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The map label for this gene is apaH

Identifier: 82701340

GI number: 82701340

Start: 219806

End: 220633

Strand: Direct

Name: apaH

Synonym: Nmul_A0206

Alternate gene names: 82701340

Gene position: 219806-220633 (Clockwise)

Preceding gene: 82701339

Following gene: 82701349

Centisome position: 6.9

GC content: 57.25

Gene sequence:

>828_bases
ATGGCCATTTACGCAGTCGGTGACTTGCAAGGTTGCTATCGCGAGTTCCGGGAACTCCTCGACCTGGTTCGTTTCGACGA
GACGAAAGACAAGCTGTGGCTGGTGGGAGACCTGGTCAACCGGGGACCGGACTCGCTCTCGGTATTGCGCTTCGTAAAAG
AGTTGAACGACTCTGCAATAATGGTACTGGGCAATCATGATCTGCATCTGCTCCTGGTTGCGGAAGGGTGCGCGGAGCTA
AGCCGGAGCGATACCTTGCAGAACATCCTCGATGCACCCGATCGGGATGAATTGCTCGATTGGCTGCGGCGACAGAAGCT
GTTGCATGTGGACGGAAACTACGTCATGGTGCACGCCGGCCTGTTGCCTTCCTGGAGTATCGAACAGGCGCAAGTGCTTG
CTGCGCTGGTAGAGAGCGCCTTACGGGGAAGCGAATTCCATGAATTCTGCCGTCAGATGTACGGGAACCGGCCGGACCAC
TGGAATGAAACCCTCCACGGATATGAACGCCTGCGTGTAATCGTCAATGCCATGACGCGGATGCGCGTGTGCACTCCCCA
TGGAAGAATGGATTTTGCCCACAAGGGTTCGGTCAAGGACATTCCTCCCGGCTATTTGCCCTGGTTCGACGTGCCGGAGC
GAGCCAGCCGGAAGGCAACCGTCATCTGCGGTCATTGGTCAGCTCTGGGTCTAGAGATCAGGGCCAATCTGATGGCGCTC
GATACCGGGTGCTTATGGGGAGGCAGTCTTACGGCTGTTCGTCTGGAGGATCGGAAGGTTTTCCAGACGGAGTGTGGGGC
AGGGGGAGCGACAAGGCATTGGCAATAG

Upstream 100 bases:

>100_bases
TGCGGCGGGCGATGGGGAGAATTTCATATCGCCCTTGTTTTTTCAAGATAACCGGTTCATTTCGTTGCCTTCAGCCTGTT
GGTAATCGTTTTTCCATCTC

Downstream 100 bases:

>100_bases
CGTGCTCCGCGCTTCTTGCAAGCTCGCGGCGATTTTTCCCATGACTATCGATCGCCTCCGTAAAGACGAGTTCGACATCG
ATATGTGGCTGGCTCAATAC

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MAIYAVGDLQGCYREFRELLDLVRFDETKDKLWLVGDLVNRGPDSLSVLRFVKELNDSAIMVLGNHDLHLLLVAEGCAEL
SRSDTLQNILDAPDRDELLDWLRRQKLLHVDGNYVMVHAGLLPSWSIEQAQVLAALVESALRGSEFHEFCRQMYGNRPDH
WNETLHGYERLRVIVNAMTRMRVCTPHGRMDFAHKGSVKDIPPGYLPWFDVPERASRKATVICGHWSALGLEIRANLMAL
DTGCLWGGSLTAVRLEDRKVFQTECGAGGATRHWQ

Sequences:

>Translated_275_residues
MAIYAVGDLQGCYREFRELLDLVRFDETKDKLWLVGDLVNRGPDSLSVLRFVKELNDSAIMVLGNHDLHLLLVAEGCAEL
SRSDTLQNILDAPDRDELLDWLRRQKLLHVDGNYVMVHAGLLPSWSIEQAQVLAALVESALRGSEFHEFCRQMYGNRPDH
WNETLHGYERLRVIVNAMTRMRVCTPHGRMDFAHKGSVKDIPPGYLPWFDVPERASRKATVICGHWSALGLEIRANLMAL
DTGCLWGGSLTAVRLEDRKVFQTECGAGGATRHWQ
>Mature_274_residues
AIYAVGDLQGCYREFRELLDLVRFDETKDKLWLVGDLVNRGPDSLSVLRFVKELNDSAIMVLGNHDLHLLLVAEGCAELS
RSDTLQNILDAPDRDELLDWLRRQKLLHVDGNYVMVHAGLLPSWSIEQAQVLAALVESALRGSEFHEFCRQMYGNRPDHW
NETLHGYERLRVIVNAMTRMRVCTPHGRMDFAHKGSVKDIPPGYLPWFDVPERASRKATVICGHWSALGLEIRANLMALD
TGCLWGGSLTAVRLEDRKVFQTECGAGGATRHWQ

Specific function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ap4A hydrolase family

Homologues:

Organism=Escherichia coli, GI1786234, Length=264, Percent_Identity=47.7272727272727, Blast_Score=248, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APAH_NITMU (Q2YCK7)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_410906.1
- ProteinModelPortal:   Q2YCK7
- SMR:   Q2YCK7
- STRING:   Q2YCK7
- GeneID:   3785880
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0206
- eggNOG:   COG0639
- HOGENOM:   HBG724457
- OMA:   LVFGHWA
- PhylomeDB:   Q2YCK7
- ProtClustDB:   PRK00166
- BioCyc:   NMUL323848:NMUL_A0206-MONOMER
- HAMAP:   MF_00199
- InterPro:   IPR004617
- InterPro:   IPR004843
- PIRSF:   PIRSF000903
- TIGRFAMs:   TIGR00668

Pfam domain/function: PF00149 Metallophos

EC number: =3.6.1.41

Molecular weight: Translated: 31163; Mature: 31032

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIYAVGDLQGCYREFRELLDLVRFDETKDKLWLVGDLVNRGPDSLSVLRFVKELNDSAI
CEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCEE
MVLGNHDLHLLLVAEGCAELSRSDTLQNILDAPDRDELLDWLRRQKLLHVDGNYVMVHAG
EEEECCCEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCEEEEEEC
LLPSWSIEQAQVLAALVESALRGSEFHEFCRQMYGNRPDHWNETLHGYERLRVIVNAMTR
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
MRVCTPHGRMDFAHKGSVKDIPPGYLPWFDVPERASRKATVICGHWSALGLEIRANLMAL
HEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCEEEEEECHHHHCCEEEEEEEEE
DTGCLWGGSLTAVRLEDRKVFQTECGAGGATRHWQ
ECCCEECCCEEEEEECCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AIYAVGDLQGCYREFRELLDLVRFDETKDKLWLVGDLVNRGPDSLSVLRFVKELNDSAI
EEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCEE
MVLGNHDLHLLLVAEGCAELSRSDTLQNILDAPDRDELLDWLRRQKLLHVDGNYVMVHAG
EEEECCCEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCEEEEEEC
LLPSWSIEQAQVLAALVESALRGSEFHEFCRQMYGNRPDHWNETLHGYERLRVIVNAMTR
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
MRVCTPHGRMDFAHKGSVKDIPPGYLPWFDVPERASRKATVICGHWSALGLEIRANLMAL
HEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCEEEEEECHHHHCCEEEEEEEEE
DTGCLWGGSLTAVRLEDRKVFQTECGAGGATRHWQ
ECCCEECCCEEEEEECCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA