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The map label for this gene is nuoF [H]

Identifier: 82702146

GI number: 82702146

Start: 1176644

End: 1177921

Strand: Direct

Name: nuoF [H]

Synonym: Nmul_A1017

Alternate gene names: 82702146

Gene position: 1176644-1177921 (Clockwise)

Preceding gene: 82702145

Following gene: 82702147

Centisome position: 36.95

GC content: 59.94

Gene sequence:

>1278_bases
ATGGAAACACCGCTGACGCATAACATTTCACCGGGCAGGGAACCTCCGGATCTTGCGCAGTACGAGAAGGCCGGAGGTTA
TGGCGCGCTGCGCAAGGCGCTCGGTATGGCGCCGGCGGAAATTCAGGCAGCGGTCAAGGAATCCAACCTGCGCGGCCGTG
GCGGAGCGGGGTTTCCAACTGCACAGAAATGGAGTTTTGTGCCGATGGGCGATGATGCGCCGCGGCCCAAGTATCTCGTT
TGCAATGCCGACGAGATGGAGCCGGGTACATTCAAGGATCGTATGTTGCTCGAGGGAGACCCCCATCAGTTGATCGAAGG
CATTATCATCAGCGCCTATGCGATCCAGGCCGATGTGGCTTACGTATTTCTGCGCTGGGCCTACAAACTGGCGGCCCGGC
GCGTGGAGCGCGCAATCGTTGAAGCATACCGCCACGGCTACCTGGGTAAAAATATCCTGGGCTCGGCTTACAGTCTGGAG
ATGCACCTGCACGTCAGTGCGGGACGCTACATATGCGGAGAGGAGACCGCGCTGCTCAATGCCCTCGAAGGCAAGCGCGC
CAACCCACGGGCCAAACCTCCCTATCCCCAGGTGAGTGGCCTGTGGGGAAAGCCTACCATTGTCAATAGCGTGGAAACCT
TGTGCAACGTTCCGCATATCGTGAAGCAGGGGGCCGAATGGTTCAGGAGCCTGAGCCGCAGCGACGACGGCGGAACGAAG
CTGTATGGGGCAAGCGGGAGAGTGAAGAACCCGGGATTATGGGAATTGCCCATGGGCACTCCTCTGCGCGAGATTCTGGA
AGAGCATGCGGGCGGCATGCGTGACGGCTATCAGTTTCGCGGGGTGCTGCCGGGTGGCGCTTCGACTGATTTTGTTACTG
CCGAGCACCTCGACGTGGCGATGGATTTCGATTCGGTGCAGAAGGCCGGCAGCCGCCTCGGCACCGGCACCATGATCATC
CTTGATGACAAGACCTGCCCCGTTGGCATGCTGCTCAATCTGGAACATTTCTTCGCCCAGGAATCATGCGGCTGGTGCAC
CCCGTGCTGGTCGGGGCTTTCCTGGATCGAACAGATATTGCAGGACATGGAGGAGGGTCGCGGCCGGGCTTCCGACCTTG
AATTGCTGGAATCCCATACGCGCCTCCTGGGTCCCGGACATACTTTTTGTGCGCTTGCCCCCGGAGCGGCCGAGCCCCTG
CAAAGCGGCCTCAAGTATTTCCGTGATGATTTCGAGCGCCATATCCATGAGAAACGCTGTCCCTGGAGCCCGACGTGA

Upstream 100 bases:

>100_bases
CCTGTCATGATGGTGGATGACGCGCATTACCAGGACCTGGATCCCGCCAGGATCGATCAGATTCTGGCAAGTTATCAACA
GGAAGAAGAAAAATCGACCG

Downstream 100 bases:

>100_bases
AAGGTGAAACAGGAAATACAGCGAGGCTGGCAAGACGAATGTGATGACGACCATTCATATCGACAATCGTCCCTATCCTG
CCAAAGAGGGTGAGAATTTA

Product: NADH-quinone oxidoreductase subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F; NUO6 [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
METPLTHNISPGREPPDLAQYEKAGGYGALRKALGMAPAEIQAAVKESNLRGRGGAGFPTAQKWSFVPMGDDAPRPKYLV
CNADEMEPGTFKDRMLLEGDPHQLIEGIIISAYAIQADVAYVFLRWAYKLAARRVERAIVEAYRHGYLGKNILGSAYSLE
MHLHVSAGRYICGEETALLNALEGKRANPRAKPPYPQVSGLWGKPTIVNSVETLCNVPHIVKQGAEWFRSLSRSDDGGTK
LYGASGRVKNPGLWELPMGTPLREILEEHAGGMRDGYQFRGVLPGGASTDFVTAEHLDVAMDFDSVQKAGSRLGTGTMII
LDDKTCPVGMLLNLEHFFAQESCGWCTPCWSGLSWIEQILQDMEEGRGRASDLELLESHTRLLGPGHTFCALAPGAAEPL
QSGLKYFRDDFERHIHEKRCPWSPT

Sequences:

>Translated_425_residues
METPLTHNISPGREPPDLAQYEKAGGYGALRKALGMAPAEIQAAVKESNLRGRGGAGFPTAQKWSFVPMGDDAPRPKYLV
CNADEMEPGTFKDRMLLEGDPHQLIEGIIISAYAIQADVAYVFLRWAYKLAARRVERAIVEAYRHGYLGKNILGSAYSLE
MHLHVSAGRYICGEETALLNALEGKRANPRAKPPYPQVSGLWGKPTIVNSVETLCNVPHIVKQGAEWFRSLSRSDDGGTK
LYGASGRVKNPGLWELPMGTPLREILEEHAGGMRDGYQFRGVLPGGASTDFVTAEHLDVAMDFDSVQKAGSRLGTGTMII
LDDKTCPVGMLLNLEHFFAQESCGWCTPCWSGLSWIEQILQDMEEGRGRASDLELLESHTRLLGPGHTFCALAPGAAEPL
QSGLKYFRDDFERHIHEKRCPWSPT
>Mature_425_residues
METPLTHNISPGREPPDLAQYEKAGGYGALRKALGMAPAEIQAAVKESNLRGRGGAGFPTAQKWSFVPMGDDAPRPKYLV
CNADEMEPGTFKDRMLLEGDPHQLIEGIIISAYAIQADVAYVFLRWAYKLAARRVERAIVEAYRHGYLGKNILGSAYSLE
MHLHVSAGRYICGEETALLNALEGKRANPRAKPPYPQVSGLWGKPTIVNSVETLCNVPHIVKQGAEWFRSLSRSDDGGTK
LYGASGRVKNPGLWELPMGTPLREILEEHAGGMRDGYQFRGVLPGGASTDFVTAEHLDVAMDFDSVQKAGSRLGTGTMII
LDDKTCPVGMLLNLEHFFAQESCGWCTPCWSGLSWIEQILQDMEEGRGRASDLELLESHTRLLGPGHTFCALAPGAAEPL
QSGLKYFRDDFERHIHEKRCPWSPT

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=394, Percent_Identity=41.8781725888325, Blast_Score=315, Evalue=8e-86,
Organism=Homo sapiens, GI260656005, Length=394, Percent_Identity=41.8781725888325, Blast_Score=314, Evalue=8e-86,
Organism=Escherichia coli, GI1788620, Length=423, Percent_Identity=56.9739952718676, Blast_Score=493, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17531727, Length=379, Percent_Identity=43.2717678100264, Blast_Score=322, Evalue=2e-88,
Organism=Drosophila melanogaster, GI19920794, Length=383, Percent_Identity=43.3420365535248, Blast_Score=327, Evalue=9e-90,
Organism=Drosophila melanogaster, GI45550452, Length=409, Percent_Identity=40.8312958435208, Blast_Score=324, Evalue=7e-89,
Organism=Drosophila melanogaster, GI24653819, Length=384, Percent_Identity=34.8958333333333, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI24653817, Length=356, Percent_Identity=33.4269662921348, Blast_Score=221, Evalue=7e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 46738; Mature: 46738

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METPLTHNISPGREPPDLAQYEKAGGYGALRKALGMAPAEIQAAVKESNLRGRGGAGFPT
CCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCC
AQKWSFVPMGDDAPRPKYLVCNADEMEPGTFKDRMLLEGDPHQLIEGIIISAYAIQADVA
CCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
YVFLRWAYKLAARRVERAIVEAYRHGYLGKNILGSAYSLEMHLHVSAGRYICGEETALLN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEEEEEECCCCEECCCHHHHHH
ALEGKRANPRAKPPYPQVSGLWGKPTIVNSVETLCNVPHIVKQGAEWFRSLSRSDDGGTK
HHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCE
LYGASGRVKNPGLWELPMGTPLREILEEHAGGMRDGYQFRGVLPGGASTDFVTAEHLDVA
EEECCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEHHHHHEE
MDFDSVQKAGSRLGTGTMIILDDKTCPVGMLLNLEHFFAQESCGWCTPCWSGLSWIEQIL
ECHHHHHHHHHHCCCCEEEEEECCCCCCHHEECHHHHHHHCCCCCCCHHHHHHHHHHHHH
QDMEEGRGRASDLELLESHTRLLGPGHTFCALAPGAAEPLQSGLKYFRDDFERHIHEKRC
HHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
PWSPT
CCCCC
>Mature Secondary Structure
METPLTHNISPGREPPDLAQYEKAGGYGALRKALGMAPAEIQAAVKESNLRGRGGAGFPT
CCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCC
AQKWSFVPMGDDAPRPKYLVCNADEMEPGTFKDRMLLEGDPHQLIEGIIISAYAIQADVA
CCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
YVFLRWAYKLAARRVERAIVEAYRHGYLGKNILGSAYSLEMHLHVSAGRYICGEETALLN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEEEEEECCCCEECCCHHHHHH
ALEGKRANPRAKPPYPQVSGLWGKPTIVNSVETLCNVPHIVKQGAEWFRSLSRSDDGGTK
HHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCE
LYGASGRVKNPGLWELPMGTPLREILEEHAGGMRDGYQFRGVLPGGASTDFVTAEHLDVA
EEECCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEHHHHHEE
MDFDSVQKAGSRLGTGTMIILDDKTCPVGMLLNLEHFFAQESCGWCTPCWSGLSWIEQIL
ECHHHHHHHHHHCCCCEEEEEECCCCCCHHEECHHHHHHHCCCCCCCHHHHHHHHHHHHH
QDMEEGRGRASDLELLESHTRLLGPGHTFCALAPGAAEPLQSGLKYFRDDFERHIHEKRC
HHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
PWSPT
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7690854; 8157582; 9205837; 9278503; 8366049 [H]