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The map label for this gene is yihU [H]

Identifier: 82546219

GI number: 82546219

Start: 3917879

End: 3918757

Strand: Direct

Name: yihU [H]

Synonym: SBO_3887

Alternate gene names: 82546219

Gene position: 3917879-3918757 (Clockwise)

Preceding gene: 82546215

Following gene: 82546220

Centisome position: 86.68

GC content: 51.54

Gene sequence:

>879_bases
ATGGCAACCATTGCATTTCTCGGGCTGGGGCAGATGGGTAGCCCAATGGCTAACAATCTATTGCAAAAAGGGCATTCATT
GCAGGTATTTGATGTCAATGCACAGGCCGTCGATGCGCTAGTTACGCAGGGGGCCACTGCGGCACAAACCCAAGCGGAAG
CAGCAGCAGGCGCTGAATTTATCATCACTATGCTTCCCAATGGTGACATTGTTCGACAGGTTCTGTTGGGGGAAAAAGGC
GTCTGTGAGGCTGTTTCATCTGACGCGTTATTGATTGATATGTCGACTATTCATCCCTTACAGACCGATGCATTAATACG
GGAGTTACAAGAAAAAGGCATCAGTATGATGGACGCTCCCGTGGGCAGAACGTCCGTGAATGCGATTGATGGCACATTGC
TGATTTTAGCGGGTGGCACTGATGAGCAGATTGCACGTGCACGCCCGATTCTTATGTGCATGGGTAATGAGCTGGTCGAG
GCTGGCGGCCCAGGAATGGGGATCCGCGTGAAGCTAATTAACAACTATATGAGCATTGCGCTTAATGCGCTGTCCTCCGA
GGCCGCTGTGTTATGTGAGTCACTGGGATTAAATCTTGATGTCGCAATTAAGGTGATGAGTGGTACGGCAGCAGGGAAAG
GACATTTTACGACCACCTGGCCTGGCAAAGTGCTGAAAGGCGATCTTTCACCCGCCTTCATGGTGGATCTGGCGTTGAAA
GATCTGCGTATTGCAGTTGACGTCGCTCGGGAGACGGGGACACCGCTCAATATGGGGATTGCAGCAGAAAGTTATTACGC
TGCAGCAAGTCAAGACGGCAAAGGGCGGCAGGACTGGAGTGCCCTGCTAAATCAGGTTCGCCAGCAGGCTGGTCTTTAA

Upstream 100 bases:

>100_bases
GTGTCGTGTTTTTGAACATAAATCACAAATATGCTCAAAAACAGACAAAAACGAATTTTCAATTGTCATTATTTTGTCAA
TGTCAGACAGGAGAGTATTC

Downstream 100 bases:

>100_bases
TTTTATCTATTAACAGGAGTTTCTATGTCATCCCACTTCACCCCATTTACGCTGAAAGATATCTCCCGCCCAGGTGGTGG
ATTTGCCATGTTAGCTGTCG

Product: dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MATIAFLGLGQMGSPMANNLLQKGHSLQVFDVNAQAVDALVTQGATAAQTQAEAAAGAEFIITMLPNGDIVRQVLLGEKG
VCEAVSSDALLIDMSTIHPLQTDALIRELQEKGISMMDAPVGRTSVNAIDGTLLILAGGTDEQIARARPILMCMGNELVE
AGGPGMGIRVKLINNYMSIALNALSSEAAVLCESLGLNLDVAIKVMSGTAAGKGHFTTTWPGKVLKGDLSPAFMVDLALK
DLRIAVDVARETGTPLNMGIAAESYYAAASQDGKGRQDWSALLNQVRQQAGL

Sequences:

>Translated_292_residues
MATIAFLGLGQMGSPMANNLLQKGHSLQVFDVNAQAVDALVTQGATAAQTQAEAAAGAEFIITMLPNGDIVRQVLLGEKG
VCEAVSSDALLIDMSTIHPLQTDALIRELQEKGISMMDAPVGRTSVNAIDGTLLILAGGTDEQIARARPILMCMGNELVE
AGGPGMGIRVKLINNYMSIALNALSSEAAVLCESLGLNLDVAIKVMSGTAAGKGHFTTTWPGKVLKGDLSPAFMVDLALK
DLRIAVDVARETGTPLNMGIAAESYYAAASQDGKGRQDWSALLNQVRQQAGL
>Mature_291_residues
ATIAFLGLGQMGSPMANNLLQKGHSLQVFDVNAQAVDALVTQGATAAQTQAEAAAGAEFIITMLPNGDIVRQVLLGEKGV
CEAVSSDALLIDMSTIHPLQTDALIRELQEKGISMMDAPVGRTSVNAIDGTLLILAGGTDEQIARARPILMCMGNELVEA
GGPGMGIRVKLINNYMSIALNALSSEAAVLCESLGLNLDVAIKVMSGTAAGKGHFTTTWPGKVLKGDLSPAFMVDLALKD
LRIAVDVARETGTPLNMGIAAESYYAAASQDGKGRQDWSALLNQVRQQAGL

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=295, Percent_Identity=32.2033898305085, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI40556376, Length=281, Percent_Identity=26.3345195729537, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1790315, Length=292, Percent_Identity=72.2602739726027, Blast_Score=433, Evalue=1e-123,
Organism=Escherichia coli, GI145693186, Length=280, Percent_Identity=37.8571428571429, Blast_Score=161, Evalue=4e-41,
Organism=Escherichia coli, GI1786719, Length=282, Percent_Identity=30.4964539007092, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1789092, Length=283, Percent_Identity=29.3286219081272, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17557316, Length=310, Percent_Identity=28.7096774193548, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24655230, Length=295, Percent_Identity=32.2033898305085, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI19922568, Length=295, Percent_Identity=32.2033898305085, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24655240, Length=65, Percent_Identity=49.2307692307692, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28574115, Length=287, Percent_Identity=21.602787456446, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: 1.1.-.- [C]

Molecular weight: Translated: 30448; Mature: 30316

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIAFLGLGQMGSPMANNLLQKGHSLQVFDVNAQAVDALVTQGATAAQTQAEAAAGAEF
CCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCHHHHHHHHHCCCEE
IITMLPNGDIVRQVLLGEKGVCEAVSSDALLIDMSTIHPLQTDALIRELQEKGISMMDAP
EEEECCCCHHHHHHHHCCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEECCC
VGRTSVNAIDGTLLILAGGTDEQIARARPILMCMGNELVEAGGPGMGIRVKLINNYMSIA
CCCCCCCCCCCEEEEEECCCCHHHHHHCCEEEECCCHHHHCCCCCCEEEEEEHHHHHHHH
LNALSSEAAVLCESLGLNLDVAIKVMSGTAAGKGHFTTTWPGKVLKGDLSPAFMVDLALK
HHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCEEEECCCHHEECCCCHHHHHHHHHH
DLRIAVDVARETGTPLNMGIAAESYYAAASQDGKGRQDWSALLNQVRQQAGL
HHHHEEEEHHHCCCCCEECEECHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATIAFLGLGQMGSPMANNLLQKGHSLQVFDVNAQAVDALVTQGATAAQTQAEAAAGAEF
CEEEEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCHHHHHHHHHCCCEE
IITMLPNGDIVRQVLLGEKGVCEAVSSDALLIDMSTIHPLQTDALIRELQEKGISMMDAP
EEEECCCCHHHHHHHHCCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEECCC
VGRTSVNAIDGTLLILAGGTDEQIARARPILMCMGNELVEAGGPGMGIRVKLINNYMSIA
CCCCCCCCCCCEEEEEECCCCHHHHHHCCEEEECCCHHHHCCCCCCEEEEEEHHHHHHHH
LNALSSEAAVLCESLGLNLDVAIKVMSGTAAGKGHFTTTWPGKVLKGDLSPAFMVDLALK
HHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCEEEECCCHHEECCCCHHHHHHHHHH
DLRIAVDVARETGTPLNMGIAAESYYAAASQDGKGRQDWSALLNQVRQQAGL
HHHHEEEEHHHCCCCCEECEECHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8346018; 9278503 [H]