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The map label for this gene is hemF [H]

Identifier: 78780059

GI number: 78780059

Start: 1564023

End: 1565051

Strand: Direct

Name: hemF [H]

Synonym: PMT9312_1674

Alternate gene names: 78780059

Gene position: 1564023-1565051 (Clockwise)

Preceding gene: 78780048

Following gene: 78780061

Centisome position: 91.51

GC content: 33.72

Gene sequence:

>1029_bases
ATGTTGAAAGAACCTCCTAAAAACTCGAGAGAAAAAACTAAAAATCTCTTATTAACTCTACAAGACAAAATTTGTTCAGG
GCTTGAAAATATAGATGGAAAAGGGAAATTTACAGAAGAATCCTGGCTAAGAGACGAAGGTGGCGGTGGAAGATCAAGAG
TATTGAAAAATGGTTCTATTTTTGAGCAAGCAGGAGTAAATTTTTCGGAAGTACAGGGAAAAGAATTACCTCAATCTATA
ATCTCCCAAAGGCCCGAAGCAAAAGGTCATGAATGGTTTGCTACGGGAACTTCTATGGTTTTGCATCCTAAGAATCCCTT
TATTCCAACAGTTCATCTGAATTATCGATATTTCGAAGCTGGTCCTGTTTGGTGGTTTGGCGGAGGTGCAGACTTAACCC
CTTTTTATCCATATCTTTCTGATGTGAGAAATTTTCATAAAGAACATAAAAAAGCTTGTGAAAAAGTTGATAAAGACTTA
CATAAAGTTTTTAAACCATGGTGTGATGAATATTTCTTCTTAAAGCACAGAAATGAATCTAGAGGAATAGGTGGTATTTT
TTATGACTATCAAGATGGTTCAGGCAATATTTATAGAGGAAATAATCAAAATGGAGAGGCATCAAAAGTTTCAGAAAATA
TTGGCAAATCTAATTTAAATTGGGATAATTTATTTTCTTTAGCGGAAAACTGTGGGCAGGCATTCCTCCCTTCATATCTG
CCTATTATTGAAAAAAGAGCTAATAAAACATATACATCAAAAGAAAGAGAATTCCAGCTATATCGAAGAGGTAGATATGT
CGAATTCAATTTAGTTTGGGATAGAGGGACAATTTTTGGATTACAAACAAACGGGAGGACTGAATCAATATTAATGTCAT
TACCACCTTTAGCCAGATGGGAGTATGGATATAAAGCTAAAAAGGGTTCTAGAGAGGAATTTCTTACATCAATCTTTACA
AAACCGCAAGATTGGTTAAATGATAAAGATTTAGAAAATTTCTGTATGGAGAATAATATTTTTGATTAA

Upstream 100 bases:

>100_bases
CGAACTATCAAATAATAGGAAATAAGGTCCCCCTAAGAGAAATTATAAAGGGAAACTTATAATTAACCAAAAAAAATTTT
CTTCAAGATTTACTAAATAC

Downstream 100 bases:

>100_bases
AAATTATCGAATTACTTTGGAATTTATCTTAAATAGGAGTTTTAAATAAAGAGCCGTCGCTTTTCAATTGAAGTTTTTCT
CCAAGTTCATTTTCTAAAGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MLKEPPKNSREKTKNLLLTLQDKICSGLENIDGKGKFTEESWLRDEGGGGRSRVLKNGSIFEQAGVNFSEVQGKELPQSI
ISQRPEAKGHEWFATGTSMVLHPKNPFIPTVHLNYRYFEAGPVWWFGGGADLTPFYPYLSDVRNFHKEHKKACEKVDKDL
HKVFKPWCDEYFFLKHRNESRGIGGIFYDYQDGSGNIYRGNNQNGEASKVSENIGKSNLNWDNLFSLAENCGQAFLPSYL
PIIEKRANKTYTSKEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKAKKGSREEFLTSIFT
KPQDWLNDKDLENFCMENNIFD

Sequences:

>Translated_342_residues
MLKEPPKNSREKTKNLLLTLQDKICSGLENIDGKGKFTEESWLRDEGGGGRSRVLKNGSIFEQAGVNFSEVQGKELPQSI
ISQRPEAKGHEWFATGTSMVLHPKNPFIPTVHLNYRYFEAGPVWWFGGGADLTPFYPYLSDVRNFHKEHKKACEKVDKDL
HKVFKPWCDEYFFLKHRNESRGIGGIFYDYQDGSGNIYRGNNQNGEASKVSENIGKSNLNWDNLFSLAENCGQAFLPSYL
PIIEKRANKTYTSKEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKAKKGSREEFLTSIFT
KPQDWLNDKDLENFCMENNIFD
>Mature_342_residues
MLKEPPKNSREKTKNLLLTLQDKICSGLENIDGKGKFTEESWLRDEGGGGRSRVLKNGSIFEQAGVNFSEVQGKELPQSI
ISQRPEAKGHEWFATGTSMVLHPKNPFIPTVHLNYRYFEAGPVWWFGGGADLTPFYPYLSDVRNFHKEHKKACEKVDKDL
HKVFKPWCDEYFFLKHRNESRGIGGIFYDYQDGSGNIYRGNNQNGEASKVSENIGKSNLNWDNLFSLAENCGQAFLPSYL
PIIEKRANKTYTSKEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKAKKGSREEFLTSIFT
KPQDWLNDKDLENFCMENNIFD

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=338, Percent_Identity=40.8284023668639, Blast_Score=267, Evalue=1e-71,
Organism=Escherichia coli, GI1788777, Length=325, Percent_Identity=49.5384615384615, Blast_Score=328, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6320249, Length=341, Percent_Identity=43.4017595307918, Blast_Score=269, Evalue=4e-73,
Organism=Drosophila melanogaster, GI17864388, Length=333, Percent_Identity=44.1441441441441, Blast_Score=278, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 39538; Mature: 39538

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKEPPKNSREKTKNLLLTLQDKICSGLENIDGKGKFTEESWLRDEGGGGRSRVLKNGSI
CCCCCCCCHHHHHHHHHEEEHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCHHHEECCCCC
FEQAGVNFSEVQGKELPQSIISQRPEAKGHEWFATGTSMVLHPKNPFIPTVHLNYRYFEA
HHHHCCCHHHHCCHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCEEEEEEEEEEC
GPVWWFGGGADLTPFYPYLSDVRNFHKEHKKACEKVDKDLHKVFKPWCDEYFFLKHRNES
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCC
RGIGGIFYDYQDGSGNIYRGNNQNGEASKVSENIGKSNLNWDNLFSLAENCGQAFLPSYL
CCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
PIIEKRANKTYTSKEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARW
HHHHHHCCCCCCCHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCCCHHHEEECCCHHHC
EYGYKAKKGSREEFLTSIFTKPQDWLNDKDLENFCMENNIFD
CCCCCCCCCCHHHHHHHHHCCCHHHCCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MLKEPPKNSREKTKNLLLTLQDKICSGLENIDGKGKFTEESWLRDEGGGGRSRVLKNGSI
CCCCCCCCHHHHHHHHHEEEHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCHHHEECCCCC
FEQAGVNFSEVQGKELPQSIISQRPEAKGHEWFATGTSMVLHPKNPFIPTVHLNYRYFEA
HHHHCCCHHHHCCHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCEEEEEEEEEEC
GPVWWFGGGADLTPFYPYLSDVRNFHKEHKKACEKVDKDLHKVFKPWCDEYFFLKHRNES
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCC
RGIGGIFYDYQDGSGNIYRGNNQNGEASKVSENIGKSNLNWDNLFSLAENCGQAFLPSYL
CCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
PIIEKRANKTYTSKEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARW
HHHHHHCCCCCCCHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCCCHHHEEECCCHHHC
EYGYKAKKGSREEFLTSIFTKPQDWLNDKDLENFCMENNIFD
CCCCCCCCCCHHHHHHHHHCCCHHHCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA