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The map label for this gene is prrB [H]

Identifier: 82701840

GI number: 82701840

Start: 813223

End: 814491

Strand: Direct

Name: prrB [H]

Synonym: Nmul_A0707

Alternate gene names: 82701840

Gene position: 813223-814491 (Clockwise)

Preceding gene: 82701839

Following gene: 82701841

Centisome position: 25.54

GC content: 54.77

Gene sequence:

>1269_bases
GTGCCCGTAATTAGGCGTGGGCTTCGCCTTCGTGTTGCACTTGCGTTTGCGATATTCTGTATTGTTGTTGTCGGAACGCT
GGGTGTCAGTCTGTATATCGCTTCCGATGACATCGAAGAAGCTCATATCGAGCAGATCATCGAAACCGAGATGGATTATC
TGCTCCAGCGCTATCGCGAGCATGTGGACTTCGTGCCGCAGGAAGGTTCCAATCTCGAAAAATACATCATCCACGATCCC
TCCGAAGAATCTCGCCTTCCTTCCTATCTGCAGGGACTGAGTTATAGGCGGCACAAGGTTTTTCGCGGACCGGAGGAAGT
GCGGGTCGCGGTCCATCACGTGGACGGGGTCAAGTTTCTTGTCGCCTATGAAATAGGCCTGCACGAAGCGCGGCAACGGG
AATTGAAACTGCTCATCGTCCTGTCGCTCATTTCCGTCGTGGGTGTCGCTGTCGTGGTGGGATATCTGCTGGCCGGAGTG
CTGGTCAAGCAGGTGACTGATCTCGCCGAGCAGGTGAGGCATCTCGCGCCGGGTGACATTCAGGGGGAAACGCTTACCCA
GCCTGGGCAGGATGAGGAGGTGGCGCAGCTCGCTCGCGCGCTGGATGACTATCAAAGCCGTATAACCCGCATGCTGCGCA
GGGAACAGGAGTTTACCGCCAATATAAGCCACGAGCTGCGCACTCCGATTACAACTATCCTGACAAGCTGTGAACTGCTG
GTCGCGGAACCGAATCTGTCGGAAAGAGCGCGCATGCGCATCGGCATGATCGAAAGTGCCGCAACCCGCATGGGCGAGCA
GTTGCAAGCCCTGTTATTTCTTGCGCGCGAGCAGTCGCTCGGGGTAATGGAACCCGTGGATCTGGCCGAGTGTGTCTACG
ATGCGGCAGAATCGATATGCGGGGAGATCTATCGAAAGCATCTTACATTCGAAGTCACGGTGGAACCGAAAGCCATGCTG
ACGCTGAATCGGCAAGCGATTCACACGGCTCTTGTGAATCTGCTGCGCAATGCGGTGCAATATACCAATAGCGGTTTCAT
ACGGGTAAATTTCAAAGGCAATCGTCTTTCCATTTCCGATTCCGGTATAGGTATTGAGCCTTCCTATCTGCCCCTCCTGT
ATGAACGCTTCTTCCGCGGTTCCACCCAGGGTGAAGGTCTGGGCATAGGGCTTGCCATCGTAAAGCGCATCTGCGACTAC
TATGGATGGAGCATAGAAGTCGAAAGCATGCCCGGACAAGGCGCGACCTTCCATATTGTGTTTCCCTGA

Upstream 100 bases:

>100_bases
CTCCGCAGTCACATGCACGAGCTTCGCCGCGCACTGACGCGCGCTGGGGGCTATGATCCAATCGAAACCGTTCACGGTCT
CGGCTATCGGCTTTCCACGC

Downstream 100 bases:

>100_bases
CCCTCGTTTTTCCTGGAGAAAGTCATTTCCCTGCAGGTTTCCCTGACTGCGCCGACATAGCGGAAGCTCTACAGTTGCCG
CTATTCGATCTTCTGCAAAA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MPVIRRGLRLRVALAFAIFCIVVVGTLGVSLYIASDDIEEAHIEQIIETEMDYLLQRYREHVDFVPQEGSNLEKYIIHDP
SEESRLPSYLQGLSYRRHKVFRGPEEVRVAVHHVDGVKFLVAYEIGLHEARQRELKLLIVLSLISVVGVAVVVGYLLAGV
LVKQVTDLAEQVRHLAPGDIQGETLTQPGQDEEVAQLARALDDYQSRITRMLRREQEFTANISHELRTPITTILTSCELL
VAEPNLSERARMRIGMIESAATRMGEQLQALLFLAREQSLGVMEPVDLAECVYDAAESICGEIYRKHLTFEVTVEPKAML
TLNRQAIHTALVNLLRNAVQYTNSGFIRVNFKGNRLSISDSGIGIEPSYLPLLYERFFRGSTQGEGLGIGLAIVKRICDY
YGWSIEVESMPGQGATFHIVFP

Sequences:

>Translated_422_residues
MPVIRRGLRLRVALAFAIFCIVVVGTLGVSLYIASDDIEEAHIEQIIETEMDYLLQRYREHVDFVPQEGSNLEKYIIHDP
SEESRLPSYLQGLSYRRHKVFRGPEEVRVAVHHVDGVKFLVAYEIGLHEARQRELKLLIVLSLISVVGVAVVVGYLLAGV
LVKQVTDLAEQVRHLAPGDIQGETLTQPGQDEEVAQLARALDDYQSRITRMLRREQEFTANISHELRTPITTILTSCELL
VAEPNLSERARMRIGMIESAATRMGEQLQALLFLAREQSLGVMEPVDLAECVYDAAESICGEIYRKHLTFEVTVEPKAML
TLNRQAIHTALVNLLRNAVQYTNSGFIRVNFKGNRLSISDSGIGIEPSYLPLLYERFFRGSTQGEGLGIGLAIVKRICDY
YGWSIEVESMPGQGATFHIVFP
>Mature_421_residues
PVIRRGLRLRVALAFAIFCIVVVGTLGVSLYIASDDIEEAHIEQIIETEMDYLLQRYREHVDFVPQEGSNLEKYIIHDPS
EESRLPSYLQGLSYRRHKVFRGPEEVRVAVHHVDGVKFLVAYEIGLHEARQRELKLLIVLSLISVVGVAVVVGYLLAGVL
VKQVTDLAEQVRHLAPGDIQGETLTQPGQDEEVAQLARALDDYQSRITRMLRREQEFTANISHELRTPITTILTSCELLV
AEPNLSERARMRIGMIESAATRMGEQLQALLFLAREQSLGVMEPVDLAECVYDAAESICGEIYRKHLTFEVTVEPKAMLT
LNRQAIHTALVNLLRNAVQYTNSGFIRVNFKGNRLSISDSGIGIEPSYLPLLYERFFRGSTQGEGLGIGLAIVKRICDYY
GWSIEVESMPGQGATFHIVFP

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium. Probably phosphorylates prrA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=331, Percent_Identity=27.7945619335347, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=30.1369863013699, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789403, Length=273, Percent_Identity=29.3040293040293, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=28.8135593220339, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI145693157, Length=217, Percent_Identity=29.0322580645161, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=26.1029411764706, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=25.7777777777778, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=222, Percent_Identity=27.4774774774775, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=27.9279279279279, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789808, Length=370, Percent_Identity=24.0540540540541, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788713, Length=247, Percent_Identity=26.7206477732794, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=25.4480286738351, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790551, Length=248, Percent_Identity=29.4354838709677, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788549, Length=216, Percent_Identity=27.3148148148148, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788279, Length=319, Percent_Identity=25.705329153605, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=235, Percent_Identity=25.1063829787234, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47405; Mature: 47274

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVIRRGLRLRVALAFAIFCIVVVGTLGVSLYIASDDIEEAHIEQIIETEMDYLLQRYRE
CCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
HVDFVPQEGSNLEKYIIHDPSEESRLPSYLQGLSYRRHKVFRGPEEVRVAVHHVDGVKFL
HCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHEEHHHHCCCEEEE
VAYEIGLHEARQRELKLLIVLSLISVVGVAVVVGYLLAGVLVKQVTDLAEQVRHLAPGDI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QGETLTQPGQDEEVAQLARALDDYQSRITRMLRREQEFTANISHELRTPITTILTSCELL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHE
VAEPNLSERARMRIGMIESAATRMGEQLQALLFLAREQSLGVMEPVDLAECVYDAAESIC
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GEIYRKHLTFEVTVEPKAMLTLNRQAIHTALVNLLRNAVQYTNSGFIRVNFKGNRLSISD
HHHHHHHCEEEEEECCHHHEEECHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEECC
SGIGIEPSYLPLLYERFFRGSTQGEGLGIGLAIVKRICDYYGWSIEVESMPGQGATFHIV
CCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEE
FP
CC
>Mature Secondary Structure 
PVIRRGLRLRVALAFAIFCIVVVGTLGVSLYIASDDIEEAHIEQIIETEMDYLLQRYRE
CCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
HVDFVPQEGSNLEKYIIHDPSEESRLPSYLQGLSYRRHKVFRGPEEVRVAVHHVDGVKFL
HCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHEEHHHHCCCEEEE
VAYEIGLHEARQRELKLLIVLSLISVVGVAVVVGYLLAGVLVKQVTDLAEQVRHLAPGDI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QGETLTQPGQDEEVAQLARALDDYQSRITRMLRREQEFTANISHELRTPITTILTSCELL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHE
VAEPNLSERARMRIGMIESAATRMGEQLQALLFLAREQSLGVMEPVDLAECVYDAAESIC
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GEIYRKHLTFEVTVEPKAMLTLNRQAIHTALVNLLRNAVQYTNSGFIRVNFKGNRLSISD
HHHHHHHCEEEEEECCHHHEEECHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEECC
SGIGIEPSYLPLLYERFFRGSTQGEGLGIGLAIVKRICDYYGWSIEVESMPGQGATFHIV
CCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEE
FP
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]