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The map label for this gene is cbbA [H]

Identifier: 82701518

GI number: 82701518

Start: 421965

End: 423029

Strand: Reverse

Name: cbbA [H]

Synonym: Nmul_A0384

Alternate gene names: 82701518

Gene position: 423029-421965 (Counterclockwise)

Preceding gene: 82701519

Following gene: 82701512

Centisome position: 13.29

GC content: 55.02

Gene sequence:

>1065_bases
ATGGCACTCGTATCATTGCGTCAACTTTTGGATCACGCGGCAGAAAATGGCTATGGCCTGCCTGCTTTCAACGTCAACAA
TCTGGAGCAGATTCACGCAATCATGCAGGCTGCGGATGAATGCGACAGCCCGGTGATCATGCAGGGCTCAGCAGGGGCGC
GTAAATATGCCGGGGAACCCTTTCTGCGCCACCTTATTGCCGCAGCCGTAGAGGCCTATCCGCACATTCCCATCGTCATG
CACCAGGATCATGGCGCTTCGCCCGCGGTTTGCGTCAATGCCATTCGCAGCGGCTTCTCCAGCGTCATGATGGATGGATC
CCTTGAAGCGGACGCGAAGACGCCCTCTTCCTATGAATACAATGTTGAAGTCACAGGCAAGGTGGTGGAAATGGCCCATG
CGGTGGGTGTTTCCGTCGAGGGTGAACTCGGGTGTCTCGGTTCTCTGGAATCCGGCATGGGTGAAGCGGAAGATGGCCAT
GGCGCCGAAGGCAAGCTGTCCCATGATCAACTGCTGACCGATCCGGAACAGGCGGCCGACTTCGTCAAGCAAACGGGTGT
GGATGCATTGGCAATCGCCATCGGCACTTCTCATGGCGCCTACAAGTTTACGCGCAAGCCAACGGGAGATATTCTCGCCA
TCGAGCGCATAAAAGAAATTCATGCCCGCATTCCCAATACTCATCTGGTGATGCATGGCTCCAGCTCCGTGCCGCAGGAT
TGGCTCGACATCATCCGTGAATACGGTGGAGAGATGAAAGAAACCTATGGTGTTCCAGTCGAGGAAATCCAGGAAGGGAT
CAAATACGGCGTACGCAAGGTCAATATCGATACCGATATCCGATTGGCGATGACCGGTGCGATACGGCGTCATCTTGCCA
AGAACAAGAGCGAATTCGACCCGCGTAAATATCTGAAGGACGCGACTGCCGCAGCCAGGGACATTTGCAAGGCGCGCTTT
GAAGCGTTTGGGTGTGCGGGACAGGCGGCTAAAATCAAACCCATTGCTCTGGACAACATGGCGGGCAAATACGCGAAGGG
GGAATTGAAAGCCGTCATCAAGTAA

Upstream 100 bases:

>100_bases
CGGAAGGTGGAATCCTGAGCAGTGCAGATATTCGTCTCGATCTTTTCACTGCCTGTGATGTTTTACCATATACACTGATT
CTAACTTTGAGGAGGTTCTA

Downstream 100 bases:

>100_bases
TCAGGCAAACTGACAGTTCCACCAGTTCAACCGCCAGCGCTGGTTTTATAAGCAACTGGAATTCGAACGGGATAAAAGGC
GAGCCGATACGGTTCGCCTT

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MALVSLRQLLDHAAENGYGLPAFNVNNLEQIHAIMQAADECDSPVIMQGSAGARKYAGEPFLRHLIAAAVEAYPHIPIVM
HQDHGASPAVCVNAIRSGFSSVMMDGSLEADAKTPSSYEYNVEVTGKVVEMAHAVGVSVEGELGCLGSLESGMGEAEDGH
GAEGKLSHDQLLTDPEQAADFVKQTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHARIPNTHLVMHGSSSVPQD
WLDIIREYGGEMKETYGVPVEEIQEGIKYGVRKVNIDTDIRLAMTGAIRRHLAKNKSEFDPRKYLKDATAAARDICKARF
EAFGCAGQAAKIKPIALDNMAGKYAKGELKAVIK

Sequences:

>Translated_354_residues
MALVSLRQLLDHAAENGYGLPAFNVNNLEQIHAIMQAADECDSPVIMQGSAGARKYAGEPFLRHLIAAAVEAYPHIPIVM
HQDHGASPAVCVNAIRSGFSSVMMDGSLEADAKTPSSYEYNVEVTGKVVEMAHAVGVSVEGELGCLGSLESGMGEAEDGH
GAEGKLSHDQLLTDPEQAADFVKQTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHARIPNTHLVMHGSSSVPQD
WLDIIREYGGEMKETYGVPVEEIQEGIKYGVRKVNIDTDIRLAMTGAIRRHLAKNKSEFDPRKYLKDATAAARDICKARF
EAFGCAGQAAKIKPIALDNMAGKYAKGELKAVIK
>Mature_353_residues
ALVSLRQLLDHAAENGYGLPAFNVNNLEQIHAIMQAADECDSPVIMQGSAGARKYAGEPFLRHLIAAAVEAYPHIPIVMH
QDHGASPAVCVNAIRSGFSSVMMDGSLEADAKTPSSYEYNVEVTGKVVEMAHAVGVSVEGELGCLGSLESGMGEAEDGHG
AEGKLSHDQLLTDPEQAADFVKQTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHARIPNTHLVMHGSSSVPQDW
LDIIREYGGEMKETYGVPVEEIQEGIKYGVRKVNIDTDIRLAMTGAIRRHLAKNKSEFDPRKYLKDATAAARDICKARFE
AFGCAGQAAKIKPIALDNMAGKYAKGELKAVIK

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=33.7386018237082, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI1789526, Length=329, Percent_Identity=32.8267477203647, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI1788072, Length=329, Percent_Identity=29.1793313069909, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789293, Length=351, Percent_Identity=24.7863247863248, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322790, Length=362, Percent_Identity=26.7955801104972, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38063; Mature: 37932

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVSLRQLLDHAAENGYGLPAFNVNNLEQIHAIMQAADECDSPVIMQGSAGARKYAGEP
CHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHCCCCH
FLRHLIAAAVEAYPHIPIVMHQDHGASPAVCVNAIRSGFSSVMMDGSLEADAKTPSSYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
NVEVTGKVVEMAHAVGVSVEGELGCLGSLESGMGEAEDGHGAEGKLSHDQLLTDPEQAAD
EEEECHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHH
FVKQTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHARIPNTHLVMHGSSSVPQD
HHHHCCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
WLDIIREYGGEMKETYGVPVEEIQEGIKYGVRKVNIDTDIRLAMTGAIRRHLAKNKSEFD
HHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PRKYLKDATAAARDICKARFEAFGCAGQAAKIKPIALDNMAGKYAKGELKAVIK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHCC
>Mature Secondary Structure 
ALVSLRQLLDHAAENGYGLPAFNVNNLEQIHAIMQAADECDSPVIMQGSAGARKYAGEP
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHCCCCH
FLRHLIAAAVEAYPHIPIVMHQDHGASPAVCVNAIRSGFSSVMMDGSLEADAKTPSSYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
NVEVTGKVVEMAHAVGVSVEGELGCLGSLESGMGEAEDGHGAEGKLSHDQLLTDPEQAAD
EEEECHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHH
FVKQTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHARIPNTHLVMHGSSSVPQD
HHHHCCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
WLDIIREYGGEMKETYGVPVEEIQEGIKYGVRKVNIDTDIRLAMTGAIRRHLAKNKSEFD
HHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PRKYLKDATAAARDICKARFEAFGCAGQAAKIKPIALDNMAGKYAKGELKAVIK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550527 [H]