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The map label for this gene is gltT [H]

Identifier: 82701766

GI number: 82701766

Start: 720720

End: 721988

Strand: Direct

Name: gltT [H]

Synonym: Nmul_A0633

Alternate gene names: 82701766

Gene position: 720720-721988 (Clockwise)

Preceding gene: 82701763

Following gene: 82701767

Centisome position: 22.63

GC content: 56.26

Gene sequence:

>1269_bases
ATGAAAAAAATCTCGCTCAATACGCAAATATTATGGGGTGTATTCGCCGGCCTCTTCCTGGGCCTGGGTTTATCCCTGCT
CGATGAAGAATCGGTGATTTTCCGAGCCGGATTATATGGCGCCGAGCTGCTTGGCACGCTGTTTATCGACCTGTTGAAAA
TGGTGCTCATTCCGCTCGTGTTCACATCGATCGCAGTAGGCGTGGCCAACTTGCGGGCGCACCAGCAGATGCATAAGGTA
TGGAAAGCAACGCTTGGTTTCTTCCTGTTTTCGATGGCGCTGGCTATTCTGCTGGGTTTGACCGCAGCCAACATTGTCCG
TCCCGGAGAAGGGCTGCAGCTCGCCATGTTCCAGGATGACATGCAGAACTTCCAGGCCGGGCAGATGCCTTTAACGGAGT
TTGTTGCGCAACTGCTTCATTCGCTGTTTCAGAACCCCATGACCGCCCTGGCTCAGGGGAATGTGCTCGCAGTGGTCGTT
TTCGCGCTCCTGCTGGGCATTGCAATGGTGGTGGGCGGGGAGCGCTACGCCAACATCCTCATACTGCTGCAGGAGCTGCT
GGAGCTGATGCTGATGCTGGTTGGCTGGATCATGCGCCTTGCTCCGCTCGGCATCATGGGACTGCTGGTAAAACTCGCTG
CCACACAGGACGTGACTTTGCTTGCCACATTGGTCGAGTTCATCGCGGTGGTGATTGGAGCCACTCTGCTGCACGGGATG
GTAGTGCTCCCGCTGATTCTTTATTTGGTCACGGGAATGACGCCGTTCAAATTCTGGCGCGGCGCCCGCGAAGCACTGCT
AACAGCTTTTGCGACCAGCTCCAGCTCAGCCACCTTACCCGTCACTTTACGCTGCGTGGAACAGCACCTGCACGTCAAAC
GCGACATTGCCGGATTTGTCATCCCGTTGGGTGCAACACTGAACATGGATGGCACTGCTTTGTACGAAGCCGTGGCAGCA
TTGTTCGTGGCCAACCTCATCGGGATAGAACTTAATCTCGCACAGCAGATGATCGTGTTTTTGACTGCGATGCTGGCTGC
CATGGGTGCTCCGGGCATACCCAGCGCGGGAATGGTCACCATGGTAGTCGTGCTGCAATCGGTCGGCTTGCCGGCGGAGG
CTATCGCCATTCTGCTGCCGGTCGACCGCTTACTGGATACATTCCGCACCGCTGTGAATGTCGAGGGGGACATGGTGGGC
AGCCTCGTCGTGCAGAAATGGGTGAGGAAGGAGTCCATACGAGGTTCCAGAAGCGATTCCGAAGGGTAA

Upstream 100 bases:

>100_bases
CCCGCTTCCAGTCCCAGATCAGGTTCGACATTGTCGGGAGAAGATTCTGAGAATGTCTGTACGAGTTCGCACATATCAGC
GCAAATCGTAAAAAACATTA

Downstream 100 bases:

>100_bases
GAGGTATTAAGAGGTCCGAAGAGGGGGCTGGTTTCCCGGCTACTTCTCGGAGGACAGATTGGACTACGGTGACAGCCAGA
CGCGCCGATATCAGCTCAAT

Product: Sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKKISLNTQILWGVFAGLFLGLGLSLLDEESVIFRAGLYGAELLGTLFIDLLKMVLIPLVFTSIAVGVANLRAHQQMHKV
WKATLGFFLFSMALAILLGLTAANIVRPGEGLQLAMFQDDMQNFQAGQMPLTEFVAQLLHSLFQNPMTALAQGNVLAVVV
FALLLGIAMVVGGERYANILILLQELLELMLMLVGWIMRLAPLGIMGLLVKLAATQDVTLLATLVEFIAVVIGATLLHGM
VVLPLILYLVTGMTPFKFWRGAREALLTAFATSSSSATLPVTLRCVEQHLHVKRDIAGFVIPLGATLNMDGTALYEAVAA
LFVANLIGIELNLAQQMIVFLTAMLAAMGAPGIPSAGMVTMVVVLQSVGLPAEAIAILLPVDRLLDTFRTAVNVEGDMVG
SLVVQKWVRKESIRGSRSDSEG

Sequences:

>Translated_422_residues
MKKISLNTQILWGVFAGLFLGLGLSLLDEESVIFRAGLYGAELLGTLFIDLLKMVLIPLVFTSIAVGVANLRAHQQMHKV
WKATLGFFLFSMALAILLGLTAANIVRPGEGLQLAMFQDDMQNFQAGQMPLTEFVAQLLHSLFQNPMTALAQGNVLAVVV
FALLLGIAMVVGGERYANILILLQELLELMLMLVGWIMRLAPLGIMGLLVKLAATQDVTLLATLVEFIAVVIGATLLHGM
VVLPLILYLVTGMTPFKFWRGAREALLTAFATSSSSATLPVTLRCVEQHLHVKRDIAGFVIPLGATLNMDGTALYEAVAA
LFVANLIGIELNLAQQMIVFLTAMLAAMGAPGIPSAGMVTMVVVLQSVGLPAEAIAILLPVDRLLDTFRTAVNVEGDMVG
SLVVQKWVRKESIRGSRSDSEG
>Mature_422_residues
MKKISLNTQILWGVFAGLFLGLGLSLLDEESVIFRAGLYGAELLGTLFIDLLKMVLIPLVFTSIAVGVANLRAHQQMHKV
WKATLGFFLFSMALAILLGLTAANIVRPGEGLQLAMFQDDMQNFQAGQMPLTEFVAQLLHSLFQNPMTALAQGNVLAVVV
FALLLGIAMVVGGERYANILILLQELLELMLMLVGWIMRLAPLGIMGLLVKLAATQDVTLLATLVEFIAVVIGATLLHGM
VVLPLILYLVTGMTPFKFWRGAREALLTAFATSSSSATLPVTLRCVEQHLHVKRDIAGFVIPLGATLNMDGTALYEAVAA
LFVANLIGIELNLAQQMIVFLTAMLAAMGAPGIPSAGMVTMVVVLQSVGLPAEAIAILLPVDRLLDTFRTAVNVEGDMVG
SLVVQKWVRKESIRGSRSDSEG

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI66773030, Length=259, Percent_Identity=45.1737451737452, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI4827012, Length=271, Percent_Identity=46.1254612546125, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI21314632, Length=415, Percent_Identity=32.289156626506, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI194239697, Length=302, Percent_Identity=40.0662251655629, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI169790839, Length=260, Percent_Identity=43.0769230769231, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI223468564, Length=268, Percent_Identity=39.5522388059701, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI223468566, Length=268, Percent_Identity=39.5522388059701, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI5032093, Length=268, Percent_Identity=39.5522388059701, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI40254478, Length=260, Percent_Identity=45, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI262359914, Length=184, Percent_Identity=41.304347826087, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI301601644, Length=166, Percent_Identity=35.5421686746988, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1790514, Length=418, Percent_Identity=30.1435406698565, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI1789947, Length=370, Percent_Identity=30, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1788024, Length=431, Percent_Identity=29.9303944315545, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789473, Length=375, Percent_Identity=29.0666666666667, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71996953, Length=449, Percent_Identity=32.0712694877506, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71983106, Length=410, Percent_Identity=33.4146341463415, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI71983099, Length=410, Percent_Identity=33.4146341463415, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI193206505, Length=444, Percent_Identity=31.3063063063063, Blast_Score=200, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17537407, Length=395, Percent_Identity=34.4303797468354, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17541374, Length=427, Percent_Identity=33.4894613583138, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI193206654, Length=403, Percent_Identity=28.7841191066998, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24583025, Length=412, Percent_Identity=30.8252427184466, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI17137668, Length=412, Percent_Identity=30.8252427184466, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI24583023, Length=412, Percent_Identity=30.8252427184466, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI281360481, Length=460, Percent_Identity=30, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281360483, Length=460, Percent_Identity=30, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17137666, Length=460, Percent_Identity=30, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45335; Mature: 45335

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKISLNTQILWGVFAGLFLGLGLSLLDEESVIFRAGLYGAELLGTLFIDLLKMVLIPLV
CCCCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
FTSIAVGVANLRAHQQMHKVWKATLGFFLFSMALAILLGLTAANIVRPGEGLQLAMFQDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHH
MQNFQAGQMPLTEFVAQLLHSLFQNPMTALAQGNVLAVVVFALLLGIAMVVGGERYANIL
HHHCCCCCCCHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
ILLQELLELMLMLVGWIMRLAPLGIMGLLVKLAATQDVTLLATLVEFIAVVIGATLLHGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VVLPLILYLVTGMTPFKFWRGAREALLTAFATSSSSATLPVTLRCVEQHLHVKRDIAGFV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHE
IPLGATLNMDGTALYEAVAALFVANLIGIELNLAQQMIVFLTAMLAAMGAPGIPSAGMVT
EECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
MVVVLQSVGLPAEAIAILLPVDRLLDTFRTAVNVEGDMVGSLVVQKWVRKESIRGSRSDS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCC
EG
CC
>Mature Secondary Structure
MKKISLNTQILWGVFAGLFLGLGLSLLDEESVIFRAGLYGAELLGTLFIDLLKMVLIPLV
CCCCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
FTSIAVGVANLRAHQQMHKVWKATLGFFLFSMALAILLGLTAANIVRPGEGLQLAMFQDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHH
MQNFQAGQMPLTEFVAQLLHSLFQNPMTALAQGNVLAVVVFALLLGIAMVVGGERYANIL
HHHCCCCCCCHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
ILLQELLELMLMLVGWIMRLAPLGIMGLLVKLAATQDVTLLATLVEFIAVVIGATLLHGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VVLPLILYLVTGMTPFKFWRGAREALLTAFATSSSSATLPVTLRCVEQHLHVKRDIAGFV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHE
IPLGATLNMDGTALYEAVAALFVANLIGIELNLAQQMIVFLTAMLAAMGAPGIPSAGMVT
EECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
MVVVLQSVGLPAEAIAILLPVDRLLDTFRTAVNVEGDMVGSLVVQKWVRKESIRGSRSDS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCC
EG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]