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The map label for this gene is gpsA

Identifier: 82702255

GI number: 82702255

Start: 1295909

End: 1296910

Strand: Direct

Name: gpsA

Synonym: Nmul_A1126

Alternate gene names: 82702255

Gene position: 1295909-1296910 (Clockwise)

Preceding gene: 82702254

Following gene: 82702258

Centisome position: 40.7

GC content: 58.48

Gene sequence:

>1002_bases
ATGAGAATAGCGGTGATGGGAGCCGGCGCATGGGGCACCGCGCTGGCTCTCAGTCTTTGTGCAAGCACCGCCTCTTCCCA
TCAGGTGACATTATGGACACGCAGCCGCCAACATCTGGCCGATCTCGTTTCACAGCGTATCAATCGCCGCTATTTTTCCG
CTTTTCCCTTACCGGCATCATTGCGGTTGACCGCAGGGCTCGAAGAGGCTGTCGAGGACGCCGAACTCGCCCTGATCGTT
GTGCCGGTTTCCGGTTTGCGCGAAACTTTGCGGGAAATTGCAGCAAGCGGGAAGAAGATCCCTGTCATCTGGGGATGCAA
GGGATTTGAATCGCAATCGGCAAAGCTGCCGCATCAGGTGGCCGAGGAGGAGTATGCCGGAGCCGCGCCATATGGCGTTC
TATCGGGTCCCAGTTTTGCGCTTGAAATCGCGCAAGGCTTGCCCGCGGCCTTGACTCTTGCCTCCAGGGATGGGGAATTC
GCACGAGAGGTAGCGGCGCAACTGCACGCTCCGCGGCTGCGGGTTTATTCTTGTACCGATGTAGTGGGTGTGGAAACGGG
GGGCGCAGTCAAGAACGTCATATCGATTGCCGCAGGCATTTGCGACGGCATGGGATTCGGGTCCAACGCCCGGGCGGCCT
TGATCACCCGTGGCCTTGCGGAAATTACCCGATTGGGTTTAAAACTGGGGGGACGCATGGAGACCTTCCTGGGTTTGACC
GGGGTGGGTGATCTGATATTGACCTGCACTGGGGATTTGTCGCGCAATCGCCGGGTTGGGCTGGCACTCGCGGCGGGTCG
CTCCCTCCCCGACATTCTGCAGGAACTGGGGCATATCGCCGAAGGTGTCCACACCGCCCGGGAGGTATTGCGATTAAGTC
ACCTGCTGGGCATTGAAATGCCGATCACAAAGGGGGTTTGCAGTATACTGGATGACGGTGTTCCGGCTGGGCAGGCAGTA
GAAGCGTTGCTCAATCGTGAACCGAAATCGGAAATCTATTGA

Upstream 100 bases:

>100_bases
TAATCCTGGAGTGGCTTGAGCCCCCGGCCAACGGATGGGTGAGGGTGCGGCATCGCGACGGTCAAACCGGGTACGTCAGG
ACCAGTCAGGTCTGGGGTTC

Downstream 100 bases:

>100_bases
GCGGATCGAAAGACATAGAGAAGACAGTACCTCAACACATTCAACTCCTCCGGCGCTATGCGAATCCCGTCTGGCGCCAT
GCCTCATAGACTATCACCGC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MRIAVMGAGAWGTALALSLCASTASSHQVTLWTRSRQHLADLVSQRINRRYFSAFPLPASLRLTAGLEEAVEDAELALIV
VPVSGLRETLREIAASGKKIPVIWGCKGFESQSAKLPHQVAEEEYAGAAPYGVLSGPSFALEIAQGLPAALTLASRDGEF
AREVAAQLHAPRLRVYSCTDVVGVETGGAVKNVISIAAGICDGMGFGSNARAALITRGLAEITRLGLKLGGRMETFLGLT
GVGDLILTCTGDLSRNRRVGLALAAGRSLPDILQELGHIAEGVHTAREVLRLSHLLGIEMPITKGVCSILDDGVPAGQAV
EALLNREPKSEIY

Sequences:

>Translated_333_residues
MRIAVMGAGAWGTALALSLCASTASSHQVTLWTRSRQHLADLVSQRINRRYFSAFPLPASLRLTAGLEEAVEDAELALIV
VPVSGLRETLREIAASGKKIPVIWGCKGFESQSAKLPHQVAEEEYAGAAPYGVLSGPSFALEIAQGLPAALTLASRDGEF
AREVAAQLHAPRLRVYSCTDVVGVETGGAVKNVISIAAGICDGMGFGSNARAALITRGLAEITRLGLKLGGRMETFLGLT
GVGDLILTCTGDLSRNRRVGLALAAGRSLPDILQELGHIAEGVHTAREVLRLSHLLGIEMPITKGVCSILDDGVPAGQAV
EALLNREPKSEIY
>Mature_333_residues
MRIAVMGAGAWGTALALSLCASTASSHQVTLWTRSRQHLADLVSQRINRRYFSAFPLPASLRLTAGLEEAVEDAELALIV
VPVSGLRETLREIAASGKKIPVIWGCKGFESQSAKLPHQVAEEEYAGAAPYGVLSGPSFALEIAQGLPAALTLASRDGEF
AREVAAQLHAPRLRVYSCTDVVGVETGGAVKNVISIAAGICDGMGFGSNARAALITRGLAEITRLGLKLGGRMETFLGLT
GVGDLILTCTGDLSRNRRVGLALAAGRSLPDILQELGHIAEGVHTAREVLRLSHLLGIEMPITKGVCSILDDGVPAGQAV
EALLNREPKSEIY

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=348, Percent_Identity=30.1724137931034, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI24307999, Length=343, Percent_Identity=29.1545189504373, Blast_Score=118, Evalue=7e-27,
Organism=Escherichia coli, GI1790037, Length=331, Percent_Identity=43.202416918429, Blast_Score=263, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI32564399, Length=350, Percent_Identity=29.1428571428571, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32564403, Length=362, Percent_Identity=28.7292817679558, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193210136, Length=362, Percent_Identity=28.7292817679558, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17507425, Length=334, Percent_Identity=28.7425149700599, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI193210134, Length=341, Percent_Identity=27.2727272727273, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324513, Length=344, Percent_Identity=29.3604651162791, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6320181, Length=345, Percent_Identity=27.8260869565217, Blast_Score=102, Evalue=9e-23,
Organism=Drosophila melanogaster, GI17136204, Length=346, Percent_Identity=26.5895953757225, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17136202, Length=346, Percent_Identity=26.5895953757225, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17136200, Length=346, Percent_Identity=26.5895953757225, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI22026922, Length=342, Percent_Identity=25.7309941520468, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI45551945, Length=351, Percent_Identity=24.7863247863248, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281362270, Length=305, Percent_Identity=25.5737704918033, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24648969, Length=306, Percent_Identity=25.1633986928105, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_NITMU (Q2Y9Z2)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411821.1
- ProteinModelPortal:   Q2Y9Z2
- SMR:   Q2Y9Z2
- STRING:   Q2Y9Z2
- GeneID:   3784239
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1126
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- PhylomeDB:   Q2Y9Z2
- ProtClustDB:   PRK00094
- BioCyc:   NMUL323848:NMUL_A1126-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 35021; Mature: 35021

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 191-191 BINDING 107-107 BINDING 107-107 BINDING 140-140 BINDING 255-255 BINDING 281-281

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAVMGAGAWGTALALSLCASTASSHQVTLWTRSRQHLADLVSQRINRRYFSAFPLPAS
CEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCC
LRLTAGLEEAVEDAELALIVVPVSGLRETLREIAASGKKIPVIWGCKGFESQSAKLPHQV
CEECCCHHHHHCCCCEEEEEEECHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHH
AEEEYAGAAPYGVLSGPSFALEIAQGLPAALTLASRDGEFAREVAAQLHAPRLRVYSCTD
HHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECC
VVGVETGGAVKNVISIAAGICDGMGFGSNARAALITRGLAEITRLGLKLGGRMETFLGLT
EEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GVGDLILTCTGDLSRNRRVGLALAAGRSLPDILQELGHIAEGVHTAREVLRLSHLLGIEM
CCCCEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PITKGVCSILDDGVPAGQAVEALLNREPKSEIY
CHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRIAVMGAGAWGTALALSLCASTASSHQVTLWTRSRQHLADLVSQRINRRYFSAFPLPAS
CEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCC
LRLTAGLEEAVEDAELALIVVPVSGLRETLREIAASGKKIPVIWGCKGFESQSAKLPHQV
CEECCCHHHHHCCCCEEEEEEECHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHH
AEEEYAGAAPYGVLSGPSFALEIAQGLPAALTLASRDGEFAREVAAQLHAPRLRVYSCTD
HHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECC
VVGVETGGAVKNVISIAAGICDGMGFGSNARAALITRGLAEITRLGLKLGGRMETFLGLT
EEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GVGDLILTCTGDLSRNRRVGLALAAGRSLPDILQELGHIAEGVHTAREVLRLSHLLGIEM
CCCCEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PITKGVCSILDDGVPAGQAVEALLNREPKSEIY
CHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA