Click here to switch to the map view.

The map label for this gene is lysA [H]

Identifier: 82701675

GI number: 82701675

Start: 623868

End: 625124

Strand: Reverse

Name: lysA [H]

Synonym: Nmul_A0541

Alternate gene names: 82701675

Gene position: 625124-623868 (Counterclockwise)

Preceding gene: 82701676

Following gene: 82701667

Centisome position: 19.63

GC content: 58.15

Gene sequence:

>1257_bases
GTGAGCGGTTTTCCTTCCTTCAGTTACCGCAATGGGCATTTGTGGGCAGAGTCGGTGCAACTGGAGCGCATCGCGCTTGA
ATTCGGCACGCCCTGCTATGCCTATTCGCGCGCGGCGCTGACTACAGCCTACTGTGAATTCGACGATGCCTTCGCAGGAC
GCGATCATCTGGTCTGTTACGCCGTCAAGGCGAATTCCAACCTTGGCATTCTCAATCTGCTCGCCCGCCTGGGTAGCGGC
TTCGACATCGTCTCCGGGGGAGAACTTCAGCGGGTATTGAAGGCGGGGGGCGATCCACAGAAAATCGTTTTTTCGGGTGT
GGGCAAGCAGCCTGCGGAAATGAAAGCGGCGCTCGAAGCGGGCATACTGTGCTTCAACGTGGAATCGGAAGCGGAGTTGC
ATGGGCTGAACCGCGTGGCCGGAGAAATGGGCAAGGTTGCGCCGGTGAGCCTGCGGGTGAACCCGGATGTGGATGCGAAA
ACGCACCCATATATTTCCACCGGACTCAAGGAAAACAAGTTCGGCATTCCTTTCGATGAGGCGGAGGCGCTTTATGCTTC
TGCGCAGGCGCTTGGCAATGTACGGGTGGCCGGTCTCGATTGCCATATCGGCTCGCAATTGACCGAACTGGCGCCTTTCA
TCGAAACCTGCAAGAAGATGCTGGGGCTGCTCGACCGGCTGGAGGCGCAAGGGTTGGAGATCGAGCACCTCGATCTGGGC
GGCGGCCTGGGGATACGTTATGCCGGGGAAAATCCCCCCTCGGCACGGGAATATGTCGAGGCGTTACGCAGCGTGGTGGG
CAACCGCAGGCAGAAAATCCTGATCGAACCGGGAAGATCGCTGGTGGGCAATGCGGGTGTACTGCTTACAACCGTCGAGT
ATCTCAAGCCTACGCCGCATCGCGATTTCGCCATTGTCGATGCAGCCATGAACGACCTGATGCGCCCGGCCTTATATAAG
GCTTACCATGAAATCCTTCCGGTGGTTGCGCGCAACGAAATGGATGCAAAAACCTATCAGGTTGTCGGTCCGGTATGCGA
AACCGGCGATTTTCTTGGGCATGACCGCCACCTGGCGCTGGCGCAGGGTGATCTGCTCGCTGTCATGTCGGCCGGCGCTT
ATGGCATGAGCATGAGCTCTAATTACAATGCGCGTCCACGCGCCGCCGAGGTGATGATCGATGGCGACCGCATTCATCTC
ATTCGCGAGCGGGAATCGGTCGAGCAATTGATGGCAGGCGAGAAAATCCTCCCATAG

Upstream 100 bases:

>100_bases
CCCTGCTGCTCAACGCATGCGGCCTCAAGGGGCCCCTCTACCTTCCGCAGGAGCCGGCTCCGGCGCAGCCACAAAAAATT
CCCGATACAGAGAAAAAGAA

Downstream 100 bases:

>100_bases
CCTCGTATGAGGTTATAGCAGGGGCTATAGCAGAAAAAGGGTTGCGAGTCCCAGGAAGATAAAAAAACCTCCGCTGTCGG
TCACCGCGGTTATCATCACG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSGFPSFSYRNGHLWAESVQLERIALEFGTPCYAYSRAALTTAYCEFDDAFAGRDHLVCYAVKANSNLGILNLLARLGSG
FDIVSGGELQRVLKAGGDPQKIVFSGVGKQPAEMKAALEAGILCFNVESEAELHGLNRVAGEMGKVAPVSLRVNPDVDAK
THPYISTGLKENKFGIPFDEAEALYASAQALGNVRVAGLDCHIGSQLTELAPFIETCKKMLGLLDRLEAQGLEIEHLDLG
GGLGIRYAGENPPSAREYVEALRSVVGNRRQKILIEPGRSLVGNAGVLLTTVEYLKPTPHRDFAIVDAAMNDLMRPALYK
AYHEILPVVARNEMDAKTYQVVGPVCETGDFLGHDRHLALAQGDLLAVMSAGAYGMSMSSNYNARPRAAEVMIDGDRIHL
IRERESVEQLMAGEKILP

Sequences:

>Translated_418_residues
MSGFPSFSYRNGHLWAESVQLERIALEFGTPCYAYSRAALTTAYCEFDDAFAGRDHLVCYAVKANSNLGILNLLARLGSG
FDIVSGGELQRVLKAGGDPQKIVFSGVGKQPAEMKAALEAGILCFNVESEAELHGLNRVAGEMGKVAPVSLRVNPDVDAK
THPYISTGLKENKFGIPFDEAEALYASAQALGNVRVAGLDCHIGSQLTELAPFIETCKKMLGLLDRLEAQGLEIEHLDLG
GGLGIRYAGENPPSAREYVEALRSVVGNRRQKILIEPGRSLVGNAGVLLTTVEYLKPTPHRDFAIVDAAMNDLMRPALYK
AYHEILPVVARNEMDAKTYQVVGPVCETGDFLGHDRHLALAQGDLLAVMSAGAYGMSMSSNYNARPRAAEVMIDGDRIHL
IRERESVEQLMAGEKILP
>Mature_417_residues
SGFPSFSYRNGHLWAESVQLERIALEFGTPCYAYSRAALTTAYCEFDDAFAGRDHLVCYAVKANSNLGILNLLARLGSGF
DIVSGGELQRVLKAGGDPQKIVFSGVGKQPAEMKAALEAGILCFNVESEAELHGLNRVAGEMGKVAPVSLRVNPDVDAKT
HPYISTGLKENKFGIPFDEAEALYASAQALGNVRVAGLDCHIGSQLTELAPFIETCKKMLGLLDRLEAQGLEIEHLDLGG
GLGIRYAGENPPSAREYVEALRSVVGNRRQKILIEPGRSLVGNAGVLLTTVEYLKPTPHRDFAIVDAAMNDLMRPALYKA
YHEILPVVARNEMDAKTYQVVGPVCETGDFLGHDRHLALAQGDLLAVMSAGAYGMSMSSNYNARPRAAEVMIDGDRIHLI
RERESVEQLMAGEKILP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=361, Percent_Identity=26.5927977839335, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1789203, Length=418, Percent_Identity=33.2535885167464, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17562780, Length=353, Percent_Identity=22.3796033994334, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322664, Length=366, Percent_Identity=24.0437158469945, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24586472, Length=340, Percent_Identity=27.0588235294118, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24586474, Length=337, Percent_Identity=25.5192878338279, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45275; Mature: 45144

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGFPSFSYRNGHLWAESVQLERIALEFGTPCYAYSRAALTTAYCEFDDAFAGRDHLVCY
CCCCCCCCCCCCCEEHHHHHHEEEHHHHCCCHHHHHHHHHHHEEECCCCCCCCCCCEEEE
AVKANSNLGILNLLARLGSGFDIVSGGELQRVLKAGGDPQKIVFSGVGKQPAEMKAALEA
EEECCCCCHHHHHHHHHCCCCEECCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
GILCFNVESEAELHGLNRVAGEMGKVAPVSLRVNPDVDAKTHPYISTGLKENKFGIPFDE
CEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHCCCCCCCCCCCCCH
AEALYASAQALGNVRVAGLDCHIGSQLTELAPFIETCKKMLGLLDRLEAQGLEIEHLDLG
HHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GGLGIRYAGENPPSAREYVEALRSVVGNRRQKILIEPGRSLVGNAGVLLTTVEYLKPTPH
CCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCCEEEEHHHHCCCCC
RDFAIVDAAMNDLMRPALYKAYHEILPVVARNEMDAKTYQVVGPVCETGDFLGHDRHLAL
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCHHHCCCCCCCCCEEEE
AQGDLLAVMSAGAYGMSMSSNYNARPRAAEVMIDGDRIHLIRERESVEQLMAGEKILP
ECCCEEEEEECCCCCEEECCCCCCCCCEEEEEECCCEEEEEECHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SGFPSFSYRNGHLWAESVQLERIALEFGTPCYAYSRAALTTAYCEFDDAFAGRDHLVCY
CCCCCCCCCCCCEEHHHHHHEEEHHHHCCCHHHHHHHHHHHEEECCCCCCCCCCCEEEE
AVKANSNLGILNLLARLGSGFDIVSGGELQRVLKAGGDPQKIVFSGVGKQPAEMKAALEA
EEECCCCCHHHHHHHHHCCCCEECCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
GILCFNVESEAELHGLNRVAGEMGKVAPVSLRVNPDVDAKTHPYISTGLKENKFGIPFDE
CEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHCCCCCCCCCCCCCH
AEALYASAQALGNVRVAGLDCHIGSQLTELAPFIETCKKMLGLLDRLEAQGLEIEHLDLG
HHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GGLGIRYAGENPPSAREYVEALRSVVGNRRQKILIEPGRSLVGNAGVLLTTVEYLKPTPH
CCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCCEEEEHHHHCCCCC
RDFAIVDAAMNDLMRPALYKAYHEILPVVARNEMDAKTYQVVGPVCETGDFLGHDRHLAL
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCHHHCCCCCCCCCEEEE
AQGDLLAVMSAGAYGMSMSSNYNARPRAAEVMIDGDRIHLIRERESVEQLMAGEKILP
ECCCEEEEEECCCCCEEECCCCCCCCCEEEEEECCCEEEEEECHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]