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The map label for this gene is nuoL [H]

Identifier: 82701842

GI number: 82701842

Start: 817625

End: 819517

Strand: Direct

Name: nuoL [H]

Synonym: Nmul_A0709

Alternate gene names: 82701842

Gene position: 817625-819517 (Clockwise)

Preceding gene: 82701841

Following gene: 82701843

Centisome position: 25.68

GC content: 50.08

Gene sequence:

>1893_bases
ATGACGATGCCGCTGCTAACCTCGCTGCTTGGGTTATTCATAATCATCCCGCTGATCGGGTTTGGGCTCACCATGCTCGT
GCCGAAAAAGAATGAGGATGCCATTTCCTGGATAGCCTACTCCACTGTCGGTTCGCACATGGTTTTGGCCTGGATATTCC
TGGTCCTCTGGCTCTTCAGCGGCTACCCGACGCTCGAGACAATTGAGCTTATCCTGTATAACACGGAAAGTTACAAGTTT
TTCATTTCATTCTATTTCGACAAAATTACCGCGGTTTATCTGTTCGTCGGTTCTTTCCTCTGCTTTCTGGTTACCGTCTA
CTCCAGATGGTACCTTCATCGCGAAAGGGGCTATAAGCGGTTTTTCAACACCATCCTGTTCTTTTTCATCGGCTACAACA
TCATCATTTTCTCCGGTAATTTCGAGACGCTCTTTATCGGTTGGGAAGTTCTGGGAATCACGTCCTTCCTCCTGATCGGG
TTCTACAGGGAGCGGTATCTGCCGGTAAAAAATGCGCTCAAGGTATTCACGGTGTTTCGCGTGGCGGATATGGGTTTGAT
TCTGGTCATCTGGATGAGCCATCATCTGTGGCACGAAAACATCACGTTCTCCAAGCTCATGCATCCGGAACTGGTTGCAC
AGACTCTTGAGGGCAACACGACACTGGGGATTTTGATCGGATTGATGCTCCTGCTGGCGGCCGCCGTGAAATCGGGTCAA
CTCCCGTTTTCTTCCTGGGTGCCCAGAGCAATGGAAGGCCCGACCCCGTCGAGTGCAATCTTTTACGGATCGCTCTCGGT
TCACTTGGGCGTCTTTCTTTTGCTGAGAACGTTCCCATTCTGGGAAAATCAGATCGTTGTGGTAGCGCCTGTGATTCTTC
TTGGCGTAGGGACTGCCGTAGTCGCGACCCTTATTTCACGCGTACAGTCCTCGATCAAGACGCAGATCGCCTACTCTTCG
GTGGCGCAGATCGGCATCATTTTCGTGGAAGTGGCGTTAGGGTTTTATGATCTTGCCTTGATCCATTTGGCAGGAAATGC
ATTCTTGCGGACGTATCAGCTTCTGGTCTCGCCATCGGCCGTGACCTTCCTGCTTCGCGATCAGTTCTACAACTTTGTTC
CAAGGGAATACATCGACAAGCATTCCACATCCAAGCAAATCGAGTATGCGGCCTATATGCTGAGCGTGAAGGAGTTCAAC
CTCGATTCGTTCATGTATTTCTTCTTCTGGGATCCCGTGAAATGGATCGGCCGGAAGCTGAACCTGGTGTTATCCGGAAC
GGGTGGTTTCATTATCGCCACCACACTTTTCCTCGTCGGCCTCGCCTGCCTCTACTACGAGCAGTCTTTACCGGTCGGTG
TCCAGCAATTCCTGCCGACGCTATTTGCCTTCATCGCCCTGATCGTCGTGCTGAAGTCTTTCTCGGAAAGAATGAGTCCC
CAGTTGAGCTGGTACTTCGTCATCATGAATCATCTCTGGGTCGCACTCGCCATCTCGTTTTATGACGAAGTGACGACCCG
GGAGATTGTCATTTATATAAGTGGCATCCTCCTTTCAGGCCTTGTGGGATACGCTTGTCTGGCACAACTGAAGTCACTTG
AGCCGAAGGTGGATTTGAAGGAACCTCAGGGTCAGGGTCATGTCTATGAATATCCTACACAGGCTTTCATTTTCCTGCTT
GCGTGTCTGGGCCTGATGGGTTTTCCTATTACGCCATCGTTCCTGGGGATAGATCTGATCTTCACCCACATTCACACAGA
CCAGATCGTATTTGCATTCATTCTCGCACTGAGTTTCATCATCGTCGGTCTCTCCTTGGTGAGAATATATTCGCGGGTTT
ATCTTGGACCTCATGTTAAAACTTACCATGCCGTCCCCTTCAAAAACTCGTGA

Upstream 100 bases:

>100_bases
TGATGGAACGGGCTAAGAAAGCGGAATCCATCGAAACCCTGGATGCGGTTCAAGAGAATTTACCTGTCTACTTTATCGAG
AAGAAGGAGAGAGTGAAAAA

Downstream 100 bases:

>100_bases
TCATGAAACCATGATGAAAGTGGGAATGGATAGACAGATGTGATGACGAAATGAAAGGCGCCGGCTTGAACCCCAGGAAA
TCAGAAGCCATGCGAGAGAA

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MTMPLLTSLLGLFIIIPLIGFGLTMLVPKKNEDAISWIAYSTVGSHMVLAWIFLVLWLFSGYPTLETIELILYNTESYKF
FISFYFDKITAVYLFVGSFLCFLVTVYSRWYLHRERGYKRFFNTILFFFIGYNIIIFSGNFETLFIGWEVLGITSFLLIG
FYRERYLPVKNALKVFTVFRVADMGLILVIWMSHHLWHENITFSKLMHPELVAQTLEGNTTLGILIGLMLLLAAAVKSGQ
LPFSSWVPRAMEGPTPSSAIFYGSLSVHLGVFLLLRTFPFWENQIVVVAPVILLGVGTAVVATLISRVQSSIKTQIAYSS
VAQIGIIFVEVALGFYDLALIHLAGNAFLRTYQLLVSPSAVTFLLRDQFYNFVPREYIDKHSTSKQIEYAAYMLSVKEFN
LDSFMYFFFWDPVKWIGRKLNLVLSGTGGFIIATTLFLVGLACLYYEQSLPVGVQQFLPTLFAFIALIVVLKSFSERMSP
QLSWYFVIMNHLWVALAISFYDEVTTREIVIYISGILLSGLVGYACLAQLKSLEPKVDLKEPQGQGHVYEYPTQAFIFLL
ACLGLMGFPITPSFLGIDLIFTHIHTDQIVFAFILALSFIIVGLSLVRIYSRVYLGPHVKTYHAVPFKNS

Sequences:

>Translated_630_residues
MTMPLLTSLLGLFIIIPLIGFGLTMLVPKKNEDAISWIAYSTVGSHMVLAWIFLVLWLFSGYPTLETIELILYNTESYKF
FISFYFDKITAVYLFVGSFLCFLVTVYSRWYLHRERGYKRFFNTILFFFIGYNIIIFSGNFETLFIGWEVLGITSFLLIG
FYRERYLPVKNALKVFTVFRVADMGLILVIWMSHHLWHENITFSKLMHPELVAQTLEGNTTLGILIGLMLLLAAAVKSGQ
LPFSSWVPRAMEGPTPSSAIFYGSLSVHLGVFLLLRTFPFWENQIVVVAPVILLGVGTAVVATLISRVQSSIKTQIAYSS
VAQIGIIFVEVALGFYDLALIHLAGNAFLRTYQLLVSPSAVTFLLRDQFYNFVPREYIDKHSTSKQIEYAAYMLSVKEFN
LDSFMYFFFWDPVKWIGRKLNLVLSGTGGFIIATTLFLVGLACLYYEQSLPVGVQQFLPTLFAFIALIVVLKSFSERMSP
QLSWYFVIMNHLWVALAISFYDEVTTREIVIYISGILLSGLVGYACLAQLKSLEPKVDLKEPQGQGHVYEYPTQAFIFLL
ACLGLMGFPITPSFLGIDLIFTHIHTDQIVFAFILALSFIIVGLSLVRIYSRVYLGPHVKTYHAVPFKNS
>Mature_629_residues
TMPLLTSLLGLFIIIPLIGFGLTMLVPKKNEDAISWIAYSTVGSHMVLAWIFLVLWLFSGYPTLETIELILYNTESYKFF
ISFYFDKITAVYLFVGSFLCFLVTVYSRWYLHRERGYKRFFNTILFFFIGYNIIIFSGNFETLFIGWEVLGITSFLLIGF
YRERYLPVKNALKVFTVFRVADMGLILVIWMSHHLWHENITFSKLMHPELVAQTLEGNTTLGILIGLMLLLAAAVKSGQL
PFSSWVPRAMEGPTPSSAIFYGSLSVHLGVFLLLRTFPFWENQIVVVAPVILLGVGTAVVATLISRVQSSIKTQIAYSSV
AQIGIIFVEVALGFYDLALIHLAGNAFLRTYQLLVSPSAVTFLLRDQFYNFVPREYIDKHSTSKQIEYAAYMLSVKEFNL
DSFMYFFFWDPVKWIGRKLNLVLSGTGGFIIATTLFLVGLACLYYEQSLPVGVQQFLPTLFAFIALIVVLKSFSERMSPQ
LSWYFVIMNHLWVALAISFYDEVTTREIVIYISGILLSGLVGYACLAQLKSLEPKVDLKEPQGQGHVYEYPTQAFIFLLA
CLGLMGFPITPSFLGIDLIFTHIHTDQIVFAFILALSFIIVGLSLVRIYSRVYLGPHVKTYHAVPFKNS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=306, Percent_Identity=32.6797385620915, Blast_Score=139, Evalue=8e-33,
Organism=Escherichia coli, GI1788614, Length=363, Percent_Identity=30.5785123966942, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788829, Length=277, Percent_Identity=27.7978339350181, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 71501; Mature: 71369

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMPLLTSLLGLFIIIPLIGFGLTMLVPKKNEDAISWIAYSTVGSHMVLAWIFLVLWLFS
CCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GYPTLETIELILYNTESYKFFISFYFDKITAVYLFVGSFLCFLVTVYSRWYLHRERGYKR
CCCCHHHEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFNTILFFFIGYNIIIFSGNFETLFIGWEVLGITSFLLIGFYRERYLPVKNALKVFTVFR
HHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VADMGLILVIWMSHHLWHENITFSKLMHPELVAQTLEGNTTLGILIGLMLLLAAAVKSGQ
HHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
LPFSSWVPRAMEGPTPSSAIFYGSLSVHLGVFLLLRTFPFWENQIVVVAPVILLGVGTAV
CCHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
VATLISRVQSSIKTQIAYSSVAQIGIIFVEVALGFYDLALIHLAGNAFLRTYQLLVSPSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VTFLLRDQFYNFVPREYIDKHSTSKQIEYAAYMLSVKEFNLDSFMYFFFWDPVKWIGRKL
HHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHCCEE
NLVLSGTGGFIIATTLFLVGLACLYYEQSLPVGVQQFLPTLFAFIALIVVLKSFSERMSP
EEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
QLSWYFVIMNHLWVALAISFYDEVTTREIVIYISGILLSGLVGYACLAQLKSLEPKVDLK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EPQGQGHVYEYPTQAFIFLLACLGLMGFPITPSFLGIDLIFTHIHTDQIVFAFILALSFI
CCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHH
IVGLSLVRIYSRVYLGPHVKTYHAVPFKNS
HHHHHHHHHHHHHHCCCCCEEEECCCCCCC
>Mature Secondary Structure 
TMPLLTSLLGLFIIIPLIGFGLTMLVPKKNEDAISWIAYSTVGSHMVLAWIFLVLWLFS
CHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GYPTLETIELILYNTESYKFFISFYFDKITAVYLFVGSFLCFLVTVYSRWYLHRERGYKR
CCCCHHHEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFNTILFFFIGYNIIIFSGNFETLFIGWEVLGITSFLLIGFYRERYLPVKNALKVFTVFR
HHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VADMGLILVIWMSHHLWHENITFSKLMHPELVAQTLEGNTTLGILIGLMLLLAAAVKSGQ
HHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
LPFSSWVPRAMEGPTPSSAIFYGSLSVHLGVFLLLRTFPFWENQIVVVAPVILLGVGTAV
CCHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
VATLISRVQSSIKTQIAYSSVAQIGIIFVEVALGFYDLALIHLAGNAFLRTYQLLVSPSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VTFLLRDQFYNFVPREYIDKHSTSKQIEYAAYMLSVKEFNLDSFMYFFFWDPVKWIGRKL
HHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHCCEE
NLVLSGTGGFIIATTLFLVGLACLYYEQSLPVGVQQFLPTLFAFIALIVVLKSFSERMSP
EEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
QLSWYFVIMNHLWVALAISFYDEVTTREIVIYISGILLSGLVGYACLAQLKSLEPKVDLK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EPQGQGHVYEYPTQAFIFLLACLGLMGFPITPSFLGIDLIFTHIHTDQIVFAFILALSFI
CCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHH
IVGLSLVRIYSRVYLGPHVKTYHAVPFKNS
HHHHHHHHHHHHHHCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]