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The map label for this gene is btuE [H]

Identifier: 78779400

GI number: 78779400

Start: 938437

End: 938916

Strand: Direct

Name: btuE [H]

Synonym: PMT9312_1016

Alternate gene names: 78779400

Gene position: 938437-938916 (Clockwise)

Preceding gene: 78779396

Following gene: 78779403

Centisome position: 54.9

GC content: 33.54

Gene sequence:

>480_bases
ATGCAAGTTGACGTACAAAATACTACTGTTTTTTCAGCAGATGGATCATCTATAAAACTTGGTCAATACTCAGGGGAAGT
AATTTTAGTGGTTAACGTAGCTAGTTATTGTGGGAATACTGCTCAGTATGAGGATCTTCAAAAGCTTCATGATTTATATT
CAAGCAAAGGGCTAAGAATACTTGCATTCCCATGTAATGATTTTGGTAAACAAGAACCAGGCTCACTTTCAGAAATAAAA
GATTTTTGTACCACAAAATATGGAGTTAAGTTTGAAATCTATGAAAAAGTTCATGCAAAAGGTGATACCACAGAACCATA
TACAACGCTTAATAAAGTTGAACCAGAGGGAGACGTTGAATGGAATTTCGAGAAGTTTCTAATAGGAAAAGATTGTAAAG
TAATTGCAAGATTCAAGCCAAGTGTTAAACCATTTGATGAAAACTTAATAGCAGCTATTGAAGTAGCTTTAGATTCATAA

Upstream 100 bases:

>100_bases
AAAACTTAAAACTTACAAAAGAAATAACACAAAATATTGAATATTTTAAACACAAAAAACGCTATACAATGTTATCTTCA
AAGGGTGATTTTTTTAAGAC

Downstream 100 bases:

>100_bases
AAATTTCCTTATAATTTACTAGAAAAATATTAAATCAAACAAACTTTATATTGAATCAAAAGATAGACAAAAATTTTGTC
GAAATAAATTTTGGAATAAA

Product: glutathione peroxidase

Products: glutathione disulfide; H2O

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MQVDVQNTTVFSADGSSIKLGQYSGEVILVVNVASYCGNTAQYEDLQKLHDLYSSKGLRILAFPCNDFGKQEPGSLSEIK
DFCTTKYGVKFEIYEKVHAKGDTTEPYTTLNKVEPEGDVEWNFEKFLIGKDCKVIARFKPSVKPFDENLIAAIEVALDS

Sequences:

>Translated_159_residues
MQVDVQNTTVFSADGSSIKLGQYSGEVILVVNVASYCGNTAQYEDLQKLHDLYSSKGLRILAFPCNDFGKQEPGSLSEIK
DFCTTKYGVKFEIYEKVHAKGDTTEPYTTLNKVEPEGDVEWNFEKFLIGKDCKVIARFKPSVKPFDENLIAAIEVALDS
>Mature_159_residues
MQVDVQNTTVFSADGSSIKLGQYSGEVILVVNVASYCGNTAQYEDLQKLHDLYSSKGLRILAFPCNDFGKQEPGSLSEIK
DFCTTKYGVKFEIYEKVHAKGDTTEPYTTLNKVEPEGDVEWNFEKFLIGKDCKVIARFKPSVKPFDENLIAAIEVALDS

Specific function: Not essential for B12 transport; however, it is an auxiliary component of the transport system [H]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=145, Percent_Identity=45.5172413793103, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI90903240, Length=145, Percent_Identity=45.5172413793103, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI90903238, Length=126, Percent_Identity=46.8253968253968, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI15618997, Length=129, Percent_Identity=39.5348837209302, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI192455698, Length=129, Percent_Identity=37.2093023255814, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI6006001, Length=148, Percent_Identity=39.1891891891892, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI33186887, Length=138, Percent_Identity=36.9565217391304, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI4557629, Length=145, Percent_Identity=35.8620689655172, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI41406084, Length=157, Percent_Identity=32.484076433121, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1788003, Length=181, Percent_Identity=39.7790055248619, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17535473, Length=160, Percent_Identity=39.375, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193210707, Length=170, Percent_Identity=37.6470588235294, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17506887, Length=147, Percent_Identity=39.4557823129252, Blast_Score=112, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71993584, Length=138, Percent_Identity=39.1304347826087, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17550320, Length=174, Percent_Identity=33.9080459770115, Blast_Score=93, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI193209493, Length=175, Percent_Identity=33.7142857142857, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71993573, Length=86, Percent_Identity=41.8604651162791, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193210709, Length=80, Percent_Identity=42.5, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71999642, Length=83, Percent_Identity=43.3734939759036, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319721, Length=135, Percent_Identity=45.1851851851852, Blast_Score=122, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322228, Length=135, Percent_Identity=42.962962962963, Blast_Score=115, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322826, Length=151, Percent_Identity=37.7483443708609, Blast_Score=107, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24656772, Length=145, Percent_Identity=37.9310344827586, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24656777, Length=145, Percent_Identity=37.9310344827586, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24656767, Length=145, Percent_Identity=37.9310344827586, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI85726443, Length=146, Percent_Identity=34.9315068493151, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: 1.11.1.9

Molecular weight: Translated: 17718; Mature: 17718

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVDVQNTTVFSADGSSIKLGQYSGEVILVVNVASYCGNTAQYEDLQKLHDLYSSKGLRI
CEEECCCCEEEECCCCEEEEECCCCCEEEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCEE
LAFPCNDFGKQEPGSLSEIKDFCTTKYGVKFEIYEKVHAKGDTTEPYTTLNKVEPEGDVE
EEECCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEEHHHCCCCCCCCCCHHCCCCCCCCCE
WNFEKFLIGKDCKVIARFKPSVKPFDENLIAAIEVALDS
ECCEEEEECCCCEEEEECCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MQVDVQNTTVFSADGSSIKLGQYSGEVILVVNVASYCGNTAQYEDLQKLHDLYSSKGLRI
CEEECCCCEEEECCCCEEEEECCCCCEEEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCEE
LAFPCNDFGKQEPGSLSEIKDFCTTKYGVKFEIYEKVHAKGDTTEPYTTLNKVEPEGDVE
EEECCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEEHHHCCCCCCCCCCHHCCCCCCCCCE
WNFEKFLIGKDCKVIARFKPSVKPFDENLIAAIEVALDS
ECCEEEEECCCCEEEEECCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutathione; H2O2

Specific reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3528129; 9097039; 9278503 [H]