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The map label for this gene is argG

Identifier: 82702172

GI number: 82702172

Start: 1206513

End: 1207736

Strand: Direct

Name: argG

Synonym: Nmul_A1043

Alternate gene names: 82702172

Gene position: 1206513-1207736 (Clockwise)

Preceding gene: 82702171

Following gene: 82702173

Centisome position: 37.89

GC content: 55.31

Gene sequence:

>1224_bases
GTGAATGTCGCTCAGATTAAAAAAGTAGTCCTGGCATTTTCCGGCGGTCTGGATACGTCGGTAATCCTGAAGTGGCTGCA
GGATACCTACCGGTGCGAAGTTGTCACCTTCACCGCTGACATTGGCCAGGGGGAGGAGGTGGAACCTGCCCGTGCAAAGG
CGAAGCAGCTTGGCGTGAGGGAAATCTTCATCGACGACTTGCGCGAAGAATTCGTACGCGATTTCGTCTTTCCCATGTTT
CGGGCCAATACCCTTTATGAAGGGGAGTACCTGCTCGGCACCAGCATCGCACGCCCGCTGATTGCCAAGCGCCAGATCGA
AATCGCGCGAGAAACCGGTGCGGACGCCGTGTCGCACGGCGCGACCGGGAAAGGCAATGATCAGGTGCGCTTTGAACTCG
GTTACTATGCGCTTCAACCGGATATCCGGGTGATTGCGCCGTGGCGCGAATGGGACCTTACATCCCGGGAAAAGCTTCTG
AAATACGCGGAGCAGCACGGCATCCCGGTGGAAATGAAGAAAAAGGAAGGCTCTCCCTACAGTATGGATGCCAACCTTCT
GCATATTTCGTATGAGGGACGTATTCTCGAAGACCCTGCGCAGGAGCCGGAAGAGTCGATGTGGCGGTGGAGTGTTTCGC
CGGAAAAAGCTCCGGATAGTCCCGAATATCTCGACCTCGAATTCAGGCAGGGCGATATCGTTGCATTGGATGGGGAAGAG
CTTTCGCCGGCGCGCCTGCTCGCCAGACTCAATGAACTGGGGGGCAAGCACGGGATAGGGCGCCTGGATCTGGTCGAAAA
CCGGTATGTCGGTATGAAGTCCCGCGGGTGCTACGAGACTCCCGGCGGCACGATCATGCTGCGTGCCCACCGGGCCATGG
AGTCCATTACACTGGACCGTGAAGTCGCACATTTGAAAGACGAGCTTATGCCACGCTATGCCGAACTGATTTACAACGGC
TATTGGTGGAGTCCCGAACGCAGAATGATGCAGACGATGATCGATGCGTCACAGGCGCATGTGAACGGCTGGGTGCGGGT
GAAGCTCTACAAGGGTAATGTGATTGTCGTGGGGAGAGACTCGAAAACAGATTCGCTGTTTGATCCCCATATTGCAACCT
TCGAGGATGACCAGGGTGCGTACAATCAGATGGATGCTGCCGGTTTCATCAAGTTGAATGCACTCAGGATGCGGATTGCC
GCCAATTTAAGAAATCGCAAATAA

Upstream 100 bases:

>100_bases
GACTGGATAACGCCTGATAGAGCAGGATTTTCAATAGGAGTTATTCGGGAAGTCAAGCCGGCATTTTTATTAATGAGACA
AGCATGGGAAAAGAAACAAG

Downstream 100 bases:

>100_bases
TAGCGCTGGAACTGCATGAGATTCTTTTGAGAAGATTGATATGCCATCATTCGATATCGTTTCCGAAGTCGACAAGCAGG
AAGTTAGAAACGCGATTGAC

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MNVAQIKKVVLAFSGGLDTSVILKWLQDTYRCEVVTFTADIGQGEEVEPARAKAKQLGVREIFIDDLREEFVRDFVFPMF
RANTLYEGEYLLGTSIARPLIAKRQIEIARETGADAVSHGATGKGNDQVRFELGYYALQPDIRVIAPWREWDLTSREKLL
KYAEQHGIPVEMKKKEGSPYSMDANLLHISYEGRILEDPAQEPEESMWRWSVSPEKAPDSPEYLDLEFRQGDIVALDGEE
LSPARLLARLNELGGKHGIGRLDLVENRYVGMKSRGCYETPGGTIMLRAHRAMESITLDREVAHLKDELMPRYAELIYNG
YWWSPERRMMQTMIDASQAHVNGWVRVKLYKGNVIVVGRDSKTDSLFDPHIATFEDDQGAYNQMDAAGFIKLNALRMRIA
ANLRNRK

Sequences:

>Translated_407_residues
MNVAQIKKVVLAFSGGLDTSVILKWLQDTYRCEVVTFTADIGQGEEVEPARAKAKQLGVREIFIDDLREEFVRDFVFPMF
RANTLYEGEYLLGTSIARPLIAKRQIEIARETGADAVSHGATGKGNDQVRFELGYYALQPDIRVIAPWREWDLTSREKLL
KYAEQHGIPVEMKKKEGSPYSMDANLLHISYEGRILEDPAQEPEESMWRWSVSPEKAPDSPEYLDLEFRQGDIVALDGEE
LSPARLLARLNELGGKHGIGRLDLVENRYVGMKSRGCYETPGGTIMLRAHRAMESITLDREVAHLKDELMPRYAELIYNG
YWWSPERRMMQTMIDASQAHVNGWVRVKLYKGNVIVVGRDSKTDSLFDPHIATFEDDQGAYNQMDAAGFIKLNALRMRIA
ANLRNRK
>Mature_407_residues
MNVAQIKKVVLAFSGGLDTSVILKWLQDTYRCEVVTFTADIGQGEEVEPARAKAKQLGVREIFIDDLREEFVRDFVFPMF
RANTLYEGEYLLGTSIARPLIAKRQIEIARETGADAVSHGATGKGNDQVRFELGYYALQPDIRVIAPWREWDLTSREKLL
KYAEQHGIPVEMKKKEGSPYSMDANLLHISYEGRILEDPAQEPEESMWRWSVSPEKAPDSPEYLDLEFRQGDIVALDGEE
LSPARLLARLNELGGKHGIGRLDLVENRYVGMKSRGCYETPGGTIMLRAHRAMESITLDREVAHLKDELMPRYAELIYNG
YWWSPERRMMQTMIDASQAHVNGWVRVKLYKGNVIVVGRDSKTDSLFDPHIATFEDDQGAYNQMDAAGFIKLNALRMRIA
ANLRNRK

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=407, Percent_Identity=47.9115479115479, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI16950633, Length=407, Percent_Identity=47.9115479115479, Blast_Score=371, Evalue=1e-103,
Organism=Escherichia coli, GI1789563, Length=409, Percent_Identity=25.4278728606357, Blast_Score=114, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6324514, Length=405, Percent_Identity=46.9135802469136, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI21358151, Length=402, Percent_Identity=45.273631840796, Blast_Score=351, Evalue=6e-97,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_NITMU (Q2YA75)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411738.1
- HSSP:   Q9X2A1
- ProteinModelPortal:   Q2YA75
- SMR:   Q2YA75
- STRING:   Q2YA75
- GeneID:   3785170
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1043
- eggNOG:   COG0137
- HOGENOM:   HBG335267
- OMA:   PLIAKRQ
- PhylomeDB:   Q2YA75
- ProtClustDB:   PRK00509
- BioCyc:   NMUL323848:NMUL_A1043-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00005
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 46361; Mature: 46361

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 39-39 BINDING 90-90 BINDING 95-95 BINDING 120-120 BINDING 122-122 BINDING 126-126 BINDING 126-126 BINDING 127-127 BINDING 130-130 BINDING 181-181 BINDING 190-190 BINDING 266-266 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVAQIKKVVLAFSGGLDTSVILKWLQDTYRCEVVTFTADIGQGEEVEPARAKAKQLGVR
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCCCCCHHHHHHHHCCHH
EIFIDDLREEFVRDFVFPMFRANTLYEGEYLLGTSIARPLIAKRQIEIARETGADAVSHG
HHHHHHHHHHHHHHHHHHHHHCCEEECCCEEECHHHHHHHHHHHHHHHHHHCCCHHHHCC
ATGKGNDQVRFELGYYALQPDIRVIAPWREWDLTSREKLLKYAEQHGIPVEMKKKEGSPY
CCCCCCCEEEEEEEEEEECCCCEEEECCHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCE
SMDANLLHISYEGRILEDPAQEPEESMWRWSVSPEKAPDSPEYLDLEFRQGDIVALDGEE
EECCEEEEEEECCEEECCCCCCCHHHHEEECCCCCCCCCCCCEEEEEECCCCEEEECCCC
LSPARLLARLNELGGKHGIGRLDLVENRYVGMKSRGCYETPGGTIMLRAHRAMESITLDR
CCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCEECCCCEEEEEEHHHHHHHHHHH
EVAHLKDELMPRYAELIYNGYWWSPERRMMQTMIDASQAHVNGWVRVKLYKGNVIVVGRD
HHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCCEEEEEEEECCEEEEECC
SKTDSLFDPHIATFEDDQGAYNQMDAAGFIKLNALRMRIAANLRNRK
CCCCCCCCCCCCEEECCCCCHHCCCCCCEEEEHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNVAQIKKVVLAFSGGLDTSVILKWLQDTYRCEVVTFTADIGQGEEVEPARAKAKQLGVR
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCCCCCHHHHHHHHCCHH
EIFIDDLREEFVRDFVFPMFRANTLYEGEYLLGTSIARPLIAKRQIEIARETGADAVSHG
HHHHHHHHHHHHHHHHHHHHHCCEEECCCEEECHHHHHHHHHHHHHHHHHHCCCHHHHCC
ATGKGNDQVRFELGYYALQPDIRVIAPWREWDLTSREKLLKYAEQHGIPVEMKKKEGSPY
CCCCCCCEEEEEEEEEEECCCCEEEECCHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCE
SMDANLLHISYEGRILEDPAQEPEESMWRWSVSPEKAPDSPEYLDLEFRQGDIVALDGEE
EECCEEEEEEECCEEECCCCCCCHHHHEEECCCCCCCCCCCCEEEEEECCCCEEEECCCC
LSPARLLARLNELGGKHGIGRLDLVENRYVGMKSRGCYETPGGTIMLRAHRAMESITLDR
CCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCEECCCCEEEEEEHHHHHHHHHHH
EVAHLKDELMPRYAELIYNGYWWSPERRMMQTMIDASQAHVNGWVRVKLYKGNVIVVGRD
HHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCCEEEEEEEECCEEEEECC
SKTDSLFDPHIATFEDDQGAYNQMDAAGFIKLNALRMRIAANLRNRK
CCCCCCCCCCCCEEECCCCCHHCCCCCCEEEEHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA