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The map label for this gene is moeZ [H]

Identifier: 82702101

GI number: 82702101

Start: 1129676

End: 1130848

Strand: Reverse

Name: moeZ [H]

Synonym: Nmul_A0972

Alternate gene names: 82702101

Gene position: 1130848-1129676 (Counterclockwise)

Preceding gene: 82702102

Following gene: 82702100

Centisome position: 35.51

GC content: 55.84

Gene sequence:

>1173_bases
ATGCAGCTATCACCGCTGGTACATCCCTCGGAAGAATTGAGTAAAGAAGAAATTTCGCGCTACAGCCGCCATCTGCTGAT
TCCGGATGTCGGTCTGGAAGGGCAGCAGCGTCTCAAGAACAGCAAGGTCCTGGTAATCGGCGCCGGAGGGCTGGGATCGC
CGACGCTCCTCTATCTGGCCGCAGCCGGCGTGGGAACCTTGGGCATTATCGATTTCGATATTGTTGATGAATCCAATCTA
CAGCGGCAGGTCATTCATCGGCAGCAGGATATCGGCAGACCCAAATGCCGGAGTGCGCAGGACTCGGTCAAGGCCCTGAA
TCCCTATATCCAGGTTCGGATTCACGATGAACGACTCGAAACAACAAATGCTATTGACATCATATCGGACTACGATCTGG
TAATAGACGGAACGGATAACTTCTCCACCCGCTATCTCGTCAACGATGCCTGCGTGCTGGCTGGAAAGCCCTATGTCTGG
GGGTCCATTTTCCGCTTCGAAGGGCAGGCCTCGGTCTTCTGGGAAGATGCGCCAGGAGGACGCGGCCTGAACTACCGCGA
CCTTTATCCCGAACCCCCGCCGCCCGAAATGGCCCCGTCGTGTGCGGAAGGCGGCGTGCTGGGCATACTGTGCGCATCCA
TCGGCGCGATCATGGCTACCGAGGCCATCAAATTGATTACCGGTCTGGGCAATACCCTGCTCGGCAGGCTTGCTGTCTAC
GATGCCCTGGATATGACCTTCAGATTCATCCCGCTGCGGCGAGCCCCGGTCAGGACACCGATCACCCGGCTGATCGATTA
CCAGGCATTTTGCGGCCTCCCGCAGTCAACGACGGGCGGCAAACCGAACGTACCCACGATCAGCGCCCTGGAATTGAAAG
AGATGCGGGATTGCAGCGTAGCCATGCAGCTTATCGATGTTCGCGGAATCCAGGAATGGAACATCGTGCATATCGAAGGG
GCAAATCATATTCCCAAGGACAGGATGATGTCCGAGGAAGTTTTAGCCCGATTGAACAAGGATGAGCTTATCGTGCTTCA
CTGCAAAATGGGCGTGCGGTCCCGGGATATTCTCATGGAGATGCGCAAGCGGGGGTTTACGAATGTCAAAAGCCTGGATG
GCGGAATCCTGGCGTGGATCAGGGATGTGGATCAGACATTGCCAAGTTATTGA

Upstream 100 bases:

>100_bases
ACCGTCCGGGGTATCCCATGCCGGGTCGGTGGGGACAAATCGGCATAGCCGCAAGCTTCTAAGAAATGATGATCCTTTGA
CTTGAACATGGAGGTTTCGA

Downstream 100 bases:

>100_bases
GCGAGTCGTCACTAGGGTAGAGCTCCAACCGACATACCCGGACGTCGGGCGAAGCCTGGCTAACCTGGCAATCCATATGC
GAAAACCTCTGGATTCCGGA

Product: UBA/THIF-type NAD/FAD binding domain-containing protein

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MQLSPLVHPSEELSKEEISRYSRHLLIPDVGLEGQQRLKNSKVLVIGAGGLGSPTLLYLAAAGVGTLGIIDFDIVDESNL
QRQVIHRQQDIGRPKCRSAQDSVKALNPYIQVRIHDERLETTNAIDIISDYDLVIDGTDNFSTRYLVNDACVLAGKPYVW
GSIFRFEGQASVFWEDAPGGRGLNYRDLYPEPPPPEMAPSCAEGGVLGILCASIGAIMATEAIKLITGLGNTLLGRLAVY
DALDMTFRFIPLRRAPVRTPITRLIDYQAFCGLPQSTTGGKPNVPTISALELKEMRDCSVAMQLIDVRGIQEWNIVHIEG
ANHIPKDRMMSEEVLARLNKDELIVLHCKMGVRSRDILMEMRKRGFTNVKSLDGGILAWIRDVDQTLPSY

Sequences:

>Translated_390_residues
MQLSPLVHPSEELSKEEISRYSRHLLIPDVGLEGQQRLKNSKVLVIGAGGLGSPTLLYLAAAGVGTLGIIDFDIVDESNL
QRQVIHRQQDIGRPKCRSAQDSVKALNPYIQVRIHDERLETTNAIDIISDYDLVIDGTDNFSTRYLVNDACVLAGKPYVW
GSIFRFEGQASVFWEDAPGGRGLNYRDLYPEPPPPEMAPSCAEGGVLGILCASIGAIMATEAIKLITGLGNTLLGRLAVY
DALDMTFRFIPLRRAPVRTPITRLIDYQAFCGLPQSTTGGKPNVPTISALELKEMRDCSVAMQLIDVRGIQEWNIVHIEG
ANHIPKDRMMSEEVLARLNKDELIVLHCKMGVRSRDILMEMRKRGFTNVKSLDGGILAWIRDVDQTLPSY
>Mature_390_residues
MQLSPLVHPSEELSKEEISRYSRHLLIPDVGLEGQQRLKNSKVLVIGAGGLGSPTLLYLAAAGVGTLGIIDFDIVDESNL
QRQVIHRQQDIGRPKCRSAQDSVKALNPYIQVRIHDERLETTNAIDIISDYDLVIDGTDNFSTRYLVNDACVLAGKPYVW
GSIFRFEGQASVFWEDAPGGRGLNYRDLYPEPPPPEMAPSCAEGGVLGILCASIGAIMATEAIKLITGLGNTLLGRLAVY
DALDMTFRFIPLRRAPVRTPITRLIDYQAFCGLPQSTTGGKPNVPTISALELKEMRDCSVAMQLIDVRGIQEWNIVHIEG
ANHIPKDRMMSEEVLARLNKDELIVLHCKMGVRSRDILMEMRKRGFTNVKSLDGGILAWIRDVDQTLPSY

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=420, Percent_Identity=37.1428571428571, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI38045948, Length=174, Percent_Identity=31.6091954022989, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4885649, Length=133, Percent_Identity=31.5789473684211, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38045944, Length=144, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38045942, Length=144, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI150417996, Length=177, Percent_Identity=26.5536723163842, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI23510338, Length=172, Percent_Identity=26.7441860465116, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI23510340, Length=172, Percent_Identity=26.7441860465116, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787048, Length=247, Percent_Identity=40.080971659919, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87082356, Length=246, Percent_Identity=41.0569105691057, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17540406, Length=404, Percent_Identity=34.4059405940594, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI193203301, Length=141, Percent_Identity=34.7517730496454, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71984476, Length=130, Percent_Identity=36.1538461538462, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321903, Length=405, Percent_Identity=36.2962962962963, Blast_Score=227, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6320598, Length=144, Percent_Identity=29.1666666666667, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322639, Length=180, Percent_Identity=28.8888888888889, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325438, Length=125, Percent_Identity=28.8, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325323, Length=114, Percent_Identity=34.2105263157895, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24582879, Length=406, Percent_Identity=40.1477832512315, Blast_Score=281, Evalue=5e-76,
Organism=Drosophila melanogaster, GI24660640, Length=136, Percent_Identity=35.2941176470588, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28573937, Length=149, Percent_Identity=30.2013422818792, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI20129973, Length=107, Percent_Identity=36.4485981308411, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 43180; Mature: 43180

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSPLVHPSEELSKEEISRYSRHLLIPDVGLEGQQRLKNSKVLVIGAGGLGSPTLLYLA
CCCCCCCCCHHHHHHHHHHHHHCEEECCCCCCCHHHHHCCCCEEEEECCCCCCCHHHHHH
AAGVGTLGIIDFDIVDESNLQRQVIHRQQDIGRPKCRSAQDSVKALNPYIQVRIHDERLE
HCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEEHHHHC
TTNAIDIISDYDLVIDGTDNFSTRYLVNDACVLAGKPYVWGSIFRFEGQASVFWEDAPGG
CCCCEEEEECCEEEEECCCCCCEEEEECCEEEECCCCCEEEEEEEECCCEEEEEECCCCC
RGLNYRDLYPEPPPPEMAPSCAEGGVLGILCASIGAIMATEAIKLITGLGNTLLGRLAVY
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
DALDMTFRFIPLRRAPVRTPITRLIDYQAFCGLPQSTTGGKPNVPTISALELKEMRDCSV
HHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHH
AMQLIDVRGIQEWNIVHIEGANHIPKDRMMSEEVLARLNKDELIVLHCKMGVRSRDILME
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
MRKRGFTNVKSLDGGILAWIRDVDQTLPSY
HHHCCCCCHHHCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQLSPLVHPSEELSKEEISRYSRHLLIPDVGLEGQQRLKNSKVLVIGAGGLGSPTLLYLA
CCCCCCCCCHHHHHHHHHHHHHCEEECCCCCCCHHHHHCCCCEEEEECCCCCCCHHHHHH
AAGVGTLGIIDFDIVDESNLQRQVIHRQQDIGRPKCRSAQDSVKALNPYIQVRIHDERLE
HCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEEHHHHC
TTNAIDIISDYDLVIDGTDNFSTRYLVNDACVLAGKPYVWGSIFRFEGQASVFWEDAPGG
CCCCEEEEECCEEEEECCCCCCEEEEECCEEEECCCCCEEEEEEEECCCEEEEEECCCCC
RGLNYRDLYPEPPPPEMAPSCAEGGVLGILCASIGAIMATEAIKLITGLGNTLLGRLAVY
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
DALDMTFRFIPLRRAPVRTPITRLIDYQAFCGLPQSTTGGKPNVPTISALELKEMRDCSV
HHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHH
AMQLIDVRGIQEWNIVHIEGANHIPKDRMMSEEVLARLNKDELIVLHCKMGVRSRDILME
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
MRKRGFTNVKSLDGGILAWIRDVDQTLPSY
HHHCCCCCHHHCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]