Click here to switch to the map view.

The map label for this gene is nuoI2

Identifier: 82702228

GI number: 82702228

Start: 1266069

End: 1266557

Strand: Direct

Name: nuoI2

Synonym: Nmul_A1099

Alternate gene names: 82702228

Gene position: 1266069-1266557 (Clockwise)

Preceding gene: 82702227

Following gene: 82702229

Centisome position: 39.76

GC content: 53.17

Gene sequence:

>489_bases
ATGAACCGAATCAAGGATTTTTTCCGCACTTTCCTACTGTTCGAGCTCATCAAAGGAATGATGCTGACAGGGCGAAACAT
GTTCGCGCGGAAGATCACGGTGTATTTTCCCGAAGAAAAGACGCCGCAATCCCCTCGTTTCAGAGGTTTGCATGCCTTGC
GCAGATATCCTAACGGAGAAGAGCGCTGCATAGCTTGCAAGCTGTGTGAAGCGGTATGCCCGGCATTGGCGATTACCATC
GAATCCGAGCAGCGCGAGGATGGTACGCGCCGTACCACGCGATATGACATCGATCTGACGAAGTGCATATTTTGCGGTTT
CTGCGAGGAATCCTGTCCGGTGGATTCCATCGTCGAGACGCGCATTCTGGAATACCACGGAGAGAAGCGTGGCGACCTCA
TCTATACCAAGCAGATGCTGCTGGCGGTCGGGGATCGGTACGAGGAACAGATAGCAAAGGATCGGGCAGCTGATGCAGGT
TACCGATGA

Upstream 100 bases:

>100_bases
TCGTCTGGATAGTGGTGCTTGGCCTGGTGATGCAGCTTCCGGCATCGATTCGGGGCGCATTCCCGCTTAACTTGTGGTTT
CACTGACACAGGAGGAAACC

Downstream 100 bases:

>100_bases
ATCGTGCCTGGTTCGCCAATATTGGCAGCGGATATTCTCATCAACCCCGGACTTGCACTGTCTTCCGTCGTGCGAGCGCT
GGACTGTTGCCGCTCGTCAC

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I 2; NDH-1 subunit I 2

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MNRIKDFFRTFLLFELIKGMMLTGRNMFARKITVYFPEEKTPQSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAITI
ESEQREDGTRRTTRYDIDLTKCIFCGFCEESCPVDSIVETRILEYHGEKRGDLIYTKQMLLAVGDRYEEQIAKDRAADAG
YR

Sequences:

>Translated_162_residues
MNRIKDFFRTFLLFELIKGMMLTGRNMFARKITVYFPEEKTPQSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAITI
ESEQREDGTRRTTRYDIDLTKCIFCGFCEESCPVDSIVETRILEYHGEKRGDLIYTKQMLLAVGDRYEEQIAKDRAADAG
YR
>Mature_162_residues
MNRIKDFFRTFLLFELIKGMMLTGRNMFARKITVYFPEEKTPQSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAITI
ESEQREDGTRRTTRYDIDLTKCIFCGFCEESCPVDSIVETRILEYHGEKRGDLIYTKQMLLAVGDRYEEQIAKDRAADAG
YR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=154, Percent_Identity=59.7402597402597, Blast_Score=194, Evalue=3e-50,
Organism=Escherichia coli, GI1788617, Length=128, Percent_Identity=39.84375, Blast_Score=107, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17555194, Length=148, Percent_Identity=58.1081081081081, Blast_Score=182, Evalue=8e-47,
Organism=Drosophila melanogaster, GI17864306, Length=153, Percent_Identity=58.8235294117647, Blast_Score=194, Evalue=2e-50,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI2_NITMU (Q2YA19)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411794.1
- ProteinModelPortal:   Q2YA19
- SMR:   Q2YA19
- STRING:   Q2YA19
- GeneID:   3784714
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1099
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   NKAADAP
- PhylomeDB:   Q2YA19
- ProtClustDB:   PRK05888
- BioCyc:   NMUL323848:NMUL_A1099-MONOMER
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 18882; Mature: 18882

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRIKDFFRTFLLFELIKGMMLTGRNMFARKITVYFPEEKTPQSPRFRGLHALRRYPNGE
CCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCC
ERCIACKLCEAVCPALAITIESEQREDGTRRTTRYDIDLTKCIFCGFCEESCPVDSIVET
HHHHHHHHHHHHHHHHEEEECCHHCCCCCCCCEEECCHHHHHHHHHCCCCCCCHHHHHHH
RILEYHGEKRGDLIYTKQMLLAVGDRYEEQIAKDRAADAGYR
HHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNRIKDFFRTFLLFELIKGMMLTGRNMFARKITVYFPEEKTPQSPRFRGLHALRRYPNGE
CCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCC
ERCIACKLCEAVCPALAITIESEQREDGTRRTTRYDIDLTKCIFCGFCEESCPVDSIVET
HHHHHHHHHHHHHHHHEEEECCHHCCCCCCCCEEECCHHHHHHHHHCCCCCCCHHHHHHH
RILEYHGEKRGDLIYTKQMLLAVGDRYEEQIAKDRAADAGYR
HHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA