Click here to switch to the map view.

The map label for this gene is tpiA [H]

Identifier: 82702218

GI number: 82702218

Start: 1256501

End: 1257262

Strand: Direct

Name: tpiA [H]

Synonym: Nmul_A1089

Alternate gene names: 82702218

Gene position: 1256501-1257262 (Clockwise)

Preceding gene: 82702217

Following gene: 82702219

Centisome position: 39.46

GC content: 57.09

Gene sequence:

>762_bases
ATGGCTATACGTTCCAAGCTGGTTGCGGGTAATTGGAAAATGCACGGCGGAACGCTGCAGAACCGGGATTTGCTGAATGC
GGTTCTTTCTGCGACGGCAGACCTGAGCGGAGTCGAGTTGGCGGTATGCGTACCTTATCCTTACTTACCCCAAGTGCAAT
CGATTCTGCAAGGTACGAACGTTTCCTGGGGCGCCCAGAACGTGAGTCAGCACGAAAAAGGCGCCTATACCGGTGAAGTT
TCAGCGTCCATGCTGCTGGATTTTGGCTGTCGCTACGTGATTGTCGGTCACTCCGAGCGGCGGGCGCTGTATGGTGAGGA
TAGCCACACTGTAGCGCTCAAATTCAGGGCGGCACAAAGCGTCGGCGTGATACCTATTTTATGTGTGGGTGAAACGCTCG
AGCAGCGGGAGGCCGGGATTACGGAGCAGGTTGTGGCAAAGCAGTTGGAGGCGGTGGTGAAGTCGGCGGGAATAAATGCC
TTGGGTACGGCGGTGCTGGCTTATGAACCGGTATGGGCCATCGGCACCGGCAAGACCGCGAGCCCTGCTCAGGCTCAGGA
GGTACATTCGTTTATTCGCGGCAGAATTGCTGCCGACGCAGCGGAAGTAGCCGAGGGATTGAAGATTCTTTATGGCGGCA
GTGTCAAGGCGGCCAACGCCGCTGAGCTCTTCGCCATGCCCGACATTGACGGTGGATTGATTGGCGGCGCTTCGCTCGTT
GCCGAAGAATTTATCGCGATTGCCCGGGCCGCGAAAGACTAA

Upstream 100 bases:

>100_bases
CTTGTCTGCCGAGCGGTTCAAGGCTTGACGCAGACCCCGATTGACCCCGTATCCATTCACGGGTAACATTCGCAGCTTTC
AAGTTAAAGGCGAATCCTTC

Downstream 100 bases:

>100_bases
TTCTTATTGGAGCAACTTTGGAAACACTGATCTGGATACTACATGTCTTGTCCGCAGCGGGCGTAATCGTCCTGGTTCTG
CTGCAGCACGGCAAAGGCGC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MAIRSKLVAGNWKMHGGTLQNRDLLNAVLSATADLSGVELAVCVPYPYLPQVQSILQGTNVSWGAQNVSQHEKGAYTGEV
SASMLLDFGCRYVIVGHSERRALYGEDSHTVALKFRAAQSVGVIPILCVGETLEQREAGITEQVVAKQLEAVVKSAGINA
LGTAVLAYEPVWAIGTGKTASPAQAQEVHSFIRGRIAADAAEVAEGLKILYGGSVKAANAAELFAMPDIDGGLIGGASLV
AEEFIAIARAAKD

Sequences:

>Translated_253_residues
MAIRSKLVAGNWKMHGGTLQNRDLLNAVLSATADLSGVELAVCVPYPYLPQVQSILQGTNVSWGAQNVSQHEKGAYTGEV
SASMLLDFGCRYVIVGHSERRALYGEDSHTVALKFRAAQSVGVIPILCVGETLEQREAGITEQVVAKQLEAVVKSAGINA
LGTAVLAYEPVWAIGTGKTASPAQAQEVHSFIRGRIAADAAEVAEGLKILYGGSVKAANAAELFAMPDIDGGLIGGASLV
AEEFIAIARAAKD
>Mature_252_residues
AIRSKLVAGNWKMHGGTLQNRDLLNAVLSATADLSGVELAVCVPYPYLPQVQSILQGTNVSWGAQNVSQHEKGAYTGEVS
ASMLLDFGCRYVIVGHSERRALYGEDSHTVALKFRAAQSVGVIPILCVGETLEQREAGITEQVVAKQLEAVVKSAGINAL
GTAVLAYEPVWAIGTGKTASPAQAQEVHSFIRGRIAADAAEVAEGLKILYGGSVKAANAAELFAMPDIDGGLIGGASLVA
EEFIAIARAAKD

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=250, Percent_Identity=42, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI226529917, Length=250, Percent_Identity=42, Blast_Score=182, Evalue=2e-46,
Organism=Escherichia coli, GI1790353, Length=250, Percent_Identity=49.2, Blast_Score=244, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI17536593, Length=248, Percent_Identity=47.5806451612903, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6320255, Length=245, Percent_Identity=41.2244897959184, Blast_Score=177, Evalue=1e-45,
Organism=Drosophila melanogaster, GI28572004, Length=248, Percent_Identity=46.3709677419355, Blast_Score=196, Evalue=9e-51,
Organism=Drosophila melanogaster, GI28572008, Length=248, Percent_Identity=46.3709677419355, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI28572006, Length=248, Percent_Identity=46.3709677419355, Blast_Score=196, Evalue=1e-50,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26459; Mature: 26328

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRSKLVAGNWKMHGGTLQNRDLLNAVLSATADLSGVELAVCVPYPYLPQVQSILQGTN
CCCCCCEEECCEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHCCCC
VSWGAQNVSQHEKGAYTGEVSASMLLDFGCRYVIVGHSERRALYGEDSHTVALKFRAAQS
CCCCCCCHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCCCCEECCCCCCEEEEEEECCCC
VGVIPILCVGETLEQREAGITEQVVAKQLEAVVKSAGINALGTAVLAYEPVWAIGTGKTA
CCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHEECCEEEECCCCCC
SPAQAQEVHSFIRGRIAADAAEVAEGLKILYGGSVKAANAAELFAMPDIDGGLIGGASLV
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCCCCCCHHHHH
AEEFIAIARAAKD
HHHHHHHHHHCCC
>Mature Secondary Structure 
AIRSKLVAGNWKMHGGTLQNRDLLNAVLSATADLSGVELAVCVPYPYLPQVQSILQGTN
CCCCCEEECCEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHCCCC
VSWGAQNVSQHEKGAYTGEVSASMLLDFGCRYVIVGHSERRALYGEDSHTVALKFRAAQS
CCCCCCCHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCCCCEECCCCCCEEEEEEECCCC
VGVIPILCVGETLEQREAGITEQVVAKQLEAVVKSAGINALGTAVLAYEPVWAIGTGKTA
CCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHEECCEEEECCCCCC
SPAQAQEVHSFIRGRIAADAAEVAEGLKILYGGSVKAANAAELFAMPDIDGGLIGGASLV
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCCCCCCHHHHH
AEEFIAIARAAKD
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA