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The map label for this gene is ureC

Identifier: 82702370

GI number: 82702370

Start: 1425586

End: 1427292

Strand: Direct

Name: ureC

Synonym: Nmul_A1241

Alternate gene names: 82702370

Gene position: 1425586-1427292 (Clockwise)

Preceding gene: 82702369

Following gene: 82702371

Centisome position: 44.77

GC content: 54.48

Gene sequence:

>1707_bases
ATGAGTTTCAAGGTTTCCCGCCAGACTTACGCGGAATTGATGGGCCCTACGACCGGCGACCGGATTCGCCTGGCTGATAC
CGAGCTGATGATCGAAATCGAGAAGGATTTCACCACCTATGGTGAAGAAGTGAAATTCGGGGGCGGCAAGGTAATACGCG
ACGGCATGGGGCAATCACAGCACAATCACGATCAAGTGATGGATACGGTCATCACCAACGCGGTAATCATCGACCACTGG
GGCATCGTCAAGGCTGATGTCGGTCTGAAGAACGGGAGGATCGCCGAGATCGGCAAAGCGGGCAATCCCGATATCCAGCC
GAATGTTACGATGTCGATCGGCGCGGCGACGGAAATCATAGCCGGCGAGAACATGATTCTGACCGCGGGTGGAATCGATT
CACATATCCACTTCATTTCCCCGCAGCAGGCAGAAGATGCGATGATGAATGGCATTACCACGATGCTGGGGGGAGGCACT
GGCCCGGCAGCGGGCACGGCAGCCACGACCTGTACGCCGGGCCCCTGGCATATTCATTCCATGTTGCGGGCCTCGGATGG
CATGGTGATGAACACCGGTTTTTACGGCAAGGGAAATGTAAGTCTTCCGACCCCGCTGGAAGAGCAGATTCTTGCCGGGG
CATGCGGACTGAAGCTGCACGAAGACTGGGGTTCGACCTACGCAGCTATCGACAATTGCCTGGCGGTGGCGGACAAGTAT
GATGTCCAGGTTGCCGTTCACACAGATACCATCAATGAAGGCGGATATCTGGAAAACACGATTGCAGCCATGAAGGACCG
TACCATCCATACTTTCCACACCGAGGGGGCCGGTGGAGGGCATGCGCCGGACATCATCGCCGTCGTAGGTCAGGAAAACG
TGCTGCCCTCATCAACCAATCCAACCCGGCCTTATACCATCAACACGCTGGATGAACATCTCGACATGCTGATGGTATGC
CATCACCTTCATGCCAACATCCCGGAAGATCTCGCGTTTGCCGAGTCGCGCATTCGTAAGGAGACCATAGCTGCGGAGGA
TATACTGCAGGATATGGGTGCAATCTCCATGATGTCCTCTGATTCGCAGGCGATGGGGCGGATTGGAGAGGTGGTTCTGC
GTACCTGGCAAACCGCGCACAAAATGAAAATACAACGCGGGACTTTGCAGGAAGATACATCGAAGAATGATAATTTCCGC
GTCAAACGCTACATCGCCAAATACACCATCAATCCGGCGATCACACATGGCATCTCGCACGCCCTCGGTTCGGTGGAGGT
GGGCAAATATGCAGATCTGGTGTTGTGGCGGCCCGCGTTTTTTGGCGTAAAGCCTTCCGTGATTCTGAAAGGTGGAATGA
TTGCGGCATCTTTAATGGGTGATCCGAACGCCTCGATTCCCACCCCGCAACCTGTCCATTACCGTTACATGTTCGGGGGA
TATGGCGGGGGTATCAAGACCTCGTGCTTTACCTTTGTCTCACAGGCAGCGCTGGCTGCAGGTCTGGTCGATCAATTGAA
GCTGGATAAGAATCTGATCGAGGTCAAGAATACGCGCAACCTGCGCAAGAAAGATATGATCCATAACTCGGCGACACCTA
AAATGGAAGTCGATCCGGAAACATACGAAGTTCGGGCGGATGGACAGTTGCTGACCTGCGGGGCGGAGGACGTTCTGCCG
ATGGCGCAAAGGTATTTCCTTTTTTAG

Upstream 100 bases:

>100_bases
GTGGAGCTGGCGGGTAACCGGATCGTCTATGGATTCAACCAGAAAGTAATGGGCAAGCTTAAGTAGAGATCGCCGCATCA
AACGAGAAAGGAGCTAAAGA

Downstream 100 bases:

>100_bases
GGGCTATAGATGCTCACCTTGAACACCAGGATAAACTCTGCGGACAAAGTATCCGCACAGCTCGTGCTACCGTATGAGTC
GCGCGAAAACAGCCGCCTGC

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MSFKVSRQTYAELMGPTTGDRIRLADTELMIEIEKDFTTYGEEVKFGGGKVIRDGMGQSQHNHDQVMDTVITNAVIIDHW
GIVKADVGLKNGRIAEIGKAGNPDIQPNVTMSIGAATEIIAGENMILTAGGIDSHIHFISPQQAEDAMMNGITTMLGGGT
GPAAGTAATTCTPGPWHIHSMLRASDGMVMNTGFYGKGNVSLPTPLEEQILAGACGLKLHEDWGSTYAAIDNCLAVADKY
DVQVAVHTDTINEGGYLENTIAAMKDRTIHTFHTEGAGGGHAPDIIAVVGQENVLPSSTNPTRPYTINTLDEHLDMLMVC
HHLHANIPEDLAFAESRIRKETIAAEDILQDMGAISMMSSDSQAMGRIGEVVLRTWQTAHKMKIQRGTLQEDTSKNDNFR
VKRYIAKYTINPAITHGISHALGSVEVGKYADLVLWRPAFFGVKPSVILKGGMIAASLMGDPNASIPTPQPVHYRYMFGG
YGGGIKTSCFTFVSQAALAAGLVDQLKLDKNLIEVKNTRNLRKKDMIHNSATPKMEVDPETYEVRADGQLLTCGAEDVLP
MAQRYFLF

Sequences:

>Translated_568_residues
MSFKVSRQTYAELMGPTTGDRIRLADTELMIEIEKDFTTYGEEVKFGGGKVIRDGMGQSQHNHDQVMDTVITNAVIIDHW
GIVKADVGLKNGRIAEIGKAGNPDIQPNVTMSIGAATEIIAGENMILTAGGIDSHIHFISPQQAEDAMMNGITTMLGGGT
GPAAGTAATTCTPGPWHIHSMLRASDGMVMNTGFYGKGNVSLPTPLEEQILAGACGLKLHEDWGSTYAAIDNCLAVADKY
DVQVAVHTDTINEGGYLENTIAAMKDRTIHTFHTEGAGGGHAPDIIAVVGQENVLPSSTNPTRPYTINTLDEHLDMLMVC
HHLHANIPEDLAFAESRIRKETIAAEDILQDMGAISMMSSDSQAMGRIGEVVLRTWQTAHKMKIQRGTLQEDTSKNDNFR
VKRYIAKYTINPAITHGISHALGSVEVGKYADLVLWRPAFFGVKPSVILKGGMIAASLMGDPNASIPTPQPVHYRYMFGG
YGGGIKTSCFTFVSQAALAAGLVDQLKLDKNLIEVKNTRNLRKKDMIHNSATPKMEVDPETYEVRADGQLLTCGAEDVLP
MAQRYFLF
>Mature_567_residues
SFKVSRQTYAELMGPTTGDRIRLADTELMIEIEKDFTTYGEEVKFGGGKVIRDGMGQSQHNHDQVMDTVITNAVIIDHWG
IVKADVGLKNGRIAEIGKAGNPDIQPNVTMSIGAATEIIAGENMILTAGGIDSHIHFISPQQAEDAMMNGITTMLGGGTG
PAAGTAATTCTPGPWHIHSMLRASDGMVMNTGFYGKGNVSLPTPLEEQILAGACGLKLHEDWGSTYAAIDNCLAVADKYD
VQVAVHTDTINEGGYLENTIAAMKDRTIHTFHTEGAGGGHAPDIIAVVGQENVLPSSTNPTRPYTINTLDEHLDMLMVCH
HLHANIPEDLAFAESRIRKETIAAEDILQDMGAISMMSSDSQAMGRIGEVVLRTWQTAHKMKIQRGTLQEDTSKNDNFRV
KRYIAKYTINPAITHGISHALGSVEVGKYADLVLWRPAFFGVKPSVILKGGMIAASLMGDPNASIPTPQPVHYRYMFGGY
GGGIKTSCFTFVSQAALAAGLVDQLKLDKNLIEVKNTRNLRKKDMIHNSATPKMEVDPETYEVRADGQLLTCGAEDVLPM
AQRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_NITMU (Q2Y9M7)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411936.1
- ProteinModelPortal:   Q2Y9M7
- SMR:   Q2Y9M7
- STRING:   Q2Y9M7
- GeneID:   3785580
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1241
- eggNOG:   COG0804
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13207
- BioCyc:   NMUL323848:NMUL_A1241-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 61516; Mature: 61385

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3

Important sites: ACT_SITE 321-321 BINDING 220-220

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFKVSRQTYAELMGPTTGDRIRLADTELMIEIEKDFTTYGEEVKFGGGKVIRDGMGQSQ
CCEECCHHHHHHHHCCCCCCEEEEECCEEEEEECCCCCCCCCEEEECCCEEEECCCCCCC
HNHDQVMDTVITNAVIIDHWGIVKADVGLKNGRIAEIGKAGNPDIQPNVTMSIGAATEII
CCHHHHHHHHHHCEEEEECCCEEEECCCCCCCCEEECCCCCCCCCCCCEEEEECCCEEEE
AGENMILTAGGIDSHIHFISPQQAEDAMMNGITTMLGGGTGPAAGTAATTCTPGPWHIHS
ECCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
MLRASDGMVMNTGFYGKGNVSLPTPLEEQILAGACGLKLHEDWGSTYAAIDNCLAVADKY
HHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEEHHHCCHHHHHHHHHHHCCCC
DVQVAVHTDTINEGGYLENTIAAMKDRTIHTFHTEGAGGGHAPDIIAVVGQENVLPSSTN
EEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCC
PTRPYTINTLDEHLDMLMVCHHLHANIPEDLAFAESRIRKETIAAEDILQDMGAISMMSS
CCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHEECCC
DSQAMGRIGEVVLRTWQTAHKMKIQRGTLQEDTSKNDNFRVKRYIAKYTINPAITHGISH
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHCCCHHHHHHHHH
ALGSVEVGKYADLVLWRPAFFGVKPSVILKGGMIAASLMGDPNASIPTPQPVHYRYMFGG
HHCCCCCCCCCCEEEECHHHCCCCCCEEEECCEEEEEECCCCCCCCCCCCCEEEEEEEEC
YGGGIKTSCFTFVSQAALAAGLVDQLKLDKNLIEVKNTRNLRKKDMIHNSATPKMEVDPE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHCCCCCCCEEECCC
TYEVRADGQLLTCGAEDVLPMAQRYFLF
EEEEEECCEEEEECCHHHHHHHHHHHCC
>Mature Secondary Structure 
SFKVSRQTYAELMGPTTGDRIRLADTELMIEIEKDFTTYGEEVKFGGGKVIRDGMGQSQ
CEECCHHHHHHHHCCCCCCEEEEECCEEEEEECCCCCCCCCEEEECCCEEEECCCCCCC
HNHDQVMDTVITNAVIIDHWGIVKADVGLKNGRIAEIGKAGNPDIQPNVTMSIGAATEII
CCHHHHHHHHHHCEEEEECCCEEEECCCCCCCCEEECCCCCCCCCCCCEEEEECCCEEEE
AGENMILTAGGIDSHIHFISPQQAEDAMMNGITTMLGGGTGPAAGTAATTCTPGPWHIHS
ECCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
MLRASDGMVMNTGFYGKGNVSLPTPLEEQILAGACGLKLHEDWGSTYAAIDNCLAVADKY
HHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEEHHHCCHHHHHHHHHHHCCCC
DVQVAVHTDTINEGGYLENTIAAMKDRTIHTFHTEGAGGGHAPDIIAVVGQENVLPSSTN
EEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCC
PTRPYTINTLDEHLDMLMVCHHLHANIPEDLAFAESRIRKETIAAEDILQDMGAISMMSS
CCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHEECCC
DSQAMGRIGEVVLRTWQTAHKMKIQRGTLQEDTSKNDNFRVKRYIAKYTINPAITHGISH
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHCCCHHHHHHHHH
ALGSVEVGKYADLVLWRPAFFGVKPSVILKGGMIAASLMGDPNASIPTPQPVHYRYMFGG
HHCCCCCCCCCCEEEECHHHCCCCCCEEEECCEEEEEECCCCCCCCCCCCCEEEEEEEEC
YGGGIKTSCFTFVSQAALAAGLVDQLKLDKNLIEVKNTRNLRKKDMIHNSATPKMEVDPE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHCCCCCCCEEECCC
TYEVRADGQLLTCGAEDVLPMAQRYFLF
EEEEEECCEEEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA