Click here to switch to the map view.

The map label for this gene is patA [H]

Identifier: 82701894

GI number: 82701894

Start: 888877

End: 890286

Strand: Direct

Name: patA [H]

Synonym: Nmul_A0761

Alternate gene names: 82701894

Gene position: 888877-890286 (Clockwise)

Preceding gene: 82701893

Following gene: 82701895

Centisome position: 27.91

GC content: 54.33

Gene sequence:

>1410_bases
ATGCCCATCGATATTAATGCCATCATTGCCGAAACTCGCGGCAAAAACTTCGAGCTTTACGAAGAGCATATAAATCCGGT
CTTCGTCAAAGTACTGCGGACACTTGGATTCAACCGGACCTGGGTGAGAGGGGAGGGGGCTTATCTGTGGGATGAGGCAG
GCACGCGCTATCTCGATTTTCTGACCAACTGGGGTGTATTCAATTTCGGGCGGCGGCATCCTGCTATCCGGAATGCACTG
CAGCAGGTAATGGATTCCGAGTTTCCCGGATGGGTCGGTTTTGATGCTCCACCGCTTGCCGCGGTACTGGCGCGCGAACT
GGTAAAGCGAATGCCACCAGGGCTGGATACCGTTTACTTCAGTAATTCCGGGACGGAAGCAATCGAAGCAGCAATCAAAT
TTGCACGTGGGTATACAGGTCGGCCCTCTACCGCGCATCTCGCCAAGGCATTTCACGGCTTGACCATGGGATCCTTGTCA
CTGAATGGGGAAGCAAGTTTTCGCAGGGGTTTTGAGCCAATGCTTCCCGGCAGTTCAGAAGTGAAAATGGGTGATCTGGC
CGGACTGGAAGCGCGTCTGGCAAAGGGCGATGTCGCGGCCTTCGTCTTTGAGCCGATACAGGGTAAGGGTGTCAATATCG
CCAGCGACGAGTATCTGCTGAGTGCACAGGAGTTGTGCCGAAAATACGGCACCTTGATGGTTTGCGATGAAATTCAATGT
GGTATGGGTCGCACTGGGCGTTTTCTGGCGAGTCAGTGGATTCCCGACTTCCGGCCAGACATCGTCTGTCTTTCCAAGGC
GCTTTCCGGAGGCTATATTCCAGTCGGCGCGACGATTACCCGACGTGCCGTTTACGATAGTGTTTACGACAGTCTGCATC
GTGCGATCGTTCACGCGTCCACTTTCGGGATGGGCAATATGGCGATGGCCGCAGCTTTGGCTTCACTCAGCGTTCTGGAC
GATGAGAAGCTCATGGATCGGGCCATTGTACTCGGGGAGCGCTTCAGGAAAGGAATCGAGGCGATGGTGCCGCGCTTTGA
ATTTCTCAAAGGGGTGCGGCAGCGCGGGCTCATGATTGCAATCGAGTTTGGTCAGCCGGAATCAATGTCGCTACGAGCCG
CGTGGGCGATGGTCAACAAGATGGATGAAAACCTTTTTGCTCAGGCAATCGTTCTTCCGCTTCTTGACGATCATCACATT
CTTACCCAGGTAGCAGGCCATGCTATGCCTATTGTCAAAATTCTGCCGCCGCTGAATATTGACGAGAGCGATGTCGACTG
GTTCCTCGCAGCCCTGGAGGATGTCATGATAAAATTGCACAAGTTCCCGGGCCCCGCCTGGGAAGTTTTGAAGAAGCTCG
GCAATCATGCGCTGACTGCCAAAAAGCGCGAGGCGCGGGCAACGGCATGA

Upstream 100 bases:

>100_bases
ACGCTGTCTGAAAACAGGCGGGGAAAGGGAAGCTTGCGAGCCTCATCCTGCTCCCCGGCAATGTTGGCATTTAACCTCGG
GTGTCTGACGGACTCGAATC

Downstream 100 bases:

>100_bases
GACGCCTGAGCAGGAGCACGAATCGGACTGTTTTTATCGGGTTTCCTTGTGTTGAAGTCCTGAACGGGTTTGCTGTATTC
CCACATTTGATTGAGGTTGC

Product: class III aminotransferase

Products: NA

Alternate protein names: Putrescine--2-oxoglutaric acid transaminase; PAT; PATase [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MPIDINAIIAETRGKNFELYEEHINPVFVKVLRTLGFNRTWVRGEGAYLWDEAGTRYLDFLTNWGVFNFGRRHPAIRNAL
QQVMDSEFPGWVGFDAPPLAAVLARELVKRMPPGLDTVYFSNSGTEAIEAAIKFARGYTGRPSTAHLAKAFHGLTMGSLS
LNGEASFRRGFEPMLPGSSEVKMGDLAGLEARLAKGDVAAFVFEPIQGKGVNIASDEYLLSAQELCRKYGTLMVCDEIQC
GMGRTGRFLASQWIPDFRPDIVCLSKALSGGYIPVGATITRRAVYDSVYDSLHRAIVHASTFGMGNMAMAAALASLSVLD
DEKLMDRAIVLGERFRKGIEAMVPRFEFLKGVRQRGLMIAIEFGQPESMSLRAAWAMVNKMDENLFAQAIVLPLLDDHHI
LTQVAGHAMPIVKILPPLNIDESDVDWFLAALEDVMIKLHKFPGPAWEVLKKLGNHALTAKKREARATA

Sequences:

>Translated_469_residues
MPIDINAIIAETRGKNFELYEEHINPVFVKVLRTLGFNRTWVRGEGAYLWDEAGTRYLDFLTNWGVFNFGRRHPAIRNAL
QQVMDSEFPGWVGFDAPPLAAVLARELVKRMPPGLDTVYFSNSGTEAIEAAIKFARGYTGRPSTAHLAKAFHGLTMGSLS
LNGEASFRRGFEPMLPGSSEVKMGDLAGLEARLAKGDVAAFVFEPIQGKGVNIASDEYLLSAQELCRKYGTLMVCDEIQC
GMGRTGRFLASQWIPDFRPDIVCLSKALSGGYIPVGATITRRAVYDSVYDSLHRAIVHASTFGMGNMAMAAALASLSVLD
DEKLMDRAIVLGERFRKGIEAMVPRFEFLKGVRQRGLMIAIEFGQPESMSLRAAWAMVNKMDENLFAQAIVLPLLDDHHI
LTQVAGHAMPIVKILPPLNIDESDVDWFLAALEDVMIKLHKFPGPAWEVLKKLGNHALTAKKREARATA
>Mature_468_residues
PIDINAIIAETRGKNFELYEEHINPVFVKVLRTLGFNRTWVRGEGAYLWDEAGTRYLDFLTNWGVFNFGRRHPAIRNALQ
QVMDSEFPGWVGFDAPPLAAVLARELVKRMPPGLDTVYFSNSGTEAIEAAIKFARGYTGRPSTAHLAKAFHGLTMGSLSL
NGEASFRRGFEPMLPGSSEVKMGDLAGLEARLAKGDVAAFVFEPIQGKGVNIASDEYLLSAQELCRKYGTLMVCDEIQCG
MGRTGRFLASQWIPDFRPDIVCLSKALSGGYIPVGATITRRAVYDSVYDSLHRAIVHASTFGMGNMAMAAALASLSVLDD
EKLMDRAIVLGERFRKGIEAMVPRFEFLKGVRQRGLMIAIEFGQPESMSLRAAWAMVNKMDENLFAQAIVLPLLDDHHIL
TQVAGHAMPIVKILPPLNIDESDVDWFLAALEDVMIKLHKFPGPAWEVLKKLGNHALTAKKREARATA

Specific function: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithi

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=393, Percent_Identity=33.587786259542, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI284507298, Length=272, Percent_Identity=35.6617647058824, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI13994255, Length=481, Percent_Identity=25.7796257796258, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI24119277, Length=438, Percent_Identity=26.9406392694064, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI37574042, Length=457, Percent_Identity=25.164113785558, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI226442705, Length=455, Percent_Identity=24.6153846153846, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI226442709, Length=388, Percent_Identity=24.4845360824742, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI145693181, Length=361, Percent_Identity=35.1800554016621, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI1787560, Length=411, Percent_Identity=31.3868613138686, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789759, Length=329, Percent_Identity=31.6109422492401, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788044, Length=403, Percent_Identity=29.5285359801489, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789016, Length=402, Percent_Identity=27.363184079602, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786349, Length=347, Percent_Identity=30.2593659942363, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1786991, Length=355, Percent_Identity=29.8591549295775, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=406, Percent_Identity=30.7881773399015, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=27.4004683840749, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71992977, Length=434, Percent_Identity=26.9585253456221, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25144274, Length=290, Percent_Identity=32.0689655172414, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17541228, Length=394, Percent_Identity=26.1421319796954, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=405, Percent_Identity=31.6049382716049, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324432, Length=354, Percent_Identity=29.9435028248588, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI21357415, Length=394, Percent_Identity=32.994923857868, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21356575, Length=426, Percent_Identity=27.9342723004695, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI161085790, Length=445, Percent_Identity=28.0898876404494, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI28574759, Length=429, Percent_Identity=27.7389277389277, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI281366494, Length=394, Percent_Identity=25.6345177664975, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667139, Length=394, Percent_Identity=25.6345177664975, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667143, Length=394, Percent_Identity=25.6345177664975, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR017747
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.82 [H]

Molecular weight: Translated: 51803; Mature: 51671

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIDINAIIAETRGKNFELYEEHINPVFVKVLRTLGFNRTWVRGEGAYLWDEAGTRYLDF
CCCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHCCCCEEEECCCCEEECCCCCHHHHH
LTNWGVFNFGRRHPAIRNALQQVMDSEFPGWVGFDAPPLAAVLARELVKRMPPGLDTVYF
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEE
SNSGTEAIEAAIKFARGYTGRPSTAHLAKAFHGLTMGSLSLNGEASFRRGFEPMLPGSSE
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEECCEEECCCHHHHCCCCCCCCCCCC
VKMGDLAGLEARLAKGDVAAFVFEPIQGKGVNIASDEYLLSAQELCRKYGTLMVCDEIQC
CCCHHHHCHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCC
GMGRTGRFLASQWIPDFRPDIVCLSKALSGGYIPVGATITRRAVYDSVYDSLHRAIVHAS
CCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
TFGMGNMAMAAALASLSVLDDEKLMDRAIVLGERFRKGIEAMVPRFEFLKGVRQRGLMIA
HCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEE
IEFGQPESMSLRAAWAMVNKMDENLFAQAIVLPLLDDHHILTQVAGHAMPIVKILPPLNI
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHCCCCCC
DESDVDWFLAALEDVMIKLHKFPGPAWEVLKKLGNHALTAKKREARATA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
PIDINAIIAETRGKNFELYEEHINPVFVKVLRTLGFNRTWVRGEGAYLWDEAGTRYLDF
CCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHCCCCEEEECCCCEEECCCCCHHHHH
LTNWGVFNFGRRHPAIRNALQQVMDSEFPGWVGFDAPPLAAVLARELVKRMPPGLDTVYF
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEE
SNSGTEAIEAAIKFARGYTGRPSTAHLAKAFHGLTMGSLSLNGEASFRRGFEPMLPGSSE
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEECCEEECCCHHHHCCCCCCCCCCCC
VKMGDLAGLEARLAKGDVAAFVFEPIQGKGVNIASDEYLLSAQELCRKYGTLMVCDEIQC
CCCHHHHCHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCC
GMGRTGRFLASQWIPDFRPDIVCLSKALSGGYIPVGATITRRAVYDSVYDSLHRAIVHAS
CCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
TFGMGNMAMAAALASLSVLDDEKLMDRAIVLGERFRKGIEAMVPRFEFLKGVRQRGLMIA
HCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEE
IEFGQPESMSLRAAWAMVNKMDENLFAQAIVLPLLDDHHILTQVAGHAMPIVKILPPLNI
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHCCCCCC
DESDVDWFLAALEDVMIKLHKFPGPAWEVLKKLGNHALTAKKREARATA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA