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The map label for this gene is dxr

Identifier: 78779621

GI number: 78779621

Start: 1153915

End: 1155141

Strand: Direct

Name: dxr

Synonym: PMT9312_1238

Alternate gene names: 78779621

Gene position: 1153915-1155141 (Clockwise)

Preceding gene: 78779620

Following gene: 78779623

Centisome position: 67.51

GC content: 35.62

Gene sequence:

>1227_bases
TTGAAATACATTACTGTTCTCGGTTCTACTGGTTCAATAGGGACTCAGACTCTCGAAATAGCTAGTGAGCAGCCTGATAA
GTTTAAAGCCGTAGCTCTTTCGGCAGGACGAAATATTACTTTATTAACTGAACAAGTTAAAACACATAAACCAGAAGTAG
TTGCAATTGAGGATGAAAATCTTATAGAAGATTTAAAAGATAATATTAATAACTTAGATTTGGATAGTGCTCCCTTGGTT
TTGGGTGGAAAGGAGGGGATTAACGCAGTTGCAGCTTGGGATAAGGCAGATACAGTTATAACCGGGATAGTAGGATGTGC
AGGCTTAATTCCAACAATGTCAGCAATTAATGCGGGGAAAAATATTGCCCTTGCTAACAAAGAAACTTTAATTGCAGCAG
GGCCAATTGTTATTCCTGCATTAAAGAAAAATAATAGTAGGCTTTTACCTGCTGATTCAGAACACTCTGCTATCTTTCAA
TGCTTACAAGGATTACCTAATTATGAAAATGCAGATTTTTCAACAGGAGTGATGCCTAAGGGTTTAAAAGCCATACATTT
AACAGCTTCTGGTGGTGCTTTCAGAGATTGGCCCGTTGAGAATTTAAAGCATGTCACAGTGGAAGATGCGACTTCACATC
CTAATTGGGATATGGGAAAAAAAATAACTGTAGATTCTGCAACTCTTATGAATAAAGGATTAGAAGTTATAGAAGCTCAT
TATTTATTTGGGACCTCTTACGAAAATATCGAAATAGTTATTCACCCTCAAAGTATTATTCATTCAATGATTGAGATGGA
AGATTCTTCAGTATTAGCTCAATTAGGTTGGCCAGATATGAAGCTACCTATTTTATATGCGATGAGTTGGCCTGAAAGGT
TTAAAACAAATTGGAAAAGATTAAACCTAAGTGAAATTGGAAAATTAACTTTTAAAGAGCCAGACGAGTTTAAATATCCA
TGCATGGGACTTGCTTATGCCGCAGGAAAATCTTCAGGGACTATGCCTGCAGTCTTAAATGCTGCTAACGAAATGGCTGT
TGAACAATTCCTTAAAGAAAAAATTTCTTTTCAAGAAATTCCAACATTTATAAGTAAAGCTTGTGAATCACATATGGAGA
ATTTGAATTTGAGTCCCGAATTGGAGGATATTCTTGAAGTGGATAATTGGGCCAGAATTTTCGTTAAGCAAGAAATAAAA
AAAGGGAAAAAATACGTAAGTATTTGA

Upstream 100 bases:

>100_bases
ACATGGATAAGGGTCTAAATTTTAAGAAAAAACCCAATTTGAAATTTTTGTTTTTTAAATACACCTTTAAGTGGGAAGAT
ATTAGAAATATCAGAGAAAA

Downstream 100 bases:

>100_bases
TAAAAGTGAATATAAAAAAGGAATTAACTGACCAAACCTTTTTTAATACTATTAGATAACTCAAGTGTTTCTATTAGTGG
GATTAGGAAGTAAGCGTCTC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MKYITVLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNITLLTEQVKTHKPEVVAIEDENLIEDLKDNINNLDLDSAPLV
LGGKEGINAVAAWDKADTVITGIVGCAGLIPTMSAINAGKNIALANKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQ
CLQGLPNYENADFSTGVMPKGLKAIHLTASGGAFRDWPVENLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAH
YLFGTSYENIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKRLNLSEIGKLTFKEPDEFKYP
CMGLAYAAGKSSGTMPAVLNAANEMAVEQFLKEKISFQEIPTFISKACESHMENLNLSPELEDILEVDNWARIFVKQEIK
KGKKYVSI

Sequences:

>Translated_408_residues
MKYITVLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNITLLTEQVKTHKPEVVAIEDENLIEDLKDNINNLDLDSAPLV
LGGKEGINAVAAWDKADTVITGIVGCAGLIPTMSAINAGKNIALANKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQ
CLQGLPNYENADFSTGVMPKGLKAIHLTASGGAFRDWPVENLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAH
YLFGTSYENIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKRLNLSEIGKLTFKEPDEFKYP
CMGLAYAAGKSSGTMPAVLNAANEMAVEQFLKEKISFQEIPTFISKACESHMENLNLSPELEDILEVDNWARIFVKQEIK
KGKKYVSI
>Mature_408_residues
MKYITVLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNITLLTEQVKTHKPEVVAIEDENLIEDLKDNINNLDLDSAPLV
LGGKEGINAVAAWDKADTVITGIVGCAGLIPTMSAINAGKNIALANKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQ
CLQGLPNYENADFSTGVMPKGLKAIHLTASGGAFRDWPVENLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAH
YLFGTSYENIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKRLNLSEIGKLTFKEPDEFKYP
CMGLAYAAGKSSGTMPAVLNAANEMAVEQFLKEKISFQEIPTFISKACESHMENLNLSPELEDILEVDNWARIFVKQEIK
KGKKYVSI

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=403, Percent_Identity=43.1761786600496, Blast_Score=319, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_PROM9 (Q319Z8)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_397733.1
- ProteinModelPortal:   Q319Z8
- SMR:   Q319Z8
- STRING:   Q319Z8
- GeneID:   3766045
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_1238
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   PMAR74546:PMT9312_1238-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 44736; Mature: 44736

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: BINDING 127-127 BINDING 154-154 BINDING 190-190 BINDING 213-213 BINDING 235-235

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYITVLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNITLLTEQVKTHKPEVVAIEDEN
CEEEEEEECCCCCCCEEEEECCCCCCCEEEEEEECCCCEEEEEHHHHCCCCCEEEECCHH
LIEDLKDNINNLDLDSAPLVLGGKEGINAVAAWDKADTVITGIVGCAGLIPTMSAINAGK
HHHHHHHCCCCCCCCCCCEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCC
NIALANKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQCLQGLPNYENADFSTGVMPK
CEEEECCCEEEEECCEEEEEEECCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
GLKAIHLTASGGAFRDWPVENLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAH
CCEEEEEEECCCCCCCCCHHCCEEEEEECCCCCCCCCCCCEEEECHHHHHHCCHHHHEEH
YLFGTSYENIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKR
HEECCCCCCEEEEECCHHHHHHHHHCCCCHHHHCCCCCCCCCEEEEEECCCHHHHCCHHE
LNLSEIGKLTFKEPDEFKYPCMGLAYAAGKSSGTMPAVLNAANEMAVEQFLKEKISFQEI
ECHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHH
PTFISKACESHMENLNLSPELEDILEVDNWARIFVKQEIKKGKKYVSI
HHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKYITVLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNITLLTEQVKTHKPEVVAIEDEN
CEEEEEEECCCCCCCEEEEECCCCCCCEEEEEEECCCCEEEEEHHHHCCCCCEEEECCHH
LIEDLKDNINNLDLDSAPLVLGGKEGINAVAAWDKADTVITGIVGCAGLIPTMSAINAGK
HHHHHHHCCCCCCCCCCCEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCC
NIALANKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQCLQGLPNYENADFSTGVMPK
CEEEECCCEEEEECCEEEEEEECCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
GLKAIHLTASGGAFRDWPVENLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAH
CCEEEEEEECCCCCCCCCHHCCEEEEEECCCCCCCCCCCCEEEECHHHHHHCCHHHHEEH
YLFGTSYENIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKR
HEECCCCCCEEEEECCHHHHHHHHHCCCCHHHHCCCCCCCCCEEEEEECCCHHHHCCHHE
LNLSEIGKLTFKEPDEFKYPCMGLAYAAGKSSGTMPAVLNAANEMAVEQFLKEKISFQEI
ECHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHH
PTFISKACESHMENLNLSPELEDILEVDNWARIFVKQEIKKGKKYVSI
HHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA