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The map label for this gene is exuT [H]

Identifier: 82546551

GI number: 82546551

Start: 4303639

End: 4304889

Strand: Direct

Name: exuT [H]

Synonym: SBO_4247

Alternate gene names: 82546551

Gene position: 4303639-4304889 (Clockwise)

Preceding gene: 82546550

Following gene: 82546553

Centisome position: 95.22

GC content: 47.24

Gene sequence:

>1251_bases
ATGAATAAAATAAAGAATTACCGGTGGCATATGATTGCCCTCGTATGCTTTATCACTGTAATCAATTATCTGGACAGAAC
GGCGTTAGGTATTGCGGCTCCAACGATTATGGAGACAACCGGAATAACTAAAGAGCAATATTCATGGATTGTCAGTGCAT
TCCAGTTGGCCTATACATTAGGGCAACCGGTAATGGGCTTCTTTATTGATACCGTGGGTCTGAAGTTAAGTTTTGCGATA
TGTGCCGCAATTTGGGGCCTGGCGACAATGGGCCATGCACTAACCGGAACGTGGTCTGGTCTGGCATTTATGCGCGCCCT
GATGGGTTTCAGCGAAGCGTCGGCAATTCCGGCGGGTGTAAAAACCGCATCAACATGGTTCCCGGCAAAAGAGCGTGGCG
TGGCGACAGGTGTTTTCAATATGGGCACCTCACTCGGCGCGATGCTTGCTCCACCGTTGATTGCCTGGTGCATTATGTTT
CATAGCTGGCAATTTGCGTTTATTGTTTCAGGTAGTCTTGCTTTGCTCGCGGCTTTATTTTGGTTCTTTTGTTATAAAGA
TCCGAAAGATGCCAAACGCCTTTCTGATGAAGAGCGCCACTATATTGAATCAGGGCAAGAACAGCATCTTAAAACAGATA
AGAAAGAAAAAACGTCAATCAAGCATATCCTCAGCCAACGTAATTTCTGGGGGATTGGCATCGCGCGTTTTCTCGCAGAC
CCGGCATGGGGAACCATTAACTTCTGGGTGCCGATTTTCTTCGTCGAAACGCTGCATTTTAGCCTGAAAGAAATTGCCAT
GTTCGTCTGGCTGCCTTTCCTGCTGGGCGATCTCGGCTGTTTAGCCAGTGGTTTTGTCGCGAAGTTCTTCCACGATCGCG
GCGTGAGTTTAATTAACTCACGAAGAATTACCTTCACTATTGCAGCCGTCATTATGATGACGATTGGCCTGGTGAGTATT
GTCGAAAATCCCTACATTGCCGTATTACTGATTAGTATTGGCGCGTTCTCGCATCAATGTCTTTCTACTGTAGCAGCAAC
TCTGGGTGGCGATCTGTTCAAAAAAGACGAAGTAGCTACCGCAGTGGGTATGGCAGTAGCCTGTGCGTGGAGCGGTCAGT
TGATTTTCAACCTGTTCATCGGGGCATTCGTTCACATTATCGGCTTCGCGCCGTTCTTTATTGCCCTGGCTTTCTTTGAC
ATTATTGGTGCTATTGCGTTGTGGACGCTGGTAATGACTCCAACTTACTGA

Upstream 100 bases:

>100_bases
CACAATAATTTTCAATATTTCCTCTGTACCTGATTTTTATTACCTATTACACGGAAATACCAACAACCAGGGTTTATTAA
TATAATTAAAAGGTTTAAAC

Downstream 100 bases:

>100_bases
TAGTGTTTTATGTTCAGATAATGCCCGATGACCTTGTCATGCAGCTCCACCGATTTTGAGAACGACAGTGACTTCCGTCC
CAGCCTTGCCAGATGTTGTC

Product: transport protein of hexuronates

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNKIKNYRWHMIALVCFITVINYLDRTALGIAAPTIMETTGITKEQYSWIVSAFQLAYTLGQPVMGFFIDTVGLKLSFAI
CAAIWGLATMGHALTGTWSGLAFMRALMGFSEASAIPAGVKTASTWFPAKERGVATGVFNMGTSLGAMLAPPLIAWCIMF
HSWQFAFIVSGSLALLAALFWFFCYKDPKDAKRLSDEERHYIESGQEQHLKTDKKEKTSIKHILSQRNFWGIGIARFLAD
PAWGTINFWVPIFFVETLHFSLKEIAMFVWLPFLLGDLGCLASGFVAKFFHDRGVSLINSRRITFTIAAVIMMTIGLVSI
VENPYIAVLLISIGAFSHQCLSTVAATLGGDLFKKDEVATAVGMAVACAWSGQLIFNLFIGAFVHIIGFAPFFIALAFFD
IIGAIALWTLVMTPTY

Sequences:

>Translated_416_residues
MNKIKNYRWHMIALVCFITVINYLDRTALGIAAPTIMETTGITKEQYSWIVSAFQLAYTLGQPVMGFFIDTVGLKLSFAI
CAAIWGLATMGHALTGTWSGLAFMRALMGFSEASAIPAGVKTASTWFPAKERGVATGVFNMGTSLGAMLAPPLIAWCIMF
HSWQFAFIVSGSLALLAALFWFFCYKDPKDAKRLSDEERHYIESGQEQHLKTDKKEKTSIKHILSQRNFWGIGIARFLAD
PAWGTINFWVPIFFVETLHFSLKEIAMFVWLPFLLGDLGCLASGFVAKFFHDRGVSLINSRRITFTIAAVIMMTIGLVSI
VENPYIAVLLISIGAFSHQCLSTVAATLGGDLFKKDEVATAVGMAVACAWSGQLIFNLFIGAFVHIIGFAPFFIALAFFD
IIGAIALWTLVMTPTY
>Mature_416_residues
MNKIKNYRWHMIALVCFITVINYLDRTALGIAAPTIMETTGITKEQYSWIVSAFQLAYTLGQPVMGFFIDTVGLKLSFAI
CAAIWGLATMGHALTGTWSGLAFMRALMGFSEASAIPAGVKTASTWFPAKERGVATGVFNMGTSLGAMLAPPLIAWCIMF
HSWQFAFIVSGSLALLAALFWFFCYKDPKDAKRLSDEERHYIESGQEQHLKTDKKEKTSIKHILSQRNFWGIGIARFLAD
PAWGTINFWVPIFFVETLHFSLKEIAMFVWLPFLLGDLGCLASGFVAKFFHDRGVSLINSRRITFTIAAVIMMTIGLVSI
VENPYIAVLLISIGAFSHQCLSTVAATLGGDLFKKDEVATAVGMAVACAWSGQLIFNLFIGAFVHIIGFAPFFIALAFFD
IIGAIALWTLVMTPTY

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI6912666, Length=309, Percent_Identity=27.5080906148867, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI9966811, Length=241, Percent_Identity=25.7261410788382, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI9945322, Length=355, Percent_Identity=25.0704225352113, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI154350196, Length=396, Percent_Identity=22.2222222222222, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI154800443, Length=269, Percent_Identity=25.6505576208178, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI148743791, Length=227, Percent_Identity=23.3480176211454, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI2367193, Length=414, Percent_Identity=47.8260869565217, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI87082320, Length=421, Percent_Identity=27.790973871734, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1789515, Length=344, Percent_Identity=27.0348837209302, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI2367379, Length=308, Percent_Identity=27.9220779220779, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789152, Length=330, Percent_Identity=23.6363636363636, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87082071, Length=233, Percent_Identity=26.6094420600858, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788573, Length=309, Percent_Identity=24.5954692556634, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87082310, Length=323, Percent_Identity=20.1238390092879, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552542, Length=219, Percent_Identity=26.9406392694064, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24583789, Length=314, Percent_Identity=25.796178343949, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24584153, Length=272, Percent_Identity=25.3676470588235, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641682, Length=299, Percent_Identity=24.7491638795987, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI20129235, Length=283, Percent_Identity=26.1484098939929, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24658666, Length=414, Percent_Identity=24.8792270531401, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45550495, Length=381, Percent_Identity=25.9842519685039, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24580790, Length=177, Percent_Identity=27.683615819209, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24658658, Length=357, Percent_Identity=22.96918767507, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI20130167, Length=394, Percent_Identity=23.6040609137056, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573299, Length=311, Percent_Identity=25.7234726688103, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24658674, Length=408, Percent_Identity=24.0196078431373, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45868; Mature: 45868

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIKNYRWHMIALVCFITVINYLDRTALGIAAPTIMETTGITKEQYSWIVSAFQLAYTL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHH
GQPVMGFFIDTVGLKLSFAICAAIWGLATMGHALTGTWSGLAFMRALMGFSEASAIPAGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCC
KTASTWFPAKERGVATGVFNMGTSLGAMLAPPLIAWCIMFHSWQFAFIVSGSLALLAALF
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHH
WFFCYKDPKDAKRLSDEERHYIESGQEQHLKTDKKEKTSIKHILSQRNFWGIGIARFLAD
HHHHCCCCHHHHHCCHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCC
PAWGTINFWVPIFFVETLHFSLKEIAMFVWLPFLLGDLGCLASGFVAKFFHDRGVSLINS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
RRITFTIAAVIMMTIGLVSIVENPYIAVLLISIGAFSHQCLSTVAATLGGDLFKKDEVAT
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AVGMAVACAWSGQLIFNLFIGAFVHIIGFAPFFIALAFFDIIGAIALWTLVMTPTY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKIKNYRWHMIALVCFITVINYLDRTALGIAAPTIMETTGITKEQYSWIVSAFQLAYTL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHH
GQPVMGFFIDTVGLKLSFAICAAIWGLATMGHALTGTWSGLAFMRALMGFSEASAIPAGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCC
KTASTWFPAKERGVATGVFNMGTSLGAMLAPPLIAWCIMFHSWQFAFIVSGSLALLAALF
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHH
WFFCYKDPKDAKRLSDEERHYIESGQEQHLKTDKKEKTSIKHILSQRNFWGIGIARFLAD
HHHHCCCCHHHHHCCHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCC
PAWGTINFWVPIFFVETLHFSLKEIAMFVWLPFLLGDLGCLASGFVAKFFHDRGVSLINS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
RRITFTIAAVIMMTIGLVSIVENPYIAVLLISIGAFSHQCLSTVAATLGGDLFKKDEVAT
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AVGMAVACAWSGQLIFNLFIGAFVHIIGFAPFFIALAFFDIIGAIALWTLVMTPTY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]