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The map label for this gene is nuoH2

Identifier: 82702227

GI number: 82702227

Start: 1264954

End: 1266054

Strand: Direct

Name: nuoH2

Synonym: Nmul_A1098

Alternate gene names: 82702227

Gene position: 1264954-1266054 (Clockwise)

Preceding gene: 82702226

Following gene: 82702228

Centisome position: 39.73

GC content: 54.22

Gene sequence:

>1101_bases
ATGGAATACGCGCAACAACTGTTCGGGGATTTTTTCGGTCCTGAGTGGGGACCTGCTCTTTTCCTGCTGGTGAAGAATGT
CCTTCTGATCGTGGCCATCGTGCTGCCACTGATGCTGGCGGTTGCCTATCTCACATTTGCCGAACGCAAGATCATTGGCT
ATATGCAGTTGCGCGTGGGTCCCAATCGGGTAACGTTCTTTGGCATTCCCTGGCTGGGGGGGTGGGCGCAGCCCATTGCC
GATGCGGTAAAGGCGGTGATGAAAGAAATCATCATCCCGAGCGGAGCGAACAAAGTCCTGTTCGTGCTTGCGCCCATACT
GACGTTCGCGCCGGCACTGGCGGCCTGGGCGGTCATTCCCTTTTCTCCGGATGTGGTTCTGGCGGACATCAATGCAGGTC
TGCTTTATATTCTGGCCATGACCTCGATGGGAGTCTATGGCATTATCATTGCGGGGTGGGCCTCCAACTCCAAATACGCA
TTCCTGGGAGCAATGCGTTCGGCGGCTCAAGTGGTTTCCTACGAACTGGCCATGGGTTTTGCGCTGGTGTGCGTGCTCAT
GATGTCCCAGAGCCTGAACCTGGGTGACATTGTCAAGGGCCAGCAAGGGGCCAGCATGCTGAACTGGTATCTGATACCGC
TGTTTCCCATGTTTCTGGTTTATTTTATTTCCGGCGTCGCGGAAACCAATCGTGCTCCATTCGATGTCGCCGAGGGTGAG
TCCGAAATCGTGGCAGGTTTTCATGTCGAGTATTCGGGCATGGCGTTCACGGTGTTTTTCCTGGCCGAATATTCCAACAT
GATTCTGGTGGCCATGCTTGCAAGCATCATATTCCTGGGTGGCTGGCTGCCTCCTGTCAACGTTGCGCCGTTTACCCTTG
TTCCCGGCTTCATCTGGCTGATCCTGAAAGCATCATTTCTATTGTTCTGTTTTCTCTGGTTCCGGGCCACGTTTCCACGT
TATCGTTACGACCAGATCATGCGTCTTGGCTGGAAGGTATTCATTCCGATCACGCTCGTCTGGATAGTGGTGCTTGGCCT
GGTGATGCAGCTTCCGGCATCGATTCGGGGCGCATTCCCGCTTAACTTGTGGTTTCACTGA

Upstream 100 bases:

>100_bases
ATAAGGGTTGCCTCCGCCCATCCTTCGACTGCGGCCTTGGGCGGAATGTTTGATCTGATCACGGTGGAAAAATCGTGACG
AACGATACTCGGATTATCTG

Downstream 100 bases:

>100_bases
CACAGGAGGAAACCATGAACCGAATCAAGGATTTTTTCCGCACTTTCCTACTGTTCGAGCTCATCAAAGGAATGATGCTG
ACAGGGCGAAACATGTTCGC

Product: respiratory-chain NADH dehydrogenase subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H 2; NDH-1 subunit H 2

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MEYAQQLFGDFFGPEWGPALFLLVKNVLLIVAIVLPLMLAVAYLTFAERKIIGYMQLRVGPNRVTFFGIPWLGGWAQPIA
DAVKAVMKEIIIPSGANKVLFVLAPILTFAPALAAWAVIPFSPDVVLADINAGLLYILAMTSMGVYGIIIAGWASNSKYA
FLGAMRSAAQVVSYELAMGFALVCVLMMSQSLNLGDIVKGQQGASMLNWYLIPLFPMFLVYFISGVAETNRAPFDVAEGE
SEIVAGFHVEYSGMAFTVFFLAEYSNMILVAMLASIIFLGGWLPPVNVAPFTLVPGFIWLILKASFLLFCFLWFRATFPR
YRYDQIMRLGWKVFIPITLVWIVVLGLVMQLPASIRGAFPLNLWFH

Sequences:

>Translated_366_residues
MEYAQQLFGDFFGPEWGPALFLLVKNVLLIVAIVLPLMLAVAYLTFAERKIIGYMQLRVGPNRVTFFGIPWLGGWAQPIA
DAVKAVMKEIIIPSGANKVLFVLAPILTFAPALAAWAVIPFSPDVVLADINAGLLYILAMTSMGVYGIIIAGWASNSKYA
FLGAMRSAAQVVSYELAMGFALVCVLMMSQSLNLGDIVKGQQGASMLNWYLIPLFPMFLVYFISGVAETNRAPFDVAEGE
SEIVAGFHVEYSGMAFTVFFLAEYSNMILVAMLASIIFLGGWLPPVNVAPFTLVPGFIWLILKASFLLFCFLWFRATFPR
YRYDQIMRLGWKVFIPITLVWIVVLGLVMQLPASIRGAFPLNLWFH
>Mature_366_residues
MEYAQQLFGDFFGPEWGPALFLLVKNVLLIVAIVLPLMLAVAYLTFAERKIIGYMQLRVGPNRVTFFGIPWLGGWAQPIA
DAVKAVMKEIIIPSGANKVLFVLAPILTFAPALAAWAVIPFSPDVVLADINAGLLYILAMTSMGVYGIIIAGWASNSKYA
FLGAMRSAAQVVSYELAMGFALVCVLMMSQSLNLGDIVKGQQGASMLNWYLIPLFPMFLVYFISGVAETNRAPFDVAEGE
SEIVAGFHVEYSGMAFTVFFLAEYSNMILVAMLASIIFLGGWLPPVNVAPFTLVPGFIWLILKASFLLFCFLWFRATFPR
YRYDQIMRLGWKVFIPITLVWIVVLGLVMQLPASIRGAFPLNLWFH

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=300, Percent_Identity=42.6666666666667, Blast_Score=236, Evalue=3e-62,
Organism=Escherichia coli, GI1788618, Length=332, Percent_Identity=40.9638554216867, Blast_Score=261, Evalue=5e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH2_NITMU (Q2YA20)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411793.1
- STRING:   Q2YA20
- GeneID:   3784713
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1098
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- PhylomeDB:   Q2YA20
- ProtClustDB:   CLSK585934
- BioCyc:   NMUL323848:NMUL_A1098-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 40531; Mature: 40531

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1147fd54)-; HASH(0x12b8d5a0)-; HASH(0x12395b98)-; HASH(0x127f79a4)-; HASH(0x13058f38)-; HASH(0x12be6b8c)-; HASH(0x12c3ae00)-; HASH(0x125bb128)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYAQQLFGDFFGPEWGPALFLLVKNVLLIVAIVLPLMLAVAYLTFAERKIIGYMQLRVG
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEC
PNRVTFFGIPWLGGWAQPIADAVKAVMKEIIIPSGANKVLFVLAPILTFAPALAAWAVIP
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEC
FSPDVVLADINAGLLYILAMTSMGVYGIIIAGWASNSKYAFLGAMRSAAQVVSYELAMGF
CCCCEEEEECCCHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
ALVCVLMMSQSLNLGDIVKGQQGASMLNWYLIPLFPMFLVYFISGVAETNRAPFDVAEGE
HHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SEIVAGFHVEYSGMAFTVFFLAEYSNMILVAMLASIIFLGGWLPPVNVAPFTLVPGFIWL
CCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ILKASFLLFCFLWFRATFPRYRYDQIMRLGWKVFIPITLVWIVVLGLVMQLPASIRGAFP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCC
LNLWFH
EEECCH
>Mature Secondary Structure
MEYAQQLFGDFFGPEWGPALFLLVKNVLLIVAIVLPLMLAVAYLTFAERKIIGYMQLRVG
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEC
PNRVTFFGIPWLGGWAQPIADAVKAVMKEIIIPSGANKVLFVLAPILTFAPALAAWAVIP
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEC
FSPDVVLADINAGLLYILAMTSMGVYGIIIAGWASNSKYAFLGAMRSAAQVVSYELAMGF
CCCCEEEEECCCHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
ALVCVLMMSQSLNLGDIVKGQQGASMLNWYLIPLFPMFLVYFISGVAETNRAPFDVAEGE
HHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SEIVAGFHVEYSGMAFTVFFLAEYSNMILVAMLASIIFLGGWLPPVNVAPFTLVPGFIWL
CCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ILKASFLLFCFLWFRATFPRYRYDQIMRLGWKVFIPITLVWIVVLGLVMQLPASIRGAFP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCC
LNLWFH
EEECCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA