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The map label for this gene is dxs

Identifier: 82701370

GI number: 82701370

Start: 250271

End: 252115

Strand: Direct

Name: dxs

Synonym: Nmul_A0236

Alternate gene names: 82701370

Gene position: 250271-252115 (Clockwise)

Preceding gene: 82701369

Following gene: 82701371

Centisome position: 7.86

GC content: 56.64

Gene sequence:

>1845_bases
ATGCACCCATTGCTCAATACCATTACCGATCCTGTCAAGCTGCGGGCACTGGACCGCAAGTTGCTGCCACAGCTTGCAGA
CGAGTTACGCCAATTCCTGGTTGAATCGGTAGCCAAAACTGGCGGTCATCTATCCTCCAATCTGGGTACGGTCGAACTGA
CCATCGCGCTGCACTACGTTTTCAATACACCCTATGACCGCCTGGTCTGGGATGTGGGCCACCAGACTTATGTCCATAAA
ATTCTGACGGGACGGCGCGAAGGCATGAGCAAATTGCGCATGCGCGGCGGTATCGCCGGCTTTCCCCGCCGGGATGAAAG
TGAATATGACGCTTTCGGCACCGCTCACTCGAGTACCTCCATCAGCGCCGCGCTCGGGATGGCAGTAGCGTCGCAGTGGG
AAGGCAAGAAGCGGTCCGTAGTCGCGGTGATCGGTGATGGCGCGATGAGTGCCGGCATGGCGTTCGAGGCTTTGAATAAT
GCCGGCGCCATGGATACCAACCTGCTGGTCATTCTGAACGACAACGATATGTCGATTTCCCGGCCAGTGGGAGCGCTCAA
CAATTATCTGGCGCGGCTCATGTCCGGCCAGTTTTATGCAACCGCGCGGCGCGCGGGCGAGAAAATGCTGGGGGTGGTTC
CACACGTGCTGGAACTTGCCAAGCGTGCCGAGGAGCATGTAAAAGGCATGGTGACGCCAAGCACGCTGTTTGAAGAGTTC
GGTTTCAATTATATCGGGCCTATTGATGGCCATGATCTTGACGTGCTTGTCAGCACGCTCAACAACATCCGGAATCTTCG
CGGTCCCCAGTTTCTGCACGTGGTAACCCGTAAAGGGGCGGGGTACAAGGCGGCGGAAGATGACCCGATTCTTTATCACG
GCGTGACCAGGTTCAATCCCGACGCGGGCATCATTCCCAAGGCTTCAGTCAAGCCGTCCTATACCCAGGTTTTCGGGGAT
TGGCTGTGTGACATGGCGGCATTGGACCAGCGTCTGGTAGGGATTACTCCGGCCATGCGAGAGGGATCGGGTATGGTGAG
ATTTTCCCACGAATATGCCGATCGTTATTTTGACGTGGGTATCGCCGAGCAGCATGCCGTCACCTTTGCAGCCGGGCTCG
CGTGCGATGGGTTGAAGCCGGTGGTGGCGATCTATTCGACATTTCTCCAGCGCGCATATGACCAGCTGATTCATGATGTC
GCCATTCAGAATCTTCCTGTCGTGTTTGCCATAGACCGTGCCGGACTGGTGGGAGCAGACGGACCTACCCATGCGGGGAG
TTTCGATCTGACTTACCTGCGCTGTATTCCGAACATTACCGTAATGGCTCCTTCGGATGAGAACGAATGTCGCCAGATGC
TGTACACCGCTTTTCAGATGAATACCCCCGCTGCTGTGCGCTATCCCCGAGGTTCAGGTAGCGGGGTGGCTCAGCAGAAA
GAGATGCAGATGCTGCCGCTCGGGCGAGGTGAAATACGGCGGGAGGGAGCGGAAATTGCATTGCTCGCGTTCGGCAGCAT
GCTCCAGCCTTGCCTTGAGGCAGCGGAAGAATTGAATGCGACAGTCGCCAATATGCGTTTTGTCAAACCCCTGGACGATG
ATCTCGTTGCATCGCTGGCGGCCAATCACGAATTGCTCGTTACGGTGGAGGAAAACACTGTCATGGGTGGCGCAGGCAGC
GCGGTTCTGGAATCACTATCTGCCCGAGGTCGTACAGTTCCGGTATTGCAGCTGGGTCTGCCGGACACTTTCCTCGACCA
GGGCGACCCTTCTCAGATGTTGAGCGAGTGCGGGCTGGATAGGGAAGGGATCGTACACGCCATAAGAGCGAGATTCCCGA
AGTAA

Upstream 100 bases:

>100_bases
TGAGGCAGGTAACCGACTTTATCATTCACCGGGAATTTTGAAGAATTTTGACGACCAGCGTGTTTCCCGGAAAAAGGATT
TTGTAATTTTCAAGGTTTAA

Downstream 100 bases:

>100_bases
ACCGCCCGCTTTTGCATCGCATGCCTTTGATATGCGATGTTCTTCCTTGCAATGGTACACGATGAACAAAATGCTCATTG
CAGATGTGCAAAGTGTGGCC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MHPLLNTITDPVKLRALDRKLLPQLADELRQFLVESVAKTGGHLSSNLGTVELTIALHYVFNTPYDRLVWDVGHQTYVHK
ILTGRREGMSKLRMRGGIAGFPRRDESEYDAFGTAHSSTSISAALGMAVASQWEGKKRSVVAVIGDGAMSAGMAFEALNN
AGAMDTNLLVILNDNDMSISRPVGALNNYLARLMSGQFYATARRAGEKMLGVVPHVLELAKRAEEHVKGMVTPSTLFEEF
GFNYIGPIDGHDLDVLVSTLNNIRNLRGPQFLHVVTRKGAGYKAAEDDPILYHGVTRFNPDAGIIPKASVKPSYTQVFGD
WLCDMAALDQRLVGITPAMREGSGMVRFSHEYADRYFDVGIAEQHAVTFAAGLACDGLKPVVAIYSTFLQRAYDQLIHDV
AIQNLPVVFAIDRAGLVGADGPTHAGSFDLTYLRCIPNITVMAPSDENECRQMLYTAFQMNTPAAVRYPRGSGSGVAQQK
EMQMLPLGRGEIRREGAEIALLAFGSMLQPCLEAAEELNATVANMRFVKPLDDDLVASLAANHELLVTVEENTVMGGAGS
AVLESLSARGRTVPVLQLGLPDTFLDQGDPSQMLSECGLDREGIVHAIRARFPK

Sequences:

>Translated_614_residues
MHPLLNTITDPVKLRALDRKLLPQLADELRQFLVESVAKTGGHLSSNLGTVELTIALHYVFNTPYDRLVWDVGHQTYVHK
ILTGRREGMSKLRMRGGIAGFPRRDESEYDAFGTAHSSTSISAALGMAVASQWEGKKRSVVAVIGDGAMSAGMAFEALNN
AGAMDTNLLVILNDNDMSISRPVGALNNYLARLMSGQFYATARRAGEKMLGVVPHVLELAKRAEEHVKGMVTPSTLFEEF
GFNYIGPIDGHDLDVLVSTLNNIRNLRGPQFLHVVTRKGAGYKAAEDDPILYHGVTRFNPDAGIIPKASVKPSYTQVFGD
WLCDMAALDQRLVGITPAMREGSGMVRFSHEYADRYFDVGIAEQHAVTFAAGLACDGLKPVVAIYSTFLQRAYDQLIHDV
AIQNLPVVFAIDRAGLVGADGPTHAGSFDLTYLRCIPNITVMAPSDENECRQMLYTAFQMNTPAAVRYPRGSGSGVAQQK
EMQMLPLGRGEIRREGAEIALLAFGSMLQPCLEAAEELNATVANMRFVKPLDDDLVASLAANHELLVTVEENTVMGGAGS
AVLESLSARGRTVPVLQLGLPDTFLDQGDPSQMLSECGLDREGIVHAIRARFPK
>Mature_614_residues
MHPLLNTITDPVKLRALDRKLLPQLADELRQFLVESVAKTGGHLSSNLGTVELTIALHYVFNTPYDRLVWDVGHQTYVHK
ILTGRREGMSKLRMRGGIAGFPRRDESEYDAFGTAHSSTSISAALGMAVASQWEGKKRSVVAVIGDGAMSAGMAFEALNN
AGAMDTNLLVILNDNDMSISRPVGALNNYLARLMSGQFYATARRAGEKMLGVVPHVLELAKRAEEHVKGMVTPSTLFEEF
GFNYIGPIDGHDLDVLVSTLNNIRNLRGPQFLHVVTRKGAGYKAAEDDPILYHGVTRFNPDAGIIPKASVKPSYTQVFGD
WLCDMAALDQRLVGITPAMREGSGMVRFSHEYADRYFDVGIAEQHAVTFAAGLACDGLKPVVAIYSTFLQRAYDQLIHDV
AIQNLPVVFAIDRAGLVGADGPTHAGSFDLTYLRCIPNITVMAPSDENECRQMLYTAFQMNTPAAVRYPRGSGSGVAQQK
EMQMLPLGRGEIRREGAEIALLAFGSMLQPCLEAAEELNATVANMRFVKPLDDDLVASLAANHELLVTVEENTVMGGAGS
AVLESLSARGRTVPVLQLGLPDTFLDQGDPSQMLSECGLDREGIVHAIRARFPK

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=666, Percent_Identity=22.5225225225225, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4507521, Length=666, Percent_Identity=22.5225225225225, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI133778974, Length=422, Percent_Identity=23.696682464455, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI156564403, Length=238, Percent_Identity=26.4705882352941, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI225637459, Length=525, Percent_Identity=23.8095238095238, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI225637461, Length=525, Percent_Identity=23.8095238095238, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI225637463, Length=525, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI291084858, Length=230, Percent_Identity=25.2173913043478, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786622, Length=611, Percent_Identity=60.0654664484452, Blast_Score=784, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=645, Percent_Identity=24.3410852713178, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319698, Length=228, Percent_Identity=26.7543859649123, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24666278, Length=668, Percent_Identity=24.4011976047904, Blast_Score=108, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45551847, Length=548, Percent_Identity=25.3649635036496, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45550715, Length=548, Percent_Identity=25.3649635036496, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24645119, Length=548, Percent_Identity=25.3649635036496, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21358145, Length=266, Percent_Identity=27.8195488721804, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24650940, Length=266, Percent_Identity=27.8195488721804, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_NITMU (Q2YCH7)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_410936.1
- ProteinModelPortal:   Q2YCH7
- SMR:   Q2YCH7
- STRING:   Q2YCH7
- GeneID:   3786318
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0236
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   Q2YCH7
- ProtClustDB:   PRK05444
- BioCyc:   NMUL323848:NMUL_A0236-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 66743; Mature: 66743

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPLLNTITDPVKLRALDRKLLPQLADELRQFLVESVAKTGGHLSSNLGTVELTIALHYV
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEE
FNTPYDRLVWDVGHQTYVHKILTGRREGMSKLRMRGGIAGFPRRDESEYDAFGTAHSSTS
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCH
ISAALGMAVASQWEGKKRSVVAVIGDGAMSAGMAFEALNNAGAMDTNLLVILNDNDMSIS
HHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCC
RPVGALNNYLARLMSGQFYATARRAGEKMLGVVPHVLELAKRAEEHVKGMVTPSTLFEEF
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
GFNYIGPIDGHDLDVLVSTLNNIRNLRGPQFLHVVTRKGAGYKAAEDDPILYHGVTRFNP
CCCEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEECCCEECC
DAGIIPKASVKPSYTQVFGDWLCDMAALDQRLVGITPAMREGSGMVRFSHEYADRYFDVG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEHHHHHHHHCCC
IAEQHAVTFAAGLACDGLKPVVAIYSTFLQRAYDQLIHDVAIQNLPVVFAIDRAGLVGAD
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECCC
GPTHAGSFDLTYLRCIPNITVMAPSDENECRQMLYTAFQMNTPAAVRYPRGSGSGVAQQK
CCCCCCCCCEEHEEECCCEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHH
EMQMLPLGRGEIRREGAEIALLAFGSMLQPCLEAAEELNATVANMRFVKPLDDDLVASLA
HHHCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHH
ANHELLVTVEENTVMGGAGSAVLESLSARGRTVPVLQLGLPDTFLDQGDPSQMLSECGLD
CCCEEEEEEECCEEECCCHHHHHHHHHHCCCEEEEEEECCCHHHHCCCCHHHHHHHCCCC
REGIVHAIRARFPK
HHHHHHHHHHCCCC
>Mature Secondary Structure
MHPLLNTITDPVKLRALDRKLLPQLADELRQFLVESVAKTGGHLSSNLGTVELTIALHYV
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEE
FNTPYDRLVWDVGHQTYVHKILTGRREGMSKLRMRGGIAGFPRRDESEYDAFGTAHSSTS
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCH
ISAALGMAVASQWEGKKRSVVAVIGDGAMSAGMAFEALNNAGAMDTNLLVILNDNDMSIS
HHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCC
RPVGALNNYLARLMSGQFYATARRAGEKMLGVVPHVLELAKRAEEHVKGMVTPSTLFEEF
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
GFNYIGPIDGHDLDVLVSTLNNIRNLRGPQFLHVVTRKGAGYKAAEDDPILYHGVTRFNP
CCCEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEECCCEECC
DAGIIPKASVKPSYTQVFGDWLCDMAALDQRLVGITPAMREGSGMVRFSHEYADRYFDVG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEHHHHHHHHCCC
IAEQHAVTFAAGLACDGLKPVVAIYSTFLQRAYDQLIHDVAIQNLPVVFAIDRAGLVGAD
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECCC
GPTHAGSFDLTYLRCIPNITVMAPSDENECRQMLYTAFQMNTPAAVRYPRGSGSGVAQQK
CCCCCCCCCEEHEEECCCEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHH
EMQMLPLGRGEIRREGAEIALLAFGSMLQPCLEAAEELNATVANMRFVKPLDDDLVASLA
HHHCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHH
ANHELLVTVEENTVMGGAGSAVLESLSARGRTVPVLQLGLPDTFLDQGDPSQMLSECGLD
CCCEEEEEEECCEEECCCHHHHHHHHHHCCCEEEEEEECCCHHHHCCCCHHHHHHHCCCC
REGIVHAIRARFPK
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA