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The map label for this gene is cah [H]

Identifier: 82701599

GI number: 82701599

Start: 516887

End: 517753

Strand: Reverse

Name: cah [H]

Synonym: Nmul_A0465

Alternate gene names: 82701599

Gene position: 517753-516887 (Counterclockwise)

Preceding gene: 82701600

Following gene: 82701598

Centisome position: 16.26

GC content: 53.17

Gene sequence:

>867_bases
ATGAATATGTCACTGTTACGCTTATCGCGTCAAACCGCACTCTTTTCAGCCCTTCTGGTGTTTGGAATGTCAACGTCACA
CGCGGAAGTCACTCCATCGGCACAGGCGGCGATGAAGTCGCAAAGCCCCATCGACTTTCGCTCGGATAGCACCTATTTCG
GTCGTCTGCCGGCGCTCAACTTCAACCTGAGTTCCGACACGTCACTTGATGTCATCAACAACGGTTCCCCCGACCCAGAA
AAAACCGCAGTACGAGGTAATGTCAATCCTGGTGCAGGTTCTCTCACGCTTTCCGGCCATGACTGGGAGCTTGCCCAGTT
TCACTTTCATACCCCTTCCGAGCATTTGTTGAATGGCGTGGCATTTCCAATGGAAATGCATCTCGTCTTCAGCGACAGCA
ATAAGGATCTTCTCGTGGTTGGCCGCTGGGTTCAGGCAGGCGCATTCAACAGCGACCTCGATCCGATTTTCTCCCAGATT
CCGCAGAACACTTCCGAGACACTCCATATCGACCACTTCAACCTCAATACACTCATTCCCTCCAACCTGGAATCCTTCCG
CTATTCGGGTTCGCTCACCACACCGCCGTTTTCTGAAGGTGTCAACTGGGTGATGTTATCGCAGCCGCTATTCATGTCCT
CGGAGCAAATCAATGCGTTCAGCTCGCTGTTTCCCGAAGGGGATGCACGCGGAATCCAGGATCTCAACGGACGCATCGTC
CTCACGGATGTGCCTGGATTCGTCACCGCCGTTCCCGAACCTGAAACTTACGCGATGATGCTGGCAGGATTATGCCTCAT
GGCATTTGTTGCCAGGGGTAAAAGCAGGCCGTTAACCAGTGATGTACCCGCCGGTTCTGTTGCATGA

Upstream 100 bases:

>100_bases
AAGTTCACAACTGCTGTGCTAGTTTAAAGTGGCAACAACATCTTATTCATTATTCATAACCCGGCGCGCACCTAATGCGC
GTCATAATTCTGGAGACTTG

Downstream 100 bases:

>100_bases
GGCAGGCTGTATCGTGTTCGGATCCGTGTAACCTTCACTTTTGAAAATCGTGAAGCAACGTGGATGAGTACCTAAGGTAG
GTACTCATCCACTTCAAACA

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MNMSLLRLSRQTALFSALLVFGMSTSHAEVTPSAQAAMKSQSPIDFRSDSTYFGRLPALNFNLSSDTSLDVINNGSPDPE
KTAVRGNVNPGAGSLTLSGHDWELAQFHFHTPSEHLLNGVAFPMEMHLVFSDSNKDLLVVGRWVQAGAFNSDLDPIFSQI
PQNTSETLHIDHFNLNTLIPSNLESFRYSGSLTTPPFSEGVNWVMLSQPLFMSSEQINAFSSLFPEGDARGIQDLNGRIV
LTDVPGFVTAVPEPETYAMMLAGLCLMAFVARGKSRPLTSDVPAGSVA

Sequences:

>Translated_288_residues
MNMSLLRLSRQTALFSALLVFGMSTSHAEVTPSAQAAMKSQSPIDFRSDSTYFGRLPALNFNLSSDTSLDVINNGSPDPE
KTAVRGNVNPGAGSLTLSGHDWELAQFHFHTPSEHLLNGVAFPMEMHLVFSDSNKDLLVVGRWVQAGAFNSDLDPIFSQI
PQNTSETLHIDHFNLNTLIPSNLESFRYSGSLTTPPFSEGVNWVMLSQPLFMSSEQINAFSSLFPEGDARGIQDLNGRIV
LTDVPGFVTAVPEPETYAMMLAGLCLMAFVARGKSRPLTSDVPAGSVA
>Mature_288_residues
MNMSLLRLSRQTALFSALLVFGMSTSHAEVTPSAQAAMKSQSPIDFRSDSTYFGRLPALNFNLSSDTSLDVINNGSPDPE
KTAVRGNVNPGAGSLTLSGHDWELAQFHFHTPSEHLLNGVAFPMEMHLVFSDSNKDLLVVGRWVQAGAFNSDLDPIFSQI
PQNTSETLHIDHFNLNTLIPSNLESFRYSGSLTTPPFSEGVNWVMLSQPLFMSSEQINAFSSLFPEGDARGIQDLNGRIV
LTDVPGFVTAVPEPETYAMMLAGLCLMAFVARGKSRPLTSDVPAGSVA

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI6005723, Length=258, Percent_Identity=30.2325581395349, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI169636420, Length=288, Percent_Identity=29.1666666666667, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI4885101, Length=249, Percent_Identity=30.5220883534137, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4502521, Length=216, Percent_Identity=29.6296296296296, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI38348436, Length=239, Percent_Identity=31.3807531380753, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI62240989, Length=209, Percent_Identity=31.1004784688995, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI258679498, Length=236, Percent_Identity=28.3898305084746, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI192447434, Length=236, Percent_Identity=28.3898305084746, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI192447432, Length=236, Percent_Identity=28.3898305084746, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI192447430, Length=236, Percent_Identity=28.3898305084746, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4502517, Length=236, Percent_Identity=28.3898305084746, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI22027500, Length=148, Percent_Identity=34.4594594594595, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4557395, Length=215, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI194097398, Length=230, Percent_Identity=31.304347826087, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4502515, Length=276, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI45935383, Length=269, Percent_Identity=27.5092936802974, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17569163, Length=235, Percent_Identity=28.0851063829787, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17569165, Length=232, Percent_Identity=27.5862068965517, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71995280, Length=240, Percent_Identity=28.75, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17568715, Length=233, Percent_Identity=28.755364806867, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21358169, Length=248, Percent_Identity=29.8387096774194, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24645604, Length=239, Percent_Identity=27.1966527196653, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17737413, Length=235, Percent_Identity=26.8085106382979, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650523, Length=225, Percent_Identity=30.2222222222222, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 31227; Mature: 31227

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00162 ALPHA_CA_1 ; PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMSLLRLSRQTALFSALLVFGMSTSHAEVTPSAQAAMKSQSPIDFRSDSTYFGRLPALN
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEECCCEEE
FNLSSDTSLDVINNGSPDPEKTAVRGNVNPGAGSLTLSGHDWELAQFHFHTPSEHLLNGV
ECCCCCCCEEEECCCCCCCCCEEEECCCCCCCCEEEECCCCCEEEEEEECCCHHHHHCCC
AFPMEMHLVFSDSNKDLLVVGRWVQAGAFNSDLDPIFSQIPQNTSETLHIDHFNLNTLIP
CCCEEEEEEEECCCCCEEEEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCC
SNLESFRYSGSLTTPPFSEGVNWVMLSQPLFMSSEQINAFSSLFPEGDARGIQDLNGRIV
CCHHHHEECCCCCCCCHHHCCCEEEECCCHHCCCHHHHHHHHHCCCCCCCCHHHCCCEEE
LTDVPGFVTAVPEPETYAMMLAGLCLMAFVARGKSRPLTSDVPAGSVA
EEECCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNMSLLRLSRQTALFSALLVFGMSTSHAEVTPSAQAAMKSQSPIDFRSDSTYFGRLPALN
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEECCCEEE
FNLSSDTSLDVINNGSPDPEKTAVRGNVNPGAGSLTLSGHDWELAQFHFHTPSEHLLNGV
ECCCCCCCEEEECCCCCCCCCEEEECCCCCCCCEEEECCCCCEEEEEEECCCHHHHHCCC
AFPMEMHLVFSDSNKDLLVVGRWVQAGAFNSDLDPIFSQIPQNTSETLHIDHFNLNTLIP
CCCEEEEEEEECCCCCEEEEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCC
SNLESFRYSGSLTTPPFSEGVNWVMLSQPLFMSSEQINAFSSLFPEGDARGIQDLNGRIV
CCHHHHEECCCCCCCCHHHCCCEEEECCCHHCCCHHHHHHHHHCCCCCCCCHHHCCCEEE
LTDVPGFVTAVPEPETYAMMLAGLCLMAFVARGKSRPLTSDVPAGSVA
EEECCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9108244; 7721686; 9761692 [H]