Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 78779836

GI number: 78779836

Start: 1363289

End: 1364875

Strand: Reverse

Name: serA [H]

Synonym: PMT9312_1452

Alternate gene names: 78779836

Gene position: 1364875-1363289 (Counterclockwise)

Preceding gene: 78779841

Following gene: 78779835

Centisome position: 79.85

GC content: 37.24

Gene sequence:

>1587_bases
ATGACAAAAGTTCTCATTACAGATCCAATTGATCAAACAGGAATTGATATTCTTTCACAGGTAGCGCAAGTAGATCAGCG
AATAGGAATCTCAAACTCTGAATTGGCATCAATTATCAAAGAATATGATGCCCTAATGATACGATCTGGCACTCAAGTGA
CTGAAGAAATTATTAACTCTTCAAATAAACTGAGGATTATTGGAAGAGCAGGAGTAGGAGTTGATAATGTAGATGTTAAA
GCTGCTACACAAAAAGGGGTTCTTGTTGTTAATTCGCCAGGAGGAAATACTATTGCTGCTGCTGAACACACCATAGCTAT
GATGTTGGCCTTATCTAGAAATATTCCAATAGCTAATAGTAGTACTTTGTTAGGTAAATGGGAGAGAAAGAAATTTGTTG
GTAATGAGCTTTATAAGAAAAAGTTAGGAGTCGTAGGTTTAGGGAAAATTGGTGCTCATGTAGCTAAAGTTGCCAATGCA
TTAGGAATGGAAGTTTACGGATATGATCCCTTTGTTTCAACTGAAAGAGCTCAACAAATAAAAGTTAAACTATCTGAATT
AGATGACCTATTCCAACAATCAGATTATGTAACTTTGCATTTACCTCGCACACCAGAGACAGAGAATTTAGTAAATATGA
AGGTGCTTAAAAGTATGAAAAGTAGCGCAAAGTTAATTAATTGTGCTCGAGGAGGTTTAATTGACGAAGAAGCATTAGCA
GAAGCTTTAAATCAATCCTTCATTGGAGGAGCAGCAATAGATGTCTTTTCTAAAGAACCTTTGGAATCTGATTCACCACT
TCTGCAAGTTGAAAAGAATCTTATTCTTACACCTCATTTAGGAGCATCTACTCGGGAAGCACAAGAAAATGTAGCTGTTG
ATGTTGCCGAACAAATAAGAGATGTATTGCTTGGTTTATCGGCTAGAACTGCCGTTAATATTCCTGGTTTAAGTCCTGAT
ATTATGGATAGCCTTAAGCCTCATTTACAGTTAGCAGAAACGATGGGACTTCTTGTAAGTCAGCTTGCAGGAGGACAGAT
TCAAAAATTAGAGGTAAAGCTTCAAGGTGAATTTGTTCAACATCCTTCCCAGCCATTAATAATTGCCAGTCTAAAAGGCC
TTCTAAGTAAAGCTTTGGGAGATAGGATCAATTATGTGAATGCTTCTCTAGAAGCAGATTCTAGGGGCATTTCAGTCGTT
GAGAGTAAAGATGAGGCAAGACCTGAATTTGCTAGTGGATCGCTTCAGTTAACTACTTATGGAGATAATGGAGACCATAG
CGTAGCGGGAAGCATTTTTGCTGATGGAGAATTAAGAATTATTAGTATTGATCAATACCCAGTAAACGTATCACCAAGCA
GATATATGTTGGTTACTAGGCATAGAGATATGCCTGGTATTATTGGCAAGCTGGGTTCTTTATTGGGTAGCAACAATGTA
AATATTGCCTCCATGCAAGTTGGGCGCAAAATTGTTAGAGGAGAAGCTGTTATGGTTTTAAGTATTGATGATCCAATACC
TAATAAGTTGCTTGACACCATTATTGAAGTAGAGGGAATTACTAGCGCTAATCCAGTTACTTTATAA

Upstream 100 bases:

>100_bases
AAGTTCATTCCTCAAATGTTTGTGTTTTATTCAAATTAATAAAATAAGATATAACTACTATAGATTAAGTTAAAGTAAAA
GATTAAAGAACAACTCGTAA

Downstream 100 bases:

>100_bases
AAAGTCTGACTAACTATAATGGCGAGTAAAGATTGGTATAAACTAAACTTTCAGATAGAAAGTGATTTAGAAGAAATTAT
TATTTGGAAATTAAATGAGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MTKVLITDPIDQTGIDILSQVAQVDQRIGISNSELASIIKEYDALMIRSGTQVTEEIINSSNKLRIIGRAGVGVDNVDVK
AATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRNIPIANSSTLLGKWERKKFVGNELYKKKLGVVGLGKIGAHVAKVANA
LGMEVYGYDPFVSTERAQQIKVKLSELDDLFQQSDYVTLHLPRTPETENLVNMKVLKSMKSSAKLINCARGGLIDEEALA
EALNQSFIGGAAIDVFSKEPLESDSPLLQVEKNLILTPHLGASTREAQENVAVDVAEQIRDVLLGLSARTAVNIPGLSPD
IMDSLKPHLQLAETMGLLVSQLAGGQIQKLEVKLQGEFVQHPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVV
ESKDEARPEFASGSLQLTTYGDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNV
NIASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVEGITSANPVTL

Sequences:

>Translated_528_residues
MTKVLITDPIDQTGIDILSQVAQVDQRIGISNSELASIIKEYDALMIRSGTQVTEEIINSSNKLRIIGRAGVGVDNVDVK
AATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRNIPIANSSTLLGKWERKKFVGNELYKKKLGVVGLGKIGAHVAKVANA
LGMEVYGYDPFVSTERAQQIKVKLSELDDLFQQSDYVTLHLPRTPETENLVNMKVLKSMKSSAKLINCARGGLIDEEALA
EALNQSFIGGAAIDVFSKEPLESDSPLLQVEKNLILTPHLGASTREAQENVAVDVAEQIRDVLLGLSARTAVNIPGLSPD
IMDSLKPHLQLAETMGLLVSQLAGGQIQKLEVKLQGEFVQHPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVV
ESKDEARPEFASGSLQLTTYGDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNV
NIASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVEGITSANPVTL
>Mature_527_residues
TKVLITDPIDQTGIDILSQVAQVDQRIGISNSELASIIKEYDALMIRSGTQVTEEIINSSNKLRIIGRAGVGVDNVDVKA
ATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRNIPIANSSTLLGKWERKKFVGNELYKKKLGVVGLGKIGAHVAKVANAL
GMEVYGYDPFVSTERAQQIKVKLSELDDLFQQSDYVTLHLPRTPETENLVNMKVLKSMKSSAKLINCARGGLIDEEALAE
ALNQSFIGGAAIDVFSKEPLESDSPLLQVEKNLILTPHLGASTREAQENVAVDVAEQIRDVLLGLSARTAVNIPGLSPDI
MDSLKPHLQLAETMGLLVSQLAGGQIQKLEVKLQGEFVQHPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVVE
SKDEARPEFASGSLQLTTYGDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNVN
IASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVEGITSANPVTL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=410, Percent_Identity=40.4878048780488, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI61743967, Length=271, Percent_Identity=36.1623616236162, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI4557497, Length=271, Percent_Identity=36.1623616236162, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI145580578, Length=288, Percent_Identity=34.375, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI4557499, Length=288, Percent_Identity=34.375, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI145580575, Length=288, Percent_Identity=34.375, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI6912396, Length=311, Percent_Identity=27.3311897106109, Blast_Score=123, Evalue=4e-28,
Organism=Escherichia coli, GI1789279, Length=323, Percent_Identity=35.9133126934984, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI87082289, Length=288, Percent_Identity=32.6388888888889, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=35.7142857142857, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1788660, Length=288, Percent_Identity=30.2083333333333, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87081824, Length=158, Percent_Identity=31.6455696202532, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=324, Percent_Identity=42.5925925925926, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI25147481, Length=300, Percent_Identity=29, Blast_Score=125, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6322116, Length=333, Percent_Identity=33.9339339339339, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320925, Length=326, Percent_Identity=34.0490797546012, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324964, Length=250, Percent_Identity=30, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=27.5720164609054, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6321253, Length=155, Percent_Identity=34.1935483870968, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=191, Percent_Identity=27.7486910994764, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325144, Length=171, Percent_Identity=27.4853801169591, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=41, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24646446, Length=301, Percent_Identity=35.8803986710963, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646448, Length=301, Percent_Identity=35.8803986710963, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646452, Length=301, Percent_Identity=35.8803986710963, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646450, Length=301, Percent_Identity=35.8803986710963, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI62472511, Length=303, Percent_Identity=35.6435643564356, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=29.4871794871795, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI45551003, Length=327, Percent_Identity=27.82874617737, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28574284, Length=327, Percent_Identity=27.82874617737, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24585514, Length=327, Percent_Identity=27.82874617737, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI28574282, Length=327, Percent_Identity=27.82874617737, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI45552429, Length=327, Percent_Identity=27.82874617737, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI28574286, Length=331, Percent_Identity=29.3051359516616, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24585516, Length=311, Percent_Identity=26.6881028938907, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56628; Mature: 56497

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00287 CYSTATIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVLITDPIDQTGIDILSQVAQVDQRIGISNSELASIIKEYDALMIRSGTQVTEEIINS
CCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCHHHHHHHCC
SNKLRIIGRAGVGVDNVDVKAATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRNIPIANS
CCCEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHCCCCCCCC
STLLGKWERKKFVGNELYKKKLGVVGLGKIGAHVAKVANALGMEVYGYDPFVSTERAQQI
CCHHCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHH
KVKLSELDDLFQQSDYVTLHLPRTPETENLVNMKVLKSMKSSAKLINCARGGLIDEEALA
HHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
EALNQSFIGGAAIDVFSKEPLESDSPLLQVEKNLILTPHLGASTREAQENVAVDVAEQIR
HHHHHHHCCCCEEECCCCCCCCCCCCCEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHH
DVLLGLSARTAVNIPGLSPDIMDSLKPHLQLAETMGLLVSQLAGGQIQKLEVKLQGEFVQ
HHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECHHHC
HPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVVESKDEARPEFASGSLQLTTY
CCCCCCHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEC
GDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNV
CCCCCCCEECEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCC
NIASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVEGITSANPVTL
EEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TKVLITDPIDQTGIDILSQVAQVDQRIGISNSELASIIKEYDALMIRSGTQVTEEIINS
CEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCHHHHHHHCC
SNKLRIIGRAGVGVDNVDVKAATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRNIPIANS
CCCEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHCCCCCCCC
STLLGKWERKKFVGNELYKKKLGVVGLGKIGAHVAKVANALGMEVYGYDPFVSTERAQQI
CCHHCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHH
KVKLSELDDLFQQSDYVTLHLPRTPETENLVNMKVLKSMKSSAKLINCARGGLIDEEALA
HHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
EALNQSFIGGAAIDVFSKEPLESDSPLLQVEKNLILTPHLGASTREAQENVAVDVAEQIR
HHHHHHHCCCCEEECCCCCCCCCCCCCEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHH
DVLLGLSARTAVNIPGLSPDIMDSLKPHLQLAETMGLLVSQLAGGQIQKLEVKLQGEFVQ
HHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECHHHC
HPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVVESKDEARPEFASGSLQLTTY
CCCCCCHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEC
GDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNV
CCCCCCCEECEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCC
NIASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVEGITSANPVTL
EEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]