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The map label for this gene is dmsA [H]

Identifier: 82543380

GI number: 82543380

Start: 844125

End: 846242

Strand: Direct

Name: dmsA [H]

Synonym: SBO_0827

Alternate gene names: 82543380

Gene position: 844125-846242 (Clockwise)

Preceding gene: 82543379

Following gene: 82543381

Centisome position: 18.68

GC content: 52.31

Gene sequence:

>2118_bases
ATGCGTCGCCGTGTCTACAATCCGGACCGCCTGAAATATCCGATGAAACGAGTCGGGGCGCGCGGTGAAGGCAAATTCGA
GCGCATTAGCTGGGAAGAAGCCTACGACATCATCGCGACCAATATGCAGCGCCTGATCAAAGAGTACGGCAACGAGTCTA
TCTATCTGAACTATGGCACCGGTACGCTGGGCGGCACCATGACCCGCTCCTGGCCGCCGGGAAATACCCTGGTCGCGCGG
CTGATGAACTGCTGCGGCGGCTATCTGAACCATTACGGCGACTACTCCTCCGCGCAAATTGCGGAAGGTTTGAACTATAC
CTACGGCGGCTGGGCAGATGGCAACAGCCCGTCGGATATCGAAAACAGTAAGCTGGTAGTGCTGTTTGGTAATAACCCTG
GCGAAACGCGAATGAGTGGCAGTGGGGTGACTTACTATCTTGAACAGGCACGCCAGAAATCTAATGCCCGCATGATCATC
ATCGATCCGCGCTATACCGACACCGGTGCCGGGCGCGAAGATGAGTGGATCCCTATTCGTCCGGGAACAGATGCCGCACT
GGTTAACGGTCTGGCGTACGTCATGATCACTGAAAACCTGGTGGATCAGGCATTCCTCGATAAATATTGCGTTGGCTACG
ATGAGAAAACCCTGCCAGCCAGTGCGCCGAAAAATGGCCACTATAAAGCTTATATTCTGGGTGAAGGGCCAGATGGCGTG
GCTAAAACACCGGAATGGGCCTCACAAATCACCGGTGTTCCGGCAGACAAAATCATCAAACTGGCTCGTGAAATCGGCAG
TACCAAACCGGCGTTTATCAGCCAGGGATGGGGCCCGCAGCGTCACGCTAACGGTGAAATCGCAACCCGTGCTATCTCGA
TGCTGGCGATTCTGACCGGTAACGTTGGTATTAACGGAGGCAACAGCGGCGCGCGTGAAGGTTCATACAGCTTACCGTTT
GTCCGTATGCCGACCTTGGAAAACCCGATCCAGACCAGCATTTCGATGTTTATGTGGACCGATGCCATTGAACGTGGCCC
GGAAATGACGGCGCTGCGTGATGGTGTACGCGGGAAAGATAAGCTGGATGTGCCGATCAAAATGATCTGGAACTATGCCG
GTAACTGCCTGATTAACCAGCATTCTGAAATCAACCGTACCCATGAAATCCTTCAGGATGATAAGAAGTGCGAGCTGATT
GTGGTTATCGACTGCCACATGACCTCATCGGCGAAATATGCTGACATCCTGCTGCCTGACTGCACCGCTTCCGAACAGAT
GGACTTTGCGCTGGATGCATCCTGCGGGAATATGTCTTACGTGATTTTCAACGATCAGGTGATTAAACCGCGCTTTGAAT
GTAAGACCATCTATGAAATGACCAGCGAACTGGCAAAACGTCTTGGCGTTGAGCAACAGTTTACTGAAGGCCGTACACAG
GAAGAGTGGATGCGGCATCTGTATGCCCAGTCGCGGGAAGCGATTCCTGAACTACCAACGTTTGAAGAGTTCCGCAAGCA
GGGGATCTTTAAAAAGCGCGACCCACAAGGGCACCACGTTGCTTATAAAGCTTTCCGTGAAGATCCTCAGGCAAATTCAC
TGACCACGCCATCGGGCAAAATTGAGATTTATTCGCAGGCGCTGGCTGACATTGCCGCTACCTGGGAATTGCCAGAAGGA
GATGTGATCGATCCACTGCCGATCTACACGCCGGGCTTTGAAAGTTATCAGGATCCGTTGAACAAACAGTATCCGCTGCA
GCTTACGGGTTTCCACTATAAATCTCGCGTTCACTCAACTTACGGCGACGTTGATGTGCTGAAAGCAGCTTGCCGTCAGG
AAATGTGGATCAACCCGCTTGATGCGCAAAAACGCGGTATCAACAACGGCGATAAAGTCAGGATCTTTAACGATCTTGGT
GAGGTTCATATTGAGGCGAAAGTGACGCCACGAATGATGCCGGGTGTGGTCGCACTGGGTGAAGGTGCCTGGTATGACCC
GGATACAAAACGTGTCGATAAGGGCGGTTGTATCAACGTACTGACCACTCAACGTCCGTCTCCTCTCGCTAAGGGGAATC
CGTCACATACAAACCTTGTTCAGGTTGAAAAGGTGTAA

Upstream 100 bases:

>100_bases
CGTCGTGGACGGTGAAATCAAATATGTCGAAACGGACAATACCGGCGATGACAATTACGACGGCCTGCACTAGGTTCGCG
CCTGCCTGCGTGGGCGTTCC

Downstream 100 bases:

>100_bases
GGAGTAACCGATGACAACCCAGTATGGATTTTTTATTGATTCCAGCCGTTGCACCGGTTGCAAAACCTGCGAGCTGGCCT
GTAAAGACTACAAAGATTTG

Product: anaerobic dimethyl sulfoxide reductase subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 705; Mature: 705

Protein sequence:

>705_residues
MRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIATNMQRLIKEYGNESIYLNYGTGTLGGTMTRSWPPGNTLVAR
LMNCCGGYLNHYGDYSSAQIAEGLNYTYGGWADGNSPSDIENSKLVVLFGNNPGETRMSGSGVTYYLEQARQKSNARMII
IDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVMITENLVDQAFLDKYCVGYDEKTLPASAPKNGHYKAYILGEGPDGV
AKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGAREGSYSLPF
VRMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYAGNCLINQHSEINRTHEILQDDKKCELI
VVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFNDQVIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQ
EEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQANSLTTPSGKIEIYSQALADIAATWELPEG
DVIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHSTYGDVDVLKAACRQEMWINPLDAQKRGINNGDKVRIFNDLG
EVHIEAKVTPRMMPGVVALGEGAWYDPDTKRVDKGGCINVLTTQRPSPLAKGNPSHTNLVQVEKV

Sequences:

>Translated_705_residues
MRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIATNMQRLIKEYGNESIYLNYGTGTLGGTMTRSWPPGNTLVAR
LMNCCGGYLNHYGDYSSAQIAEGLNYTYGGWADGNSPSDIENSKLVVLFGNNPGETRMSGSGVTYYLEQARQKSNARMII
IDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVMITENLVDQAFLDKYCVGYDEKTLPASAPKNGHYKAYILGEGPDGV
AKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGAREGSYSLPF
VRMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYAGNCLINQHSEINRTHEILQDDKKCELI
VVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFNDQVIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQ
EEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQANSLTTPSGKIEIYSQALADIAATWELPEG
DVIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHSTYGDVDVLKAACRQEMWINPLDAQKRGINNGDKVRIFNDLG
EVHIEAKVTPRMMPGVVALGEGAWYDPDTKRVDKGGCINVLTTQRPSPLAKGNPSHTNLVQVEKV
>Mature_705_residues
MRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIATNMQRLIKEYGNESIYLNYGTGTLGGTMTRSWPPGNTLVAR
LMNCCGGYLNHYGDYSSAQIAEGLNYTYGGWADGNSPSDIENSKLVVLFGNNPGETRMSGSGVTYYLEQARQKSNARMII
IDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVMITENLVDQAFLDKYCVGYDEKTLPASAPKNGHYKAYILGEGPDGV
AKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGAREGSYSLPF
VRMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYAGNCLINQHSEINRTHEILQDDKKCELI
VVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFNDQVIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQ
EEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQANSLTTPSGKIEIYSQALADIAATWELPEG
DVIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHSTYGDVDVLKAACRQEMWINPLDAQKRGINNGDKVRIFNDLG
EVHIEAKVTPRMMPGVVALGEGAWYDPDTKRVDKGGCINVLTTQRPSPLAKGNPSHTNLVQVEKV

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=705, Percent_Identity=99.1489361702128, Blast_Score=1464, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=709, Percent_Identity=67.5599435825106, Blast_Score=1025, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=709, Percent_Identity=66.2905500705219, Blast_Score=999, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=761, Percent_Identity=31.8002628120894, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI145693196, Length=756, Percent_Identity=31.8783068783069, Blast_Score=300, Evalue=3e-82,
Organism=Escherichia coli, GI87081994, Length=753, Percent_Identity=31.2084993359894, Blast_Score=274, Evalue=2e-74,
Organism=Escherichia coli, GI3868721, Length=726, Percent_Identity=25.068870523416, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI3868720, Length=360, Percent_Identity=28.3333333333333, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI3868719, Length=356, Percent_Identity=26.123595505618, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1787477, Length=237, Percent_Identity=25.7383966244726, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787741, Length=198, Percent_Identity=25.7575757575758, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 78715; Mature: 78715

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIATNMQRLIKEYGNESIYLNYGT
CCCCCCCCHHHCCCHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GTLGGTMTRSWPPGNTLVARLMNCCGGYLNHYGDYSSAQIAEGLNYTYGGWADGNSPSDI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCC
ENSKLVVLFGNNPGETRMSGSGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIR
CCCEEEEEECCCCCCCEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECC
PGTDAALVNGLAYVMITENLVDQAFLDKYCVGYDEKTLPASAPKNGHYKAYILGEGPDGV
CCCCHHHHCCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
AKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRAISMLAILTG
CCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
NVGINGGNSGAREGSYSLPFVRMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKD
CCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCC
KLDVPIKMIWNYAGNCLINQHSEINRTHEILQDDKKCELIVVIDCHMTSSAKYADILLPD
CCCCHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCEEEEECCC
CTASEQMDFALDASCGNMSYVIFNDQVIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQ
CCCCCCCCEEEECCCCCEEEEEECCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCH
EEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQANSLTTPSGK
HHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
IEIYSQALADIAATWELPEGDVIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHST
EEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEECCHHHHHHHHC
YGDVDVLKAACRQEMWINPLDAQKRGINNGDKVRIFNDLGEVHIEAKVTPRMMPGVVALG
CCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEEECCCCEEEEEEECCCCCCCEEEEC
EGAWYDPDTKRVDKGGCINVLTTQRPSPLAKGNPSHTNLVQVEKV
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIATNMQRLIKEYGNESIYLNYGT
CCCCCCCCHHHCCCHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GTLGGTMTRSWPPGNTLVARLMNCCGGYLNHYGDYSSAQIAEGLNYTYGGWADGNSPSDI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCC
ENSKLVVLFGNNPGETRMSGSGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIR
CCCEEEEEECCCCCCCEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECC
PGTDAALVNGLAYVMITENLVDQAFLDKYCVGYDEKTLPASAPKNGHYKAYILGEGPDGV
CCCCHHHHCCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
AKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRAISMLAILTG
CCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
NVGINGGNSGAREGSYSLPFVRMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKD
CCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCC
KLDVPIKMIWNYAGNCLINQHSEINRTHEILQDDKKCELIVVIDCHMTSSAKYADILLPD
CCCCHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCEEEEECCC
CTASEQMDFALDASCGNMSYVIFNDQVIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQ
CCCCCCCCEEEECCCCCEEEEEECCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCH
EEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQANSLTTPSGK
HHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
IEIYSQALADIAATWELPEGDVIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHST
EEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEECCHHHHHHHHC
YGDVDVLKAACRQEMWINPLDAQKRGINNGDKVRIFNDLGEVHIEAKVTPRMMPGVVALG
CCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEEECCCCEEEEEEECCCCCCCEEEEC
EGAWYDPDTKRVDKGGCINVLTTQRPSPLAKGNPSHTNLVQVEKV
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]