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The map label for this gene is zwf2 [H]

Identifier: 82701600

GI number: 82701600

Start: 518270

End: 519664

Strand: Reverse

Name: zwf2 [H]

Synonym: Nmul_A0466

Alternate gene names: 82701600

Gene position: 519664-518270 (Counterclockwise)

Preceding gene: 82701601

Following gene: 82701599

Centisome position: 16.32

GC content: 55.56

Gene sequence:

>1395_bases
ATGCGAAAAACCAATGACTACACCAAGCCATCCGATGCACTGGTGCTGTTTGGGATAACGGGTGACCTCGCTTATAAAAA
GATCTTTCCGGCGCTGTACGCGATGATCAAAAAGGGCATGCTCGATGTGCCGCTGGTCGGTGTCGCCTCGACACCCTGGA
GTCTCGATCAACTCAAGGAACGGGCGACCCAGTCCATCAGCGACTCCGGAAAGATTGATGACAAACGGGCGCTGGATCAC
CTCCTTTCCCTGCTGCGATATGTGCGTGGAGACTACAACAACCTCGATACGTTCAAGGCACTCAAACAGGCTCTGGGAGA
TGCACGTCATCCCGTGCACTATCTCGCCATCCCCCCTCTTCTTTTCGAGAATGTCATAAGAGGTCTTGGTGCGCTCGATC
TGGCCGCAGGCGCGCGCGTCATTGTGGAAAAACCTTTTGGACGGGATCTTGAGTCAGCACGTGAACTGAACCGTATTGCA
CGCTCCGTGTTCCCCGAGGAAGCGATATTCCGTATCGACCATTTTCTCGGAAAAGAGGCGATCATGAATATTCTTTATTT
CAGATTCGCCAATTCATTTCTGGAACCGATATGGAATCGTAATTATGTAGCCAGCGTGCAGATCACATTGGCTGAGGAAT
TCGGGGTTGAAGAACGAGGCGCATTTTACGAATCCGCCGGCTGCCTGCGCGACGTGATCCAGAATCATCTTTTCCAGATT
GTTGCGCTGCTGGCCATGGAACCTCCCGCTTATCGCGGTCTCGGAACGGTCCAAAGCGAAAAAATCAACATATTTCACGC
CATGCGCCCCCTTGTACCCGAGGACCTGGTGCGGGGACAATATGTGGGCTACCGTCAGGAACCGGGTGTGGCGGAGGACT
CCGATGTCGAGACATTCTGCGCCCTGCGGCTTTTCATCGACTCCTGGCGCTGGGAAGGGGTCCCCTGGTATCTGCGTTCC
GGCAAGTGTCTGGCCAAGACTGCTGCGGAGGTCCTTGTCCAGCTGAAGCCGCCGCCGCAAAAGCTTTTTGCCGATTCGGC
AAGCGCCGCATGTGATGCCAATTATCTCAGGTTCCGCCTTTCTCCCGTCTCAGCGGTTGCCATTGCAGCGAGAGTCAAGC
ATCCCGGAAAAGAGTTCAAAGGCGATCAGCAGGAGTTGTGCCTGGTCGAGGAGCACTTCGGGCGCGAATCGCCTTATGAA
CGTCTCCTGCATGATGCAATGATTGGTGACGACACCCTGTTTACCAAGAGGGAAGCGGTGGAGGCATCCTGGACAGCACT
CGATCCTGTGCTCAAGACATATCCTCACGTTCTGCCCTACGAGCGCGGCAGTTGGGGCCCCGCCGCAGCCGACGCGCTGA
TCGAGGCGGATGGCTGCTGGCACAATCCGGGATAG

Upstream 100 bases:

>100_bases
GCAAGTTAGAGTTTTTATACCGGCATTCCCGCTGTAGCCGGTCAATCGACAGCTCCTGAACAGGTTTCGTCTTTTACTGC
AGGAAGGGAGGAGTGACGAA

Downstream 100 bases:

>100_bases
GCGTCCCTAGCCTGTCAATACTTGTTTCGACGGTGTGAAACGAGTATTGACGGGCCCTGTTGATCCGACCATAAAATCCC
ATGAATTTCGTATTTCAGGC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MRKTNDYTKPSDALVLFGITGDLAYKKIFPALYAMIKKGMLDVPLVGVASTPWSLDQLKERATQSISDSGKIDDKRALDH
LLSLLRYVRGDYNNLDTFKALKQALGDARHPVHYLAIPPLLFENVIRGLGALDLAAGARVIVEKPFGRDLESARELNRIA
RSVFPEEAIFRIDHFLGKEAIMNILYFRFANSFLEPIWNRNYVASVQITLAEEFGVEERGAFYESAGCLRDVIQNHLFQI
VALLAMEPPAYRGLGTVQSEKINIFHAMRPLVPEDLVRGQYVGYRQEPGVAEDSDVETFCALRLFIDSWRWEGVPWYLRS
GKCLAKTAAEVLVQLKPPPQKLFADSASAACDANYLRFRLSPVSAVAIAARVKHPGKEFKGDQQELCLVEEHFGRESPYE
RLLHDAMIGDDTLFTKREAVEASWTALDPVLKTYPHVLPYERGSWGPAAADALIEADGCWHNPG

Sequences:

>Translated_464_residues
MRKTNDYTKPSDALVLFGITGDLAYKKIFPALYAMIKKGMLDVPLVGVASTPWSLDQLKERATQSISDSGKIDDKRALDH
LLSLLRYVRGDYNNLDTFKALKQALGDARHPVHYLAIPPLLFENVIRGLGALDLAAGARVIVEKPFGRDLESARELNRIA
RSVFPEEAIFRIDHFLGKEAIMNILYFRFANSFLEPIWNRNYVASVQITLAEEFGVEERGAFYESAGCLRDVIQNHLFQI
VALLAMEPPAYRGLGTVQSEKINIFHAMRPLVPEDLVRGQYVGYRQEPGVAEDSDVETFCALRLFIDSWRWEGVPWYLRS
GKCLAKTAAEVLVQLKPPPQKLFADSASAACDANYLRFRLSPVSAVAIAARVKHPGKEFKGDQQELCLVEEHFGRESPYE
RLLHDAMIGDDTLFTKREAVEASWTALDPVLKTYPHVLPYERGSWGPAAADALIEADGCWHNPG
>Mature_464_residues
MRKTNDYTKPSDALVLFGITGDLAYKKIFPALYAMIKKGMLDVPLVGVASTPWSLDQLKERATQSISDSGKIDDKRALDH
LLSLLRYVRGDYNNLDTFKALKQALGDARHPVHYLAIPPLLFENVIRGLGALDLAAGARVIVEKPFGRDLESARELNRIA
RSVFPEEAIFRIDHFLGKEAIMNILYFRFANSFLEPIWNRNYVASVQITLAEEFGVEERGAFYESAGCLRDVIQNHLFQI
VALLAMEPPAYRGLGTVQSEKINIFHAMRPLVPEDLVRGQYVGYRQEPGVAEDSDVETFCALRLFIDSWRWEGVPWYLRS
GKCLAKTAAEVLVQLKPPPQKLFADSASAACDANYLRFRLSPVSAVAIAARVKHPGKEFKGDQQELCLVEEHFGRESPYE
RLLHDAMIGDDTLFTKREAVEASWTALDPVLKTYPHVLPYERGSWGPAAADALIEADGCWHNPG

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=32.7835051546392, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI108773793, Length=485, Percent_Identity=32.7835051546392, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI52145310, Length=477, Percent_Identity=30.188679245283, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1788158, Length=478, Percent_Identity=37.0292887029289, Blast_Score=290, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17538218, Length=481, Percent_Identity=33.8877338877339, Blast_Score=273, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6324088, Length=470, Percent_Identity=35.531914893617, Blast_Score=273, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24643350, Length=475, Percent_Identity=33.4736842105263, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI24643352, Length=475, Percent_Identity=33.4736842105263, Blast_Score=268, Evalue=8e-72,
Organism=Drosophila melanogaster, GI221513548, Length=472, Percent_Identity=28.3898305084746, Blast_Score=179, Evalue=4e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 52024; Mature: 52024

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTNDYTKPSDALVLFGITGDLAYKKIFPALYAMIKKGMLDVPLVGVASTPWSLDQLKE
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHH
RATQSISDSGKIDDKRALDHLLSLLRYVRGDYNNLDTFKALKQALGDARHPVHYLAIPPL
HHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHH
LFENVIRGLGALDLAAGARVIVEKPFGRDLESARELNRIARSVFPEEAIFRIDHFLGKEA
HHHHHHHHCCHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IMNILYFRFANSFLEPIWNRNYVASVQITLAEEFGVEERGAFYESAGCLRDVIQNHLFQI
HHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHCCCCHHCCHHHHHHHHHHHHHHHHHHH
VALLAMEPPAYRGLGTVQSEKINIFHAMRPLVPEDLVRGQYVGYRQEPGVAEDSDVETFC
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHH
ALRLFIDSWRWEGVPWYLRSGKCLAKTAAEVLVQLKPPPQKLFADSASAACDANYLRFRL
HHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHEECCCCHHHHHHCCCCHHCCCCHHEEEE
SPVSAVAIAARVKHPGKEFKGDQQELCLVEEHFGRESPYERLLHDAMIGDDTLFTKREAV
CHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHH
EASWTALDPVLKTYPHVLPYERGSWGPAAADALIEADGCWHNPG
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRKTNDYTKPSDALVLFGITGDLAYKKIFPALYAMIKKGMLDVPLVGVASTPWSLDQLKE
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHH
RATQSISDSGKIDDKRALDHLLSLLRYVRGDYNNLDTFKALKQALGDARHPVHYLAIPPL
HHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHH
LFENVIRGLGALDLAAGARVIVEKPFGRDLESARELNRIARSVFPEEAIFRIDHFLGKEA
HHHHHHHHCCHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IMNILYFRFANSFLEPIWNRNYVASVQITLAEEFGVEERGAFYESAGCLRDVIQNHLFQI
HHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHCCCCHHCCHHHHHHHHHHHHHHHHHHH
VALLAMEPPAYRGLGTVQSEKINIFHAMRPLVPEDLVRGQYVGYRQEPGVAEDSDVETFC
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHH
ALRLFIDSWRWEGVPWYLRSGKCLAKTAAEVLVQLKPPPQKLFADSASAACDANYLRFRL
HHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHEECCCCHHHHHHCCCCHHCCCCHHEEEE
SPVSAVAIAARVKHPGKEFKGDQQELCLVEEHFGRESPYERLLHDAMIGDDTLFTKREAV
CHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHH
EASWTALDPVLKTYPHVLPYERGSWGPAAADALIEADGCWHNPG
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]