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The map label for this gene is ntpA [H]

Identifier: 82543704

GI number: 82543704

Start: 1182899

End: 1183351

Strand: Reverse

Name: ntpA [H]

Synonym: SBO_1188

Alternate gene names: 82543704

Gene position: 1183351-1182899 (Counterclockwise)

Preceding gene: 82543705

Following gene: 82543703

Centisome position: 26.18

GC content: 52.32

Gene sequence:

>453_bases
GTGAAGGATAAAGTGTATAAGCGTCCCGTTTCGATCTTAGTGGTCATCTATGCACAAGATACGAAACGGGTGCTGATGTT
GCAGCGGCGTGACGATCCCGATTTCTGGCAGTCGGTAACCGGCAGCGTGGAAGAGGGTGAAACCGCGCCGCAAGCTGCCA
TGCGCGAAGTAAAGGAAGAGGTCACCATTGATGTTGTCGCTGAACAACTGACCTTAATTGACAGTCAGCGCACGGTAGAG
TTTGAAATTTTTTCACATTTACGTCATCGCTATGCGCCGGGCGTGACGCGTAATACGGAATCATGGTTCTGTCTTGCGCT
TCCGCACGAGCGGCAGATCGTTTTCACTGAACATCTGGCTTACAAGTGGCTTGATGCGCCTGCTGCGGCGGCGCTCACTA
AGTCCTGGAGCAACCGGCAGGCGATTGAACAGTTTGTAATTAACGCTGCCTGA

Upstream 100 bases:

>100_bases
AAATCATTCGCGTTGCATCAAGGCGGCAATTGAGTGAACTCCCATGAGCATAGATAACTATGTGAATGGGATGAGCGAAG
GCAGTCAACGAAGAGGCAGC

Downstream 100 bases:

>100_bases
ACAGGCAGGGCTATCTGGAGATATTTTTATGGCAGGTCATAGTAAATGGGCCAACACCAGACATCGTAAAGCTGCGCAGG
ATGCTAAGCGCGGTAAAATC

Product: dATP pyrophosphohydrolase

Products: dAMP; pyrophosphate [C]

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MKDKVYKRPVSILVVIYAQDTKRVLMLQRRDDPDFWQSVTGSVEEGETAPQAAMREVKEEVTIDVVAEQLTLIDSQRTVE
FEIFSHLRHRYAPGVTRNTESWFCLALPHERQIVFTEHLAYKWLDAPAAAALTKSWSNRQAIEQFVINAA

Sequences:

>Translated_150_residues
MKDKVYKRPVSILVVIYAQDTKRVLMLQRRDDPDFWQSVTGSVEEGETAPQAAMREVKEEVTIDVVAEQLTLIDSQRTVE
FEIFSHLRHRYAPGVTRNTESWFCLALPHERQIVFTEHLAYKWLDAPAAAALTKSWSNRQAIEQFVINAA
>Mature_150_residues
MKDKVYKRPVSILVVIYAQDTKRVLMLQRRDDPDFWQSVTGSVEEGETAPQAAMREVKEEVTIDVVAEQLTLIDSQRTVE
FEIFSHLRHRYAPGVTRNTESWFCLALPHERQIVFTEHLAYKWLDAPAAAALTKSWSNRQAIEQFVINAA

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=150, Percent_Identity=99.3333333333333, Blast_Score=308, Evalue=7e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 17290; Mature: 17290

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKVYKRPVSILVVIYAQDTKRVLMLQRRDDPDFWQSVTGSVEEGETAPQAAMREVKEE
CCCCHHHCCEEEEEEEEECCCCEEEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHH
VTIDVVAEQLTLIDSQRTVEFEIFSHLRHRYAPGVTRNTESWFCLALPHERQIVFTEHLA
HHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEHHHHH
YKWLDAPAAAALTKSWSNRQAIEQFVINAA
HHHHCCCHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKDKVYKRPVSILVVIYAQDTKRVLMLQRRDDPDFWQSVTGSVEEGETAPQAAMREVKEE
CCCCHHHCCEEEEEEEEECCCCEEEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHH
VTIDVVAEQLTLIDSQRTVEFEIFSHLRHRYAPGVTRNTESWFCLALPHERQIVFTEHLA
HHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEHHHHH
YKWLDAPAAAALTKSWSNRQAIEQFVINAA
HHHHCCCHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]