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The map label for this gene is glmU [H]

Identifier: 82701446

GI number: 82701446

Start: 334820

End: 336208

Strand: Direct

Name: glmU [H]

Synonym: Nmul_A0312

Alternate gene names: 82701446

Gene position: 334820-336208 (Clockwise)

Preceding gene: 82701445

Following gene: 82701447

Centisome position: 10.51

GC content: 53.35

Gene sequence:

>1389_bases
ATGAATGTGTCCAAACTGAACATCGTCGTTCTTGCTGCCGGTCTCGGAAAACGCATGTACTCTGCGCTGCCGAAAGTGTT
GCATCCCCTCGCAGGCAAGCCTCTCCTGGTGCACGTGCTCGATACCGCCCGCGCATTAGCGCCCCATACAACTTGTGTCA
TTTACGGGCATGGGGGGGAAACAGTCCCGCAAACAATAGCGGATGAAAGCCTTATCTGGGTGCCACAGATCCCACAACTC
GGAACGGGTCACGCAGTGATGCAGGCGCTGCCTCATATCGAGAAAGAGGGCATTACACTTATTCTGTATGGCGACGTGCC
TCTGACCAGTGTCGAAACATTAAAAAAACTGATCGCGATGGCGGGAAAGCAAACATTAGGTTTGCTGACGGTAGAACTTC
CTGATCCAGCGGGCTACGGTAGAATCGTTCGGCATAGCGAAACGGGTGAAGTCGCCGCTATTGTCGAGGAGAAAGACGCC
AGTGAATCCCAGCGCAGCATCGGTGAAATCAATACGGGCATCATGGCGGTTCCGAATCGCTATCTTCACGGCTGGTTGTG
CAAGCTTGAAAACAACAACGCGCAAGGTGAGTATTATCTGACGGATATTGTCGCGATGGCGGTAAAGGATGGGGTAAAGG
TAGCAACAGCCAATCCCGCTTATGTATGGGAAACTACGGGAGTCAACAGCAAGGTTCAGCTCGCCGGACTGGAACGCATC
TATCAGACAGCGCAGGCCAATAAATTGCTGGAGCAGGGCGTAGCGCTGGCTGATCCGGCGCGCATCGATATCCGCGGTAA
ACTTTCTTGCGGCAGAGATGTTATGATCGATATCAACTGCATATTTGAAGGGGACGTTCAACTGGATGATGGCGTAAAAG
TGGGTGCTCACACCATACTGAAAGACGTGCGGGTAGCCGCGGATTCGGTCATCGCGCCATTCAGCCTGATAGAGGCTGCG
GAAATTGGTCGAAATTGTCGTATCGGTCCTTACGCCCGTATTCGGCCGGGCACGCGACTGGAGGATGAAGTGCACATCGG
CAATTTCGTCGAAGTCAAGAACAGTGCCCTTGCGGCTGGCAGCAAGGCAAACCACCTGAGTTACATCGGAGATGCCGTGG
TGGGCAGGAGTGTCAACATCGGCGCAGGCACGATTACCTGCAATTATGACGGCGCCAACAAATACCAGACCATCATCGAG
GATGATGTCTTTGTGGGCTCCGATACCCAGTTGATAGCACCGGTCAGAGTTGCCCGCGGTTCCACGATCGGTGCAGGTTC
GACCATTACCAGGGATACGCCACCTGATATGTTGACGCTTTCGCGAGCGAAGCAGTTGAGTATCGATGGTTGGAAACGCC
CCGTAAAAAAACCGAAGCCCAAAAATTAA

Upstream 100 bases:

>100_bases
TCCGGTTTCCATTTGTAAATCCGCTTCAACCTCAACTTCCTGCAGTTGATCTACCTTTGCGGGTTGAATATTACACGTTC
CCGCATGTCCTGATATTTTC

Downstream 100 bases:

>100_bases
GCATAGCCTTCATCTTTTTCCATCCTTGAACCGCGCCAATTGCTGGTATCTGTAAGAAAGGAGTCTTTTGATGTGTGGAA
TCGTCGGTGCAGTCGCAAAA

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MNVSKLNIVVLAAGLGKRMYSALPKVLHPLAGKPLLVHVLDTARALAPHTTCVIYGHGGETVPQTIADESLIWVPQIPQL
GTGHAVMQALPHIEKEGITLILYGDVPLTSVETLKKLIAMAGKQTLGLLTVELPDPAGYGRIVRHSETGEVAAIVEEKDA
SESQRSIGEINTGIMAVPNRYLHGWLCKLENNNAQGEYYLTDIVAMAVKDGVKVATANPAYVWETTGVNSKVQLAGLERI
YQTAQANKLLEQGVALADPARIDIRGKLSCGRDVMIDINCIFEGDVQLDDGVKVGAHTILKDVRVAADSVIAPFSLIEAA
EIGRNCRIGPYARIRPGTRLEDEVHIGNFVEVKNSALAAGSKANHLSYIGDAVVGRSVNIGAGTITCNYDGANKYQTIIE
DDVFVGSDTQLIAPVRVARGSTIGAGSTITRDTPPDMLTLSRAKQLSIDGWKRPVKKPKPKN

Sequences:

>Translated_462_residues
MNVSKLNIVVLAAGLGKRMYSALPKVLHPLAGKPLLVHVLDTARALAPHTTCVIYGHGGETVPQTIADESLIWVPQIPQL
GTGHAVMQALPHIEKEGITLILYGDVPLTSVETLKKLIAMAGKQTLGLLTVELPDPAGYGRIVRHSETGEVAAIVEEKDA
SESQRSIGEINTGIMAVPNRYLHGWLCKLENNNAQGEYYLTDIVAMAVKDGVKVATANPAYVWETTGVNSKVQLAGLERI
YQTAQANKLLEQGVALADPARIDIRGKLSCGRDVMIDINCIFEGDVQLDDGVKVGAHTILKDVRVAADSVIAPFSLIEAA
EIGRNCRIGPYARIRPGTRLEDEVHIGNFVEVKNSALAAGSKANHLSYIGDAVVGRSVNIGAGTITCNYDGANKYQTIIE
DDVFVGSDTQLIAPVRVARGSTIGAGSTITRDTPPDMLTLSRAKQLSIDGWKRPVKKPKPKN
>Mature_462_residues
MNVSKLNIVVLAAGLGKRMYSALPKVLHPLAGKPLLVHVLDTARALAPHTTCVIYGHGGETVPQTIADESLIWVPQIPQL
GTGHAVMQALPHIEKEGITLILYGDVPLTSVETLKKLIAMAGKQTLGLLTVELPDPAGYGRIVRHSETGEVAAIVEEKDA
SESQRSIGEINTGIMAVPNRYLHGWLCKLENNNAQGEYYLTDIVAMAVKDGVKVATANPAYVWETTGVNSKVQLAGLERI
YQTAQANKLLEQGVALADPARIDIRGKLSCGRDVMIDINCIFEGDVQLDDGVKVGAHTILKDVRVAADSVIAPFSLIEAA
EIGRNCRIGPYARIRPGTRLEDEVHIGNFVEVKNSALAAGSKANHLSYIGDAVVGRSVNIGAGTITCNYDGANKYQTIIE
DDVFVGSDTQLIAPVRVARGSTIGAGSTITRDTPPDMLTLSRAKQLSIDGWKRPVKKPKPKN

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=452, Percent_Identity=53.7610619469027, Blast_Score=497, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 49476; Mature: 49476

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVSKLNIVVLAAGLGKRMYSALPKVLHPLAGKPLLVHVLDTARALAPHTTCVIYGHGGE
CCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCEEEEECCCCC
TVPQTIADESLIWVPQIPQLGTGHAVMQALPHIEKEGITLILYGDVPLTSVETLKKLIAM
CCCHHHCCCCEEECCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
AGKQTLGLLTVELPDPAGYGRIVRHSETGEVAAIVEEKDASESQRSIGEINTGIMAVPNR
CCCCEEEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEECCCH
YLHGWLCKLENNNAQGEYYLTDIVAMAVKDGVKVATANPAYVWETTGVNSKVQLAGLERI
HCEEEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCEEEHHHHHHH
YQTAQANKLLEQGVALADPARIDIRGKLSCGRDVMIDINCIFEGDVQLDDGVKVGAHTIL
HHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEEEEEECCEEECCCCCHHHHHHH
KDVRVAADSVIAPFSLIEAAEIGRNCRIGPYARIRPGTRLEDEVHIGNFVEVKNSALAAG
HHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCEECCCEEEECCCCEECC
SKANHLSYIGDAVVGRSVNIGAGTITCNYDGANKYQTIIEDDVFVGSDTQLIAPVRVARG
CCCCHHHHHHHHHHCCEEECCCEEEEEECCCCCCCHHEECCCEEECCCCEEEEEEEEECC
STIGAGSTITRDTPPDMLTLSRAKQLSIDGWKRPVKKPKPKN
CCCCCCCCCCCCCCCCCEEHHHHHCCCCCHHHCCCCCCCCCC
>Mature Secondary Structure
MNVSKLNIVVLAAGLGKRMYSALPKVLHPLAGKPLLVHVLDTARALAPHTTCVIYGHGGE
CCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCEEEEECCCCC
TVPQTIADESLIWVPQIPQLGTGHAVMQALPHIEKEGITLILYGDVPLTSVETLKKLIAM
CCCHHHCCCCEEECCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
AGKQTLGLLTVELPDPAGYGRIVRHSETGEVAAIVEEKDASESQRSIGEINTGIMAVPNR
CCCCEEEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEECCCH
YLHGWLCKLENNNAQGEYYLTDIVAMAVKDGVKVATANPAYVWETTGVNSKVQLAGLERI
HCEEEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCEEEHHHHHHH
YQTAQANKLLEQGVALADPARIDIRGKLSCGRDVMIDINCIFEGDVQLDDGVKVGAHTIL
HHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEEEEEECCEEECCCCCHHHHHHH
KDVRVAADSVIAPFSLIEAAEIGRNCRIGPYARIRPGTRLEDEVHIGNFVEVKNSALAAG
HHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCEECCCEEEECCCCEECC
SKANHLSYIGDAVVGRSVNIGAGTITCNYDGANKYQTIIEDDVFVGSDTQLIAPVRVARG
CCCCHHHHHHHHHHCCEEECCCEEEEEECCCCCCCHHEECCCEEECCCCEEEEEEEEECC
STIGAGSTITRDTPPDMLTLSRAKQLSIDGWKRPVKKPKPKN
CCCCCCCCCCCCCCCCCEEHHHHHCCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA