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The map label for this gene is yfhK [H]

Identifier: 82702288

GI number: 82702288

Start: 1336779

End: 1338335

Strand: Direct

Name: yfhK [H]

Synonym: Nmul_A1159

Alternate gene names: 82702288

Gene position: 1336779-1338335 (Clockwise)

Preceding gene: 82702287

Following gene: 82702289

Centisome position: 41.98

GC content: 54.21

Gene sequence:

>1557_bases
ATGAGGCATGCAAATAAAATTGCTTCGATTCCTCAAAGGAACCAAAGAAGAGAAATGATTGCCCCCGTGGAAGCCGGAAG
ACAGGATAGCGTAAGCGGTTCATGGGTAAGACTGCGGCGTAAGCCCAAATCCTTTGTCAAACTCATTCTGCTGGGTTTTG
CTCTGGTTGGCTTGCCACTGATCGTGGCGCTCATCAATAGCGCTTTTTCCATTGACCGGTTGGCAAATCAGAGCCGGAAG
GCTGTATATCAGGCGGCGGAGATTGCGCACAGCAGCCGCGCTCTTGCGGATGAAATCGCGAATATGGAGCGGGCGGTGCG
CCAGACTCACATTCTGGGCGATACTGCCCTGCTGGAGGGTTATTTCCGTGGACATGCCGGATTCGAGAAAATCGCCGCGG
GCCTTGCCGAACTCTCTCTCAGCGATGAGCAGAGACGATTGCTGGGACAGCTGAAATCAGAGGAGGCCGCTATTTTCGAG
GAAATTTCAGCCGTTAAGCAATCACCGGAAGAGTTGCGTAAGCTGATCGGCAATTTTGGTCATCTGCGGGATTCCGCACG
CTTCTTTTTCTCGCTCGGGTACGCGCTCATAGAGCGCGAAGTGGACGAAATGCAGGATATGGCGGGATCAGCGCGCTTTA
CCGTTGGCTGGCAACTGCTTGCACTGATTCCATTTGCCATATTACTTGCCTTCTTTTTTTCCTTCCGGATCGCCCGCCCG
ATTCGCCAGATTGAAGAGGCTATCCGCAGCATGGGACAGGGAAAGCTGCATAAGGCGATTCGGGTGGATGGTCCTCAGGA
CTTGGTTTATTTTGGCGAAAGACTGGACTGGATGAGACAGCGCCTGCTAAAGCTCGAAGAACAGAAGACGCGGTTCCTGC
AGCATGTTTCTCACGAACTCAAGACCCCGCTGACAGCCATGCGGGAAGGGGCGGATTTGCTCGTGGAAGGTGTGGCGGGC
AAGCTGACGGAAGAGCAGCAGCGCGTTGCCAGCATTCTTCATAGCAATAGCCTGCAGTTGCAGCGCCGCATCGAGGACTT
GCTGAGTTATAGCGCCCTTCAGACCGAGAAAGCCGCACTGGTGAAACAGGAGGTGGATTTGAAGAAGATTCTGGATGTGG
TATTGCACGATCAGAATCTCATCATTATGAACAAAGGCCTGCGAATGGATTTGTCTTGCCCGGAAGTGATGCTGGAGTGC
GAGCCGCAAAAAGTCAAAGTGATTGTGGACAATCTTTTATCGAACGCTGTGAAATTCTCCCCCCGGGGAGGGTGCATCCG
CATCTGGACAAGTGAGACAGCAGGGGTTGCGCAACTGGATATAGTGGACGCTGGACCCGGAGTGGATGATGCCGATCGGG
AGAAAGTATTCGAACCGTTTTATCAAGGGCGGAGAGTGCTTGACAGTCACGTGAGGGGAACGGGCTTGGGATTGTCGATC
GCCCGGGAGTATGCGCTTGCGCATGGCGGGAACATCGAGCTCGTACCGCTGCCTGACCGCGGCGCCCACTTTCGGCTCAC
TCTCCCCGTTCATGATGTGCCTGAAGGATCAGCATGA

Upstream 100 bases:

>100_bases
TAGAACCAGTAAGTATCCTGCCTCGCGCTGCCAAATTCCGGCACTTCCGATCGTTTGAATCACCACAAGGGGGTTTCCAA
GCCTGAGTGGCAGGATCAGT

Downstream 100 bases:

>100_bases
GGAGCATGGTGCGCATACGAGAACTCGGGCTGGTTCCGCCGATAGCGGCGTTGATGTTTCTGACCGCGTGCGTAGCCGTT
GAAAGCGTTGAAAGCCCGCA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MRHANKIASIPQRNQRREMIAPVEAGRQDSVSGSWVRLRRKPKSFVKLILLGFALVGLPLIVALINSAFSIDRLANQSRK
AVYQAAEIAHSSRALADEIANMERAVRQTHILGDTALLEGYFRGHAGFEKIAAGLAELSLSDEQRRLLGQLKSEEAAIFE
EISAVKQSPEELRKLIGNFGHLRDSARFFFSLGYALIEREVDEMQDMAGSARFTVGWQLLALIPFAILLAFFFSFRIARP
IRQIEEAIRSMGQGKLHKAIRVDGPQDLVYFGERLDWMRQRLLKLEEQKTRFLQHVSHELKTPLTAMREGADLLVEGVAG
KLTEEQQRVASILHSNSLQLQRRIEDLLSYSALQTEKAALVKQEVDLKKILDVVLHDQNLIIMNKGLRMDLSCPEVMLEC
EPQKVKVIVDNLLSNAVKFSPRGGCIRIWTSETAGVAQLDIVDAGPGVDDADREKVFEPFYQGRRVLDSHVRGTGLGLSI
AREYALAHGGNIELVPLPDRGAHFRLTLPVHDVPEGSA

Sequences:

>Translated_518_residues
MRHANKIASIPQRNQRREMIAPVEAGRQDSVSGSWVRLRRKPKSFVKLILLGFALVGLPLIVALINSAFSIDRLANQSRK
AVYQAAEIAHSSRALADEIANMERAVRQTHILGDTALLEGYFRGHAGFEKIAAGLAELSLSDEQRRLLGQLKSEEAAIFE
EISAVKQSPEELRKLIGNFGHLRDSARFFFSLGYALIEREVDEMQDMAGSARFTVGWQLLALIPFAILLAFFFSFRIARP
IRQIEEAIRSMGQGKLHKAIRVDGPQDLVYFGERLDWMRQRLLKLEEQKTRFLQHVSHELKTPLTAMREGADLLVEGVAG
KLTEEQQRVASILHSNSLQLQRRIEDLLSYSALQTEKAALVKQEVDLKKILDVVLHDQNLIIMNKGLRMDLSCPEVMLEC
EPQKVKVIVDNLLSNAVKFSPRGGCIRIWTSETAGVAQLDIVDAGPGVDDADREKVFEPFYQGRRVLDSHVRGTGLGLSI
AREYALAHGGNIELVPLPDRGAHFRLTLPVHDVPEGSA
>Mature_518_residues
MRHANKIASIPQRNQRREMIAPVEAGRQDSVSGSWVRLRRKPKSFVKLILLGFALVGLPLIVALINSAFSIDRLANQSRK
AVYQAAEIAHSSRALADEIANMERAVRQTHILGDTALLEGYFRGHAGFEKIAAGLAELSLSDEQRRLLGQLKSEEAAIFE
EISAVKQSPEELRKLIGNFGHLRDSARFFFSLGYALIEREVDEMQDMAGSARFTVGWQLLALIPFAILLAFFFSFRIARP
IRQIEEAIRSMGQGKLHKAIRVDGPQDLVYFGERLDWMRQRLLKLEEQKTRFLQHVSHELKTPLTAMREGADLLVEGVAG
KLTEEQQRVASILHSNSLQLQRRIEDLLSYSALQTEKAALVKQEVDLKKILDVVLHDQNLIIMNKGLRMDLSCPEVMLEC
EPQKVKVIVDNLLSNAVKFSPRGGCIRIWTSETAGVAQLDIVDAGPGVDDADREKVFEPFYQGRRVLDSHVRGTGLGLSI
AREYALAHGGNIELVPLPDRGAHFRLTLPVHDVPEGSA

Specific function: Probable member of a two-component regulatory system yfhA/yfhK. May activate yfhA by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082128, Length=428, Percent_Identity=31.0747663551402, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=27.0491803278689, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=30.7692307692308, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787894, Length=304, Percent_Identity=26.6447368421053, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=30.0847457627119, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790346, Length=276, Percent_Identity=27.8985507246377, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=25.7352941176471, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788713, Length=269, Percent_Identity=26.7657992565056, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87081816, Length=238, Percent_Identity=29.8319327731092, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790861, Length=255, Percent_Identity=28.6274509803922, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789808, Length=293, Percent_Identity=25.2559726962457, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1789149, Length=239, Percent_Identity=28.8702928870293, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788549, Length=433, Percent_Identity=25.1732101616628, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=257, Percent_Identity=25.2918287937743, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=24.3478260869565, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786783, Length=298, Percent_Identity=24.1610738255034, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788279, Length=273, Percent_Identity=25.6410256410256, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=285, Percent_Identity=25.6140350877193, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790551, Length=276, Percent_Identity=24.2753623188406, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57937; Mature: 57937

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHANKIASIPQRNQRREMIAPVEAGRQDSVSGSWVRLRRKPKSFVKLILLGFALVGLPL
CCCCHHHHCCCCCCCHHHHHCHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
IVALINSAFSIDRLANQSRKAVYQAAEIAHSSRALADEIANMERAVRQTHILGDTALLEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
YFRGHAGFEKIAAGLAELSLSDEQRRLLGQLKSEEAAIFEEISAVKQSPEELRKLIGNFG
HHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
HLRDSARFFFSLGYALIEREVDEMQDMAGSARFTVGWQLLALIPFAILLAFFFSFRIARP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRQIEEAIRSMGQGKLHKAIRVDGPQDLVYFGERLDWMRQRLLKLEEQKTRFLQHVSHEL
HHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTPLTAMREGADLLVEGVAGKLTEEQQRVASILHSNSLQLQRRIEDLLSYSALQTEKAAL
HCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VKQEVDLKKILDVVLHDQNLIIMNKGLRMDLSCPEVMLECEPQKVKVIVDNLLSNAVKFS
HHHHCCHHHHHHHHHCCCCEEEEECCCEECCCCHHHHHHCCCHHHHHHHHHHHHHHHEEC
PRGGCIRIWTSETAGVAQLDIVDAGPGVDDADREKVFEPFYQGRRVLDSHVRGTGLGLSI
CCCCEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AREYALAHGGNIELVPLPDRGAHFRLTLPVHDVPEGSA
HHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MRHANKIASIPQRNQRREMIAPVEAGRQDSVSGSWVRLRRKPKSFVKLILLGFALVGLPL
CCCCHHHHCCCCCCCHHHHHCHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
IVALINSAFSIDRLANQSRKAVYQAAEIAHSSRALADEIANMERAVRQTHILGDTALLEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
YFRGHAGFEKIAAGLAELSLSDEQRRLLGQLKSEEAAIFEEISAVKQSPEELRKLIGNFG
HHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
HLRDSARFFFSLGYALIEREVDEMQDMAGSARFTVGWQLLALIPFAILLAFFFSFRIARP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRQIEEAIRSMGQGKLHKAIRVDGPQDLVYFGERLDWMRQRLLKLEEQKTRFLQHVSHEL
HHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTPLTAMREGADLLVEGVAGKLTEEQQRVASILHSNSLQLQRRIEDLLSYSALQTEKAAL
HCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VKQEVDLKKILDVVLHDQNLIIMNKGLRMDLSCPEVMLECEPQKVKVIVDNLLSNAVKFS
HHHHCCHHHHHHHHHCCCCEEEEECCCEECCCCHHHHHHCCCHHHHHHHHHHHHHHHEEC
PRGGCIRIWTSETAGVAQLDIVDAGPGVDDADREKVFEPFYQGRRVLDSHVRGTGLGLSI
CCCCEEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AREYALAHGGNIELVPLPDRGAHFRLTLPVHDVPEGSA
HHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]