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The map label for this gene is ubiB [C]

Identifier: 78780192

GI number: 78780192

Start: 1705529

End: 1707385

Strand: Direct

Name: ubiB [C]

Synonym: PMT9312_1806

Alternate gene names: 78780192

Gene position: 1705529-1707385 (Clockwise)

Preceding gene: 78780188

Following gene: 78780193

Centisome position: 99.78

GC content: 31.39

Gene sequence:

>1857_bases
ATGAAAGAAGATTTTACTGATTTTATTGAAGTATCTGGACTGTTGGATTATGATCCAGATACAATATCTAAAATTTACAA
AAAAAACCCTAAAAGACTTTTAAAAAGACTTTGGCAAACACTTATACCTATTTTTGCTTATATATTTTCTGTAGGGTGGG
ATAAATTAACTGGTAAATTAAATAATAATGAAACTGCAAGATTTAGGGCAAAAGAATTAACAAATTTATTAGTAGAACTT
GGGCCAGCATTTGTTAAAGCAGGTCAAGCTTTATCAACAAGGCCAGATATAATTCCAGGGATTCTTCTTGAAGAATTATC
TAACTTGCAAGATCAACTACCAGGATTTAATGGTGATAAGGCTATGGAATTAATAGAAGAAGATTTAGGATCCAAAATAG
ATGAAATTTTTTTAGCAATTGATAAAGAACCAATTTCTGCTGCTTCTCTAGGTCAAGTGCATAAAGGTAAACTAAAGAAT
GAAGAAATTGTTGCAGTTAAAGTGCAACGACCAGGTTTAAGAGAACAGATTACTTTAGACCTTTACATAGTAAGAAATAT
TGCCTATTGGCTAAAAAACAATATTGGATTAATAAGAAGTGATCTCGTGGCATTGATTGATGAATTAGGCAAGAGAGTTT
TTGAAGAGATGGATTACTTAAACGAAGCTGAAAATGCAGAAAAGTTTAGAAATATGCATAAACATAACCAAATGATTGCC
GTGCCAAAAATTTATAAAGAAATAACATCAAGAAGAGTTTTAACAATGGAATGGATCGAAGGTACAAAATTAACTAATTT
AGAAGATGTAAAAAAATTAGGAATCGATCCTGACAAGATGATAGATATAGGCGTGCAGTGCAGCTTAGAACAGCTTTTAG
AACATGGTTTTTTTCACGCTGACCCTCATCCAGGAAATTTATTAGCCTTGAAAGATGGCAGATTATGTTATTTAGATTTT
GGAATGATGAGCGAAGTATCTAGAGACTCTAGGTCTGGTTTAATACAAGCAGTTGTACATTTAGTAAATAAAAACTTCGA
TAAATTATCTCAAGATTTTGTAAAATTAGGATTTTTATCCGAAGAAGTTAATCTTGAACCAATAGTTCCCGCATTTCAGG
ATATTTTCATTAATGCAGTTGAACAAGGAGTTTCAAAAATGGATTTCAAGAGCGTTACAGACGACATGTCTGGTGTTATG
TATAAATTCCCATTCAGATTACCCCCATACTATGCGCTTATAATCAGGTCATTACTGACATTAGAAGGTATTGCATTAAG
CGTCGACCCAAATTTTAAAATATTAGGTGCAGCTTATCCATATTTTGCGAGAAGATTGATGGAAGATCCTGACCCACAAT
TAAGAGAAAGTTTGAAAGAAATGCTTTTTGATGATAAAAAATTTAAATGGGACCGCTTAGAAGATCTTCTTTCTAACGCT
GCAAAGCAAACAAATCTTGATTTAGAAAAGCTTTTAGATGAAGTCATCAATCTTCTCTTTTCACCAAAAGGAGGGTTTCT
AAGAAATGAAATAATTGAAGGCCTAACAAATCAAATAGATTTAATAAGTCTTAAACTACTGAAAAATTTAAATCACTATC
TTCCTAACTCAATTAAATTAAATATGACTGATGAAAATAACAACTTAAGTGACCTTATAATGTATGTAACACCATTAAGA
AACTTTTTAGAGATTTTACAGAAAGTACCAGGATATTCTATTGATATTTTTCTAAAAAGAGTTCCTCGACTTATTAACGA
GCCTTATACAAAAGAAATGGGTATAAAAATTGCAAAAAAAGTAACCGAAAAAGGAGTAGTTAGACTCGTAAAGATTGCCG
CTGGAGCAAATATCTAA

Upstream 100 bases:

>100_bases
GCTATATTTTTTATTTTTAATTGTATTAGCATGATAAATCTTCCATATAAAAAAATTAACTTCTTTTTTAAAAAAATAAA
GGTATTAAATATATAAAGTT

Downstream 100 bases:

>100_bases
TATGAACTTTAATAAAATTATAATAATAAAATTATTTTTTATTATTATAAATTTTCAATTTCTTTTTAATATTCCAAAAG
CTAATGCTGCTGAAGAAATT

Product: putative protein kinase:ABC1 family

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MKEDFTDFIEVSGLLDYDPDTISKIYKKNPKRLLKRLWQTLIPIFAYIFSVGWDKLTGKLNNNETARFRAKELTNLLVEL
GPAFVKAGQALSTRPDIIPGILLEELSNLQDQLPGFNGDKAMELIEEDLGSKIDEIFLAIDKEPISAASLGQVHKGKLKN
EEIVAVKVQRPGLREQITLDLYIVRNIAYWLKNNIGLIRSDLVALIDELGKRVFEEMDYLNEAENAEKFRNMHKHNQMIA
VPKIYKEITSRRVLTMEWIEGTKLTNLEDVKKLGIDPDKMIDIGVQCSLEQLLEHGFFHADPHPGNLLALKDGRLCYLDF
GMMSEVSRDSRSGLIQAVVHLVNKNFDKLSQDFVKLGFLSEEVNLEPIVPAFQDIFINAVEQGVSKMDFKSVTDDMSGVM
YKFPFRLPPYYALIIRSLLTLEGIALSVDPNFKILGAAYPYFARRLMEDPDPQLRESLKEMLFDDKKFKWDRLEDLLSNA
AKQTNLDLEKLLDEVINLLFSPKGGFLRNEIIEGLTNQIDLISLKLLKNLNHYLPNSIKLNMTDENNNLSDLIMYVTPLR
NFLEILQKVPGYSIDIFLKRVPRLINEPYTKEMGIKIAKKVTEKGVVRLVKIAAGANI

Sequences:

>Translated_618_residues
MKEDFTDFIEVSGLLDYDPDTISKIYKKNPKRLLKRLWQTLIPIFAYIFSVGWDKLTGKLNNNETARFRAKELTNLLVEL
GPAFVKAGQALSTRPDIIPGILLEELSNLQDQLPGFNGDKAMELIEEDLGSKIDEIFLAIDKEPISAASLGQVHKGKLKN
EEIVAVKVQRPGLREQITLDLYIVRNIAYWLKNNIGLIRSDLVALIDELGKRVFEEMDYLNEAENAEKFRNMHKHNQMIA
VPKIYKEITSRRVLTMEWIEGTKLTNLEDVKKLGIDPDKMIDIGVQCSLEQLLEHGFFHADPHPGNLLALKDGRLCYLDF
GMMSEVSRDSRSGLIQAVVHLVNKNFDKLSQDFVKLGFLSEEVNLEPIVPAFQDIFINAVEQGVSKMDFKSVTDDMSGVM
YKFPFRLPPYYALIIRSLLTLEGIALSVDPNFKILGAAYPYFARRLMEDPDPQLRESLKEMLFDDKKFKWDRLEDLLSNA
AKQTNLDLEKLLDEVINLLFSPKGGFLRNEIIEGLTNQIDLISLKLLKNLNHYLPNSIKLNMTDENNNLSDLIMYVTPLR
NFLEILQKVPGYSIDIFLKRVPRLINEPYTKEMGIKIAKKVTEKGVVRLVKIAAGANI
>Mature_618_residues
MKEDFTDFIEVSGLLDYDPDTISKIYKKNPKRLLKRLWQTLIPIFAYIFSVGWDKLTGKLNNNETARFRAKELTNLLVEL
GPAFVKAGQALSTRPDIIPGILLEELSNLQDQLPGFNGDKAMELIEEDLGSKIDEIFLAIDKEPISAASLGQVHKGKLKN
EEIVAVKVQRPGLREQITLDLYIVRNIAYWLKNNIGLIRSDLVALIDELGKRVFEEMDYLNEAENAEKFRNMHKHNQMIA
VPKIYKEITSRRVLTMEWIEGTKLTNLEDVKKLGIDPDKMIDIGVQCSLEQLLEHGFFHADPHPGNLLALKDGRLCYLDF
GMMSEVSRDSRSGLIQAVVHLVNKNFDKLSQDFVKLGFLSEEVNLEPIVPAFQDIFINAVEQGVSKMDFKSVTDDMSGVM
YKFPFRLPPYYALIIRSLLTLEGIALSVDPNFKILGAAYPYFARRLMEDPDPQLRESLKEMLFDDKKFKWDRLEDLLSNA
AKQTNLDLEKLLDEVINLLFSPKGGFLRNEIIEGLTNQIDLISLKLLKNLNHYLPNSIKLNMTDENNNLSDLIMYVTPLR
NFLEILQKVPGYSIDIFLKRVPRLINEPYTKEMGIKIAKKVTEKGVVRLVKIAAGANI

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=290, Percent_Identity=31.0344827586207, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI41393593, Length=263, Percent_Identity=30.4182509505703, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI217035081, Length=231, Percent_Identity=32.4675324675325, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI27363457, Length=324, Percent_Identity=29.320987654321, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI34147522, Length=299, Percent_Identity=29.4314381270903, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI217416386, Length=288, Percent_Identity=29.5138888888889, Blast_Score=94, Evalue=5e-19,
Organism=Escherichia coli, GI2367309, Length=407, Percent_Identity=25.5528255528256, Blast_Score=163, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17559152, Length=269, Percent_Identity=35.3159851301115, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI32565180, Length=304, Percent_Identity=26.9736842105263, Blast_Score=82, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6323282, Length=240, Percent_Identity=33.75, Blast_Score=123, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6325148, Length=435, Percent_Identity=23.2183908045977, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321319, Length=264, Percent_Identity=28.4090909090909, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI22024280, Length=300, Percent_Identity=30.6666666666667, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24662575, Length=268, Percent_Identity=33.2089552238806, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI18859849, Length=260, Percent_Identity=28.4615384615385, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 70519; Mature: 70519

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEDFTDFIEVSGLLDYDPDTISKIYKKNPKRLLKRLWQTLIPIFAYIFSVGWDKLTGKL
CCCHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCC
NNNETARFRAKELTNLLVELGPAFVKAGQALSTRPDIIPGILLEELSNLQDQLPGFNGDK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHH
AMELIEEDLGSKIDEIFLAIDKEPISAASLGQVHKGKLKNEEIVAVKVQRPGLREQITLD
HHHHHHHHHCCHHHHHHHHCCCCCCCHHHHCCHHCCCCCCCCEEEEEECCCCCCHHHHHH
LYIVRNIAYWLKNNIGLIRSDLVALIDELGKRVFEEMDYLNEAENAEKFRNMHKHNQMIA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VPKIYKEITSRRVLTMEWIEGTKLTNLEDVKKLGIDPDKMIDIGVQCSLEQLLEHGFFHA
HHHHHHHHHCCCEEEEEHHCCCCCCCHHHHHHHCCCHHHHEECCCCCCHHHHHHCCCCCC
DPHPGNLLALKDGRLCYLDFGMMSEVSRDSRSGLIQAVVHLVNKNFDKLSQDFVKLGFLS
CCCCCCEEEEECCCEEEEECHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
EEVNLEPIVPAFQDIFINAVEQGVSKMDFKSVTDDMSGVMYKFPFRLPPYYALIIRSLLT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
LEGIALSVDPNFKILGAAYPYFARRLMEDPDPQLRESLKEMLFDDKKFKWDRLEDLLSNA
HCCEEEEECCCEEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AKQTNLDLEKLLDEVINLLFSPKGGFLRNEIIEGLTNQIDLISLKLLKNLNHYLPNSIKL
HHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEE
NMTDENNNLSDLIMYVTPLRNFLEILQKVPGYSIDIFLKRVPRLINEPYTKEMGIKIAKK
EECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHH
VTEKGVVRLVKIAAGANI
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKEDFTDFIEVSGLLDYDPDTISKIYKKNPKRLLKRLWQTLIPIFAYIFSVGWDKLTGKL
CCCHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCC
NNNETARFRAKELTNLLVELGPAFVKAGQALSTRPDIIPGILLEELSNLQDQLPGFNGDK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHH
AMELIEEDLGSKIDEIFLAIDKEPISAASLGQVHKGKLKNEEIVAVKVQRPGLREQITLD
HHHHHHHHHCCHHHHHHHHCCCCCCCHHHHCCHHCCCCCCCCEEEEEECCCCCCHHHHHH
LYIVRNIAYWLKNNIGLIRSDLVALIDELGKRVFEEMDYLNEAENAEKFRNMHKHNQMIA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VPKIYKEITSRRVLTMEWIEGTKLTNLEDVKKLGIDPDKMIDIGVQCSLEQLLEHGFFHA
HHHHHHHHHCCCEEEEEHHCCCCCCCHHHHHHHCCCHHHHEECCCCCCHHHHHHCCCCCC
DPHPGNLLALKDGRLCYLDFGMMSEVSRDSRSGLIQAVVHLVNKNFDKLSQDFVKLGFLS
CCCCCCEEEEECCCEEEEECHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
EEVNLEPIVPAFQDIFINAVEQGVSKMDFKSVTDDMSGVMYKFPFRLPPYYALIIRSLLT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
LEGIALSVDPNFKILGAAYPYFARRLMEDPDPQLRESLKEMLFDDKKFKWDRLEDLLSNA
HCCEEEEECCCEEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AKQTNLDLEKLLDEVINLLFSPKGGFLRNEIIEGLTNQIDLISLKLLKNLNHYLPNSIKL
HHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEE
NMTDENNNLSDLIMYVTPLRNFLEILQKVPGYSIDIFLKRVPRLINEPYTKEMGIKIAKK
EECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHH
VTEKGVVRLVKIAAGANI
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]