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The map label for this gene is ilvA [H]

Identifier: 82701571

GI number: 82701571

Start: 484639

End: 486150

Strand: Direct

Name: ilvA [H]

Synonym: Nmul_A0437

Alternate gene names: 82701571

Gene position: 484639-486150 (Clockwise)

Preceding gene: 82701566

Following gene: 82701572

Centisome position: 15.22

GC content: 54.5

Gene sequence:

>1512_bases
ATGAAGAACAGTTACCTCGAAAGAATTCTTACAGCGCGGGTTTATGACGTTGCGATAGAGAGTCCTCTGGAGCTTGCGCC
GAATCTGTCCACACGTATAAATAATCAGCTGTTCCTGAAACGGGAAGATGTGCAGGATGTTTTCTCGTTCAAAGTGCGGG
GAGCTTACAACAAAATGGTCAAGCTTTCTCCCGCGGCGCTCGAACGCGGAGTGGTGACGGCCTCTGCCGGCAACCATGCG
CAAGGTGTGGCCCTCGCTGCACAGCGATTGGGGTGTCGGGCAACCATAGTGATGCCTGTCACCACGCCCCAGATCAAGTT
GCAGGCGGTCGAGGCACGCGGAGCGACAGTGGTTTCCTATGGGGACTCCTATGACGAAGCCTATGCTCACGCCCACGAAT
TCGCCGAAAAGAACCAGGTAACCTTCGTACACCCCTATGACGATCCCGATGTCATTGCCGGGCAGGGAACGATCGGAATG
GAGATACTGCGCCAGCATCCGGGTGAAATTCATGCGATATTCGCGCCCATCGGTGGAGGCGGGTTGATTTCGGGGGTTGC
GGCTTATGTAAAAAGGCTCTATCCGGAAATCAGGATTATCGGTGTGGAACCCGTCGACGCCGACTCGATGTATCAGTCGC
TAAAAAAGAACCGGCGTGTCCGGTTGGCGCGAGTCGGATTGTTTGCAGACGGGGTCGCTGTCAAGCAGGTAGGAGTGGAA
ACTTTTCATTTATGCCGCGAACTGGTCGACGAGATCCTGCTGGTAGACACGGATGCCATCTGTGCGGCAATCAAGGATGT
GTTCGAGGATACGCGCGCCATACTGGAACCTTCGGGAGCGCTCTCGATTGCAGGGGCCAAGGCGTATGCAAAGCGGGAAG
GTATCCGCGGCAAGAACCTGATTGCCATCGCCTCCGGTGCGAATATGAATTTCGACCGATTGCGCCATGTGTCCGAACGG
GCGGAACTGGGAGAGCAGCGGGAAGCGGTCATGGCGGTGACGATTCCCGAGGAACCCGGCAGTTTCAAGAAGTTCTGCGC
AATGCTGGGACCGAGAAGTATCACAGAGTTCAACTATCGTTTTGCCGGTCCAAAAGAAGCGCATGTGTTTGTAGGGGTGT
CGGTAAGAAACCGGGAGGAAGCGGCGAAACTGATCAAGGATCTGGAGAACAACGGCTTGCGCACCGAGGATCTGAGCGAC
AATGAAATGGCAAAATTGCATATCCGCCATCTCGTGGGTGGGCATGCACGTGATGTTAAAAATGAAATCGTCTATCGTTT
TGAGTTCCCCGATCGTCCGGGGGCGCTCATGCAATTTCTGAACAGCATGAGCCATCATTGGAATATCAGTCTGTTTCATT
ACCGTAATCACGGGGCAGACTATGGGCGGGTGCTGGTGGGCATGGAGGTGCCCCCGGAGGAGAAGGCGGATTTCAAGGCA
TTTCTCGCTCAGCTCGACAATCGTTATTGGGACGAAACCCACAATCCGGCCTACAAATTATTCCTGGGATAG

Upstream 100 bases:

>100_bases
TGAGCATAATACTATCAGCCCATTTTAACAATGAAGCTGGGCATTTAGCGTTTCGCGACATGTTAAAATGCTCAACCTTT
AAAATCGCAACCCCATTTCG

Downstream 100 bases:

>100_bases
GGACGGACAGCGCTGCCTGTTTATCCCCGACAAGTTTGGTGCATCCTCGAAATCGAGCGTTGCGCGGGTTGCAGTGTTAA
ACCTTCAGTAGTCCAAATCA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MKNSYLERILTARVYDVAIESPLELAPNLSTRINNQLFLKREDVQDVFSFKVRGAYNKMVKLSPAALERGVVTASAGNHA
QGVALAAQRLGCRATIVMPVTTPQIKLQAVEARGATVVSYGDSYDEAYAHAHEFAEKNQVTFVHPYDDPDVIAGQGTIGM
EILRQHPGEIHAIFAPIGGGGLISGVAAYVKRLYPEIRIIGVEPVDADSMYQSLKKNRRVRLARVGLFADGVAVKQVGVE
TFHLCRELVDEILLVDTDAICAAIKDVFEDTRAILEPSGALSIAGAKAYAKREGIRGKNLIAIASGANMNFDRLRHVSER
AELGEQREAVMAVTIPEEPGSFKKFCAMLGPRSITEFNYRFAGPKEAHVFVGVSVRNREEAAKLIKDLENNGLRTEDLSD
NEMAKLHIRHLVGGHARDVKNEIVYRFEFPDRPGALMQFLNSMSHHWNISLFHYRNHGADYGRVLVGMEVPPEEKADFKA
FLAQLDNRYWDETHNPAYKLFLG

Sequences:

>Translated_503_residues
MKNSYLERILTARVYDVAIESPLELAPNLSTRINNQLFLKREDVQDVFSFKVRGAYNKMVKLSPAALERGVVTASAGNHA
QGVALAAQRLGCRATIVMPVTTPQIKLQAVEARGATVVSYGDSYDEAYAHAHEFAEKNQVTFVHPYDDPDVIAGQGTIGM
EILRQHPGEIHAIFAPIGGGGLISGVAAYVKRLYPEIRIIGVEPVDADSMYQSLKKNRRVRLARVGLFADGVAVKQVGVE
TFHLCRELVDEILLVDTDAICAAIKDVFEDTRAILEPSGALSIAGAKAYAKREGIRGKNLIAIASGANMNFDRLRHVSER
AELGEQREAVMAVTIPEEPGSFKKFCAMLGPRSITEFNYRFAGPKEAHVFVGVSVRNREEAAKLIKDLENNGLRTEDLSD
NEMAKLHIRHLVGGHARDVKNEIVYRFEFPDRPGALMQFLNSMSHHWNISLFHYRNHGADYGRVLVGMEVPPEEKADFKA
FLAQLDNRYWDETHNPAYKLFLG
>Mature_503_residues
MKNSYLERILTARVYDVAIESPLELAPNLSTRINNQLFLKREDVQDVFSFKVRGAYNKMVKLSPAALERGVVTASAGNHA
QGVALAAQRLGCRATIVMPVTTPQIKLQAVEARGATVVSYGDSYDEAYAHAHEFAEKNQVTFVHPYDDPDVIAGQGTIGM
EILRQHPGEIHAIFAPIGGGGLISGVAAYVKRLYPEIRIIGVEPVDADSMYQSLKKNRRVRLARVGLFADGVAVKQVGVE
TFHLCRELVDEILLVDTDAICAAIKDVFEDTRAILEPSGALSIAGAKAYAKREGIRGKNLIAIASGANMNFDRLRHVSER
AELGEQREAVMAVTIPEEPGSFKKFCAMLGPRSITEFNYRFAGPKEAHVFVGVSVRNREEAAKLIKDLENNGLRTEDLSD
NEMAKLHIRHLVGGHARDVKNEIVYRFEFPDRPGALMQFLNSMSHHWNISLFHYRNHGADYGRVLVGMEVPPEEKADFKA
FLAQLDNRYWDETHNPAYKLFLG

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=317, Percent_Identity=37.2239747634069, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI33469958, Length=316, Percent_Identity=26.2658227848101, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI19923959, Length=311, Percent_Identity=26.3665594855305, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790207, Length=499, Percent_Identity=52.9058116232465, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1789505, Length=309, Percent_Identity=36.5695792880259, Blast_Score=171, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI71991565, Length=329, Percent_Identity=33.434650455927, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17537387, Length=327, Percent_Identity=33.6391437308869, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17508781, Length=291, Percent_Identity=29.2096219931272, Blast_Score=121, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6320930, Length=513, Percent_Identity=51.8518518518518, Blast_Score=494, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6322631, Length=301, Percent_Identity=35.8803986710963, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319788, Length=269, Percent_Identity=27.8810408921933, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21355833, Length=314, Percent_Identity=32.8025477707006, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24645328, Length=252, Percent_Identity=31.7460317460317, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55841; Mature: 55841

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSYLERILTARVYDVAIESPLELAPNLSTRINNQLFLKREDVQDVFSFKVRGAYNKMV
CCHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHCCCEEEEEHHHHHHHHHHHHCCCHHHHE
KLSPAALERGVVTASAGNHAQGVALAAQRLGCRATIVMPVTTPQIKLQAVEARGATVVSY
EECHHHHHCCEEEECCCCCCHHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCCCEEEEC
GDSYDEAYAHAHEFAEKNQVTFVHPYDDPDVIAGQGTIGMEILRQHPGEIHAIFAPIGGG
CCCHHHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCHHHHHHHCCCCCEEEEEEECCCC
GLISGVAAYVKRLYPEIRIIGVEPVDADSMYQSLKKNRRVRLARVGLFADGVAVKQVGVE
HHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHH
TFHLCRELVDEILLVDTDAICAAIKDVFEDTRAILEPSGALSIAGAKAYAKREGIRGKNL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHCCCCCCCE
IAIASGANMNFDRLRHVSERAELGEQREAVMAVTIPEEPGSFKKFCAMLGPRSITEFNYR
EEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEECCEE
FAGPKEAHVFVGVSVRNREEAAKLIKDLENNGLRTEDLSDNEMAKLHIRHLVGGHARDVK
ECCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCC
NEIVYRFEFPDRPGALMQFLNSMSHHWNISLFHYRNHGADYGRVLVGMEVPPEEKADFKA
CCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEECCCCCCCHHHHHH
FLAQLDNRYWDETHNPAYKLFLG
HHHHHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure
MKNSYLERILTARVYDVAIESPLELAPNLSTRINNQLFLKREDVQDVFSFKVRGAYNKMV
CCHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHCCCEEEEEHHHHHHHHHHHHCCCHHHHE
KLSPAALERGVVTASAGNHAQGVALAAQRLGCRATIVMPVTTPQIKLQAVEARGATVVSY
EECHHHHHCCEEEECCCCCCHHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCCCEEEEC
GDSYDEAYAHAHEFAEKNQVTFVHPYDDPDVIAGQGTIGMEILRQHPGEIHAIFAPIGGG
CCCHHHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCHHHHHHHCCCCCEEEEEEECCCC
GLISGVAAYVKRLYPEIRIIGVEPVDADSMYQSLKKNRRVRLARVGLFADGVAVKQVGVE
HHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHH
TFHLCRELVDEILLVDTDAICAAIKDVFEDTRAILEPSGALSIAGAKAYAKREGIRGKNL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHCCCCCCCE
IAIASGANMNFDRLRHVSERAELGEQREAVMAVTIPEEPGSFKKFCAMLGPRSITEFNYR
EEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEECCEE
FAGPKEAHVFVGVSVRNREEAAKLIKDLENNGLRTEDLSDNEMAKLHIRHLVGGHARDVK
ECCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCC
NEIVYRFEFPDRPGALMQFLNSMSHHWNISLFHYRNHGADYGRVLVGMEVPPEEKADFKA
CCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEECCCCCCCHHHHHH
FLAQLDNRYWDETHNPAYKLFLG
HHHHHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA