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The map label for this gene is fhuB [H]

Identifier: 82542753

GI number: 82542753

Start: 157615

End: 159597

Strand: Direct

Name: fhuB [H]

Synonym: SBO_0142

Alternate gene names: 82542753

Gene position: 157615-159597 (Clockwise)

Preceding gene: 82542752

Following gene: 82542755

Centisome position: 3.49

GC content: 59.46

Gene sequence:

>1983_bases
GTGAGTAAACGAATTGCGCTTTTCCCGGCGTTATTGCTGGCGCTGCTGGTGATTGTCGCTACGGCGCTGACCTGGATGAA
CTTTTCGCAGGCGCTGCCGCGTAGCCAGTGGGCGCAGGCCGCCTGGTCGCCGGATATTGACGTCATCGAGCAGATGATTT
TTCACTACAGCTTGCTGCCGCGTCTGGCGATTTCGCTGCTGGTGGGCGCAGGCCTGGGGCTGGTGGGCGTGCTGTTTCAG
CAAGTGCTGCGTAATCCGCTGGCGGAACCGACGACACTTGGCGTTGCTACAGGCGCGCAACTGGGGATTACCGTCACTAC
GCTCTGGGCGATCCCAGGGGCGATGGCGAGTCAGTTTGCTGCGCTGGCGGGCGCTTGCGTTGTTGGCTTAATCGTCTTTG
GCGTCGCGTGGGGGAAACGGCTTTCGCCGGTAACGCTGATCCTCGCGGGGCTGGTAGTGAGCCTTTATTGTGGGGCAATC
AATCAGTTACTGGTTATCTTCCACCATGACCAACTGCAAAGCATGTTCCTGTGGAGCACCGGAACGCTGACGCAAACCGA
CTGGGGCGGTGTTGAGCGTTTATGGCCGCAGTTGCTGGGCGGTGTGATGCTGACGTTGCTGCTACTTCGCCCGTTAACCC
TGATGGGGCTTGATGATGGCGTGGCGCGCAATCTCGGGCTGGCCTTGTCGCTCGCGCGTCTGGCGGCGCTGTCGCTGGCG
ATTGTCATCAGTGCGCTGCTGGTGAACGCGGTGGGGATTATCGGCTTTATCGGGTTGTTTGCGCCGTTGCTGGCAAAAAT
GCTGGGGGCGCGGCGTCTGCTGCCGCGACTGATGCTGGCGTCGTTGATTGGTGCGCTGATCCTCTGGCTTTCCGATCAAA
TCATCCTCTGGCTGACTCGCGTGTGGATGGAAGTGTCCACCGGTTCGGTCACTGCGTTGATCGGTGCGCCGCTGCTACTG
TGGCTGTTGCCGCGTTTACGCAGCATTAGCGCGCCGGATATGAAGGTCAACGATCGTGTCGCGGCTGAACGCCAACATGT
GCTGGCGTTTGCCCTCGCGGGCGGCGTGCTGCTGTTGATGGCTGTGGTGGTGGCGCTGTCGTTTGGTCGTGATGCGCACG
GCTGGATGTGGGCGAGCGGGGCGTTGCTCGATGATTTAATGCCCTGGCGCTGGCCGCGAATTATGGCGGCGCTATTTGCG
GGCGTCATGCTGGCGGTGGCGGGCTGTATTATTCAGCGACTGACCGGCAACCCGATGGCAAGCCCGGAAGTGCTGGGGAT
TAGCTCCGGCGCAGCGTTTGGCGTGGTACTGATGCTGTTTCTGGTACCGGGTAATGCTTTTGGCTGGCTGTTACCCGCGG
GAAGTATCGGTGCCGCGGTGACGCTGTTGATTATTATGATCGCCGCCGGGCGCGGTGGATTTTCCCCACACCGCATGTTA
CTGGCGGGGATGGCGTTAAGTACCGCATTCACCATGCTTTTAATGATGTTGCAGGCGAGTGGTGACCCGCGAATGGCGCA
AGTGCTCACCTGGATCTCTGGTTCGACCTACAACGCCACCGATGCGCAGGTCTGGCGTACCGGAATTGTGATGGTGATTT
TGCTGGCGATTACCCCGCTGTACCGCCGCTGGCTGACCATTTTACCTCTGGGCGGTGATACCGCACGAGCTGTGGGAATG
GCGCTGACGCCGACGCGAATTGCGCTGCTGCTGTTAGCGGCTTGCCTGACGGCGACCTCGACGATGACTATTGGACCGTT
GAGTTTTGTTGGTTTAATGGCACCGCATATTGCGCGGATGATGGGTTTTCGACGGACGATGCCACACATCGTAATTTCGG
CGCTGGTGGGTGGTTTACTGCTGGTATTCGCTGACTGGTGTGGGCGGATGGTGCTGTTTCCATTCCAGATCCCGGCGGGG
CTGCTGTCGACCTTTATCGGCGCGCCATATTTTATCTATTTGTTGAGAAAGCAGAGCCGTTAA

Upstream 100 bases:

>100_bases
CCGGACGCTTTCAGCGCGTACCCGCAGTCTGGTTTTATGGTGCGACGCTCTCGGCAATGCACTTTGTGCGCGTTCTGGAT
AACGCCATCGGAGGTAAAGC

Downstream 100 bases:

>100_bases
TTGAGTGCCTCGCCCGGTGGGCGAGGCAAAATTATCACAACTTCGCAAATACCCGACGTGCAGCATCGATGGTGTTATTG
ATATCTTCCATGCTGTGCGC

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSKRIALFPALLLALLVIVATALTWMNFSQALPRSQWAQAAWSPDIDVIEQMIFHYSLLPRLAISLLVGAGLGLVGVLFQ
QVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGAMASQFAALAGACVVGLIVFGVAWGKRLSPVTLILAGLVVSLYCGAI
NQLLVIFHHDQLQSMFLWSTGTLTQTDWGGVERLWPQLLGGVMLTLLLLRPLTLMGLDDGVARNLGLALSLARLAALSLA
IVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLPRLMLASLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLL
WLLPRLRSISAPDMKVNDRVAAERQHVLAFALAGGVLLLMAVVVALSFGRDAHGWMWASGALLDDLMPWRWPRIMAALFA
GVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGSIGAAVTLLIIMIAAGRGGFSPHRML
LAGMALSTAFTMLLMMLQASGDPRMAQVLTWISGSTYNATDAQVWRTGIVMVILLAITPLYRRWLTILPLGGDTARAVGM
ALTPTRIALLLLAACLTATSTMTIGPLSFVGLMAPHIARMMGFRRTMPHIVISALVGGLLLVFADWCGRMVLFPFQIPAG
LLSTFIGAPYFIYLLRKQSR

Sequences:

>Translated_660_residues
MSKRIALFPALLLALLVIVATALTWMNFSQALPRSQWAQAAWSPDIDVIEQMIFHYSLLPRLAISLLVGAGLGLVGVLFQ
QVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGAMASQFAALAGACVVGLIVFGVAWGKRLSPVTLILAGLVVSLYCGAI
NQLLVIFHHDQLQSMFLWSTGTLTQTDWGGVERLWPQLLGGVMLTLLLLRPLTLMGLDDGVARNLGLALSLARLAALSLA
IVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLPRLMLASLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLL
WLLPRLRSISAPDMKVNDRVAAERQHVLAFALAGGVLLLMAVVVALSFGRDAHGWMWASGALLDDLMPWRWPRIMAALFA
GVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGSIGAAVTLLIIMIAAGRGGFSPHRML
LAGMALSTAFTMLLMMLQASGDPRMAQVLTWISGSTYNATDAQVWRTGIVMVILLAITPLYRRWLTILPLGGDTARAVGM
ALTPTRIALLLLAACLTATSTMTIGPLSFVGLMAPHIARMMGFRRTMPHIVISALVGGLLLVFADWCGRMVLFPFQIPAG
LLSTFIGAPYFIYLLRKQSR
>Mature_659_residues
SKRIALFPALLLALLVIVATALTWMNFSQALPRSQWAQAAWSPDIDVIEQMIFHYSLLPRLAISLLVGAGLGLVGVLFQQ
VLRNPLAEPTTLGVATGAQLGITVTTLWAIPGAMASQFAALAGACVVGLIVFGVAWGKRLSPVTLILAGLVVSLYCGAIN
QLLVIFHHDQLQSMFLWSTGTLTQTDWGGVERLWPQLLGGVMLTLLLLRPLTLMGLDDGVARNLGLALSLARLAALSLAI
VISALLVNAVGIIGFIGLFAPLLAKMLGARRLLPRLMLASLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLLW
LLPRLRSISAPDMKVNDRVAAERQHVLAFALAGGVLLLMAVVVALSFGRDAHGWMWASGALLDDLMPWRWPRIMAALFAG
VMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGSIGAAVTLLIIMIAAGRGGFSPHRMLL
AGMALSTAFTMLLMMLQASGDPRMAQVLTWISGSTYNATDAQVWRTGIVMVILLAITPLYRRWLTILPLGGDTARAVGMA
LTPTRIALLLLAACLTATSTMTIGPLSFVGLMAPHIARMMGFRRTMPHIVISALVGGLLLVFADWCGRMVLFPFQIPAGL
LSTFIGAPYFIYLLRKQSR

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=660, Percent_Identity=99.0909090909091, Blast_Score=1255, Evalue=0.0,
Organism=Escherichia coli, GI1790740, Length=276, Percent_Identity=36.5942028985507, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790741, Length=281, Percent_Identity=35.2313167259786, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI1786804, Length=278, Percent_Identity=31.6546762589928, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1786805, Length=277, Percent_Identity=35.0180505415162, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1788004, Length=274, Percent_Identity=32.1167883211679, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 70501; Mature: 70370

Theoretical pI: Translated: 11.37; Mature: 11.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRIALFPALLLALLVIVATALTWMNFSQALPRSQWAQAAWSPDIDVIEQMIFHYSLLP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHH
RLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGAMASQFA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHCCHHHHHHHH
ALAGACVVGLIVFGVAWGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWST
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTLTQTDWGGVERLWPQLLGGVMLTLLLLRPLTLMGLDDGVARNLGLALSLARLAALSLA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
IVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLPRLMLASLIGALILWLSDQIILWLTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWMEVSTGSVTALIGAPLLLWLLPRLRSISAPDMKVNDRVAAERQHVLAFALAGGVLLLM
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVVVALSFGRDAHGWMWASGALLDDLMPWRWPRIMAALFAGVMLAVAGCIIQRLTGNPMA
HHHHHHHCCCCCCCCEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGSIGAAVTLLIIMIAAGRGGFSPHRML
CCCEEECCCCHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHH
LAGMALSTAFTMLLMMLQASGDPRMAQVLTWISGSTYNATDAQVWRTGIVMVILLAITPL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YRRWLTILPLGGDTARAVGMALTPTRIALLLLAACLTATSTMTIGPLSFVGLMAPHIARM
HHHHHHEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHH
MGFRRTMPHIVISALVGGLLLVFADWCGRMVLFPFQIPAGLLSTFIGAPYFIYLLRKQSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHCCHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure 
SKRIALFPALLLALLVIVATALTWMNFSQALPRSQWAQAAWSPDIDVIEQMIFHYSLLP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHH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PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3020380; 8202364; 9278503; 2823072 [H]