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The map label for this gene is lysP [H]

Identifier: 82544626

GI number: 82544626

Start: 2146927

End: 2148396

Strand: Direct

Name: lysP [H]

Synonym: SBO_2171

Alternate gene names: 82544626

Gene position: 2146927-2148396 (Clockwise)

Preceding gene: 82544625

Following gene: 82544628

Centisome position: 47.5

GC content: 53.67

Gene sequence:

>1470_bases
ATGGTTTCCGAAACTAAAACCACAGAAGCGCCGGGCTTACGCCGTGAATTAAAGGCGCGTCACCTGACGATGATTGCCAT
TGGCGGTTCCATCGGTACAGGTCTTTTTGTTGCCTCTGGCGCAACGATTCCTCAGGCAGGTCCGGGCGGGGCATTGCTCT
CGTATATGCTGATTGGCCTGATGGTTTACTTCCTGATGACCAGTCTCGGTGAACTGGCTGCATATATGCCGGTTTCCGGT
TCGTTTGCCACTTACGGTCAGAACTATGTCGAACAAGGCTTTGGCTTCGCGCTGGGCTGGAACTACTGGTACAACTGGGC
GGTGACTATCGCCGTTGACCTGGTTGCAGCTCAGCTGGTCATGAGCTGGTGGTTCCCGGATACACCGGGCTGGATCTGGA
GTGCGTTGTTCCTCGGCGTTATCTTCCTGCTGAACTACATCTCAGTTCGTGGCTTTGGTGAAGCGGAATACTGGTTCTCA
CTGATCAAAGTCACGACAGTTATTGTCTTTATCATCGTTGGCGTGCTGATGATTATCGGTATCTTCAAAGGCGCGCAGCC
TGCGGGCTGGAGCAACTGGACAATCGGCGAAGCGCCGTTTGCTGGTGGTTTTGCGGCGATGATCGGCGTAGCTATGATTG
TCGGCTTCTCTTTCCAGGGAACCGAGCTGATCGGTATTGCTGCAGGCGAGTCCGAAGATCCGGCGAAAAACATTCCACGC
GCGGTACGTCAGGTGTTCTGGCGAATCCTGTTGTTCTATGTGTTCGCGATCCTGATTATCAGCCTGATTATTCCGTACAC
CGATCCGAGCCTGCTGCGTAACGATGTTAAAGACATCAGCGTTAGTCCGTTCACCCTGGTGTTCCAGCACGCGGGTCTGC
TCTCTGCGGCGGCGGTGATGAACGCAGTTATTCTGACGGCGGTGCTGTCAGCCGGTAACTCCGGTATGTATGCGTCTACT
CGTATGCTGTACACCCTGGCGTGTGACGGTAAAGCGCCGCGCATTTTCGCTAAACTGTCGCGTGGTGGCGTGCCGCGTAA
TGCGCTGTATGCGACGACGGTGATTGCCGGTCTGTGCTTCCTGACCTCCATGTTTGGCAACCAGACGGTATACCTGTGGC
TGCTGAACACCTCCGGGATGACGGGTTTTATCGCCTGGCTGGGGATTGCCATTAGCCACTATCGCTTCCGTCGCGGTTAC
GTATTGCAGGGACACGACATTAACGATCTGCCGTACCGTTCAGGTTTCTTCCCACTGGGGCCGATCTTCGCATTCATTCT
GTGTCTGATTATCACTTTGGGCCAGAACTACGAAGCGTTCCTGAAAGATACCATTGACTGGGGCGGCGTAGCGGCAACGT
ATATTGGTATCCCGCTGTTCCTGATTATTTGGTTCGGCTACAAGCTGATTAAAGGAACTCACTTCGTACGCTACAGCGAA
ATGAAGTTCCCGCAGAACGATAAGAAATAA

Upstream 100 bases:

>100_bases
GCGATCATGAAGGTGTCTTATAACCGTGTATTTCTGCCGGAAGGATTGCCAATCGTCTGCTACAATCGCGCCTCATTTTT
AAGATGGATAGCATTTTTGT

Downstream 100 bases:

>100_bases
GTTTCCTCCCTTCCTTGCTAAGCCCTCTCAACCGAGAGGGCTTTTTCAATTCCATTTCCCTGACAAATCATGCGGATATA
AAATTTAACATTTGGATTGA

Product: lysine transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATIPQAGPGGALLSYMLIGLMVYFLMTSLGELAAYMPVSG
SFATYGQNYVEQGFGFALGWNYWYNWAVTIAVDLVAAQLVMSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFS
LIKVTTVIVFIIVGVLMIIGIFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPAKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VLQGHDINDLPYRSGFFPLGPIFAFILCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLIIWFGYKLIKGTHFVRYSE
MKFPQNDKK

Sequences:

>Translated_489_residues
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATIPQAGPGGALLSYMLIGLMVYFLMTSLGELAAYMPVSG
SFATYGQNYVEQGFGFALGWNYWYNWAVTIAVDLVAAQLVMSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFS
LIKVTTVIVFIIVGVLMIIGIFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPAKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VLQGHDINDLPYRSGFFPLGPIFAFILCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLIIWFGYKLIKGTHFVRYSE
MKFPQNDKK
>Mature_489_residues
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATIPQAGPGGALLSYMLIGLMVYFLMTSLGELAAYMPVSG
SFATYGQNYVEQGFGFALGWNYWYNWAVTIAVDLVAAQLVMSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFS
LIKVTTVIVFIIVGVLMIIGIFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPAKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VLQGHDINDLPYRSGFFPLGPIFAFILCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLIIWFGYKLIKGTHFVRYSE
MKFPQNDKK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=371, Percent_Identity=25.0673854447439, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1788480, Length=489, Percent_Identity=99.5910020449898, Blast_Score=978, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=438, Percent_Identity=39.9543378995434, Blast_Score=324, Evalue=7e-90,
Organism=Escherichia coli, GI48994972, Length=435, Percent_Identity=39.0804597701149, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1786789, Length=418, Percent_Identity=37.799043062201, Blast_Score=271, Evalue=9e-74,
Organism=Escherichia coli, GI1786302, Length=392, Percent_Identity=35.969387755102, Blast_Score=254, Evalue=7e-69,
Organism=Escherichia coli, GI1790653, Length=422, Percent_Identity=34.8341232227488, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1789017, Length=392, Percent_Identity=34.1836734693878, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI87081915, Length=400, Percent_Identity=34, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1786602, Length=406, Percent_Identity=36.6995073891626, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI87081869, Length=395, Percent_Identity=24.0506329113924, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87082023, Length=339, Percent_Identity=23.3038348082596, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082250, Length=236, Percent_Identity=28.3898305084746, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=389, Percent_Identity=24.6786632390745, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=474, Percent_Identity=36.4978902953587, Blast_Score=320, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6324990, Length=487, Percent_Identity=34.9075975359343, Blast_Score=309, Evalue=7e-85,
Organism=Saccharomyces cerevisiae, GI6324061, Length=495, Percent_Identity=33.5353535353535, Blast_Score=303, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6322892, Length=475, Percent_Identity=36.6315789473684, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6324059, Length=476, Percent_Identity=35.5042016806723, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6324924, Length=483, Percent_Identity=33.3333333333333, Blast_Score=274, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6321629, Length=502, Percent_Identity=29.8804780876494, Blast_Score=262, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6324553, Length=429, Percent_Identity=35.4312354312354, Blast_Score=260, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6319824, Length=472, Percent_Identity=29.2372881355932, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6322967, Length=470, Percent_Identity=31.4893617021277, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6321053, Length=464, Percent_Identity=29.0948275862069, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6320717, Length=482, Percent_Identity=27.5933609958506, Blast_Score=226, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6319543, Length=474, Percent_Identity=29.535864978903, Blast_Score=222, Evalue=9e-59,
Organism=Saccharomyces cerevisiae, GI6319542, Length=472, Percent_Identity=27.3305084745763, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6324981, Length=490, Percent_Identity=31.0204081632653, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6320251, Length=480, Percent_Identity=25.8333333333333, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6319608, Length=493, Percent_Identity=27.789046653144, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320364, Length=562, Percent_Identity=25.6227758007117, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI281366235, Length=396, Percent_Identity=23.4848484848485, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007820, Length=396, Percent_Identity=23.4848484848485, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221512776, Length=358, Percent_Identity=23.7430167597765, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24666159, Length=358, Percent_Identity=23.7430167597765, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53586; Mature: 53586

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATIPQAGPGGALLSYMLIGL
CCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
MVYFLMTSLGELAAYMPVSGSFATYGQNYVEQGFGFALGWNYWYNWAVTIAVDLVAAQLV
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHH
MSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFSLIKVTTVIVFIIVGVLMIIG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPAKNIPR
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NAVILTAVLSAGNSGMYASTRMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCF
HHHHHHHHHHCCCCCCEEHHEEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
LTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVLQGHDINDLPYRSGFFPLG
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHH
PIFAFILCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLIIWFGYKLIKGTHFVRYSE
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
MKFPQNDKK
CCCCCCCCC
>Mature Secondary Structure
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATIPQAGPGGALLSYMLIGL
CCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
MVYFLMTSLGELAAYMPVSGSFATYGQNYVEQGFGFALGWNYWYNWAVTIAVDLVAAQLV
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHH
MSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFSLIKVTTVIVFIIVGVLMIIG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPAKNIPR
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NAVILTAVLSAGNSGMYASTRMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCF
HHHHHHHHHHCCCCCCEEHHEEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
LTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVLQGHDINDLPYRSGFFPLG
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHH
PIFAFILCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLIIWFGYKLIKGTHFVRYSE
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
MKFPQNDKK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]