHHHHHHHHHHCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]