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The map label for this gene is pntAA [H]

Identifier: 82702280

GI number: 82702280

Start: 1328140

End: 1329267

Strand: Direct

Name: pntAA [H]

Synonym: Nmul_A1151

Alternate gene names: 82702280

Gene position: 1328140-1329267 (Clockwise)

Preceding gene: 82702279

Following gene: 82702281

Centisome position: 41.71

GC content: 58.69

Gene sequence:

>1128_bases
ATGCATATAGGAATACCGGCAGAGACCCGTGGGGGAGAAACCCGGGTTGCCGCCACGCCGGAGACGGTCAAGAAATTTAC
CGCCAAAGGTTTGCATGTCGTTCTGGTGCAGTCGGGCGCGGGTGCGGGCGCGAGCATAGCGGATGAGGAATACCAGGCTG
CCGGCGCAAGTATCGTGACCGATCCCGGCGAACTGTATGGGCAATCTCAGATCGTGCTCAAGGTGCGGGCCCCCGAAGCG
TCTGAACTCGCATTGATGCGCAAGGATGCCGTATTGGTTGGACTGCTTTCTCCACATCAGGCCGAGGGTATCGAAGTGCT
TGCCGCTCACGGTATAACCGCTTTTTCGATGGAGAAACTGCCGCGTATTTCGCGTGCCCAGAGCATGGATGTGCTGTCGT
CACAGGCCAACATCGCCGGATACAAGGCGGTGATCATGGCAGCCAATATCTACCAGAAATTTTTCCCCATGCTGATGACA
GCGGCGGGTACGGTAAAGGCGGCGAGAGTACTGGTTCTGGGCGCAGGAGTGGCGGGATTGCAGGCCATTGCCACCGCCAA
ACGGCTGGGGGCGGTAATCGAAGCATTCGATGTGCGCCCGGCAGCCAAGGAACAGGTGGAAAGCCTGGGCGCCAAGTTTG
TCGAGGTTGCGCTCAGCGACGAGGAAAAGGCGCAAGCGGAAACCGCAGGTGGATACGCGCGGGAAATGTCGGAGGATTAC
AAACGCCGCCAGGGCGAACTGGTGCACCAGCGCGCCTCTGCAGCCGACATCATCATTACGACGGCGCTGATTCCCGGCCG
TCCGGCCCCCGTGCTGATCCGGGAAGAAACGGTGCAGGCGATGAAACCGGGTTCCGTCATTGTCGACCTGGCGGTTGAAG
CCGGTGGCAACTGTCCCTTGTCTGAATTGAACAAGGTCGTCGTGAAACATGGCGTGCATCTCGTCGGCATTGCCAATCTG
CCCGGACTGGTAGCCGCCGATTCCAGCGCCCTGTATGCGCGCAACCTGATGAATTTCGTGAACCTGATGCTCGATGCAAA
GACAGGCGAACTCAACATAAATCGTGAAGACGAAATCATCGCCGGAACCTTGGTATGCGCCAACGGGGAAGTCATCGGGA
AAACCTGA

Upstream 100 bases:

>100_bases
TTCGGGGTTTTTGTTGGAACAGGGCTCCGCGATGGGTGCGAGGGGCTTTTTACCTCGCCACCGAGCGTGGCGCATACAAG
AAAGATAAAGGGAGATATTC

Downstream 100 bases:

>100_bases
AGGAAAACACGCCTCGGACTGAAAAGCACCGCCTGTGTCTTAACCGTTGCTTTTCCTCCCCCGGTTCGTGTCCTGGTAAA
AAGTTAACAGATTAGAAGGA

Product: NAD(P)(+) transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MHIGIPAETRGGETRVAATPETVKKFTAKGLHVVLVQSGAGAGASIADEEYQAAGASIVTDPGELYGQSQIVLKVRAPEA
SELALMRKDAVLVGLLSPHQAEGIEVLAAHGITAFSMEKLPRISRAQSMDVLSSQANIAGYKAVIMAANIYQKFFPMLMT
AAGTVKAARVLVLGAGVAGLQAIATAKRLGAVIEAFDVRPAAKEQVESLGAKFVEVALSDEEKAQAETAGGYAREMSEDY
KRRQGELVHQRASAADIIITTALIPGRPAPVLIREETVQAMKPGSVIVDLAVEAGGNCPLSELNKVVVKHGVHLVGIANL
PGLVAADSSALYARNLMNFVNLMLDAKTGELNINREDEIIAGTLVCANGEVIGKT

Sequences:

>Translated_375_residues
MHIGIPAETRGGETRVAATPETVKKFTAKGLHVVLVQSGAGAGASIADEEYQAAGASIVTDPGELYGQSQIVLKVRAPEA
SELALMRKDAVLVGLLSPHQAEGIEVLAAHGITAFSMEKLPRISRAQSMDVLSSQANIAGYKAVIMAANIYQKFFPMLMT
AAGTVKAARVLVLGAGVAGLQAIATAKRLGAVIEAFDVRPAAKEQVESLGAKFVEVALSDEEKAQAETAGGYAREMSEDY
KRRQGELVHQRASAADIIITTALIPGRPAPVLIREETVQAMKPGSVIVDLAVEAGGNCPLSELNKVVVKHGVHLVGIANL
PGLVAADSSALYARNLMNFVNLMLDAKTGELNINREDEIIAGTLVCANGEVIGKT
>Mature_375_residues
MHIGIPAETRGGETRVAATPETVKKFTAKGLHVVLVQSGAGAGASIADEEYQAAGASIVTDPGELYGQSQIVLKVRAPEA
SELALMRKDAVLVGLLSPHQAEGIEVLAAHGITAFSMEKLPRISRAQSMDVLSSQANIAGYKAVIMAANIYQKFFPMLMT
AAGTVKAARVLVLGAGVAGLQAIATAKRLGAVIEAFDVRPAAKEQVESLGAKFVEVALSDEEKAQAETAGGYAREMSEDY
KRRQGELVHQRASAADIIITTALIPGRPAPVLIREETVQAMKPGSVIVDLAVEAGGNCPLSELNKVVVKHGVHLVGIANL
PGLVAADSSALYARNLMNFVNLMLDAKTGELNINREDEIIAGTLVCANGEVIGKT

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=387, Percent_Identity=38.7596899224806, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI122939153, Length=387, Percent_Identity=38.7596899224806, Blast_Score=257, Evalue=1e-68,
Organism=Escherichia coli, GI1787887, Length=373, Percent_Identity=46.3806970509383, Blast_Score=308, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17550456, Length=372, Percent_Identity=43.2795698924731, Blast_Score=284, Evalue=6e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39234; Mature: 39234

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGIPAETRGGETRVAATPETVKKFTAKGLHVVLVQSGAGAGASIADEEYQAAGASIVT
CCCCCCCCCCCCCEEEEECHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHCCCEEEE
DPGELYGQSQIVLKVRAPEASELALMRKDAVLVGLLSPHQAEGIEVLAAHGITAFSMEKL
CCHHHCCCCEEEEEEECCCHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHC
PRISRAQSMDVLSSQANIAGYKAVIMAANIYQKFFPMLMTAAGTVKAARVLVLGAGVAGL
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHH
QAIATAKRLGAVIEAFDVRPAAKEQVESLGAKFVEVALSDEEKAQAETAGGYAREMSEDY
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHEEEEEECCCHHHHHHHCCCHHHHHHHHH
KRRQGELVHQRASAADIIITTALIPGRPAPVLIREETVQAMKPGSVIVDLAVEAGGNCPL
HHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEHHHHHHCCCCCEEEEEEEECCCCCCH
SELNKVVVKHGVHLVGIANLPGLVAADSSALYARNLMNFVNLMLDAKTGELNINREDEII
HHHHHHHHHCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHHEECCCCEEECCCCCCEE
AGTLVCANGEVIGKT
EEEEEEECCEEECCC
>Mature Secondary Structure
MHIGIPAETRGGETRVAATPETVKKFTAKGLHVVLVQSGAGAGASIADEEYQAAGASIVT
CCCCCCCCCCCCCEEEEECHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHCCCEEEE
DPGELYGQSQIVLKVRAPEASELALMRKDAVLVGLLSPHQAEGIEVLAAHGITAFSMEKL
CCHHHCCCCEEEEEEECCCHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHC
PRISRAQSMDVLSSQANIAGYKAVIMAANIYQKFFPMLMTAAGTVKAARVLVLGAGVAGL
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHH
QAIATAKRLGAVIEAFDVRPAAKEQVESLGAKFVEVALSDEEKAQAETAGGYAREMSEDY
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHEEEEEECCCHHHHHHHCCCHHHHHHHHH
KRRQGELVHQRASAADIIITTALIPGRPAPVLIREETVQAMKPGSVIVDLAVEAGGNCPL
HHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEHHHHHHCCCCCEEEEEEEECCCCCCH
SELNKVVVKHGVHLVGIANLPGLVAADSSALYARNLMNFVNLMLDAKTGELNINREDEII
HHHHHHHHHCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHHEECCCCEEECCCCCCEE
AGTLVCANGEVIGKT
EEEEEEECCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]