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The map label for this gene is rspB [H]

Identifier: 82546223

GI number: 82546223

Start: 3920478

End: 3921488

Strand: Direct

Name: rspB [H]

Synonym: SBO_3891

Alternate gene names: 82546223

Gene position: 3920478-3921488 (Clockwise)

Preceding gene: 82546222

Following gene: 82546226

Centisome position: 86.74

GC content: 52.72

Gene sequence:

>1011_bases
ATGGATAAAATTACCCAGGTTTTATTTTCAGATATTGGGAAAGTCACCACTCAATATGTTGAAGTACCACACCAGGAACT
TAAACCGCACGAAGTGCGGATTGCGCCTGTGTTCTATGGGATATGCGGTTCGGATCTGCATGTTCTGAAAGGCGGTCATC
CGTTTGCCAAACCACCTGTCGTCCCCGGTCATGAAATTGCAGCGCGCGTTACGGAAGTTGGCAGCGACGTTAAAAATGTA
CAGCCGGGCGATCATGTTGTGGTCGATCCCATCATGGCTTGCATGGAATGCCGAGCCTGCAAAGCAGGACGTTTTAATCT
TTGTGAACCACCGCAGGTTGCTAGTTTTCGCGCACCGGGCTTTGCTCGCTCACAACACATTGTTCCTGCGCGTAATTGCC
ATGTCGCACCAGCCTCTTTACCGCTAAAAGTGTTGGCCTTTGCCGAACCGGCGGCTTGTGCCCGTCACTGCGTTAACCGA
ATGCCGAAAGCTTCTCTGGAAAGCGTACTGGTAATTGGTGCCGGAACGATAGGCTTATCCATCGTGCAGGCACTGCGCAT
TATGGGGGCAGGTAAGATTACCGTGATTGAACCTGACGCTGCCAAACGCGCGCTGGCGTTAAAGCTGGGCGCAGCAGAAG
TTTGGGCACCAGGTGAGCTGGCCGCAGATGTGCGATTTACGGGGGCGATTGATGTCGTTGCAGCGCAGGCCACGCTTAAC
GATGCATGTACCCGTGTATATGCCGGAGGCACCGTCGTGTGCATGGGCGTACCAAGTGGGCCGCGTGAAATACCATTACC
GATGATGCAACGTTTCGAGCGTGACTTGCTCAACTCTGGCATGTACATCCCTGAAGATTTCGATGCTGTTATCGAATGGC
TGGCGGATGGGCGGTTTGATACCAGTGAACTGGTTACCGATTTATTTGCCATTGAGGATGCAGCGGCGGCATTTGAACGC
GCGCAGCAAAATGACTCCATAAAGGTCATGCTGCAATTTGCGCCGGAATGA

Upstream 100 bases:

>100_bases
ATCATACACTAAATCAGTAAGTTGGCAGCATTACCGAAATTGTCGATGAAGGTATCGCGCAACGCTAATCCCCTATGGAT
ATCGATTCTGGAGAATAACA

Downstream 100 bases:

>100_bases
TTTTCTAAATCTCTGTCTGGCGCTGCGTCACGTCAGCGCCACCCTACAACAATTAAAAAGGACACTGCGATGAGTCAAAT
CACCAGTCCTGCAACTTATT

Product: dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MDKITQVLFSDIGKVTTQYVEVPHQELKPHEVRIAPVFYGICGSDLHVLKGGHPFAKPPVVPGHEIAARVTEVGSDVKNV
QPGDHVVVDPIMACMECRACKAGRFNLCEPPQVASFRAPGFARSQHIVPARNCHVAPASLPLKVLAFAEPAACARHCVNR
MPKASLESVLVIGAGTIGLSIVQALRIMGAGKITVIEPDAAKRALALKLGAAEVWAPGELAADVRFTGAIDVVAAQATLN
DACTRVYAGGTVVCMGVPSGPREIPLPMMQRFERDLLNSGMYIPEDFDAVIEWLADGRFDTSELVTDLFAIEDAAAAFER
AQQNDSIKVMLQFAPE

Sequences:

>Translated_336_residues
MDKITQVLFSDIGKVTTQYVEVPHQELKPHEVRIAPVFYGICGSDLHVLKGGHPFAKPPVVPGHEIAARVTEVGSDVKNV
QPGDHVVVDPIMACMECRACKAGRFNLCEPPQVASFRAPGFARSQHIVPARNCHVAPASLPLKVLAFAEPAACARHCVNR
MPKASLESVLVIGAGTIGLSIVQALRIMGAGKITVIEPDAAKRALALKLGAAEVWAPGELAADVRFTGAIDVVAAQATLN
DACTRVYAGGTVVCMGVPSGPREIPLPMMQRFERDLLNSGMYIPEDFDAVIEWLADGRFDTSELVTDLFAIEDAAAAFER
AQQNDSIKVMLQFAPE
>Mature_336_residues
MDKITQVLFSDIGKVTTQYVEVPHQELKPHEVRIAPVFYGICGSDLHVLKGGHPFAKPPVVPGHEIAARVTEVGSDVKNV
QPGDHVVVDPIMACMECRACKAGRFNLCEPPQVASFRAPGFARSQHIVPARNCHVAPASLPLKVLAFAEPAACARHCVNR
MPKASLESVLVIGAGTIGLSIVQALRIMGAGKITVIEPDAAKRALALKLGAAEVWAPGELAADVRFTGAIDVVAAQATLN
DACTRVYAGGTVVCMGVPSGPREIPLPMMQRFERDLLNSGMYIPEDFDAVIEWLADGRFDTSELVTDLFAIEDAAAAFER
AQQNDSIKVMLQFAPE

Specific function: Not Known; Probable Catabolic Enzyme. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=330, Percent_Identity=29.3939393939394, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI71743840, Length=350, Percent_Identity=24.8571428571429, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4501929, Length=355, Percent_Identity=26.7605633802817, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI262073058, Length=350, Percent_Identity=24.8571428571429, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501933, Length=355, Percent_Identity=26.7605633802817, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI34577061, Length=355, Percent_Identity=26.1971830985915, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI71565152, Length=356, Percent_Identity=23.314606741573, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI71565154, Length=228, Percent_Identity=25.4385964912281, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787863, Length=316, Percent_Identity=31.0126582278481, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI226510992, Length=306, Percent_Identity=31.3725490196078, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788073, Length=347, Percent_Identity=29.1066282420749, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788407, Length=204, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790045, Length=329, Percent_Identity=25.531914893617, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790718, Length=314, Percent_Identity=28.0254777070064, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1786518, Length=268, Percent_Identity=30.5970149253731, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786552, Length=354, Percent_Identity=25.9887005649718, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786825, Length=184, Percent_Identity=31.5217391304348, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788075, Length=345, Percent_Identity=24.3478260869565, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=353, Percent_Identity=30.8781869688385, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17562878, Length=348, Percent_Identity=29.0229885057471, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25146526, Length=349, Percent_Identity=24.9283667621776, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=351, Percent_Identity=24.7863247863248, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=350, Percent_Identity=24.2857142857143, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=318, Percent_Identity=25.4716981132075, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=24.7787610619469, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319257, Length=363, Percent_Identity=31.129476584022, Blast_Score=126, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6319258, Length=368, Percent_Identity=28.804347826087, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322619, Length=354, Percent_Identity=26.5536723163842, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=354, Percent_Identity=26.271186440678, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=349, Percent_Identity=26.647564469914, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=347, Percent_Identity=25.9365994236311, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=270, Percent_Identity=29.6296296296296, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=273, Percent_Identity=27.8388278388278, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=274, Percent_Identity=27.7372262773723, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=273, Percent_Identity=26.3736263736264, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737897, Length=361, Percent_Identity=28.808864265928, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI17137530, Length=362, Percent_Identity=28.1767955801105, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17737895, Length=353, Percent_Identity=26.0623229461756, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 35996; Mature: 35996

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKITQVLFSDIGKVTTQYVEVPHQELKPHEVRIAPVFYGICGSDLHVLKGGHPFAKPPV
CCHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEEEECCCCCEEEEECCCCCCCCCC
VPGHEIAARVTEVGSDVKNVQPGDHVVVDPIMACMECRACKAGRFNLCEPPQVASFRAPG
CCCHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
FARSQHIVPARNCHVAPASLPLKVLAFAEPAACARHCVNRMPKASLESVLVIGAGTIGLS
CCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCHHCCCEEEEEECCHHHHH
IVQALRIMGAGKITVIEPDAAKRALALKLGAAEVWAPGELAADVRFTGAIDVVAAQATLN
HHHHHHHHCCCEEEEECCCHHHHEEHEEECCHHCCCCCCCEECEEECCCEEEEEHHHHHH
DACTRVYAGGTVVCMGVPSGPREIPLPMMQRFERDLLNSGMYIPEDFDAVIEWLADGRFD
HHHHHEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
TSELVTDLFAIEDAAAAFERAQQNDSIKVMLQFAPE
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCC
>Mature Secondary Structure
MDKITQVLFSDIGKVTTQYVEVPHQELKPHEVRIAPVFYGICGSDLHVLKGGHPFAKPPV
CCHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEEEECCCCCEEEEECCCCCCCCCC
VPGHEIAARVTEVGSDVKNVQPGDHVVVDPIMACMECRACKAGRFNLCEPPQVASFRAPG
CCCHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
FARSQHIVPARNCHVAPASLPLKVLAFAEPAACARHCVNRMPKASLESVLVIGAGTIGLS
CCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCHHCCCEEEEEECCHHHHH
IVQALRIMGAGKITVIEPDAAKRALALKLGAAEVWAPGELAADVRFTGAIDVVAAQATLN
HHHHHHHHCCCEEEEECCCHHHHEEHEEECCHHCCCCCCCEECEEECCCEEEEEHHHHHH
DACTRVYAGGTVVCMGVPSGPREIPLPMMQRFERDLLNSGMYIPEDFDAVIEWLADGRFD
HHHHHEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
TSELVTDLFAIEDAAAAFERAQQNDSIKVMLQFAPE
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]