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The map label for this gene is ada [H]

Identifier: 82702342

GI number: 82702342

Start: 1398192

End: 1399085

Strand: Direct

Name: ada [H]

Synonym: Nmul_A1213

Alternate gene names: 82702342

Gene position: 1398192-1399085 (Clockwise)

Preceding gene: 82702333

Following gene: 82702354

Centisome position: 43.91

GC content: 60.07

Gene sequence:

>894_bases
ATGCAATTTTCCTGTTCCATTCCCTTACCTGCGACCTTTCGTCCCGGCGATATCTTGGCCTTTCATCGGCGCGACCGGCA
AGAGATCGCAGAGCGTGTCAACCATGCCTCCGTGCAAAAAGCCATGATCTGGTGCGGCGCCCCGGCGTACCTTTCTATCA
GCTTTGAGCCGGGATTGGCAAAGGCTTCACTGGTCATCGATGGCAAAATAGCGGAGGATCGCCAGCCCATCTTCGAAGGT
ATGGTCCGGCGCATGCTGGGTCTGACCCAGGAGATCGAGATCTTCGAGGAACGGTATCGCGATCATCCGCAATTGGGCAT
CCTGATCGCGCAACAACCCGGTTTACGGGTGCCGGTCACTGCCACCCCATTCGAGGCCCTGACCTGGGCAGTCACCGGCC
AACAAATCAGCGTCAACGCCGCGGTTTCCCTGCGGCGAAAGCTGATCGGCGCGACCAATACCCCTCACTCCTGTGGCCTG
TTCTGCTACCCGGACGCGCGCCGAATTCTCGAGCTGCCCGAAGAGACGTTACGGCAAGCGGGTTTTTCGACAACCAAAAC
CAGGACTTTGCTTGCACTCTCCGCCCTCGTGGCTGACAACGAGCTTCCATTGGATGCGTGGGTGGAGACGCTTCCGGTCG
ATGTCATTCGCGAAAAACTGGAAGCAGTCCGCGGCATCGGTCCGTGGACGGTGAATTATGGATTGCTGCGCGGTTTCGGC
TGGCTCGACGGCTCACTGCACGGCGATGCAGCAGTCCGGCGAGGCCTGCAAGCCTTGCTCGGGGCGCAGGACAAAATCAG
CGAGGAAAATACGAAGGTCTGGCTCGCGCAATTCTCCCCCTGGCGAGCCCTGGTCGGCGCCCATCTGTGGGCAGCCCCGG
TTGCGATTGCCTGA

Upstream 100 bases:

>100_bases
AAACAGGATTTCGCGCAAGGTATCCTGGGACCATAATCGTTTCATTTAGCCGAATAATCCGGCAGATACTTCTTTCCGTT
CCGGAAATCCGAAAGCGACC

Downstream 100 bases:

>100_bases
CGGGAATTCGATGCGCCTCATTGTGGTCCGACAGTCTCGTTGTGCGATACGGACAGCAATTTGGATGATACGTTTCTGTG
CCCTTGAGCAACAGGCGGGG

Product: HhH-GPD

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MQFSCSIPLPATFRPGDILAFHRRDRQEIAERVNHASVQKAMIWCGAPAYLSISFEPGLAKASLVIDGKIAEDRQPIFEG
MVRRMLGLTQEIEIFEERYRDHPQLGILIAQQPGLRVPVTATPFEALTWAVTGQQISVNAAVSLRRKLIGATNTPHSCGL
FCYPDARRILELPEETLRQAGFSTTKTRTLLALSALVADNELPLDAWVETLPVDVIREKLEAVRGIGPWTVNYGLLRGFG
WLDGSLHGDAAVRRGLQALLGAQDKISEENTKVWLAQFSPWRALVGAHLWAAPVAIA

Sequences:

>Translated_297_residues
MQFSCSIPLPATFRPGDILAFHRRDRQEIAERVNHASVQKAMIWCGAPAYLSISFEPGLAKASLVIDGKIAEDRQPIFEG
MVRRMLGLTQEIEIFEERYRDHPQLGILIAQQPGLRVPVTATPFEALTWAVTGQQISVNAAVSLRRKLIGATNTPHSCGL
FCYPDARRILELPEETLRQAGFSTTKTRTLLALSALVADNELPLDAWVETLPVDVIREKLEAVRGIGPWTVNYGLLRGFG
WLDGSLHGDAAVRRGLQALLGAQDKISEENTKVWLAQFSPWRALVGAHLWAAPVAIA
>Mature_297_residues
MQFSCSIPLPATFRPGDILAFHRRDRQEIAERVNHASVQKAMIWCGAPAYLSISFEPGLAKASLVIDGKIAEDRQPIFEG
MVRRMLGLTQEIEIFEERYRDHPQLGILIAQQPGLRVPVTATPFEALTWAVTGQQISVNAAVSLRRKLIGATNTPHSCGL
FCYPDARRILELPEETLRQAGFSTTKTRTLLALSALVADNELPLDAWVETLPVDVIREKLEAVRGIGPWTVNYGLLRGFG
WLDGSLHGDAAVRRGLQALLGAQDKISEENTKVWLAQFSPWRALVGAHLWAAPVAIA

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=190, Percent_Identity=28.4210526315789, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 32792; Mature: 32792

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFSCSIPLPATFRPGDILAFHRRDRQEIAERVNHASVQKAMIWCGAPAYLSISFEPGLA
CCEECCCCCCCCCCCCCEEEEHHCCHHHHHHHHHHHHHHHHHHEECCCEEEEEEECCCCC
KASLVIDGKIAEDRQPIFEGMVRRMLGLTQEIEIFEERYRDHPQLGILIAQQPGLRVPVT
EEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCEECEE
ATPFEALTWAVTGQQISVNAAVSLRRKLIGATNTPHSCGLFCYPDARRILELPEETLRQA
CCCHHHEEEEEECCEEEEHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHCCHHHHHHC
GFSTTKTRTLLALSALVADNELPLDAWVETLPVDVIREKLEAVRGIGPWTVNYGLLRGFG
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCEECHHHHHHCC
WLDGSLHGDAAVRRGLQALLGAQDKISEENTKVWLAQFSPWRALVGAHLWAAPVAIA
CCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQFSCSIPLPATFRPGDILAFHRRDRQEIAERVNHASVQKAMIWCGAPAYLSISFEPGLA
CCEECCCCCCCCCCCCCEEEEHHCCHHHHHHHHHHHHHHHHHHEECCCEEEEEEECCCCC
KASLVIDGKIAEDRQPIFEGMVRRMLGLTQEIEIFEERYRDHPQLGILIAQQPGLRVPVT
EEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCEECEE
ATPFEALTWAVTGQQISVNAAVSLRRKLIGATNTPHSCGLFCYPDARRILELPEETLRQA
CCCHHHEEEEEECCEEEEHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHCCHHHHHHC
GFSTTKTRTLLALSALVADNELPLDAWVETLPVDVIREKLEAVRGIGPWTVNYGLLRGFG
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCEECHHHHHHCC
WLDGSLHGDAAVRRGLQALLGAQDKISEENTKVWLAQFSPWRALVGAHLWAAPVAIA
CCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]