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The map label for this gene is glmS [H]

Identifier: 82701447

GI number: 82701447

Start: 336279

End: 338126

Strand: Direct

Name: glmS [H]

Synonym: Nmul_A0313

Alternate gene names: 82701447

Gene position: 336279-338126 (Clockwise)

Preceding gene: 82701446

Following gene: 82701455

Centisome position: 10.56

GC content: 57.85

Gene sequence:

>1848_bases
ATGTGTGGAATCGTCGGTGCAGTCGCAAAAACCAATATCGTCCCCACTCTGATTGAAGGCCTGCGCCGACTGGAATACCG
CGGATATGATTCAGCCGGCATTGCCCTGAACAATGGTCGCCTGCATCGGTTGCGCACCACCGGTCGAGTCGCCGAACTCA
GCAAACTTGCGGATGAGCAACACTTCACCGGGGACGTGGGTATTGCCCATACCCGCTGGGCTACCCACGGCGCTCCATCC
GAGCGCAATGCCCATCCTCATTTTTCCGGAGAGACCCCAAAAGTGGCGGTGGTGCATAACGGCATTATCGAAAATCATGA
AGTGCTGCGGCAGCGTTTGCAGAAGACAGGGTTCGAATTCAGTTCCGAGACCGACACGGAAGTCATCGCTCATCTCATTT
CGTCTCATCTCAGGGAAAACCCGGATTTATTCGAAGCGGTATGCCGTTCGGTGGGCGAATTGCGGGGCGCGTATGCAATT
GCAGTAATGGAGGAAGCAAGGCCGGAGCGCCTCATCGTTTGCCGCAATGGAGCGCCACTGCTGCTTGGCTTGGGCGAAAA
CGGGATCTACGCTGCGTCGGATGCTTCCGCCTTGCTGCAGGTTACCCGGCGCATGATCTATCTGGAAGAGGGCGATGTCG
CCGAATTGCGCCAGGACGGCTACCGCATCGTCAATTGCCGCTACGATGGCGCCCGCGCAGAAGTCGCACGTGCGGTACAG
GAAAGTGAGCTGACAAACGAAGCGGTGGAGATGGGCCCTTATGCCCACTTCATGCAGAAGGAGATATTCGAGCAACCCGG
CGTCGTGGCGAACACGCTGGAAATGGTGCTCAATGCGCAATCCATCTCTCCGCGCCTGTTTGGCACCGAGGCGGAGAACA
TCTTCAAAAATACCAGAAGTATCCTCATCCTGGCGTGTGGCACCAGCTATCACGCTGGCGTCGTCGCCCGCTACTGGCTC
GAAACCGTGGCCGGAATTCCCTGCAATGTCGAGATCGCGAGCGAATATCGCTACCGTAATCCGGCGGTTGGAGCAGATAC
CCTGATCGTGGGCATCTCCCAATCGGGAGAAACAGCGGATACCCTGGCCGCCCTGAGTTATGCAAAATCACTCGGGCATC
GTTACAGTCTGGGGATCTGCAATGTGGCTGAAAGCGCGCTCGTGCGCCAGACGGACTTACGCTTTCTCACCCGGGCTGGC
CCGGAAATCGGTGTGGCCTCGACCAAGGCGTTCACCACACAGCTTGCCGCGCTGATGCTGCTCACCATGACGCTGGCGAA
ATTGAACGGCAAACTGTCGGGTGAGAGTGAGCGCCAGATGATTGCTGCGCTGCGCCACCTGCCCGTCGCGCTTCAGCACA
GCCTGCAGGTGGAGCCGCAGGTGAAAGCCTGGGCGGAAAGATTTGCCGAGAAACGCCATGCCCTGTTTCTTGGCCGCGGC
ATGCACTATCCCATTGCGCTGGAGGGCGCGCTCAAGCTCAAGGAAATTTCCTATATCCATGCCGAAGCTTATGCTGCCGG
GGAACTGAAGCACGGTCCGCTTGCGCTGGTGGATAAGGATATGCCCGTCGTCGCCATAGCTCCCAATGATGCACTGCTGG
AAAAACTCAAGTCAAACCTGCAGGAAGTACGTGCCCGTGGGGGAGAGCTCTACGTTTTCGCCGATGCCGATTCCCACATC
CAGGAAAGCGAAGGCGTACACATCATTCGTCTGGCGGAACATGCGGGAATGCTCAGCCCCATCCTCCACACCATCCCCCT
GCAGCTTCTCGCCTATCACGTCGCGCTGCAAAAAGGTACGGATGTGGATAAGCCGAGAAACCTGGCGAAATCAGTGACGG
TGGAGTAA

Upstream 100 bases:

>100_bases
CCCGTAAAAAAACCGAAGCCCAAAAATTAAGCATAGCCTTCATCTTTTTCCATCCTTGAACCGCGCCAATTGCTGGTATC
TGTAAGAAAGGAGTCTTTTG

Downstream 100 bases:

>100_bases
GAAGTATCTATTGAACTGACTATTGGCTAAAGCCGGTTTTCAGCCATATAGTTGCAGTTGCATCCCGGCGGCAGTGCCCA
GCGAACACTCAGGTTGTTTC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MCGIVGAVAKTNIVPTLIEGLRRLEYRGYDSAGIALNNGRLHRLRTTGRVAELSKLADEQHFTGDVGIAHTRWATHGAPS
ERNAHPHFSGETPKVAVVHNGIIENHEVLRQRLQKTGFEFSSETDTEVIAHLISSHLRENPDLFEAVCRSVGELRGAYAI
AVMEEARPERLIVCRNGAPLLLGLGENGIYAASDASALLQVTRRMIYLEEGDVAELRQDGYRIVNCRYDGARAEVARAVQ
ESELTNEAVEMGPYAHFMQKEIFEQPGVVANTLEMVLNAQSISPRLFGTEAENIFKNTRSILILACGTSYHAGVVARYWL
ETVAGIPCNVEIASEYRYRNPAVGADTLIVGISQSGETADTLAALSYAKSLGHRYSLGICNVAESALVRQTDLRFLTRAG
PEIGVASTKAFTTQLAALMLLTMTLAKLNGKLSGESERQMIAALRHLPVALQHSLQVEPQVKAWAERFAEKRHALFLGRG
MHYPIALEGALKLKEISYIHAEAYAAGELKHGPLALVDKDMPVVAIAPNDALLEKLKSNLQEVRARGGELYVFADADSHI
QESEGVHIIRLAEHAGMLSPILHTIPLQLLAYHVALQKGTDVDKPRNLAKSVTVE

Sequences:

>Translated_615_residues
MCGIVGAVAKTNIVPTLIEGLRRLEYRGYDSAGIALNNGRLHRLRTTGRVAELSKLADEQHFTGDVGIAHTRWATHGAPS
ERNAHPHFSGETPKVAVVHNGIIENHEVLRQRLQKTGFEFSSETDTEVIAHLISSHLRENPDLFEAVCRSVGELRGAYAI
AVMEEARPERLIVCRNGAPLLLGLGENGIYAASDASALLQVTRRMIYLEEGDVAELRQDGYRIVNCRYDGARAEVARAVQ
ESELTNEAVEMGPYAHFMQKEIFEQPGVVANTLEMVLNAQSISPRLFGTEAENIFKNTRSILILACGTSYHAGVVARYWL
ETVAGIPCNVEIASEYRYRNPAVGADTLIVGISQSGETADTLAALSYAKSLGHRYSLGICNVAESALVRQTDLRFLTRAG
PEIGVASTKAFTTQLAALMLLTMTLAKLNGKLSGESERQMIAALRHLPVALQHSLQVEPQVKAWAERFAEKRHALFLGRG
MHYPIALEGALKLKEISYIHAEAYAAGELKHGPLALVDKDMPVVAIAPNDALLEKLKSNLQEVRARGGELYVFADADSHI
QESEGVHIIRLAEHAGMLSPILHTIPLQLLAYHVALQKGTDVDKPRNLAKSVTVE
>Mature_615_residues
MCGIVGAVAKTNIVPTLIEGLRRLEYRGYDSAGIALNNGRLHRLRTTGRVAELSKLADEQHFTGDVGIAHTRWATHGAPS
ERNAHPHFSGETPKVAVVHNGIIENHEVLRQRLQKTGFEFSSETDTEVIAHLISSHLRENPDLFEAVCRSVGELRGAYAI
AVMEEARPERLIVCRNGAPLLLGLGENGIYAASDASALLQVTRRMIYLEEGDVAELRQDGYRIVNCRYDGARAEVARAVQ
ESELTNEAVEMGPYAHFMQKEIFEQPGVVANTLEMVLNAQSISPRLFGTEAENIFKNTRSILILACGTSYHAGVVARYWL
ETVAGIPCNVEIASEYRYRNPAVGADTLIVGISQSGETADTLAALSYAKSLGHRYSLGICNVAESALVRQTDLRFLTRAG
PEIGVASTKAFTTQLAALMLLTMTLAKLNGKLSGESERQMIAALRHLPVALQHSLQVEPQVKAWAERFAEKRHALFLGRG
MHYPIALEGALKLKEISYIHAEAYAAGELKHGPLALVDKDMPVVAIAPNDALLEKLKSNLQEVRARGGELYVFADADSHI
QESEGVHIIRLAEHAGMLSPILHTIPLQLLAYHVALQKGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=690, Percent_Identity=37.9710144927536, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI205277386, Length=685, Percent_Identity=37.956204379562, Blast_Score=423, Evalue=1e-118,
Organism=Escherichia coli, GI1790167, Length=617, Percent_Identity=56.4019448946515, Blast_Score=683, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=173, Percent_Identity=28.3236994219653, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87082251, Length=333, Percent_Identity=20.7207207207207, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=39.4431554524362, Blast_Score=295, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17532899, Length=431, Percent_Identity=38.7470997679814, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17532897, Length=431, Percent_Identity=38.7470997679814, Blast_Score=290, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6322745, Length=434, Percent_Identity=38.0184331797235, Blast_Score=293, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6323731, Length=431, Percent_Identity=32.2505800464037, Blast_Score=225, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=37.0731707317073, Blast_Score=121, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323958, Length=172, Percent_Identity=27.3255813953488, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21357745, Length=689, Percent_Identity=37.0101596516691, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI28573187, Length=256, Percent_Identity=26.5625, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24659598, Length=260, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67251; Mature: 67251

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAKTNIVPTLIEGLRRLEYRGYDSAGIALNNGRLHRLRTTGRVAELSKLADEQ
CCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCHHHHHHHHHHHC
HFTGDVGIAHTRWATHGAPSERNAHPHFSGETPKVAVVHNGIIENHEVLRQRLQKTGFEF
CCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCC
SSETDTEVIAHLISSHLRENPDLFEAVCRSVGELRGAYAIAVMEEARPERLIVCRNGAPL
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCE
LLGLGENGIYAASDASALLQVTRRMIYLEEGDVAELRQDGYRIVNCRYDGARAEVARAVQ
EEEECCCCEEECCCHHHHHHHHHHHEEECCCCHHHHHHCCCEEEEEEECCHHHHHHHHHH
ESELTNEAVEMGPYAHFMQKEIFEQPGVVANTLEMVLNAQSISPRLFGTEAENIFKNTRS
HHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCE
ILILACGTSYHAGVVARYWLETVAGIPCNVEIASEYRYRNPAVGADTLIVGISQSGETAD
EEEEEECCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCCHHH
TLAALSYAKSLGHRYSLGICNVAESALVRQTDLRFLTRAGPEIGVASTKAFTTQLAALML
HHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LTMTLAKLNGKLSGESERQMIAALRHLPVALQHSLQVEPQVKAWAERFAEKRHALFLGRG
HHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHEEEEECC
MHYPIALEGALKLKEISYIHAEAYAAGELKHGPLALVDKDMPVVAIAPNDALLEKLKSNL
CCCCEEECCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHH
QEVRARGGELYVFADADSHIQESEGVHIIRLAEHAGMLSPILHTIPLQLLAYHVALQKGT
HHHHHCCCEEEEEECCCCCHHHCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHCCC
DVDKPRNLAKSVTVE
CCCCHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVAKTNIVPTLIEGLRRLEYRGYDSAGIALNNGRLHRLRTTGRVAELSKLADEQ
CCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCHHHHHHHHHHHC
HFTGDVGIAHTRWATHGAPSERNAHPHFSGETPKVAVVHNGIIENHEVLRQRLQKTGFEF
CCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCC
SSETDTEVIAHLISSHLRENPDLFEAVCRSVGELRGAYAIAVMEEARPERLIVCRNGAPL
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCE
LLGLGENGIYAASDASALLQVTRRMIYLEEGDVAELRQDGYRIVNCRYDGARAEVARAVQ
EEEECCCCEEECCCHHHHHHHHHHHEEECCCCHHHHHHCCCEEEEEEECCHHHHHHHHHH
ESELTNEAVEMGPYAHFMQKEIFEQPGVVANTLEMVLNAQSISPRLFGTEAENIFKNTRS
HHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCE
ILILACGTSYHAGVVARYWLETVAGIPCNVEIASEYRYRNPAVGADTLIVGISQSGETAD
EEEEEECCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCCHHH
TLAALSYAKSLGHRYSLGICNVAESALVRQTDLRFLTRAGPEIGVASTKAFTTQLAALML
HHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LTMTLAKLNGKLSGESERQMIAALRHLPVALQHSLQVEPQVKAWAERFAEKRHALFLGRG
HHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHEEEEECC
MHYPIALEGALKLKEISYIHAEAYAAGELKHGPLALVDKDMPVVAIAPNDALLEKLKSNL
CCCCEEECCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHH
QEVRARGGELYVFADADSHIQESEGVHIIRLAEHAGMLSPILHTIPLQLLAYHVALQKGT
HHHHHCCCEEEEEECCCCCHHHCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHCCC
DVDKPRNLAKSVTVE
CCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]