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The map label for this gene is fppS [H]

Identifier: 82701369

GI number: 82701369

Start: 249318

End: 250211

Strand: Direct

Name: fppS [H]

Synonym: Nmul_A0235

Alternate gene names: 82701369

Gene position: 249318-250211 (Clockwise)

Preceding gene: 82701368

Following gene: 82701370

Centisome position: 7.83

GC content: 57.27

Gene sequence:

>894_bases
ATGACCGCTGATTTCCAGGATTGGGCGAGAAGCCACCAGGTACGCATCGAAAATTCCCTGCAGACCCTGCTTCCCGCCGC
AGACGTCGCGCCTGAGCGCTTGCATGAAGCGATGCGCTACACCGTTCTGGGTGGGGGCAAGCGCGTCCGGCCTTTACTCG
CTTTTGCAGCCGGCGAACTGAACAAGGCGAATGAGGAGAGGGTAACGATTGCTGCTATCGCAGTGGAACTCATTCATGTC
TATTCACTCGTGCACGACGATTTGCCCTGCATGGATGACGATGTATTGCGCCGGGGCAAGCCCACCTGCCATATCGAATA
TGGGGAAGCAATAGCGCTATTGACGGGTGACAGCTTGCAGAGCCTCGCTTTTCAGTTGCTGGCCGAATATTCCCTGGCCG
ACACCCCGAAGATGCAACTTGAAATGATCAGGCGCCTGGCGCAAGCGGCGGGTTCGCGCGGCATGGCGGGAGGGCAGGCT
GTCGATCTTGCCAGCGTGGGCAGGACACTAAGCCTCCCCGAACTGGAATTCATGCATATTCACAAGACAGGCGCACTTAT
TCGAGCCGCGGTAATGCTGGGTGCCTATTGTGGGAGCAGGTTGGACGAAGCCCAGTTGGCAGCCCTTGATCATTTTGCCA
AATGCATCGGTCTTGCATTTCAAGTTGTCGACGACGTTCTCGACGCCGAGGCAACCACTGCCGCCCTCGGCAAGACTGCC
GGCAAGGATGCCGAAAACAATAAGCCTACCTATGTGAGTATTCTGGGGAGCAAACGGGCCCGTGAACTCGCGGAGGAGTT
GCGGCGGGAAGCCTATGCATCCCTGGAGATGTTTGAGGCAGCTGCGGGGCGGTTGAGGCAGGTAACCGACTTTATCATTC
ACCGGGAATTTTGA

Upstream 100 bases:

>100_bases
GAATTGCTACAATATTGCCACTCCAAGTTGCAGGATGCTCAGCAGCAGGTACGCCTCCTTGAAGCCAACACACTGAAAAA
TTTCTCCCCTTCCGGTATTG

Downstream 100 bases:

>100_bases
AGAATTTTGACGACCAGCGTGTTTCCCGGAAAAAGGATTTTGTAATTTTCAAGGTTTAAATGCACCCATTGCTCAATACC
ATTACCGATCCTGTCAAGCT

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MTADFQDWARSHQVRIENSLQTLLPAADVAPERLHEAMRYTVLGGGKRVRPLLAFAAGELNKANEERVTIAAIAVELIHV
YSLVHDDLPCMDDDVLRRGKPTCHIEYGEAIALLTGDSLQSLAFQLLAEYSLADTPKMQLEMIRRLAQAAGSRGMAGGQA
VDLASVGRTLSLPELEFMHIHKTGALIRAAVMLGAYCGSRLDEAQLAALDHFAKCIGLAFQVVDDVLDAEATTAALGKTA
GKDAENNKPTYVSILGSKRARELAEELRREAYASLEMFEAAAGRLRQVTDFIIHREF

Sequences:

>Translated_297_residues
MTADFQDWARSHQVRIENSLQTLLPAADVAPERLHEAMRYTVLGGGKRVRPLLAFAAGELNKANEERVTIAAIAVELIHV
YSLVHDDLPCMDDDVLRRGKPTCHIEYGEAIALLTGDSLQSLAFQLLAEYSLADTPKMQLEMIRRLAQAAGSRGMAGGQA
VDLASVGRTLSLPELEFMHIHKTGALIRAAVMLGAYCGSRLDEAQLAALDHFAKCIGLAFQVVDDVLDAEATTAALGKTA
GKDAENNKPTYVSILGSKRARELAEELRREAYASLEMFEAAAGRLRQVTDFIIHREF
>Mature_296_residues
TADFQDWARSHQVRIENSLQTLLPAADVAPERLHEAMRYTVLGGGKRVRPLLAFAAGELNKANEERVTIAAIAVELIHVY
SLVHDDLPCMDDDVLRRGKPTCHIEYGEAIALLTGDSLQSLAFQLLAEYSLADTPKMQLEMIRRLAQAAGSRGMAGGQAV
DLASVGRTLSLPELEFMHIHKTGALIRAAVMLGAYCGSRLDEAQLAALDHFAKCIGLAFQVVDDVLDAEATTAALGKTAG
KDAENNKPTYVSILGSKRARELAEELRREAYASLEMFEAAAGRLRQVTDFIIHREF

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786623, Length=268, Percent_Identity=47.3880597014925, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1789578, Length=215, Percent_Identity=33.953488372093, Blast_Score=100, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24651612, Length=234, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32430; Mature: 32298

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADFQDWARSHQVRIENSLQTLLPAADVAPERLHEAMRYTVLGGGKRVRPLLAFAAGEL
CCCCHHHHHHHCCCHHHHHHHHHHCHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
NKANEERVTIAAIAVELIHVYSLVHDDLPCMDDDVLRRGKPTCHIEYGEAIALLTGDSLQ
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECCCEEEEEECCHHH
SLAFQLLAEYSLADTPKMQLEMIRRLAQAAGSRGMAGGQAVDLASVGRTLSLPELEFMHI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHCCCCCCCCCCHHEEE
HKTGALIRAAVMLGAYCGSRLDEAQLAALDHFAKCIGLAFQVVDDVLDAEATTAALGKTA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
GKDAENNKPTYVSILGSKRARELAEELRREAYASLEMFEAAAGRLRQVTDFIIHREF
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TADFQDWARSHQVRIENSLQTLLPAADVAPERLHEAMRYTVLGGGKRVRPLLAFAAGEL
CCCHHHHHHHCCCHHHHHHHHHHCHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
NKANEERVTIAAIAVELIHVYSLVHDDLPCMDDDVLRRGKPTCHIEYGEAIALLTGDSLQ
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECCCEEEEEECCHHH
SLAFQLLAEYSLADTPKMQLEMIRRLAQAAGSRGMAGGQAVDLASVGRTLSLPELEFMHI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHCCCCCCCCCCHHEEE
HKTGALIRAAVMLGAYCGSRLDEAQLAALDHFAKCIGLAFQVVDDVLDAEATTAALGKTA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
GKDAENNKPTYVSILGSKRARELAEELRREAYASLEMFEAAAGRLRQVTDFIIHREF
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9655913; 12597275 [H]