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The map label for this gene is gpmA1

Identifier: 82701556

GI number: 82701556

Start: 469345

End: 470058

Strand: Reverse

Name: gpmA1

Synonym: Nmul_A0422

Alternate gene names: 82701556

Gene position: 470058-469345 (Counterclockwise)

Preceding gene: 82701557

Following gene: 82701555

Centisome position: 14.76

GC content: 55.04

Gene sequence:

>714_bases
ATGACACAACTCGTTCTGCTGCGACATGGAGAAAGCGTCTCGAACCGCGACGGATGCTTTACCGGGTGGGGGGATGCTCC
TTTGACGCCCCGAGGCGAGCGGGAGGCAGAGCAGGCGGGCAATCTCTTGAAAAAAGCAGGACACAAGTTCGATATCTGCT
TCACCTCCGAGCTCAGCCGCGCGAATGACACGCTCCGCATCGTGCTATCGGTCATGGGGCAGGATGAACCGGTGGTGCAA
CGAAACTGGCGCTTGAATGAACGCCACTATGGGGCTCTGGAAGGAATCAATCGCTGGAAGGCAATCAGGAAATACGGCTT
TTGCCCTATTCTCAGTTCGCAATGCCGTTTTGATGCTCCGCCACCCCCACTTGATCCTGCCGATATCCGTTTTCCCGGAA
ACCAGGCGTGCTATGCAACCATCGATCCTGGGGAACTGCCGCTTGGTGAGAGCATGCGACAAGCCTTCGCGCGAATGCTG
CCTTACTGGCAGCAAACAATCACCCCGGAAATCCAGCGCGGCAAGCGAGTGCTCATTGTCGCCCACAAGCATATCCTGAG
AGGGTTGATAATGCAGTTGGATGGCCTATCCATTATTCAGCTCATAAAATTGTCAGTGGCCACTGGTCGTCCACTGATCT
ATGAGCTTGACGATAACCTGCATCCAATCCGGCATTACTACGCAGACACCGGATTGACCGGCCATACAGGTTGA

Upstream 100 bases:

>100_bases
AAATTTCAGATCAAATGACACCCTCATGCAAAAGAGATGCTGTCCCCCCCCGGAGCATGCCCATGTCGAATCCATTCCCT
AATCGAGAAGCAAACCCTAT

Downstream 100 bases:

>100_bases
GCGGTGAACAGAAGACGCAGCCAGTATTCCGACGACGCCGGAATGATAGCTGAATCAGAGTCTGCAAGCCTCCGTATAGC
GAACTTGTGCTACAAGATGA

Product: phosphoglycerate mutase 1 family protein

Products: NA

Alternate protein names: BPG-dependent PGAM 1; PGAM 1; Phosphoglyceromutase 1; dPGM 1

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTQLVLLRHGESVSNRDGCFTGWGDAPLTPRGEREAEQAGNLLKKAGHKFDICFTSELSRANDTLRIVLSVMGQDEPVVQ
RNWRLNERHYGALEGINRWKAIRKYGFCPILSSQCRFDAPPPPLDPADIRFPGNQACYATIDPGELPLGESMRQAFARML
PYWQQTITPEIQRGKRVLIVAHKHILRGLIMQLDGLSIIQLIKLSVATGRPLIYELDDNLHPIRHYYADTGLTGHTG

Sequences:

>Translated_237_residues
MTQLVLLRHGESVSNRDGCFTGWGDAPLTPRGEREAEQAGNLLKKAGHKFDICFTSELSRANDTLRIVLSVMGQDEPVVQ
RNWRLNERHYGALEGINRWKAIRKYGFCPILSSQCRFDAPPPPLDPADIRFPGNQACYATIDPGELPLGESMRQAFARML
PYWQQTITPEIQRGKRVLIVAHKHILRGLIMQLDGLSIIQLIKLSVATGRPLIYELDDNLHPIRHYYADTGLTGHTG
>Mature_236_residues
TQLVLLRHGESVSNRDGCFTGWGDAPLTPRGEREAEQAGNLLKKAGHKFDICFTSELSRANDTLRIVLSVMGQDEPVVQR
NWRLNERHYGALEGINRWKAIRKYGFCPILSSQCRFDAPPPPLDPADIRFPGNQACYATIDPGELPLGESMRQAFARMLP
YWQQTITPEIQRGKRVLIVAHKHILRGLIMQLDGLSIIQLIKLSVATGRPLIYELDDNLHPIRHYYADTGLTGHTG

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=224, Percent_Identity=42.4107142857143, Blast_Score=187, Evalue=7e-48,
Organism=Homo sapiens, GI4505753, Length=224, Percent_Identity=44.6428571428571, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI71274132, Length=224, Percent_Identity=42.4107142857143, Blast_Score=167, Evalue=9e-42,
Organism=Homo sapiens, GI4502445, Length=230, Percent_Identity=36.5217391304348, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI40353764, Length=230, Percent_Identity=36.5217391304348, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=42.8571428571429, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786970, Length=227, Percent_Identity=44.0528634361233, Blast_Score=207, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6322697, Length=230, Percent_Identity=42.1739130434783, Blast_Score=187, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324516, Length=277, Percent_Identity=26.7148014440433, Blast_Score=99, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24646216, Length=228, Percent_Identity=39.4736842105263, Blast_Score=174, Evalue=5e-44,
Organism=Drosophila melanogaster, GI85725270, Length=224, Percent_Identity=41.9642857142857, Blast_Score=170, Evalue=8e-43,
Organism=Drosophila melanogaster, GI85725272, Length=224, Percent_Identity=41.9642857142857, Blast_Score=170, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24650981, Length=224, Percent_Identity=41.9642857142857, Blast_Score=170, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24648979, Length=219, Percent_Identity=32.8767123287671, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28571817, Length=219, Percent_Identity=32.8767123287671, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28571815, Length=219, Percent_Identity=32.8767123287671, Blast_Score=125, Evalue=3e-29,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA1_NITMU (Q2YBZ1)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411122.1
- ProteinModelPortal:   Q2YBZ1
- SMR:   Q2YBZ1
- STRING:   Q2YBZ1
- GeneID:   3784172
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0422
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   ILPEIRQ
- PhylomeDB:   Q2YBZ1
- ProtClustDB:   CLSK585197
- BioCyc:   NMUL323848:NMUL_A0422-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 26694; Mature: 26563

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLVLLRHGESVSNRDGCFTGWGDAPLTPRGEREAEQAGNLLKKAGHKFDICFTSELSR
CCEEEEEECCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHC
ANDTLRIVLSVMGQDEPVVQRNWRLNERHYGALEGINRWKAIRKYGFCPILSSQCRFDAP
CCHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PPPLDPADIRFPGNQACYATIDPGELPLGESMRQAFARMLPYWQQTITPEIQRGKRVLIV
CCCCCCCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEE
AHKHILRGLIMQLDGLSIIQLIKLSVATGRPLIYELDDNLHPIRHYYADTGLTGHTG
EHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TQLVLLRHGESVSNRDGCFTGWGDAPLTPRGEREAEQAGNLLKKAGHKFDICFTSELSR
CEEEEEECCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHC
ANDTLRIVLSVMGQDEPVVQRNWRLNERHYGALEGINRWKAIRKYGFCPILSSQCRFDAP
CCHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PPPLDPADIRFPGNQACYATIDPGELPLGESMRQAFARMLPYWQQTITPEIQRGKRVLIV
CCCCCCCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEE
AHKHILRGLIMQLDGLSIIQLIKLSVATGRPLIYELDDNLHPIRHYYADTGLTGHTG
EHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA