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The map label for this gene is manC [H]

Identifier: 78779713

GI number: 78779713

Start: 1244072

End: 1244410

Strand: Direct

Name: manC [H]

Synonym: PMT9312_1329

Alternate gene names: 78779713

Gene position: 1244072-1244410 (Clockwise)

Preceding gene: 78779710

Following gene: 78779714

Centisome position: 72.79

GC content: 30.38

Gene sequence:

>339_bases
ATGCCTAAAATAGAAAATAAACCTTGGGGAACTTTTGAAAACATATTGGATGAAACTTATTGTAAGGTTAAAAGGATAAT
TATTAAACCGGGTGAAAGGCCAAGCTACCAATATCATTATAAAAGAAGTGAGCATTGGATAATTGTTAGTGGTTCAGCAA
AAGTCACTCTAGAAGGTGAAGAAAAAGAATTTTCAGTTGGGGATTATATTTATATCCCTCTTAAGGCAAAACATAGGGTA
GAAAATATTGGAAAGAATGATTTAATTTTTATTGAAATTCAGACAGGGCAATATTTTGGAGAAGATGACATTGTAAGAGT
ATCAAATGATTATGTTTAA

Upstream 100 bases:

>100_bases
GGGATTATTGTTACAATTACAATATAAAATTAAATTATTAATAAGCAATTATTGGTATTCTATATTTTAATAATAGAATT
TAAAAAATTATTTTTAGTTA

Downstream 100 bases:

>100_bases
GTAGTTATTAAGTAAGGTTTTGAGGCTATAATATTGTTTGAAGATTAACAGCTTGATGGCTTTACCAAAGATATATATAG
GGCCAATAAGTAAAAATTGT

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 112; Mature: 111

Protein sequence:

>112_residues
MPKIENKPWGTFENILDETYCKVKRIIIKPGERPSYQYHYKRSEHWIIVSGSAKVTLEGEEKEFSVGDYIYIPLKAKHRV
ENIGKNDLIFIEIQTGQYFGEDDIVRVSNDYV

Sequences:

>Translated_112_residues
MPKIENKPWGTFENILDETYCKVKRIIIKPGERPSYQYHYKRSEHWIIVSGSAKVTLEGEEKEFSVGDYIYIPLKAKHRV
ENIGKNDLIFIEIQTGQYFGEDDIVRVSNDYV
>Mature_111_residues
PKIENKPWGTFENILDETYCKVKRIIIKPGERPSYQYHYKRSEHWIIVSGSAKVTLEGEEKEFSVGDYIYIPLKAKHRVE
NIGKNDLIFIEIQTGQYFGEDDIVRVSNDYV

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0662

COG function: function code G; Mannose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=105, Percent_Identity=46.6666666666667, Blast_Score=106, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 13157; Mature: 13026

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKIENKPWGTFENILDETYCKVKRIIIKPGERPSYQYHYKRSEHWIIVSGSAKVTLEGE
CCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCEEEEEECCCEEEEEECCEEEEEECC
EKEFSVGDYIYIPLKAKHRVENIGKNDLIFIEIQTGQYFGEDDIVRVSNDYV
CCEEECCCEEEEEECCCCHHHCCCCCCEEEEEEECCCEECCCCEEEECCCCC
>Mature Secondary Structure 
PKIENKPWGTFENILDETYCKVKRIIIKPGERPSYQYHYKRSEHWIIVSGSAKVTLEGE
CCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCEEEEEECCCEEEEEECCEEEEEECC
EKEFSVGDYIYIPLKAKHRVENIGKNDLIFIEIQTGQYFGEDDIVRVSNDYV
CCEEECCCEEEEEECCCCHHHCCCCCCEEEEEEECCCEECCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]